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Metabolic reprogramming: a new option for the treatment of spinal cord injury

Neural Regeneration Research 2025年第4期20卷 1042-1057页

作者： Jiangjie Chen Jinyang Chen Chao Yu Kaishun Xia Biao Yang ronghao wang Yi Li Kesi Shi Yuang Zhang Haibin Xu Xuesong Zhang Jingkai wang Qixin Chen Chengzhen Liang Department of Orthopedics The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang ProvinceChina Orthopedics Research Institute of Zhejiang University Zhejiang UniversityHangzhouZhejiang ProvinceChina Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province HangzhouZhejiang ProvinceChina Clinical Research Center of Motor System Disease of Zhejiang Province HangzhouZhejiang ProvinceChina Qiandongnan Prefecture People’s Hospital KailiGuizhou ProvinceChina Department of Orthopedics Fourth Medical CenterChinese PLA General HospitalBeijingChina

Spinal cord injuries impose a notably economic burden on society,mainly because of the severe after-effects they *** the ongoing development of various therapies for spinal cord injuries,their effectiveness remains ***,a deeper understanding of metabolism has opened up a new therapeutic opportunity in the form of metabolic *** this review,we explore the metabolic changes that occur during spinal cord injuries,their consequences,and the therapeutic tools available for metabolic *** spinal cord metabolism is characterized by independent cellular metabolism and intercellular metabolic ***,spinal cord injury results in metabolic disorders that include disturbances in glucose metabolism,lipid metabolism,and mitochondrial *** metabolic disturbances lead to corresponding pathological changes,including the failure of axonal regeneration,the accumulation of scarring,and the activation of *** rescue spinal cord injury at the metabolic level,potential metabolic reprogramming approaches have emerged,including replenishing metabolic substrates,reconstituting metabolic couplings,and targeting mitochondrial therapies to alter cell *** available evidence suggests that metabolic reprogramming holds great promise as a next-generation approach for the treatment of spinal cord *** further advance the metabolic treatment of the spinal cord injury,future efforts should focus on a deeper understanding of neurometabolism,the development of more advanced metabolomics technologies,and the design of highly effective metabolic interventions.

关键词： axons glycolysis metabolic reprogramming metabolism mitochondria neural regeneration neuroprotection oxidative phosphorylation spinal cord injury therapy

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间歇通信下具有双层拓扑结构的多智能体系统一致性研究

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动力学与控制学报 2024年第7期22卷 13-18页

作者：段朝霞戴君邵振王荣浩河海大学人工智能与自动化学院南京210098 陆军工程大学国防工程学院南京210007

本文研究了在间歇通信机制下具有两层网络拓扑结构的多智能体系统一致性问题.首先,提出了一种在间歇通信机制下的一致性控制协议,通过建立网络结构模型和误差系统模型,将一致性问题等效转化为线性时滞系统的渐近稳定性问题.其次,利用Lya... 详细信息

本文研究了在间歇通信机制下具有两层网络拓扑结构的多智能体系统一致性问题.首先,提出了一种在间歇通信机制下的一致性控制协议,通过建立网络结构模型和误差系统模型,将一致性问题等效转化为线性时滞系统的渐近稳定性问题.其次,利用Lyapunov-Krasovskii泛函分析方法,导出了多智能体网络在间歇通信机制下达到一致性的充分条件,结论以一组LMI形式给出.最后,通过仿真算例验证了该方法的有效性.

关键词：多智能体系统间歇通信双层拓扑结构一致性

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含执行器故障的切换非线性系统的事件触发自适应模糊容错控制

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动力学与控制学报 2024年第1期22卷 69-78页

作者：王芳李实王荣浩南京师范大学电气与自动化工程学院南京210023 陆军工程大学国防工程学院南京210007

本文研究在平均驻留时间约束下,一类含有执行器故障的切换非线性系统输出反馈自适应模糊事件触发容错控制问题.首先,建立了一个模态依赖的状态观测器估计不可测量状态.利用模糊逻辑系统来逼近未知项.其次,构建自适应模糊容错事件触发控... 详细信息

本文研究在平均驻留时间约束下,一类含有执行器故障的切换非线性系统输出反馈自适应模糊事件触发容错控制问题.首先,建立了一个模态依赖的状态观测器估计不可测量状态.利用模糊逻辑系统来逼近未知项.其次,构建自适应模糊容错事件触发控制方案能够节省网络资源和数据传输.然后,通过构造多Lyapunov函数和平均驻留时间法,证明闭环系统所有状态半全局一致最终有界的同时排除了Zeno现象.最后,通过数值仿真验证该方法的有效性.

关键词：事件触发控制切换非线性系统输出反馈平均驻留时间执行器故障

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A High-Throughput Phenotyping Pipeline for Image Processing and Functional Growth Curve Analysis

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Plant Phenomics 2020年第1期2卷 188-195页

作者： ronghao wang Yumou Qiu Yuzhen Zhou Zhikai Liang James C.Schnable Department of Statistics University of Nebraska-LincolnLincoln 68503USA Department of Statistics Iowa State UniversityAmes 50011USA Department of Plant and Microbial Biology University of MinnesotaSaint PaulMN 55108USA Center for Plant Science Innovation Department of Agronomy and HorticultureUniversity of Nebraska-LincolnLincoln 68503USA

High-throughput phenotyping system has become more and more popular in plant science *** data analysis for such a system typically involves two steps:plant feature extraction through image processing and statistical analysis for the extracted *** current approach is to perform those two steps on different *** develop the package“implant”in R for both robust feature extraction and functional data *** image processing,the“implant”package provides methods including thresholding,hidden Markov random field model,and morphological *** statistical analysis,this package can produce nonparametric curve fitting with its confidence region for plant growth.A functional ANOVA model to test for the treatment and genotype effects on the plant growth dynamics is also provided.

关键词： steps image operations

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INTERFERENCE ESTIMATION AND ITS APPLICATIONS IN COGNITIVE RADIO NETWORKS

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Journal of Electronics(China) 2010年第5期27卷 630-638页

作者： Chen ronghao Chen Wei wang Jun Li Shaoqian National key Laboratory of Science and Technology on Communications University of Electronic Science and Technology of ChinaChengdu 61173China

Cognitive Radio(CR) has been proposed as a system-level means to improve the spectrum utilization *** most significant premise for CR networks is to avoid harmful interference to the licensed ***,it is very important to estimate the potential inter-ference introduced by the deployment of CR networks so that CR networks can be coexistence with Licensed User(LU) networks by designing proper system *** this paper,two statistical models of potential interference due to CR networks are developed based on transmitter and receiver oriented spectrum sensing schemes,*** approximate probability dis-tributions of aggregate interference introduced by CR networks are then derived with respect to the obtained *** the help of these probability distributions,a method is further pre-sented to get the critical system parameter,i.e.,sensing distance and user density of the CR networks,so that the introduced interference can be controlled to predefined *** results validate the proposed interference estimation method and confirm the effectiveness of in-terference distribution based system parameter design.

关键词： Cognitive Radio (CR) Spectrum sensing Interference estimation

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A convenient method for measuring gas-liquid volumetric mass transfer coefficient in micro reactors

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Chinese Chemical Letters 2024年第4期35卷 389-392页

作者： Haoyang wang ronghao Zhang Yanlun Ren Li Zhang School of Mechanical and Power Engineering East China University of Science and TechnologyShanghai 200237China

The research on gas-liquid multiphase reactions using micro reactors is becoming increasingly widespread, given their excellent mass transfer performance. Establishing an accurate and reliable method to measure the gas-liquid mass transfer performance of micro reactors is crucial for evaluating and optimizing the design of micro reactor structure. In this paper, the physical absorption method of aqueous solution-CO_(2) and the chemical absorption method of sodium carbonate solution-CO_(2) were proposed. By analyzing the chemical reaction equilibrium during the absorption process, the relationship between the mass transfer of CO_(2) and the solubility of hydroxide ions in the solution was established, and the total gas-liquid mass transfer coefficient was immediately obtained by measuring the p H value. The corresponding testing platform and process have been established based on the characteristics of the proposed method to ensure fast and accurate measurement. In addition, the chemical absorption method takes into account temperature factors that were not previously considered. The volumetric mass transfer coefficient measured by these two methods is in the same range as those measured by other methods using the same microchannel structure in previous literature. The methods have the advantages of low equipment cost, faster measurement speed, and simpler procedures, which can facilitate its wide application to the evaluation of the mass transfer performance and hence can guide the structure optimization of microchannel reactors.

关键词： Volumetric mass transfer coefficient measurement Gas-liquid two phase Micro reactors Physical absorption Chemical absorption

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An Improved MAC Protocol for Underwater Acoustic Networks

An Improved MAC Protocol for Underwater Acoustic Networks

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第25届中国控制与决策会议

作者： wang Ping Fu Donghao Xing Jianchun Yang Qiliang wang ronghao Wu Wenhao The PLA University of Science and Technology Urumuqi Urban construction Archives

ISBN: (纸本)9781467355339

Considering the particularity of underwater acoustic channel and the performance of underwater acoustic sensor networks, this paper presents a MAC layer protocol based on CDMA with throughput adaptive regulation and energy-efficient （TAEE-CDMA） protocol. On the premise that the MAI problem was suppressed, the protocol firstly used Lagrange multiplier method to make the node run with minimum energy consumption, then adjusted the transmit power of node to change the throughput size according to the dynamic changes of the node cache queue, which can ensure the monitoring task of network be completed and make the network run with optimal performance. The analysis and simulation results showed that the protocol had advantages of energy-efficient, real-time and high reliability.

关键词： Underwater Acoustic Network Throughput Energy-efficient Adaptive Regulation MAC

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普通烟草HSP20基因家族成员鉴定及表达分析

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中国烟草学报 2024年第4期30卷 74-83页

作者：赵泽玉杜甫李子玮王琰琰王荣浩施友志孙晋浩田震赵清海管恩森孙刚王大海王朔李志远湖北中烟工业有限责任公司湖北省武汉市430040 中国农业科学院烟草研究所山东省青岛市266101 江苏中烟工业有限责任公司技术中心江苏省南京市210019 山东潍坊烟草有限公司山东省潍坊市261031

【背景和目的】热休克蛋白20(Heat Shock Protein 20,HSP20)是一个重要的蛋白质家族,在植物生长发育及抗逆胁迫中发挥重要作用,目前HSP20基因在烟草中还未有广泛的研究。【方法】通过茄科数据库,利用生物信息学分析手段,确定普通烟草中H... 详细信息

【背景和目的】热休克蛋白20(Heat Shock Protein 20,HSP20)是一个重要的蛋白质家族,在植物生长发育及抗逆胁迫中发挥重要作用,目前HSP20基因在烟草中还未有广泛的研究。【方法】通过茄科数据库,利用生物信息学分析手段,确定普通烟草中HSP20家族成员并进行相关分析。【结果】在烟草中鉴定得到了58个HSP20家族基因,进化分析将其划分为13个亚家族,分布在13条染色体上;共线性分析表明烟草中有5对基因存在染色体片段复制;顺式作用元件分析表明NtHSP20成员上游存在生长发育、胁迫响应等多种顺式作用元件;HSP20家族基因具有显著的组织特异表达性,在根、茎中基因表达数量和表达水平较明显,在花中的表达数量和表达水平较低;qRT-PCR分析表明NtHSP20家族部分成员对干旱胁迫具有特异性响应,且在不同的胁迫阶段不同基因表达量有显著差异。【结论】该研究为后续烟草HSP20家族生长发育和抗逆胁迫等机理研究奠定了基础。

关键词：烟草 NtHSP20 进化分析抗逆胁迫表达分析

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Finite-time Reliable Stabilization for Switched Stochastic Systems Under Asynchronous Switching 25th

Finite-time Reliable Stabilization for Switched Stochastic S...

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第25届中国控制与决策会议

作者： wang ronghao Qian Zhigen Xing Jianchun wang Ping Yang Qiliang College of Defense Engineering PLA University of Science and Technology PLA Academy of National Defense Information

ISBN: (纸本)9781467355339

In this paper, the finite-time stabilization problems for switched stochastic systems are addressed. Firstly, when there exists asynchronous switching between the controller and the system, a sufficient condition for the existence of stabilizing switching law for switched stochastic systems is derived. It is proved that the switched stochastic systems are finite-time stabilizable under asynchronous switching satisfying the average dwell-time condition. Furthermore, the problem of reliable control for switched stochastic systems under asynchronous switching is also investigated. Finally, a numerical example is given to illustrate the effectiveness of the proposed method.

关键词： Asynchronous Switching Switched Stochastic Systems Average Dwell-time Finite-time Reliable Control

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考虑计算延迟的Boost变换器异步切换控制方法

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东南大学学报（自然科学版） 2021年第1期51卷 92-100页

作者：王荣浩中国人民解放军陆军工程大学国防工程学院南京210007

为应对Boost变换器电路中控制律的计算延迟及高频切换,提出一种基于时间切换的有限时间异步控制方法实现变换器的稳定控制.首先利用切换系统方法建立Boost变换器在开关动作和电路拓扑切换间发生延迟的异步控制模型;然后结合平均驻留时... 详细信息

为应对Boost变换器电路中控制律的计算延迟及高频切换,提出一种基于时间切换的有限时间异步控制方法实现变换器的稳定控制.首先利用切换系统方法建立Boost变换器在开关动作和电路拓扑切换间发生延迟的异步控制模型;然后结合平均驻留时间方法与多Lyapunov函数,利用占空比实现变换器的混杂切换控制;最后基于有限时间控制原理,得到控制律的计算时间、切换信号驻留时间与系统稳定运行时间之间的定量关系.结果表明,在0.9 ms运行时间内,当电路系统的切换信号与实际控制律切换信号间存在0.05 ms的延迟时,异步切换控制总切换次数为5,少于同步切换控制总切换次数11,未出现高频振动现象.异步切换控制方法能够有效抑制电路输出响应在平衡点附近的高频振动,控制性能更优.

关键词： Boost变换器切换系统计算延迟平均驻留时间多Lyapunov函数有限时间异步控制

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