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Quantitative determination of the electron beam radiation dose for SARS-CoV-2 inactivation to decontaminate frozen food packaging

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Virologica Sinica 2022年第6期37卷 823-830页

作者： Zihao Wang Zhentao Liang rongguo wei Hongwei Wang Fang Cheng Yang Liu Songdong Meng Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing100101China University of Chinese Academy of Sciences Beijing100049China Department of Clinical Laboratory The Fifth Affiliated Hospital of Guangxi Medical UniversityNanning530022China China Isotope and Radiaton Corporation Beijing100089China Changchun CNNC CIRC Radiation Technology Co. LTDChangchun130022China

The spread of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) from cold-chain foods to frontline workers poses a serious public health threat during the current global pandemic. There is an urgent need to design concise approaches for effective virus inactivation under different physicochemical conditions to reduce the risk of contagion through viral contaminated surfaces of cold-chain foods. By employing a time course of electron beam exposure to a high titer of SARS-CoV-2 at cold-chain temperatures, a radiation dose of 2 kGy was demonstrated to reduce the viral titer from 10^(4.5)to 0 median tissue culture infectious dose(TCID_(50))/mL. Next,using human coronavirus OC43(HCoV-OC43) as a suitable SARS-CoV-2 surrogate, 3 kGy of high-energy electron radiation was defined as the inactivation dose for a titer reduction of more than 4 log units on tested packaging materials. Furthermore, quantitative reverse transcription PCR(RT-qPCR) was used to test three viral genes,namely, E, N, and ORF1ab. There was a strong correlation between TCID50and RT-qPCR for SARS-CoV-2detection. However, RT-qPCR could not differentiate between the infectivity of the radiation-inactivated and nonirradiated control viruses. As the defined radiation dose for effective viral inactivation fell far below the upper safe dose limit for food processing, our results provide a basis for designing radiation-based approaches for the decontamination of SARS-CoV-2 in frozen food products. We further demonstrate that cell-based virus assays are essential to evaluate the SARS-CoV-2 inactivation efficiency for the decontaminating strategies.

关键词： Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) Inactivation Electron beam radiation Food decontamination Cold-chain

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Thyroid disruption by technical decabromodiphenyl ether (DE-83R) at low concentrations in Xenopus laevis

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Journal of Environmental Sciences 2010年第5期22卷 744-751页

作者： Xiaofei Qin Xijuan Xia Zhongzhi Yang Shishuai Yan Yaxian Zhao rongguo wei Yan Li Mi Tian Xingru Zhao Zhanfen Qin Xiaobai Xu State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-environmental Sciences Chinese Academy of Sciences Beijing 100085 China Chinese Research Academy of Environmental Sciences Beijing 100012 China

Decabromodiphenyl ether （decaBDE）,as a flame retardant,is widely produced and used.To study the thyroid disruption by technical decaBDE at low concentrations,Xenopus laevis tadpoles were exposed to technical decaBDE mixture DE-83R （1-1000 ng/L） in water from stage 46/47 （free swimming larvae,system of Nieuwkoop and Faber） to stage 62.DE-83R at concentration of 1000 ng/L significantly delayed the time to metamorphosis （presented by forelimb emergence,FLE）.Histological examination showed that DE83R at all tested concentrations caused histological alterations-multilayer follicular epithelial cell and markedly increased follicle size accompanied by partial colloid depletion and increase in the peripheral colloid vacuolation,in thyroid glands.All tested concentrations of DE-83R also induced a down-regulation of thyroid receptor mRNA expression.These results demonstrated that technical decaBDE disrupted the thyroid system in X.laevis tadpoles.Analysis of polybrominated diphenyl ethers （PBDEs）（sum of 39 congeners） in X.laevis indicated that mean concentrations of total PBDEs in X.laevis exposed to 1,10,100,1000 ng/L were 11.0,128.1,412.1,1400.2 ng/g wet weight,respectively.Considering that PBDEs burden of X.laevis tadpoles was close to PBDEs levels in amphibians as reported in previous studies,our study has raised new concerns for thyroid disruption in amphibians of technical decaBDE at environmentally relevant concentrations.

关键词： decabromodiphenyl ether Xenopus laevis thyroid disruption metamorphosis thyroid hormone receptor

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Investigation of MXene nanosheets based radio-frequency electronics by skin depth effect

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Nano Research 2024年第4期17卷 3061-3067页

作者： rongguo Song Yunfa Si wei Qian Haoran Zu Bilei Zhou Qinglei Du Daping He Yongliang Wang Air Force Early Warning Academy Wuhan 430019China Hubei Engineering Research Center of RF-Microwave Technology and Application Wuhan University of TechnologyWuhan 430070China Hainan Research Institute Wuhan University of TechnologySanya 572000China

Various new conductive materials with exceptional properties are utilized for the preparation of electronic devices.Achieving ultra-high conductivity is crucial to attain excellent electrical performance.However,there is a lack of systematic research on the impact of conductor material thickness on device performance.Here,we investigate the effect of conductor thickness on power transmission and radiation in radio-frequency(RF)and microwave electronics based on MXene nanosheets material transmission lines and antennas.The MXene transmission line with thickness above the skin depth exhibits a good transmission coefficient of approximately-3 dB,and the realized gain of MXene antennas exceeds 2 dBi.Additionally,the signal transmission strength of MXene antenna with thickness above the skin depth is higher than 5-μm MXene antenna approximately 5.5 dB.Transmission lines and antennas made from MXene materials with thickness above the skin depth exhibit stable and reliable performance,which has significant implications for obtaining high-performance RF and microwave electronics based on new conductive materials.

关键词： MXene film radiao-frequency electronics antenna transmission line skin depth

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全氟辛烷磺酸盐(PFOS)、全氟己烷磺酸盐(PFHS)和全氟丁烷磺酸盐(PFBS)对非洲爪蟾胚胎的发育毒性

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生态毒理学报 2012年第5期7卷 542-548页

作者：韦荣国苏红巧秦占芬中国科学院生态环境研究中心环境化学和生态毒理学国家重点实验室北京100085

全氟烷基磺酸盐(PFASs)在工业生产和生活中广泛应用,某些PFASs已成为环境中普遍的污染物。鉴于对动物和人类的潜在毒性,全氟辛烷磺酸盐(PFOS)已被禁用,由一些半衰期相对较短的短链PFASs(如全氟丁烷磺酸盐,PFBS)替代。虽然四碳的PFBS和... 详细信息

全氟烷基磺酸盐(PFASs)在工业生产和生活中广泛应用,某些PFASs已成为环境中普遍的污染物。鉴于对动物和人类的潜在毒性,全氟辛烷磺酸盐(PFOS)已被禁用,由一些半衰期相对较短的短链PFASs(如全氟丁烷磺酸盐,PFBS)替代。虽然四碳的PFBS和六碳的全氟己烷磺酸盐(PFHS)已经广泛使用,但目前对其毒性及其机制的了解很少。通过检测发育毒性和致畸性的非洲爪蟾胚胎致畸试验(FETAX),得到PFOS、PFHS和PFBS半致死浓度(LC50),半致畸浓度(EC50)和最小抑制生长浓度(MCIG),比较研究了3种化合物的发育毒性。结果发现,PFOS的LC50、EC50和MCIG分别为51.46、108.20和35mg·L-1。PFHS和PFBS的LC50大于100mg·L-1,对胚胎形态和生长没有明显影响。PFASs暴露引起非洲爪蟾胚胎运动行为异常。FETAX结果表明,PFOS急性发育毒性明显大于PFHS和PFBS。

关键词：非洲爪蟾全氟辛烷磺酸盐(PFOS) 全氟己烷磺酸盐(PFHS) 全氟丁烷磺酸盐(PFBS) 发育毒性

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全氟化合物发育神经毒性研究进展

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生态毒理学报 2012年第5期7卷 483-490页

作者：韦荣国张银凤秦占芬中国科学院生态环境研究中心环境化学和生态毒理学国家重点实验室北京100085

全氟化合物(PFCs)在工业生产和生活中广泛应用,已成为环境中一类普遍的污染物。由于PFCs污染表现出全球性、持久性和富集性等特征,其毒性备受关注。近期研究结果显示,PFCs除对肝脏、免疫系统和生殖内分泌系统等有明显影响外,还具有发育... 详细信息

全氟化合物(PFCs)在工业生产和生活中广泛应用,已成为环境中一类普遍的污染物。由于PFCs污染表现出全球性、持久性和富集性等特征,其毒性备受关注。近期研究结果显示,PFCs除对肝脏、免疫系统和生殖内分泌系统等有明显影响外,还具有发育神经毒性。在总结了近年来PFCs发育神经毒性的研究进展基础上,讨论了PFCs发育神经毒性可能的几个机制,并且分析该领域研究存在的问题,提出应该加强环境相关剂量下PFCs发育神经毒性研究,关注PFCs与其他神经毒物复合暴露的发育神经毒性,以推进对实际环境中PFCs所产生的神经损伤的认识。

关键词：全氟化合物发育神经毒性环境相关剂量

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全氟辛烷磺酸盐(PFOS)及其替代品对两栖类胚胎的发育毒性

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生态毒理学报 2012年第5期7卷 561-564页

作者：任东凯苏红巧刘芃岩韦荣国秦占芬河北大学化学与环境科学学院保定071002 中国科学院生态环境研究中心环境化学和生态毒理学国家重点实验室北京100085

用非洲爪蟾胚胎致畸实验和黑斑蛙胚胎发育毒性实验,比较研究了PFOS及其4种替代品对两栖动物胚胎的发育毒性。结果发现,用调聚法合成的织物三防整理剂和50%的全氟丁基有机铵盐阳离子表面活性剂同PFOS一样对非洲爪蟾胚胎有明显毒性,且织... 详细信息

用非洲爪蟾胚胎致畸实验和黑斑蛙胚胎发育毒性实验,比较研究了PFOS及其4种替代品对两栖动物胚胎的发育毒性。结果发现,用调聚法合成的织物三防整理剂和50%的全氟丁基有机铵盐阳离子表面活性剂同PFOS一样对非洲爪蟾胚胎有明显毒性,且织物三防整理剂和表面活性剂的毒性强于PFOS;电解氟化法合成的C4织物及C6织物三防整理剂(以下简称C4及C6织物三防整理剂)对非洲爪蟾胚胎没有明显毒性。与非洲爪蟾不同,PFOS和4种替代品对黑斑蛙胚胎没有明显毒性。结果显示,从生物安全性的角度分析,C4和C6织物三防整理剂可作为PFOS的替代品使用,而织物三防整理剂和表面活性剂的毒性比PFOS大,作为PFOS替代品使用需要慎重考虑。

关键词： PFOS 替代品非洲爪蟾黑斑蛙发育毒性

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An optimal dose of tea polyphenols protects against global cerebral ischemia/reperfusion injury

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Neural Regeneration Research 2013年第9期8卷 783-791页

作者： Jianrui Lv Rongliang Xue Jing Zhao Xin wei Hui Gao rongguo Fu Gang Wu wei Li Xiaoming Lei Junbin Tian Department of Anesthesiology Second Affiliated Hospital Medical School of Xi'an Jiaotong University

Previous studies addressing the protection of tea polyphenols against cerebral ischemia/ reperfusion injury often use focal cerebral ischemia models, and the optimal dose is not unified. In this experiment, a cerebral ischemia/reperfusion injury rat model was established using a modified four-vessel occlusion method. Rats were treated with different doses of tea polyphenols （25, 50, 100, 150, 200 mg/kg） via intraperitoneal injection. Results showed that after 2, 6, 12, 24, 48 and 72 hours of reperfusion, peroxide dismutase activity and total antioxidant capacity in brain tissue gradually increased, while malondialdehyde content gradually decreased after tea polyphenol intervention. Tea polyphenols at 200 mg/kg resulted in the most apparent changes. Terminal deoxynucleotidyl transferase-mediated nick end labeling and flow cytometry showed that 200 mg/kg tea polyphenols significantly reduced the number and percentage of apoptotJc cells in the hippocampal CA1 region of rats after cerebral ischemia/reperfusion injury. The open field test and elevated plus maze experiments showed that tea polyphenols at 200 mg/kg strengthened exploratory behavior and reduced anxiety of cerebral ischemia/reperfusion injured rats. Experimental findings indicate that tea polyphenols protected rats against cerebral ischemia/ reperfusion injury and 200 mg/kg is regarded as the optimal dose.

关键词： neural regeneration brain injury traditional Chinese medicine tea polyphenols brain ischemia/reperfusion injury oxidative stress neuroethology apoptosis grants-supported paper photographs-containing paper neuroregeneration

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Influence of structure of integrated optical thin-film filter on performance

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Science China Technological Sciences 2013年第3期56卷 563-566页

作者： WU YiLong LIU Shuang wei GuangLu LU rongguo LIU Yong ZHONG ZhiYong School of optoelectronic information University of Electronic Science and Technology of China

Thermo-optic tunable thin-film filter based on Fabry-Perot(F-P) cavity structure is a very attractive alternative integrated optical device.In this simulation-based paper,the key performance of typical thermo-optic tunable F-P filter is discussed by analyzing the structure of Distributed Bragger Reflectors(DBR) and the thermo-optic property of cavity thin-film material.The results indicate a negative correlation between the number of DBR periodical layers and full width at half maximum(FWHM),and a proportional relation between thermal-optic coefficient of material and tuning range.In addition,the cavity is more sensitive to the optical property than the reflection layers according to the analysis of thickness error of the film.And to solve slow thermal response without incurring other performance loss,a novel structure of the suspended cavity is proposed,in which only the cavity is heated.

关键词： tunable filter Distributed Bragger Reflectors(DBR) Fabry-Perot cavity thickness error suspended cavity structure

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Antifouling Potential of Bacteria Isolated from a Marine Biofilm

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Journal of Ocean University of China 2014年第5期13卷 799-804页

作者： GAO Min WANG Ke SU rongguo LI Xuzhao LU wei Key Laboratory of Marine Chemistry Theory and Technology of Ministry of Education Ocean University of China Marine Chemical Research Institute

Marine microorganisms are a new source of natural antifouling compounds. In this study, two bacterial strains, Kytococcus sedentarius QDG-B506 and Bacillus cereus QDG-B509, were isolated from a marine biofilm and identified. The bacteria fermentation broth could exert inhibitory effects on the growth of Skeletonema costatum and barnacle larvae. A procedure was employed to extract and identify the antifouling compounds. Firstly, a toxicity test was conducted by graduated pH and liquid-liquid extraction to determine the optimal extraction conditions. The best extraction conditions were found to be pH 2 and 100% petroleum ether. The EC50 value of the crude extract of K. sedentarius against the test microalgae was 236.7 ± 14.08 μg mL-1, and that of B. cereus was 290.6 ± 27.11 μg mL-1. Secondly, HLB SPE columns were used to purify the two crude extracts. After purification, the antifouling activities of the two extracts significantly increased: the EC50 of the K. sedentarius extract against the test microalgae was 86.4 ± 3.71 μg mL-1, and that of B. cereus was 92.6 ± 1.47 μg mL-1. These results suggest that the metabolites produced by the two bacterial strains are with high antifouling activities and they should be fatty acid compounds. Lastly, GC-MS was used for the structural elucidation of the compounds. The results show that the antifouling compounds produced by the two bacterial strains are myristic, palmitic and octadecanoic acids.

关键词：细菌发酵液海洋生物膜防污蜡状芽孢杆菌粗提取物生长抑制作用提取条件 EC50

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Antialgal and Antilarval Activities of Bioactive Compounds Extracted from the Marine Dinoflagellate Amphidinium carterae

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Journal of Ocean University of China 2016年第6期15卷 1014-1020页

作者： KONG Xianyu HAN Xiurong GAO Min SU rongguo WANG Ke LI Xuzhao LU wei Key Laboratory of Marine Chemistry Theory and Technology Ministry of Education Ocean University of ChinaQingdao 266100 P. R. China Marine Chemical Research Institute Qingdao 266071 P. R. China

With the global ban on the application of organotin-based marine coatings by the International Maritime Organization, the development of environmentally friendly, low-toxic and nontoxic antifouling compounds for marine industries has become an urgent need. Marine microorganisms have been considered as a potential source of natural antifoulants. In this study, the antifouling potential of marine dinoflagellate Amphidinium carterae, the toxic and red-tide microalgae, was investigated. We performed a series of operations to extract the bioactive substances from Amphidinium carterae and tested their antialgal and antilarval activities. The crude extract of Amphidinium carterae showed significant antialgal activity and the EC50 value against Skeletonema costatum was 55.4 μg m L^(-1). After purification, the isolated bioactive substances(the organic extract C) exhibited much higher antialgal and antilarval activities with EC50 of 12.9 μg m L^(-1) against Skeletonema costatum and LC50 of 15.1 μg m L^(-1) against Amphibalanus amphitrite larvae. Subsequently, IR, Q-TOFMS, and GC-MS were utilized for the structural elucidation of the bioactive compounds, and a series of unsaturated and saturated 16- to 22-carbon fatty acids were detected. The data suggested the bioactive compounds isolated from Amphidinium carterae exhibited a significant inhibiting effect against the diatom Skeletonema costatum and Amphibalanus amphitrite larvae, and could be substitutes for persistent, toxic antifouling compounds.

关键词：生物活性化合物海洋涂料粗提取物幼虫生物活性物质中肋骨条藻甲藻国际海事组织

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