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基于层间邻域信息熵的时序网络节点重要性评估方法

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复杂系统与复杂性科学 2024年第1期21卷 20-27,42页

作者：洪成蒋沅严玉为余荣斌杨松青南昌航空大学信息工程学院南昌330063

为识别时序网络中的重要节点,提出基于层间邻域信息熵的时序网络节点重要性评估方法。受明显路径流网络模型的启发,该方法通过引入参数ω,融合节点在相邻时间快照的层间邻域拓扑信息,使用信息熵来刻画网络结构的复杂性,并且兼顾了相邻... 详细信息

为识别时序网络中的重要节点,提出基于层间邻域信息熵的时序网络节点重要性评估方法。受明显路径流网络模型的启发,该方法通过引入参数ω,融合节点在相邻时间快照的层间邻域拓扑信息,使用信息熵来刻画网络结构的复杂性,并且兼顾了相邻时间快照的全局拓扑信息。通过使用SIR传播模型、Kendall相关系数、以及Top-k指标来验证该方法的有效性与适用性,在6个真实数据集上与其他6种评估方法进行比较。实验结果表明,提出的方法能够更为有效的识别出时序网络中的重要节点,同时对重要性排名靠前的节点的识别更为准确;可根据时序网络的拓扑结构调整ω从而提升该方法的评估效果;该方法的时间复杂度仅为O(mn),适用于大型时序网络。

关键词：时序网络层间邻域节点重要性信息熵

基于成果导向教育理念的医学院校学生评教指标体系构建研究

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中华医学教育杂志 2024年第6期44卷 454-457页

作者：侯菁媛钱文溢王萱萱喻荣彬南京医科大学2021级公共管理专业南京211166 南京医科大学医学教育研究所南京211166 南京医科大学医政学院公共管理学系南京211166 南京医科大学教务处南京211166

目的构建基于成果导向教育理念的医学院校学生评教指标体系,为医学教育者提供参考。方法通过文献分析法初步构建指标体系,并采用德尔菲法对24位专家进行2轮专家咨询,再运用层次分析法计算各项指标的权重。结果2轮专家咨询问卷回收率均为... 详细信息

目的构建基于成果导向教育理念的医学院校学生评教指标体系,为医学教育者提供参考。方法通过文献分析法初步构建指标体系,并采用德尔菲法对24位专家进行2轮专家咨询,再运用层次分析法计算各项指标的权重。结果2轮专家咨询问卷回收率均为100.0%,专家权威程度均为0.87,Kendall协调系数分别为0.241、0.157、0.125和0.280、0.166、0.131,且差异均具有统计学意义(均P<0.05)。最终构建的指标体系包含4个一级指标、11个二级指标和24个三级指标。一级指标权重最高的是学习收获(0.501),二级指标权重最高的是能力培养(0.246)。结论构建的医学院校学生评教指标体系具有科学性,且充分体现了成果导向理念并结合医学教育特点,可以为之后评估工具的构建提供依据。

关键词：学生,医科成果导向教育德尔菲法指标体系学生评教

Prevalence and risk factors of HIV and syphilis,and knowledge and risk behaviors related to HIV/AIDS among men who have sex with men in Chongqing,China

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The Journal of Biomedical Research 2016年第2期30卷 101-111页

作者： Wenzhe Ma Guohui Wu Hui Zheng Wenjuan Zhang Zhihang Peng rongbin yu NingWang Department of Epidemiology and Biostatistics School of Public Health Nanjing Medical University Nanjing Jiangsu 211166 China Chongqing Center for Disease Control and Prevention Chongqing China National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and Prevention Beijing China

High HIV prevalence and incidence burdens have been reported in men who have sex with men（MSM）in Chongqing,*** aimed to estimate the prevalence of HIV and other sexually transmitted infections（STIs）,to appraise the knowledge and risk behaviors related to HIV/AIDS among MSM,and to analyze the possible causes of deviation between behavior and knowledge to make better *** recruited 617 MSM from February to July in 2008 by using a respondent-driven sampling（RDS） method in Chongqing,*** the collection of questionnaire-based data and biological testing results from all objects,we launched a crosssectional ***/SE was used for data analysis by frequency,ANOVA,rank sum test and logistic regression *** with syphilis（OR=4.16,95%CI：2.35-7.33,P〈0.0001） were more likely to be HIV *** a company employee（OR=3.64,95%CI：1.22-10.08,P〈0.0001） and having bought male for sex（OR=3.52,95%CI：1.10-11.32,P〈0.034） were associated with a higher probability of *** with younger age,higher education and greater monthly income had a higher mean knowledge *** who had HIV testing had a higher mean knowledge score than those who never ***,venues for finding sex partners by Internet and homosexuals in MSM had a higher mean knowledge score compared to other occupations,venues for finding sex partners and sexual *** is an urgent need for delivery of barrier and biomedical interventions with coordinated behavioral and structural strategies to improve the effect of HIV interventions among MSM.

关键词： HIV/AIDS men who have sex with men Chongqing China

Effective integration of highly-efficient focusing apodized grating and quantum dots on a solid substrate for scalable quantum photonic circuits

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Science China(Physics,Mechanics & Astronomy) 2024年第9期67卷 99-107页

作者： Beimeng Yao rongbin Su Shunfa Liu Changkun Song Ying yu Jin Liu Xuehua Wang State Key Laboratory of Optoelectronic Materials and Technologies School of PhysicsSun Yat-sen UniversityGuangzhou 510275China State Key Laboratory of Optoelectronic Materials and Technologies School of Electronics and Information TechnologySun Yat-sen UniversityGuangzhou 510275China

Recent advancements in quantum photonic circuits have significantly influenced the field of quantum information *** pursuit of an integrated quantum photonic circuit that offers an active,stable platform for large-scale integration and high processing efficiency remains a key *** grating coupler,as a crucial element for an efficient transformation output interface in the integrated quantum photonic circuits,presents significant potential for practical ***,we demonstrate the integration block of a highly efficient shallow-etched focusing apodized grating coupler with indium arsenide(InAs)quantum dots(QDs)in gallium arsenide(GaAs)on a SiO2substrate for active quantum photonic *** designed grating couplers possess a high efficiency over 90% in the broadband(900-930 nm)from the circuit to free space,and a nearly-perfect match with the fiber ***,the efficiency to free space reaches 81.8%,and the match degree with the fiber mode is high up to 92.1%.The proposed integration block offers the potential for large-scale integration of active quantum photonic circuits due to its stable solid substrate and highly performant output for quantum measurements.

关键词： quantum dot grating coupler wafer bonding quantum photonic circuit

Host genetic variations are associated with virological response to interferon therapy of chronic HCV in Han Chinese patients

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The Journal of Biomedical Research 2014年第6期28卷 476-483页

作者： Hongbo Chen yuanyuan Zhang Peng Huang Yin Xu Jie Wang Jing Su rongbin yu Department of Infectious Diseases Jurong Peoples' Hospital Department of Epidemiology and Biostatistics School of Public HealthNanjing Medical University Department of General Practice Kangda CollegeNanjing Medical University

Previous studies have suggested that host genetic polymorphisms may affect virological response to pegylatedinterferon and ribavirin（PEG-IFN/ ribavirin） therapy in chronic HCV ***28 B and MxA are the most intensively studied genes in Chinese Han *** current research is to summarize published data and evaluate the overall association of meaningful SNPs in these two genes with virological response to interferon-based *** search was performed in online database and a systematic review was conducted based on the search *** single nucleotide polymorphisms（SNPs） were summarized and analyzed for odds ratio（OR） and 95%confidence intervals（95%CI）.Data manipulation and statistical analyses were performed by using STATA 12.0and Review Manager version *** papers were included for final data *** SNPs of IL28 B and two SNPs of MxA were found to be associated with higher sustained virological response（SVR） to interferon *** ORs and 95%CIs of each variant were：IL28B rs8099917 TT（OR：4.35,95%CI：3.10-6.12）,IL28 B rs12979860CC（OR：5.37,95%CI：3.95-7.31）,IL28 B rs7248668 CC（OR：3.50,95%CI：2.30-5.35）,MxA rs2071430 GT（OR：2.03,95%CI：1.31-3.13）,and MxA rsl7000900 AC/AA（OR：1.82,95%CI：1.17-2.83）.The genotypes of IL28 B rs8099917,rsl2979860,rs7248668,MxA rs2071430,and MxA rs17000900 were strong SVR predictors for PEG-IFN/ribavirin-treated HCV patients in Han Chinese *** findings suggest that host genetic variations are associated with virological response to interferon therapy of chronic HCV in Han Chinese patients.

关键词： hepatitis C virus therapy virological response IL28B MxA meta-analysis

新型冠状病毒感染疫情前后流行性感冒流行特征比较

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医学动物防制 2024年第5期40卷 430-434页

作者：许纯王寅董玉颖周乐吴程张秀玲喻荣彬南京医科大学公共卫生学院江苏南京211100 扬州市疾病预防控制中心

目的比较新型冠状病毒感染疫情前后扬州市流行性感冒(简称流感)的监测数据,了解新型冠状病毒感染疫情防控对流感病毒流行的影响。方法收集扬州市2018—2019年和2020—2021年3家流感监测哨点医院流感样病例(influenza-like illness,ILI)... 详细信息

目的比较新型冠状病毒感染疫情前后扬州市流行性感冒(简称流感)的监测数据,了解新型冠状病毒感染疫情防控对流感病毒流行的影响。方法收集扬州市2018—2019年和2020—2021年3家流感监测哨点医院流感样病例(influenza-like illness,ILI)和流感样病例就诊百分比(ILI%)监测数据、病原学数据和暴发疫情资料,使用描述性流行病学方法分析数据,并通过χ^(2)检验,比较新型冠状病毒感染疫情前后流感的流行变化。结果2018—2019年、2020—2021年扬州市3家流感监测哨点医院ILI%分别为6.92%(108278/1565487)、4.29%(57120/1330976),差异有统计学意义(χ^(2)=9206.151,P<0.001)。2018—2019年3家哨点医院的ILI%整体基本高于2020—2021年。2018—2019年、2020—2021年ILI标本的阳性率分别为11.46%(755/6589)、3.52%(224/6361),差异有统计学意义(χ^(2)=291.755,P<0.001)。结论新型冠状病毒感染疫情形势下,流感流行趋势会发生改变,3家流感监测哨点医院的ILI、ILI%和流感病毒检出阳性率均会受影响。

关键词：扬州市流感流行特征病毒分型新型冠状病毒感染

Associations of IFN-γ rs2430561 T/A,IL28B rs12979860 C/T and ERα rs2077647 T/C polymorphisms with outcomes of hepatitis B virus infection:a meta-analysis

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The Journal of Biomedical Research 2014年第6期28卷 484-493页

作者： Shaidi Tang Ming yue Jiajia Wang yun Zhang rongbin yu Jing Su Zhihang Peng Jie Wang Department of Epidemiology and Biostatistics School of Public HealthNanjing Medical University Department of Infectious Diseases the First Affiliated Hospital of Nanjing Medical University Institute of Epidemiology and Microbiology the Institute of Military Medicine of Nanjing Command State Key Laboratory of Reproductive Medicine Nanjing Medical University Department of General Practice Kangda CollegeNanjing Medical University

Several studies investigated associations of IFN-γ rs2430561 T/A,IL28 B rs12979860 C/T and ERα rs2077647 T/C gene polymorphisms with outcomes of hepatitis B virus（HBV） infection,but the results were ***,we performed a meta-analysis of all published observational studies to address this *** was searched in online database and a systematic review was conducted based on the search results.A total of 24 studies were included and dichotomous data were presented as odds ratio（OR） with a 95%confidence interval（CI）.The rs2430561 T allele was associated with reduced persistent HBV infection risk（T vs.A：OR,0.690;95%CI,[0.490,0.971]）,while the rs2077647 T allele significantly increased the risk of persistent HBV infection（T vs.C：OR.1.678;95%CI,[1.212,2.3231）.Rs 2077647 CC might play a role in protecting individuals against HBV persistence（TT ***：OR,4.109;95%CI,[2.609,6.473]）.Furthermore,carriers of the rs2430561 TT genotype were more likely to clear HBV spontaneously compared with those of the AA genotype（TT ***：OR,0.555;95%CI,[0.359,0.856]）.For rs12979860 C/T polymorphism,no significant correlation with HBV infection outcomes was *** subgroup analyses,the results were similar to those of overall ***,for rs2077647 TT ***＋CC,significantly increased risks were observed in the Asian and hospital-based population,but not in the overall ***-γrs2430561 T/A and ERα rs2077647 T/C genetic polymorphisms were associated with outcomes of HBV infection,but no association was found between IL28 B rs12979860 C/T and HBV infection.

关键词： meta-analysis single nucleotide polymorphism,IFN-γ rs2430561 T/A IL28B rs12979860 C/T ,ERα rs2077647 T/C,hepatitis B virus

Prevalence and trends of aminoglycoside resistance in Shigella worldwide, 1999-2010

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The Journal of Biomedical Research 2013年第2期27卷 103-115页

作者： Bing Gu Xing Ke Shiyang Pan Yan Cao Ling Zhuang rongbin yu Huimin Qian Genyan Liu Mingqing Tong Department of Laboratory Medicine the First Affiliated Hospital Nanjing Medical University National Key Clinical Department of Laboratory Medicine Department of Acute Infectious Disease Prevention and Control Jiangsu Provincial Center for Disease Prevention and Control Department of Epidemiology and Biostatistics School of Public Health Nanjing Medical University

Shigellosis causes diarrheal disease in humans in both developed and developing countries, and multi-drug resistance in Shigella is an emerging problem. Understanding changing resistance patterns is important in determining appropriate antibiotic treatments. This meta-analysis systematically evaluated aminoglycoside resistance in Shigella. A systematic review was constructed based on MEDLINE and EMBASE databases. Randomeffect models or fixed-effect models were used based on P value considering the possibility of heterogeneity between studies for meta-analysis. Data manipulation and statistical analyses were performed using software STATA 11.0. By means of meta-analysis, we found a lower resistance to three kinds of aminoglycosides in the Europe-America areas during the 12 year study period than that of the Asia-Africa areas. Kanamycin resistance was observed to be the most common drug resistance among Shigella isolates with a prevalence of 6.88% （95%CI： 6.36%-7.43%）. Comparison of data from Europe-America and Asia-Africa areas revealed that Shigella flexneri resistance was greater than the resistance calculated for Shigella sonnei. Importantly, Shigella sonnei has played a significant role in aminoglycoside-resistance in recent years. Similarly, data showed that resistance to these drugs in children was higher than the corresponding data of adults. In conclusion, aminoglycoside-resistant Shigella is not an unusual phenomenon worldwide. Distribution in Shigella resistance differs sharply based on geographic areas, periods of time and subtypes. The results from the present study highlight the need for con- tinuous surveillance of resistance and control of antibiotic usage.

关键词： Shigella aminoglycoside resistance patterns prevalence trends meta-analysis

A survey of HIV infection and related high-risk factors among men who have sex with men in Suzhou,Jiangsu,China

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The Journal of Biomedical Research 2011年第1期25卷 17-24页

作者： Hongling Bai Xiping Huan Weiming Tang Xin Chen Hongjing Yan Xiaoyan Liu Haitao Yang Zhihang Peng Xiuping Zhao rongbin yu Hao yu Feng Chen Department of Epidemiology and Biostatistics School of Public Health Nanjing Medical University Nanjing Jiangsu 210029 China Center for Disease Control and Prevention of Jiangsu Province Nanjing Jiangsu 210009 China Suzhou Center for Disease Prevention and Control Suzhou Jiangsu 215004 China.

A cross-sectional study using the snowball sampling method was conducted in May 2008 to investigate human immunodeficiency virus （HIV） infection status and related high risk factors among men who have sex with men （MSM） in Suzhou city of Jiangsu province. The researchers carried out a face-to-face questionnaire interview among MSM, and collected their blood samples to test for HIV and other sexually transmitted diseases （STDs）. Among the 280 respondents, 91.1% had homosexual acts in the past 6 months and 87.5% had multiple homosex- ual partners; 46.4% had heterosexual sex in the past 6 months and 33.1% had multiple heterosexual partners. The rate of continued condom use was 44.3% in homosexual sex in the past 6 months, while the rate in heterosexual sex was 33.9%. Laboratory test results showed that the prevalences of HIV and syphilis were 7.1% （20/280） and 15.0% （42/280）, respectively, but no HCV-positive person was found. In the multivariate logistic regression model, subjects with a monthly income of more than RMB $ 1,000 （OR=4.83,95% CI=1.44-16.22）, subjects who often went to bars for sexual partners （OR=2.25, 95%CI=1.21-4.20）, and subjects who had more than one sexual partner in the past 6 months （OR=0.49, 95%CI=0.25-0.97） and had sex with fixed sexual partners in the past 6 months （OR=0.42, 95%CI=0.25-0.75） were significantly associated with the rate of continued condom use in homosexual sex in the past 6 months. Unprotected sex and multiple sexual partners were more common among MSM in Suzhou city; furthermore, the prevalences of HIV infection and syphilis were relatively high. HIV preventive measures should be designed to address these risk factors and control the spread of HIV among MSM.

关键词： men who have sex with men knowledge behavior HIV infection risk factor