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PRaG 3.0 therapy for human epidermal growth factor receptor 2-positive metastatic pancreatic ductal adenocarcinoma:A case report

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World Journal of Gastroenterology 2024年第9期30卷 1237-1249页

作者： Yue-Hong Kong Mei-Ling Xu Jun-Jun Zhang Guang-Qiang Chen Zhi-Hui Hong Hong Zhang Xiao-Xiao Dai Yi-Fu Ma xiang-rong zhao Chen-Yang Zhang rong-Zheng Chen Peng-Fei Xing Li-Yuan Zhang Center for Cancer Diagnosis and Treatment The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Radiotherapy&Oncology The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Institution of Radiotherapy&Oncology Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Radiology The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Nuclear Medicine The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Clinical Laboratory The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Pathology The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina

BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is a highly fatal disease with limited effective treatment especially after first-line *** human epidermal growth factor receptor 2(HER-2)immunohistochemistry(IHC)positive is associated with more aggressive clinical behavior and shorter overall survival in *** SUMMARY We present a case of multiple metastatic PDAC with IHC mismatch repair proficient but HER-2 IHC weakly positive at diagnosis that didn’t have tumor regression after first-line nab-paclitaxel plus gemcitabine and PD-1 inhibitor treatment.A novel combination therapy PRaG 3.0 of RC48(HER2-antibody-drug conjugate),radio-therapy,PD-1 inhibitor,granulocyte-macrophage colony-stimulating factor and interleukin-2 was then applied as second-line therapy and the patient had confirmed good partial response with progress-free-survival of 6.5 months and overall survival of 14.2 *** had not developed any grade 2 or above treatment-related adverse events at any *** of peripheral CD8^(+) Temra and CD4^(+) Temra were increased during first two activation cycles of PRaG 3.0 treatment containing radiotherapy but deceased to the baseline during the maintenance cycles containing no *** PRaG 3.0 might be a novel strategy for HER2-positive metastatic PDAC patients who failed from previous first-line approach and even PD-1 immunotherapy but needs more data in prospective trials.

关键词： Pancreatic ductal adenocarcinoma PRaG 3.0 therapy Human epidermal growth factor receptor 2 Novel combination therapy Case report

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Whole exome sequencing identifies risk variants associated with intracranial epidermoid cyst deterioration:A case report

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World Journal of Clinical Oncology 2024年第11期15卷 1428-1434页

作者： zhao-Na Song Yan Cheng Dan-Dan Wang Ming-Jun Li xiang-rong zhao Fa-Wang Li Zhen Liu Xiao-Ru Zhu Xiao-Dong Jia Yu-Fang Wang Feng-Fan Liang Joint Laboratory for Translational Medicine Research Liaocheng People's HospitalLiaocheng 252000Shandong ProvinceChina Harbin Genars Technology Co. Ltd.Harbin 150060Heilongjiang ProvinceChina Department of Radiotherapy Liaocheng People's HospitalLiaocheng 252000Shandong ProvinceChina Department of Medical laboratory Qilu Hospital of Shandong University Dezhou HospitalDezhou 253600Shandong ProvinceChina

BACKGROUND Intracranial epidermoid cyst(IEC)transformation to malignant squamous cell carcinoma(SCC)is extremely rare,and its etiology is yet ***,SCC is treated by performing surgery,followed by a combination of radiotherapy and *** is crucial to identify efficient and trustworthy therapeutic targets for SCC to improve its diagnosis,prognosis,and *** SUMMARY In this study,we report the case of a 47-year-old female patient with SCC,which progressed from IEC in the left internal capsule *** patient was sought treatment at our hospital for severe diplopic vision,accompanied with speech disorder and memory *** on the clinical and postoperative pathology,this patient was finally diagnosed with *** identify disease-causing variants,whole exome sequencing(WES)was performed on the *** revealed two pathogenic missense mutations on Gap junction protein beta 2(GJB2)(c.257C>T)and Toll-like receptor 2(TLR2)(c.1039A>G),*** This study provided the first clinical evidence for demonstrating the role of GJB2 and TLR2 in IEC development and *** further confirmed WES as a robust and reliable technique for underlying rare and complex disease-related genetic factor identification.

关键词： Intracranial epidermoid cyst Squamous cell carcinoma Whole exome sequencing Variants Case report

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New analytical solution for the analysis and design of permanent magnet thrust bearings

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第8期10卷 1199-1204页

作者： Huan YANG rong-xiang zhao Shi-you YANG School of Electrical Engineering Zhejiang University Hangzhou 310027 China

On the basis of the current sheet model, a new analytical solution for permanent magnet （PM） bearings is developed. Compared with analytical methods based on the coupling energy model and the magnetic dipole model, the proposed one is more physically intuitive and convenient for engineering designers. According to the analytical model, the thrust characteristics of a novel PM thrust bearing is studied and verified by finite element analysis （FEA）. In the proposed thrust bearing configuration, the rotor is composed of stacked PM tings with alternative axial magnetization directions, and the stator with alternative radial magnetization directions while copper rings are used to separate adjacent PM rings. A prototype PM thrust bearing with the proposed configuration is designed and fabricated. The performances of the PM thrust beating are experimentally validated. It is shown that the calculation accuracy of the presented analytical solution is satisfying.

关键词： Permanent magnet (PM) Current sheet model Thrust bearing Vibration

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Ce_(2)(MoO_(4))_(3) as an efficient catalyst for aerobic oxidative desulfurization of fuels

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Petroleum Science 2022年第2期19卷 861-869页

作者： Xiao-Yi Liu Xiu-Ping Li rong-xiang zhao School of Petrochemical Engineering Liaoning Petrochemical UniversityFushun113001LiaoningChina

Ce_(2)(MoO_(4))_(3)was synthesized by a simple reflux method using cerium nitrate hexahydrate and ammonium molybdate as *** as-prepared Ce_(2)(MoO_(4))_(3)was characterized by Fourier transform infrared spectroscopy(FT-IR),X-ray diffraction(XRD),Scanning electron microscope(SEM),and X-ray photoelectron spectroscopy(XPS).The removal of dibenzothiophene(DBT)in model oil was studied using Ce_(2)(MoO_(4))_(3)as catalyst and oxygen as *** reaction factors such as reaction temperature,amount of catalyst,and sulfide type on sulfur removal were *** results prove that both Ce3+and MoO42-play significant role in the conversion from DBT to *** Ce_(2)(MoO_(4))_(3)catalyst has an excellent performance for the sulfur removal of *** the optimum reaction conditions,sulfur removal of 99.6%was *** recycling five times,no significant loss in catalyst activity of Ce_(2)(MoO_(4))_(3).Mechanism of aerobic oxidative desulfurization was proposed based on the experiment of free radical capture and infrared characterization.

关键词： Ce_(2)(MoO_(4))_(3) Aerobic oxidative desulfurization Dibenzothiophene Reflux Renewability

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Hydrodynamic Performance of An Integrated System of Breakwater and A Multi-Chamber OWC Wave Energy Converter

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China Ocean Engineering 2024年第4期38卷 543-556页

作者： NING De-zhi ZHANG xiang-yu WANG rong-quan zhao Ming State Key Laboratory of Coastal and Offshore Engineering Dalian University of TechnologyDalian 116024China Dalian Key Laboratory of Offshore Renewable Energy Dalian University of TechnologyDalian 116024China School of Computing Engineering and MathematicsUniversity of Western SydneyPenrith NSW 2751Australia

A multi-chamber oscillating water column wave energy converter(OWC-WEC)integrated to a breakwater is *** hydrodynamic characteristics of the device are analyzed using an analytical model based on the linear potential flow theory.A pneumatic model is employed to investigate the relationship between the air mass flux in the chamber and the turbine *** effects of chamber width,wall draft and wall thickness on the hydrodynamic performance of a dual-chamber OWC-WEC are *** results demonstrate that the device,with a smaller front wall draft and a wider rear chamber exhibits a broader effective frequency *** device with a chamber-width-ratio of 1:3 performs better in terms of power ***,results from the analysis of a triplechamber OWC-WEC demonstrate that reducing the front chamber width and increasing the rearward chamber width can improve the total performance of the *** the number of chambers from 1 to 2 or 3 can widen the effective frequency bandwidth.

关键词： oscillating water column power extraction efficiency potential flow theory wave energy converter multi-chamber

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Emergence of lesions outside of the basal ganglia and irreversible damage to the basal ganglia with severeβ-ketothiolase deficiency:A case report

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World Journal of Clinical Cases 2021年第30期9卷 9276-9284页

作者： Jun Guo Dan Ren Zhong-Jie Guo Jing Yu Fu Liu rong-xiang zhao Yu Wang Department of Paediatrics Mianyang Central HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaMianyang 621000Sichuan ProvinceChina Department of Medical Image Mianyang Central HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaMianyang 621000Sichuan ProvinceChina Department of Pharmacy Mianyang Central HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaMianyang 621000Sichuan ProvinceChina

BACKGROUNDβ-ketothiolase deficiency(β-KTD)is an inherited disease,and insufficient attention has been paid to imageology due to its lower ***,few lesions outside the basal ganglia have been found before,and the persistent pathological changes have rarely been *** SUMMARY A 10-mo-old Chinese female patient with a free previous medical history but with poor physical and athletic development had received the haemophilus influenzae vaccine and then developed a low fever 2 d *** was initially diagnosed with severe brain injury,central respiratory failure,metabolic acidosis complicated with respiratory alkalosis,hyper-IgE,*** further examination,a definite diagnosis ofβ-KTD was *** treatment was *** days later,the dyspnea was improved evidently and the ventilator was removed,but there were still obvious abnormalities on magnetic resonance imaging(MRI).The lesions mainly invaded the corpus striatum but were not limited to the basal ***,the patient’s disease improved and discharged approximately 1 mo later,and the abnormal lesions on MRI had partially ***,for about 1 year,the residual irreversible lesions were observed on MRI,the mental and physical development of the patient was obviously regressive,and extra rehabilitation training was *** The case highlights the critical importance of one view that the range of lesions in some patients may be more extensive than previously thought in someβ-KTD *** addition to biochemical tests,genetic tests and magnetic resonance imaging are not only conducive to quickly diagnosingβ-KTD but also to partially evaluating the short-and long-term ***,more attention should be paid to the two mutations(c.478 C>G;c.951 C>T)that may be associated with severeβ-KTD.

关键词： Life-threatening symptoms Severeβ-ketothiolase deficiency Lesions outside of the basal ganglia Irreversible damage to the basal ganglia Magnetic resonance imaging New mutation Case report

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Sinomenine promotes differentiation of induced pluripotent stem cells into immature dendritic cells with high induction of immune tolerance

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World Journal of Stem Cells 2022年第8期14卷 599-615页

作者： Xiao-Yan Huang Zhan-Kui Jin Meng Dou Bing-Xuan Zheng xiang-rong zhao Qing Feng Yang-Meng Feng xiang-Long Duan Pu-Xun Tian Cui-xiang Xu Shaanxi Provincial Key Laboratory of Infection and Immune Diseases Shaanxi Provincial People’s HospitalXi'an 710068Shaanxi ProvinceChina Department of Orthopedics Shaanxi Provincial People’s HospitalXi'an 710068Shaanxi ProvinceChina Department of Kidney Transplantation The First Affiliated Hospital of Xi’an Jiaotong UniversityXi'an 710061Shaanxi ProvinceChina Second Department of General Surgery Shaanxi Provincial People's HospitalXi'an 710068Shaanxi ProvinceChina

BACKGROUND Immature dendritic cells(imDCs)play an important role in the induction of donor-specific transplant ***,these cells have limitations,such as rapid maturation and a short lifespan in *** previous studies,induced pluripotent stem cells(iPSCs)differentiated into imDCs,and sinomenine(SN)was used to inhibit the maturation of *** To study the capacity of SN to maintain iPSC-derived imDCs(SN-iPSCs-imDCs)in an immature state and the mechanism by which SN-iPSCs-imDCs induce *** In this study,mouse iPSCs were induced to differentiate into imDCs in culture medium without or with SN(iPSCs-imDCs and SN-iPSCs-imDCs).The imDCrelated surface markers,endocytotic capacity of fluorescein isothiocyanate Dextran and apoptosis were analyzed by flow *** effects of iPSCs-imDCs and SNiPSCs-imDCs on T-cell stimulatory function,and regulatory T(Treg)cell proliferative function in vitro were analyzed by mixed lymphocyte *** expression was detected by *** apoptosis-related proteins of iPSCs-DCs and SN-iPSCs-DCs were analyzed by western *** induced immunotolerance of SN-iPSCs-DCs was evaluated by treating recipient Balb/c skin graft *** evaluation of graft survival was performed using Kaplan–Meier *** Both iPSCs-imDCs and SN-iPSCs-imDCs were successfully obtained,and their biological characteristics and ability to induce immunotolerance were ***-iPSCs-imDCs exhibited higher CD11c levels and lower CD80 and CD86 levels compared with *** major histocompatibility complex II expression,worse T-cell stimulatory function,higher Treg cell proliferative function and stronger endocytotic capacity were observed with SN-iPSCs-imDCs(P<0.05).The levels of interleukin(IL)-2,IL-12,interferon-γin SN-iPSCs-imDCs were lower than those in iPSCs-imDCs,whereas IL-10 and transforming growth factor-βlevels were higher(P<0.05).The apoptosis rate of these cells was significan

关键词： Immature dendritic cells Induced pluripotent stem cells Sinomenine Immune tolerance Organ transplantation

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Maximal operators of pseudo-differential operators with rough symbols

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Applied Mathematics(A Journal of Chinese Universities) 2024年第1期39卷 174-180页

作者： Ramla Benhamoud ZHU xiang-rong School of Mathematical Sciences Zhejiang Normal UniversityJinhua 321004China

Consider a pseudo-differential operator T_(a)f(x)=∫_(R^(n))e^(ix,ζ)a(x,ζ)f(ζ)dζwhere the symbol a is in the rough Hormander class L^(∞)S_(ρ)^(m)with m∈R andρ∈[0,1].In this note,when 1≤p≤2,if n(ρ-1)/p and a∈L^(∞)S_(ρ)^(m),then for any f∈S(R^(n))and x∈R^(n),we prove that M(T_(a)f)(x)≤C(M(|f|^(p))(x))^(1/p) where M is the Hardy-Littlewood maximal *** theorem improves the known results and the bound on m is sharp,in the sense that n(ρ-1)/p can not be replaced by a larger constant.

关键词： pseudo-differential operator rough Hormander class H-L maximal operator

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Reinforcement of High Impact Polystyrene by Aramid Nanoparticle Fillers Prepared via an In situ Bottom-up Approach

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Chinese Journal of Polymer Science 2024年第8期42卷 1167-1176页

作者： xiang-Jun Gong Zhi-Ping zhao Chang-Mei Sun Ying Zhang rong-Jun Qu Ying Wang School of Chemistry and Materials Science Ludong UniversityYantai 264025China

In this work,aramid nanoparticles(ANPs)were prepared in dimethyl formamide(DMF)solution containing high impact polystyrene(HIPS)via a bottom-up *** electron microscopy(TEM)images showed that the obtained ANPs were evenly distributed in the HIPS matrix without any *** composition of the ANPs,i.e.,poly(p-phenyl-p-phenylenediamine)(PPTA),was confirmed by Fourier transform infrared spectroscopy(FTIR),X-ray photoelectron spectroscopy(XPS)and X-ray diffractometer(XRD).The ANP/HIPS composites,obtained after ethanol precipitation,were added to neat HIPS as fillers to fabricate ANP/HIPS composite *** surface roughness and the glass transition temperature(T_g)of the sheets were characterized by atomic force microscope(AFM)and differential scanning calorimetry(DSC),*** with neat HIPS,the mechanical properties of the composite sheet were significantly improved,and the Young's modulus increased from 246.55 MPa to 2025.12 MPa,the tensile strength increased from 3.07 MPa to 29.76 MPa,and the toughness increased from 0.32 N/mm^2 to 3.92 N/mm^2,with an increase rate of 721%,869%and 1125%,***,the thermal stability of the composites improved with the increase in ANP content.

关键词： High impact polystyrene PPTA nanoparticle Reinforce Mechanical property

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Haploinsufficiency of Lipin3 leads to hypertriglyceridemia and obesity by disrupting the expression and nucleocytoplasmic localization of Lipin1

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Frontiers of Medicine 2024年第1期18卷 180-191页

作者： Fang Wang Yuxing Liu Yi Dong Meifang zhao Hao Huang Jieyuan Jin Liangliang Fan rong xiang Department of Endocrinology The Third Xiangya Hospital of Central South UniversityChangsha410013China Department of Cellular Biology School of Life SciencesKey Laboratory of Pediatric Rare DiseasesMinistry of EducationCentral South UniversityChangsha410013China

Lipin proteins including Lipin 1–3 act as transcriptional co-activators and phosphatidic acid phosphohydrolase enzymes,which play crucial roles in lipid ***,little is known about the function of Lipin3 in triglyceride(TG)***,we identified a novel mutation(NM_001301860:p.1835A>T/p.D612V)of Lipin3 in a large family with hypertriglyceridemia(HTG)and obesity through whole-exome sequencing and Sanger *** studies revealed that the novel variant altered the half-life and stability of the Lipin3 ***,we generated Lipin3 heterozygous knockout(Lipin3-heKO)mice and cultured primary hepatocytes to explore the pathophysiological roles of Lipin3 in TG *** found that Lipin3-heKO mice exhibited obvious obesity,HTG,and non-alcoholic fatty liver *** study demonstrated that the haploinsufficiency of Lipin3 in primary hepatocytes may induce the overexpression and abnormal distribution of Lipin1 in cytosol and *** increased expression of Lipin1 in cytosol may contribute to TG anabolism,and the decreased Lipin1 in nucleoplasm can reduce PGC1α,further leading to mitochondrial dysfunction and reduced TG *** study suggested that Lipin3 was a novel disease-causing gene inducing obesity and *** also established a relationship between Lipin3 and mitochondrial dysfunction.

关键词： Lipin3 Lipin1 hypertriglyceridemia obesity mitochondrial dysfunction

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