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The SmNPR4-SmTGA5 module regulates SA-mediated phenolic acid biosynthesis in Salvia miltiorrhiza hairy roots

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Horticulture Research 2023年第5期10卷 260-270页

作者： Meiling Ding Bin Zhang Shuo Zhang rongrong hao Yu Xia Pengda Ma Juane Dong College of Life Sciences Northwest A&F UniversityYangling 712100China

Phenolic acids are the main bioactive compounds in Salvia miltiorrhiza,which can be increased by salicylic acid(SA)***,the specific molecular mechanism remains *** nonexpresser of PR genes 1(NPR1)and its family members are essential components of the SA signaling ***,we report an NPR protein,SmNPR4,that showed strong expression in hairy root after SA treatment,acting as a negative moderator of SA-induced phenolic acid biosynthesis in ***(***).Moreover,a basic leucine zipper family transcription factor SmTGA5 was identified and was found to interact with ***5 activates the expression of phenolic acid biosynthesis gene SmTAT1 through binding to the as-1 ***,a series of biochemical assays and dual gene overexpression analysis demonstrated that the SmNPR4 significantly inhibited the function of SmTGA5,and SA can alleviate the inhibitory effect of SmNPR4 on ***,our results reveal the molecular mechanism of salicylic acid regulating phenolic acid biosynthesis in *** and provide new insights for SA signaling to regulate secondary metabolic biosynthesis.

关键词： element phenolic roots

兼顾江汉平原水稻产量和品质提高的优化施锌量研究

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河南农业科学 2024年第3期53卷 43-52页

作者：刘越周梦罗海伟党程成郝蓉蓉胡玉婷严鹏陈龙周刘洋旋田小海长江大学农学院湖北荆州434025 长江大学主要粮食作物产业化湖北省协同创新中心湖北荆州434025 大悟楚才高中湖北孝感432000 湖北省智慧农业有限公司湖北武汉430000

在大田条件下,以4个水稻品种(立香85、象牙香占、合两优927、昌两优8号)为试验材料,通过基施锌肥研究不同施锌量[0 kg/hm^(2)(CK)、7.5 kg/hm^(2)(Zn1)、15 kg/hm^(2)(Zn2)、30 kg/hm^(2)(Zn3)]下水稻产量、品质的变化,为江汉平原优质... 详细信息

在大田条件下,以4个水稻品种(立香85、象牙香占、合两优927、昌两优8号)为试验材料,通过基施锌肥研究不同施锌量[0 kg/hm^(2)(CK)、7.5 kg/hm^(2)(Zn1)、15 kg/hm^(2)(Zn2)、30 kg/hm^(2)(Zn3)]下水稻产量、品质的变化,为江汉平原优质稻锌肥施用提供理论依据。结果表明,施锌可以显著提高水稻产量,且水稻产量随着施锌量的增加呈先上升后降低的趋势,总体上以Zn2处理最高,Zn1处理次之。立香85、合两优927、昌两优8号以Zn2处理产量最高;象牙香占以Zn1处理产量最高,Zn2处理次之。施锌处理产量较CK增加了8.1%~28.8%。施锌对稻米加工品质有明显的改善作用,整体以Zn1和Zn2处理下糙米率、精米率、整精米率较高。不同施锌处理下直链淀粉含量因品种而异,其中,立香85以Zn1处理最高,昌两优8号以Zn2处理最高,象牙香占和合两优927以Zn3处理最高。对于淀粉RVA谱特征值,立香85、象牙香占、昌两优8号均以Zn1处理崩解值最高;消减值表现为立香85和合两优927在CK下最低,象牙香占和昌两优8号在Zn1处理下最低。各品种粗蛋白含量随施锌量的增加呈先升高后降低的趋势,其中,立香85、合两优927均以Zn1处理粗蛋白含量最高,象牙香占和昌两优8号均以Zn2处理粗蛋白含量最高。总体上,清蛋白、球蛋白和醇溶蛋白含量均以Zn2处理最高,谷蛋白含量以Zn1处理最高。糙米、精米锌含量也随着施锌量的增加呈现先增加后降低的趋势。其中,立香85、合两优927均以Zn1处理糙米锌含量最高,分别为23.1、19.8 mg/kg;象牙香占和昌两优8号均以Zn2处理最高,分别为20.0、17.7mg/kg。各品种糙米锌含量均大于精米锌含量。综合水稻产量、品质等多方面因素来看,江汉平原施锌处理以Zn1—Zn2为优,施锌量为7.5~15 kg/hm^(2)。

关键词：水稻锌肥产量品质锌含量

A Novel Trajectory Tracking Control of AGV Based on Udwadia-Kalaba Approach

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IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 1069-1071页

作者： rongrong Yu Han Zhao Shengchao Zhen Kang Huang Xianmin Chen hao Sun Ke Shao the School of Mechanical Engineering Hefei University of TechnologyHefei 230009China the College of Mechanical and Electronic Engineering Shandong University of Science and TechnologyQingdao 266590China the University of Science and Technology of China Hefei 230026China

Dear Editor,This letter is about an automated guided vehicle(AGV)trajectory tracking control method based on Udwadia-Kalaba(U-K)*** method provides a novel,concise and explicit motion equation for constrained mechanical systems with holonomic and/or nonholonomic constraints as well as constraints that may be ideal or *** this letter.

关键词： letter constraints constrained

A Novel Approach for Trajectory Tracking Control of an Under-Actuated Quad-Rotor UAV

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IEEE/CAA Journal of Automatica Sinica 2024年第9期11卷 2030-2032页

作者： Ke Shao Kang Huang Shengchao Zhen hao Sun rongrong Yu School of Civil Aviation Northwestern Polytechnical UniversityXi’an 710072 School of Mechanical Engineering Hefei University of TechnologyHefei 230009China

Dear Editor,This letter presents a novel Udwadia-Kalaba(U-K)approach for the trajectory tracking control of a quad-rotor unmanned aerial vehicle(UAV).Compared to conventional control approaches,the desired trajectorie... 详细信息

关键词： letter desired constraints

Reversing artemisinin resistance by leveraging thermo-responsive nanoplatform to downregulating GSH

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Chinese Chemical Letters 2024年第6期35卷 392-397页

作者： Yong-Dan Zhao Yidan Wang rongrong Wang Lina Chen Hengtong Zuo Xi Wang Jihong Qiang Geng Wang Qingxia Li Canqi Ping Shuqiu Zhang hao Wang School of Pharmacy Shanxi Medical UniversityTaiyuan 030001China National Center for Nanoscience and Technology Beijing 100190China Artemisinin Research Center Institute of Chinese Materia MedicaBeijing 100700China

Artemisinin(ART)resistance has been an emerging clinical problem,severely compromising antimalarial efficacy and threatening the global malaria elimination *** intensive studies about the molecular mechanism for ART resistance are under way,no effective therapeutic targets for reversing resistance have been ***,we explore glutathione(GSH)as a therapeutic target to develop a thermo-responsive nanoplatform to specifically co-deliver ART and GSH synthesis inhibitor(L-buthionine sulfoximine,BSO)in a sustained manner,effectively reversing ART resistance in *** combining with BSO,ART exerts increased antimalarial activity with reduced half-maximal inhibitory concentration(IC50)by 7.43-fold in ART-resistant *** work reveals that the GSH in ART-resistant parasites can be a promising therapeutic target for reversing ART resistance,paving the way for developing drug candidates and intelligent nanomedicines in malaria therapy.

关键词： Nanomedicines Drug delivery Artemisinins resistance Malaria Glutathione

Arecoline causes cognitive impairment and potential addiction via disturbing Kenyon cells in bumblebee brain

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Food Science and Human Wellness 2024年

作者： Huiling Liu Xiaohuan Mu rongrong Fan Jieteng Chen Jie Ma Liang Meng Xiaosong Hu hao Zheng Shanshan Liu Xiaofei Wang College of Food Science and Nutritional Engineering National Engineering Research Center for Fruit and Vegetable Processing Key Laboratory of Fruits and Vegetables Processing Ministry of Agriculture Engineering Research Centre for Fruits and Vegetables Processing Ministry of Education China Agricultural University BGI-Qingdao

Areca nut is the basic ingredient of betel quid， which is chewed by hundreds of millions of people in south-eastern Asia. Chewing of areca nut has been associated with oral cancers potentially due to its specific alkaloids， among which arecoline constitutes about 90% of total fraction. Being the world’s fourth most commonly used psychoactive substance， arecoline evokes stimulation， addiction， and other direct neurological effects， while its misuse correlates to neurotoxic effects. However， what might underlie its neurotoxic mechanisms has been poorly documented. The brain is encoded by a complex network of neuronal and glial cell types， and neurotoxicity of hazardous compounds present transcriptional heterogeneity. Recently， the eusocial bumblebee has been used as a model for studying brain effects， with sophisticated cognitive capability and precisely measured brain architecture. Here， we decipher cell-type-specific mental risks to arecoline using bumblebees. Arecoline induced locomotor hyperactivity and cognitive impairment. Single nucleus RNA sequencing (snRNA-seq) unearthed arecoline-induced cell-specific responses， primarily targeted on Kenyon cells (KC). Moreover， high-dose arecoline induced distinctive cell responses among KC subtypes， particularly class I large Kenyon cell (lKC)， leading to DNA damage， excitatory/inhibitory (E/I) imbalance， and calcium dyshomeostasis， which potentially resulted in cognitive impairment. Given arecoline’s popularity and growing exposure risks to humans， neurological health risks of areca nut warrant serious consideration.

关键词：

Reliable ferroelectricity down to cryogenic temperature in wakeup free Hf_(0.5)Zr_(0.5)O_(2)thin films by thermal atomic layer deposition

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Journal of Semiconductors 2024年第3期45卷 33-37页

作者： Shuyu Wu rongrong Cao hao Jiang Yu Li Xumeng Zhang Yang Yang Yan Wang Yingfen Wei Qi Liu State Key Laboratory of Fabrication Technologies for Integrated Circuits Institute of MicroelectronicsChinese Academy of SciencesBeijing 100029China Frontier institute of Chip and System Fudan UniversityShanghai 200433China College of Electronic Science and Technology National University of Defense TechnologyChangsha 410073China University of Chinese Academy of Sciences Beijing 100049China

The performance and reliability of ferroelectric thin films at temperatures around a few Kelvin are critical for their application in *** this work,TiN/Hf_(0.5)Zr_(0.5)O_(2)/TiN capacitors that are free from the wake-up effect are investigated systematically from room temperature(300 K)to cryogenic temperature(30 K).We observe a consistent decrease in permittivity(εr)and a progressive increase in coercive electric field(Ec)as temperatures *** investigation reveals exceptional stability in the double remnant polarization(2P_(r))of our ferroelectric thin films across a wide temperature ***,at 30 K,a 2P_(r)of 36μC/cm^(2)under an applied electric field of 3.0 MV/cm is ***,we observed a reduced fatigue effect at 30 K in comparison to 300 *** stable ferroelectric properties and endurance characteristics demonstrate the feasibility of utilizing HfO_(2)based ferroelectric thin films for cryo-electronics applications.

关键词： hafnia-zirconia solid solution ferroelectricity cryogenic temperature wake-up effect

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第三方惩罚行为的认知神经机制

心理科学进展 2024年第2期32卷 398-412,I0015-I0021页

作者：郑好陈荣荣买晓琴中国人民大学心理学系北京100872

第三方惩罚(third-party punishment,TPP)指个体作为第三方或者观察者为维护社会规范对违规者所实施的惩罚行为。大量研究为揭示TPP行为的神经机制提供了启示,但鲜有研究关注不同功能性脑网络在其中发挥的整体作用。本文综述了近10年来... 详细信息

第三方惩罚(third-party punishment,TPP)指个体作为第三方或者观察者为维护社会规范对违规者所实施的惩罚行为。大量研究为揭示TPP行为的神经机制提供了启示,但鲜有研究关注不同功能性脑网络在其中发挥的整体作用。本文综述了近10年来TPP相关的研究,对相关理论模型和脑网络进行总结,并在此基础上提出TPP的认知神经网络模型,系统地对TPP行为背后的神经机制进行解释和整合。在该模型中,情绪系统和奖赏系统是TPP的动力来源,认知系统主要负责责任评估以及惩罚的选择;奖赏网络、突显网络、默认模式网络和中央执行网络分别参与不同认知加工阶段。该模型建立了TPP相关研究在心理层面和认知神经层面上的联系,对TPP行为的发生和发展机制进行了更加整体、全面的解释。未来可以引入元分析或基于机器学习的分析方法,在不同的背景信息和更加复杂的社交情境下探讨第三方干预偏好以及背后的认知神经机制。

关键词：第三方惩罚认知神经机制脑网络 fMRI

求解电动汽车车辆路径问题的双种群协同进化算法

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智能系统学报 2024年第2期19卷 438-445页

作者：王朝秦芳刘蓉蓉江浩安徽大学人工智能学院安徽合肥230601

绿色物流领域新兴的电动汽车车辆路径问题,由于需要对车辆路径和充电决策同时优化,搜索空间急剧增大,且需要同时满足容量和电量双重约束,现有方法难以快速找到质量较优的可行解。为此,提出一种基于双种群的协同进化算法,通过忽略电量约... 详细信息

绿色物流领域新兴的电动汽车车辆路径问题,由于需要对车辆路径和充电决策同时优化,搜索空间急剧增大,且需要同时满足容量和电量双重约束,现有方法难以快速找到质量较优的可行解。为此,提出一种基于双种群的协同进化算法,通过忽略电量约束构造简单带容量约束的车辆路径问题,辅助原始复杂问题的快速求解。为实现其间信息交互,设计一种基于改进距离邻接矩阵的解序列特征表示方法,旨在同时获取客户访问顺序和车辆指派信息;利用降噪自编码器构建2个问题解之间转换关系,以实现问题域间知识迁移。将该算法与目前常用的3种启发式算法和2种进化算法在不同规模测试集上进行对比,试验结果表明所提算法具有更快收敛速度且所获解集具有更好收敛性。

关键词：绿色物流电动汽车车辆路径问题电量约束双种群进化算法距离邻接矩阵降噪自编码器知识迁移

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