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Didymin attenuates doxorubicin-induced cardiotoxicity by inhibiting oxidative stress

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Chinese Herbal Medicines 2022年第1期14卷 70-78页

作者： rongchang chen Guibo Sun Lijiao Xu Xu Zhang Wenying Zeng Xiaobo Sun Institute of Medicinal Plant Development Peking Union Medical College and Chinese Academy of Medical SciencesBeijing 100193China Department of Comprehensive Medicine Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing 100091China

Objective:This study was designed to investigate the protective effects of didymin(Did)on doxorubicin(DOX)-induced ***:After pretreatment with Did(2,4,8 mg/kg intraperitoneal i.p.)for 7 d,the male C57 mice were injected with single dose of DOX(20 mg/kg i.p.).The cardioprotective effect of Did was observed on the 7th day after DOX ***:DOX delayed body growth and caused cardiac tissue injury,oxidative stress,and mitochondrial *** experiments in H9C2 cardiomyocytes showed that DOX reduced cell viability,increased generation of reactive oxygen species(ROS)and fragmentation of DNA,decreased mitochondrial membrane potential,and induced cardiomyocyte ***,all of these adverse effects were suppressed by Did *** increased protein expression of glutamate-L-cysteine ligase catalytic subunit(GCL),heme oxygenase 1(HO-1),and nuclear factor erythroid 2-related factor 2(Nrf2).Besides,Did also induced activation of PI3K/***:These findings indicated Did prevented DOX-induced cardiac injury and apoptosis via activating PI3K/AKT/Nrf2 signaling pathway.

关键词： cardiotoxicity didymin doxorubicin Nrf2 PI3K/Akt

Control of an Intermittent Outbreak Caused by an Emerging Pandrug-Resistant Acinetobacter baumannii Clone ST457 in a Tertiary Hospital

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Infectious Microbes & Diseases 2021年第4期3卷 210-213页

作者： Chuqiu Zhang Tingting Xu Yang Ji Wenping Zheng Jingsong Wu Yuemei Lu Huiping Li rongchang chen chen Qiu Kai Zhou Shenzhen Institute of Respiratory Diseases Second Clinical Medical College(Shenzhen People’s Hospital)Jinan UniversityShenzhenGuangdongChina The First Affiliated Hospital(Shenzhen People’s Hospital) Southern University of Science and TechnologyShenzhenGuangdongChina Administration Department of Nosocomial Infection Second Clinical Medical College(Shenzhen People’s Hospital)Jinan UniversityShenzhenGuangdongChina Clinical Laboratory Second Clinical Medical College(Shenzhen People’s Hospital)Jinan UniversityShenzhenGuangdongChina

Acinetobacter baumannii is a frequent cause of nosocomial *** we report an intermittent outbreak caused by the emerging carbapenem-resistant ***(CRAB)clone ST457 and assess the effectiveness of patient screening for outbreak *** isolates were collected from 74 patients admitted to the respiratory intensive care unit of a tertiary hospital between May 2018 and March *** CRAB isolates were assigned to ST457,and 13 belonged to an outbreak clone,as determined by phylogenomic *** patient screening was started at the respiratory intensive care unit on May 2019,through which a ST457-positive patient transferred from the intensive care unit was *** positive patients were detected within 3months *** results of this study highlight the importance of rigorous infection prevention and control measures,combined with patient screening,in controlling the CRAB outbreak.

关键词： Acinetobacter baumannii carbapenem resistance nosocomial outbreak respiratory intensive care unit ST457

Character of diaphragm compound muscle action potential and phrenic nerve conduction time in patients with obstructive sleep apnea-hypopnea syndrome

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Neural Regeneration Research 2008年第5期3卷 533-537页

作者： Yuhong HOU rongchang chen Jinbing Pan Yuanming Luo Nanshan Zhong Department of Emergency the First Affiliated Hospital Zhengzhou University Zhengzhou 450052 Henan Province China Guangzhou Institute of Respiratory Disease First Affiliated Hospital Guangzhou Medical College Guangzhou 510120 Guangdong Province China Department of Respiratory Medicine Henan Provincial Hospital Zhengzhou 450003 Henan Province China

BACKGROUND： Both hypoxia *** dioxide retention can damage phrenic nerve and muscle conduction, as well as diaphragm function. Diaphragm compound muscle action potential and phrenic nerve conduction time are reliable indicators for measuring phrenic nerve and diaphragm function. OBJECTIVES： To verify the hypothesis that changes of phrenic nerve conduction time （PNCT） and diaphragm compound muscle action potential （CMAP） in obstructive sleep apnea-hypopnea syndrome （OSAHS） patients might contribute to the decline of phrenic nerve and diaphragm function. PNCT and CMAP were measured with multipair esophageal electrodes combined with unilateral magnetic stimulation. DESIGN, TIME AND SETTING： Case controlled study. The experiment was carried out in Guangzhou Institute of Respiratory Disease, Guangzhou MediCal College, from June 2005 to April 2006. PARTICIPANTS： Twenty seven OSAHS patients and eight primary snoring subjects from Guangzhou Institute of Respiratory Disease, Guangzhou Medical College were recruited and all subjects were diagnosed by polysomnography （PSG）. Sixteen healthy, non-snoring subjects in the hospital for medical examination during the same time period were selected as the control group. METHODS： Esophageal electrodes, made by Guangzhou Institute of Respiratory Disease, combined with unilateral magnetic stimulation, were used to measure PNCT and CMAP of all subjects. PNCT was defined as the time from stimulation artifact to the onset of CMAP and diaphragm CMAP amplitude was measured from peak to peak. Oxygen desaturation index and apnea-hypopnea index were measured using PSG, and their relevance to PNCT and CMAP were analyzed. PNCT and CMAP in five OSAHS patients were repeatedly measured after effective nasal continuous positive airway pressure treatment for more than 2 months. MAIN OUTCOME MEASURES：（1） PNCT and diaphragm CMAP of subjects in each group. （2） Relevance of oxygen desaturation index and apnea-hypopnea index to PNCT and CMAP. （3） Ch

关键词： sleep apnea syndrome action potentials phrenic nerve

Serum and Induced Sputum Surfactant Protein D in Prediction of Response to Treatment in Chronic Obstructive Pulmonary Disease

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Serum and Induced Sputum Surfactant Protein D in Prediction ...

中华医学会呼吸病学年会——2013（第十四次全国呼吸病学学术会议）

作者： Wei Liu rongchang chen Zhiguang Liu The respiratory department People’s Hospital of Hunan Province the first affiliated hospital of Hunan Normal University State Key Laboratory of the Respiratory Disease Guangzhou Institute of respiratory diseasethe first affiliated hospital of Guangzhou Medical College

Objective To determine the express of serum and sputum surfactant protein D(SP-D) in Chronic Obstructive Pulmonary Disease(COPD) and its relationship to treatment response. Methods 65 cases of COPD treatment naive patients were recruited for the *** concentrations of serum and sputum SP-D were measured,and the associations of SP-D with pulmonary function,Modified Medical Research Council dyspnea scale(mMRC),St.

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The incidence of respiratory virus infection in adults with acute asthma and stable asthma

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The incidence of respiratory virus infection in adults with ...

中华医学会呼吸病学年会——2013（第十四次全国呼吸病学学术会议）

作者： Hua Liao rongchang chen Zifeng Yang The First Affiliated Hospital of Guangzhou Medical University Guangzhou linstitute of Respiratory Diseases

Objective Todescribe the the incidence of respiratory virus infection in adults with asthma exacerbation in Guangzhou,south of China. Methods Subjects with stable asthma or asthma exacerbation presenting to the respiratory clinic or emergency department of the First Affiliated Hospital of Guangzhou Medical University were recruited from February 2012 to February *** additon,50 healthy subjects were also recruited *** swabs were collected and detected

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Clinical outcomes of a novel breathing training manoeuvre in patients with stable COPD.

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中华医学会呼吸病学年会——2013（第十四次全国呼吸病学学术会议）

作者： Weili Gu rongchang chen Chuanbing Zhu Guangzhou Institute of Respiratory Diseases

Objective:A prospective,randomized,controlled study was conducted to evaluate the clinical effects and potential mechanisms of this novel breathing training manoeuvre with the following outcome:improvement of dyspnea and exercise tolerance. Subjects and methods:Stable moderate to severe COPD patients were enrolled in the out-patient clinics of The First Affiliated Hospital of Guangzhou Medical College from April 2010 to December *** COPD

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NDM-1-Producing Enterobacteriaceae in 8 Community Patients without History of Foreign Travel in southern China,2011 to 2012

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NDM-1-Producing Enterobacteriaceae in 8 Community Patients w...

中华医学会呼吸病学年会——2013（第十四次全国呼吸病学学术会议）

作者： Shu Xia Chao Zhuo Shunian Xiao rongchang chen State Key Laboratory of Respiratory Diseases the First Affiliated Hospital of Guangzhou Medical College

Objective NDM-1(New Delhi metallo-/Mactamase),a recently identified metallo-fi-lactamase(MBL),is reported to be detected in Klebsiella *** ?.coli among Enterobacteriaceae ***,we early report eight cases infected or harboring NDM-1-Producing Enterobacteriaceae isolates in southern China,from 2011 to 2012. Methods The bacterial strains were identified by automated systems and progressed with the

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心功能不全与缺氧

中国实用内科杂志 2001年第3期21卷 132-133页

作者：陈荣昌广州呼吸病研究所 510120

缺氧(hypoxia)是指氧的供应不能满足机体代谢的需要或组织的氧的利用过程发生障碍，使机体的代谢、机能和形态结构发生变化，甚至危及生命的一系列病理变化过程。缺氧的原因诸多，按照发生机制可以将缺氧粗略地分为低氧血症性、循环性... 详细信息

缺氧(hypoxia)是指氧的供应不能满足机体代谢的需要或组织的氧的利用过程发生障碍，使机体的代谢、机能和形态结构发生变化，甚至危及生命的一系列病理变化过程。缺氧的原因诸多，按照发生机制可以将缺氧粗略地分为低氧血症性、循环性和组织性缺氧。心功能不全是循环性缺氧的常见原因之一。

关键词：心功能不全缺氧临床表现治疗

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网络平台数据治理的正当性、困境及路径

宁夏社会科学 2021年第1期 72-80页

作者：陈荣昌湖南大学法学院湖南长沙410082

数据是型构网络空间的基础资源,在资本与技术力量的共同作用下,网络平台成为掌握数据的重要主体。网络平台具有的私有性、公共性和风险性相互交叠,加之平衡多元博弈的现实需要,对网络平台数据进行治理具有正当性。但由于相关议题较新,... 详细信息

数据是型构网络空间的基础资源,在资本与技术力量的共同作用下,网络平台成为掌握数据的重要主体。网络平台具有的私有性、公共性和风险性相互交叠,加之平衡多元博弈的现实需要,对网络平台数据进行治理具有正当性。但由于相关议题较新,当前网络平台数据治理还面临观念难题、法律缺陷、主体障碍和机制问题。现阶段,法治构成新时代国家发展的基本底色,网络平台数据治理优化亦需回归法治逻辑,不断推动治理观念变革、创新完善法律规则、夯实多主体共治基础、改进治理机制,从而驱动网络平台数据治理法治化和现代化转型。

关键词：网络平台数据正当性治理转型法治化