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Regulation of AMPA receptor surface trafficking and synaptic scaling by Pb2+ exposure

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Regulation of AMPA receptor surface trafficking and synaptic...

Analyzing the Dissemination of News by Model Averaging and Subsampling

2018环境与健康学术会议--精准环境健康：跨学科合作的挑战

作者： JinJun Ding rongxin zou HuiMing He YuQing Tang HuiLi Wang School of Food Science and Engineering Hefei University of Technology

Homeostatic synaptic plasticity(HSP) helps to stabilize the neuronal network activity,which is essential for optimal information *** scaling is a form of homeostatic plasticity that stabilizes neuronal firing in response to activity ***(Pb) is a ubiquitous environmental neuro-toxicant and can impair the input-specific Hebbian type synaptic plasticity,but whether Pb exerts effects in HSP remains *** previously reported that blocking L-type calcium channel induces synaptic scaling,which stimulates the synthesis of all-trans retinoic acid(RA)a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid(AMPA) *** Pb is a potent blocker of calcium channel,we hypothesized Pb may participate in synaptic scaling accompanied by RA synthesis and AMPA receptor *** this study,cultured hippocampal neurons were treated with Pb(1μM 5 min,15 min,4 h or 24 h and10μM 24 h) alone or in combination with tetrodotoxin(TTX,1 mM,24 h).The results showed that Pb alone,either at 1 mM or 10 mM,cannot induce synaptic *** Pb participated in synaptic scaling when concurrent with TTX(10μM Pb+1 mM TTX,24 h).Further results showed that surface heteromeric GluAl and GluA2 AMPA receptors were increased in TTX+ Pb induced synaptic *** addition,RA was proved not to participate in TTX+ Pb mediated synaptic *** together,our work support that TTX+ Pb could induce synaptic scaling and enhance synaptic accumulation of AMPAR GluAl and GluA2 during synaptic up *** study would help for elucidation of the Pb-induced neuronal network instability mechanism.

关键词： Pb exposure synaptic scaling AMPA receptor retinoic acid

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Journal of Systems Science & Complexity 2024年第5期37卷 2104-2131页

作者： zou Jiahui School of Statistics Capital University of Economics and BusinessBeijing 100070China

The dissemination of news is a vital topic in management science,social science and data *** the development of technology,the sample sizes and dimensions of digital news data increase *** alleviate the computational burden in big data,this paper proposes a method to deal with massive and moderate-dimensional data for linear regression models via combing model averaging and subsampling *** author first samples a subsample from the full data according to some special probabilities and split covariates into several groups to construct candidate ***,the author solves each candidate model and calculates the model-averaging weights to combine these estimators based on this ***,the asymptotic optimality in subsampling form is proved and the way to calculate optimal subsampling probabilities is *** author also illustrates the proposed method via simulations,which shows it takes less running time than that of the full data and generates more accurate estimations than uniform ***,the author applies the proposed method to analyze and predict the sharing number of news,and finds the topic,vocabulary and dissemination time are the determinants.

关键词： Asymptotic optimality dissemination of news linear regression models model averaging optimal subsampling.

Conceptual transition from molecular to atomic: unleashing a new era in hydrogen therapy for chronic disease

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National Science Review 2024年第04期11卷 17-18页

作者： Zhigang zou Eco-materials and Renewable Energy Research Center (ERERC) Jiangsu Key Laboratory for Nano Technology National Laboratory of Solid State Microstructures and Department of PhysicsNanjing University

The dysregulated overexpression of reactive oxygen and nitrogen species (RONS)intricately links to the occurrence and development of diverse chronic diseases[1–3]. Hydrogen therapy stands out as a promising treatment methodology recognized for effectively mitigating RONS and maintaining intracellular redox equilibrium, thereby yielding therapeutic benefits [4,5].

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Image Fusion Based on Bioinspired Rattlesnake Visual Mechanism Under Lighting Environments of Day and Night Two Levels

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Journal of Bionic Engineering 2024年第3期21卷 1496-1510页

作者： Yong Wang Hongmin zou College of Communication Engineering Jilin UniversityChangchun130012China

This study,grounded in Waxman fusion method,introduces an algorithm for the fusion of visible and infrared images,tailored to a two-level lighting environment,inspired by the mathematical model of the visual receptive field of rattlesnakes and the two-mode cells'*** research presented here is segmented into three *** the first segment,we design a preprocessing module to judge the ambient light intensity and divide the lighting environment into two levels:day and *** second segment proposes two distinct network structures designed specifically for these daytime and nighttime *** the daytime images,where visible light information is predominant,we feed the ON-VIS signal and the IR-enhanced visual signal into the central excitation and surrounding suppression regions of the ON-center receptive field in the B channel,***,for nighttime images where infrared information takes precedence,the ON-IR signal and the Visual-enhanced IR signal are separately input into the central excitation and surrounding suppression regions of the ON-center receptive field in the B *** outcome is a pseudo-color fused *** third segment employs five different no-reference image quality assessment methods to evaluate the quality of thirteen sets of pseudo-color images produced by fusing infrared and visible *** images are then compared with those obtained by six other methods cited in the relevant *** empirical results indicate that this study's outcomes surpass the comparative results in terms of average gradient and spatial *** one or two sets of fused images underperformed in terms of standard deviation and entropy when compared to the control *** sets of fused images did not perform as well as the comparison in the QAB/F *** conclusion,the fused images generated through the proposed method show superior performance in terms of scene detail,visual perception,and image sharpness

关键词： Rattlesnake Visible image Infrared image Daylight Bionic

Security-Reliability Tradeoff Analysis for Jamming Aided Decode-and-Forward Relay Networks

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China Communications 2024年第5期21卷 218-228页

作者： zou Ronggui zou Yulong Zhu Jia Li Bin School of Telecommunications and Information Engineering Nanjing University of Posts and TelecommunicationsNanjing 210003China

In this paper,we explore a cooperative decode-and-forward(DF)relay network comprised of a source,a relay,and a destination in the presence of an *** improve physical-layer security of the relay system,we propose a jamming aided decodeand-forward relay(JDFR)scheme combining the use of artificial noise and DF relaying which requires two stages to transmit a ***,in stage one,the source sends confidential message to the relay while the destination acts as a friendly jammer and transmits artificial noise to confound the *** stage two,the relay forwards its re-encoded message to the destination while the source emits artificial noise to confuse the *** addition,we analyze the security-reliability tradeoff(SRT)performance of the proposed JDFR scheme,where security and reliability are evaluated by deriving intercept probability(IP)and outage probability(OP),*** the purpose of comparison,SRT of the traditional decode-and-forward relay(TDFR)scheme is also *** results show that the SRT performance of the proposed JDFR scheme is better than that of the TDFR ***,it is shown that for the JDFR scheme,a better SRT performance can be obtained by the optimal power allocation(OPA)between the friendly jammer and user.

关键词： decode-and-forward relay friendly jammer physical layer security power allocation security-reliability tradeoff

Design of Robust Var Reserve Contract for Enhancing Reactive Power Ancillary Service Market Efficiency

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 767-771页

作者： Yunyang zou Yan Xu School of Electrical and Electronic Engineering Nanyang Technological UniversitySingapore 639798Singapore

In a deregulated Var market, market power issue is more serious than in an energy market since reactive power cannot be transmitted over long distances. This letter designs a multi-timescale Var market framework, where market power that may arise in the hourly-ahead Var support service market due to system configuration deficiency and market structure flaws can be eliminated by day-ahead contract-based Var reserve service market. Settlement of day-ahead Var reserve contract is formulated as a two-stage robust optimization (TSRO) model considering worst case of uncertainty realization and potential market power that may arise in hourly-ahead market. TSRO with integer recourses is then solved by a new column and constraint generation algorithm. Results show a robust Var reserve contract can fully eliminate market power, and prevent suppliers from manipulating market prices.

关键词： Market efficiency market power reactive power ancillary service two-stage robust optimization Var reserve

Dynamic Development Characteristics and Driving Factors of High Quality Development Level in China’s Five Major Urban Agglomerations

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Chinese Geographical Science 2024年第5期34卷 777-790页

作者： zou Weiyong XU Lingli School of Economics Guangdong Ocean UniversityZhanjiang 524088China School of Economics Shanghai UniversityShanghai 200444China

High-quality development is the primary task of comprehensively building a socialist,modern country,as well as the primary task of building urban agglomerations in *** on the five development concepts,this paper used the entropy method to measure the High Quality Development Index(HQDI)of the five major urban *** results showed that the HQDI of the five major urban agglomerations shows a fluctuating upward ***,using the Dagum Gini coefficient to explore the sources of HQDI development differences in urban agglomerations,we found that the main source of HQDI differences in urban agglomerations was inter-regional differences,while intra-regional differences were not ***,kernel density estimation was used to test the dynamic evolution trend of HQDI within urban *** was a polarisation phenomenon in the HQDI of urban agglomerations,such as the Pearl River Delta urban agglomeration and the Chengdu-Chongqing urban *** overall,the degree of imbalance had ***,using geographic detectors to examine the driving factors of HQDI in urban agglomerations,we found that the main driving forces for improving HQDI in urban agglomerations were economic growth,artificial intelligence technology and fiscal *** the interaction factors had greater explanatory power for the spatial differentiation of HQDI,which can be divided into two types:two-factor improvement and non-linear *** study is conducive to improving and enriching the theoretical system for evaluating the high quality development of urban agglomerations,and provides policy references for promoting the high quality development of urban agglomerations.

关键词： urban agglomeration High Quality Development Index(HQDI) spatio-temporal evolution driving factors

Forming process chain for manufacturing complex conical-section profiled rings:On a co-design method

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Chinese Journal of Aeronautics 2024年第6期37卷 485-503页

作者： Lei LIANG Chaojiang zou Lianggang GUO State Key Laboratory of Solidification Processing School of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Guizhou Aviation Technology Development Co.Ltd Guiyang 550081China

The final quality of complex conical-section rings depends on co-design of multiple processes in forming process *** this study,for a complex aeroengine casing ring with a large slope and a flange on its end,a co-design method of the forming process chain is put forward towards the objective of precision forming,which not only proposes a standard process route composed of multiple processes of upsetting,punching,rectangular ring rolling,loose tooling forging and profiled ring rolling,but also presents co-design methods of dies and blanks for all the *** profiled ring rolling,a design method of preformed blank that makes the blank and the target conical-section ring have the same axial volume distribution is *** the method,the axial metal redistribution during the process can be alleviated greatly thus improving the forming stability and precision of the *** on the geometric features of designed preformed blank,design methods of blanks and dies for loose tolling forging,rectangular ring rolling,punching and upsetting are proposed *** view of the key roles of loose tooling forging(manufacturing the preformed blank)and profiled ring rolling on the final quality of the conical ring parts,inherited FE simulations for these two processes are performed to verify the proposed design methods and determine appropriate design *** is demonstrated that the proposed design method has significant advantages in improving forming ***,a suggestive value 1.5 of the rolling ratio for profiled ring rolling(a key design parameter)is given based on comprehensive consideration of multiple indicators such as ring roundness,deformation uniformity and forming *** corresponding industrial experiments performed illustrate that a high forming precision of the conical-section aeroengine casing ring is achieved.

关键词： Complex conical-section ring Co-design of forming process chain Profiled ringrolling Preformed blank Loose tooling forging

Set-Membership Filtering Approach to Dynamic Event-Triggered Fault Estimation for a Class of Nonlinear Time-Varying Complex Networks

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IEEE/CAA Journal of Automatica Sinica 2024年第3期11卷 638-648页

作者： Xiaoting Du Lei zou Maiying Zhong the College of Electrical Engineering and Automation Shandong University of Science and TechnologyQingdao 266590China IEEE the College of Information Science and Technology Donghua UniversityShanghai 201620 the Engineering Research Center of Digitalized Textile and Fashion Technology Ministry of EducationShanghai 201620China

The present study addresses the problem of fault estimation for a specific class of nonlinear time-varying complex networks,utilizing an unknown-input-observer approach within the framework of dynamic event-triggered mechanism(DETM).In order to optimize communication resource utilization,the DETM is employed to determine whether the current measurement data should be transmitted to the estimator or *** guarantee a satisfactory estimation performance for the fault signal,an unknown-input-observer-based estimator is constructed to decouple the estimation error dynamics from the influence of fault *** aim of this paper is to find the suitable estimator parameters under the effects of DETM such that both the state estimates and fault estimates are confined within two sets of closed ellipsoid *** techniques of recursive matrix inequality are applied to derive sufficient conditions for the existence of the desired estimator,ensuring that the specified performance requirements are met under certain ***,the estimator gains are derived by minimizing the ellipsoid domain in the sense of trace and a recursive estimator parameter design algorithm is then ***,a numerical example is conducted to demonstrate the effectiveness of the designed estimator.

关键词： Dynamic event-triggered mechanism(DETM) fault estimation nonlinear time-varying complex networks set-member-ship filtering unknown input observer