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Isotoosendanin exerts inhibition on triple-negative breast cancer through abrogating TGF-β-induced epithelial—mesenchymal transition via directly targeting TGFβR1

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药学学报:英文版 2023年第7期13卷 2990-3007页

作者： Jingnan Zhang Ze Zhang Zhenlin Huang Manlin Li Fan Yang Zeqi wu qian Guo Xiyu Mei Bin Lu Changhong Wang Zhengtao Wang Lili Ji The MOE Key Laboratory for Standardization of Chinese Medicines Shanghai Key Laboratory of Compound Chinese Medicines and the SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese MedicinesInstitute of Chinese Materia MedicaShanghai University of Traditional Chinese MedicineShanghai 201203China

As the most aggressive breast cancer,triple-negative breast cancer(TNBC) is still incurable and very prone to *** transform growth factor β(TGF-β)-induced epithelial—mesenchymal transition(EMT) is crucially involved in the growth and metastasis of *** study reported that a natural compound isotoosendanin(ITSN) reduced TNBC metastasis by inhibiting TGF-β-induced EMT and the formation of *** can directly interact with TGF-β receptor type-1(TGFβR1) and abrogated the kinase activity of TGFβR1,thereby blocking the TGF-β-initiated downstream signaling ***,the ITSN-provided inhibition on metastasis obviously disappeared in TGFβR1-overexpressed TNBC cells in vitro as well as in mice bearing TNBC cells overexpressed TGFβ***,Lys232 and Asp351 residues in the kinase domain of TGFβR1 were found to be crucial for the interaction of ITSN with TGFβ***,ITSN also improved the inhibitory efficacy of programmed cell death 1 ligand 1(PD-L1) antibody for TNBC in vivo via inhibiting the TGF-β-mediated EMT in the tumor *** findings not only highlight the key role of TGFβR1 in TNBC metastasis,but also provide a leading compound targeting TGFβR1 for the treatment of TNBC ***,this study also points out a potential strategy for TNBC treatment by using the combined application of anti-PD-L1 with a TGFβR1 inhibitor.

关键词： TNBC Isotoosendanin Metastasis TGFβR1 Epithelial-mesenchymal transition Invadopodia PD-L1 Tumor microenvironment

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SOCS1/JAK2/STAT3 axis regulates early brain injury induced by subarachnoid hemorrhage via inflammatory responses

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Neural Regeneration Research 2021年第12期16卷 2453-2464页

作者： Yang Wang Xiang-qian Kong Fei wu Bin Xu De-Jun Bao Chuan-Dong Cheng Xiang-Ping Wei Yong-Fei Dong Chao-Shi Niu Department of Neurosurgery First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Vascular Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinanShandong ProvinceChina Department of Vascular Surgery Shandong Provincial HospitalCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Anhui Medical College Anhui Provincial Medical Genetics CenterHefeiAnhui ProvinceChina Anhui Province Key Laboratory of Brain Function and Brain Disease HefeiAnhui ProvinceChina

The SOCS1/JAK2/STAT3 axis is strongly associated with tumor growth and progression,and participates in cytokine secretion in many ***,the effects of the SOCS1/JAK2/STAT3 axis in experimental subarachnoid hemorrhage remain to be studied.A subarachnoid hemorrhage model was established in rats by infusing autologous blood into the optic chiasm *** rats were first treated with JAK2/STAT3 small interfering RNA(Si-JAK2/Si-STAT3)or overexpression plasmids of JAK2/*** the brains of subarachnoid hemorrhage model rats,the expression levels of both JAK2 and STAT3 were upregulated and the expression of SOCS1 was downregulated,reaching a peak at 48 hours after ***,the interactions between JAK2 and SOCS1 were *** contrast,the interactions between JAK2 and STAT3 were markedly ***-JAK2 and Si-STAT3 treatment alleviated cortical neuronal cell apoptosis and necrosis,destruction of the blood-brain barrier,brain edema,and cognitive functional impairment after subarachnoid *** was accompanied by decreased phosphorylation of JAK2 and STAT3 protein,decreased total levels of JAK2 and STAT3 protein,and increased SOCS1 protein ***,overexpression of JAK2 and STAT3 exerted opposite effects,aggravating subarachnoid hemorrhage-induced early brain ***-JAK2 and Si-STAT3 inhibited M1-type microglial conversion and the release of pro-inflammatory factors(inducible nitric oxide synthase,interleukin-1β,and tumor necrosis factor-α)and increased the release of anti-inflammatory factors(arginase-1,interleukin-10,and interleukin-4).Furthermore,primary neurons stimulated with oxyhemoglobin were used to simulate subarachnoid hemorrhage in vitro,and the JAK2 inhibitor AG490 was used as an *** in vitro results also suggested that neuronal protection is mediated by the inhibition of JAK2 and STAT3 ***,our findings indicate that the SOCS1/JAK2/STAT3 axis contributes to early brain injury after

关键词： brain injury cytokines in vitro model in vivo model inflammation microglia SOCS1/JAK2/STAT3 axis subarachnoid hemorrhage

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便携式尿酸分析仪校准方法研究

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计量科学与技术 2024年第4期68卷 45-49,30页

作者：崔宏恩殷格漫武利庆杨铮于海容周倩张凯江苏省计量科学研究院南京210023 中国计量科学研究院北京100029 江苏省医疗器械检验所南京210009 山东省计量科学研究院济南250014 三诺生物传感股份有限公司长沙410215 江苏鱼跃凯立特生物科技有限公司镇江212300

便携式尿酸分析仪的准确与否对痛风和高尿酸血症患者日常监测尿酸有着直接影响,针对其校准规范的缺失,需制定其校准规范。基于搭建的便携式尿酸分析仪校准装置,通过提出便携式尿酸分析仪校准方法,确定其技术指标,结合校准案例进行验证... 详细信息

便携式尿酸分析仪的准确与否对痛风和高尿酸血症患者日常监测尿酸有着直接影响,针对其校准规范的缺失,需制定其校准规范。基于搭建的便携式尿酸分析仪校准装置,通过提出便携式尿酸分析仪校准方法,确定其技术指标,结合校准案例进行验证以及对相关影响因素进行分析。依据校准方法,便携式尿酸分析仪的示值误差和重复性的验证结果符合技术要求,成功建立的便携式尿酸分析仪校准方法,可为《便携式尿酸分析仪校准规范》的编写提供有益参考,促进便携式尿酸分析仪的量值溯源和标准化。

关键词：计量学尿酸计量特性校准溯源便携式尿酸分析仪

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How light affect the magnetotactic behavior and reproduction of ellipsoidal multicellular magnetoglobules?

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Journal of Oceanology and Limnology 2021年第6期39卷 2005-2014页

作者： Xinxin qian Yicong ZHAO Claire-Lise SANTINI Hongmiao PAN Tian XIAO Haitao CHEN Tao SONG Jinhua LI Francois ALBERTO Sophie BRUSTLEIN Long-Fei wu State Key Laboratory of Microbial Resources Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Aix Marseille University CNRSLCBCenturiIM2BIMMMarseille 13009France International Associated Laboratory of Evolution and Development of Magnetotactic Multicellular Organisms(LIA-MagMC) CNRS-CASMarseille 13402France CAS Key Laboratory of Marine Ecology and Environmental Sciences Institute of OceanologyChinese Academy of SciencesQingdao 266071China Institute of Electrical Engineering Chinese Academy of SciencesBeijing 100190China Key Laboratory of Earth and Planetary Physics Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China Aix Marseille University CenturiMarseille 13009France

Magnetotactic bacteria(MTB)synthesize intracellular magnetic organelles,magnetosomes,which consist of magnetic crystals that are enveloped in a *** are organized into a chain(s)and confer on cells a magnetic dipolar *** magnetic property allows MTB cells to align and swim along geomagnetic field lines,a movement referred to as *** MTB species change their swim direction in response to illumination by UV,violet and blue *** we analyzed the polarity of morphology,magnetism,and motion in Mediterranean multicellular magnetotactic prokaryotes,also called,magnetoglobules or *** magnetoglobules were assembled from 60-80 cells into an asymmetric ellipsoidal morphology with a relative narrow and large *** swam dominantly northward,parallel to the direction of the magnetic field,with the narrow-end as the leading *** response to a reversal in the direction of the magnetic field,they aligned quickly along the magnetic field lines and kept swimming ***,under constant illumination,385-nm UV light,magnetoglobules changed their swimming direction southward anti-parallel to the direction of the magnetic field,with the large-end as the leading *** change from a northward to southward direction occurred along with an increase of swimming speed.A minimum of 35-mW/cm^(2) irradiance of UV light was sufficient to trigger the swimming *** radiation also triggered the unidirectional division of *** these results revealed a coordination of the polarity of magnetoglobule morphology,magnetic moment,and swimming orientation,in response to magnetic and optical *** UV triggered the reversal of magnetotaxis and magnetoglobule division indicating the ecological significance of light for multicellular magnetotactic prokaryotes.

关键词： photo-response magnetic alignment coordinated swimming

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Two-particle correlation and finite size effects of rapiditybin in ultra-relativistic heavy-ion collisions

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Nuclear Science and Techniques 1998年第2期9卷 78-81页

作者： Zhou Dai-Cui Cai Xu Liu Lian-Shou qian Wan-Yan Wang Xiao-rong Yang Chun-Bin and Yan Wen-Biao (Institute of Particle Physics, Hua-Zhong Normal University wuhan 430079) Institute of Particle Physics Hua-Zhong Normal University Wuhan 430079 China

Using an aspect of rapidity bins with finite sizes the short-range and longrange behaviors of two-particle correlation, the connection of two particle correlation function with factorial moment and factorial correlator are investigated; and experimental data for 16 O+Em interactions at 14.6, 60 and 200 A GeV and 32 S+197Au interactions at 200A GeV are analyzed. It is shown that the bin-average of two-particle correlation function can naturally give a coordinate description of dynamical fluctuation such as the second order factorial moment and 1+1 order factorial correlator .

关键词：重离子超相对论碰撞二粒子关联有限尺度效应

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Synergistic anti-liver cancer effects of curcumin and total ginsenosides

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World Journal of Gastrointestinal Oncology 2020年第10期12卷 1091-1103页

作者： Zhe Deng Xiao-Yan Xu Fenny Yunita Qing Zhou Yong-rong wu Yu-Xing Hu Zhi-Qi Wang Xue-Fei Tian Department of Internal Medicine College of Integrated Chinese and Western MedicineHunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Hunan Key Laboratory of Translational Research in Formulas and Zheng of Traditional Chinese Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina The First Affiliated Hospital Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina School of Basic Chinese Medical Sciences Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina College of Pharmaceutical Sciences Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina

BACKGROUND Liver cancer is the sixth most frequently occurring cancer in the world and the fourth most common cause of cancer *** pathogenesis of liver cancer is closely associated with inflammation and immune response in the tumor *** therapeutic agents for liver cancer,which can control inflammation and restore cellular immunity,are ***(Cur)is a natural anti-inflammatory drug,and total ginsenosides(TG)are a commonly used immunoregulatory *** note,both Cur and TG have been shown to exert anti-liver cancer *** To determine the synergistic immunomodulatory and anti-inflammatory effects of Cur combined with TG in a mouse model of subcutaneous liver *** A subcutaneous liver cancer model was established in BALB/c mice by a subcutaneous injection of hepatoma cell *** were treated with Cur(200 mg/kg per day),TG(104 mg/kg per day or 520 mg/kg per day),the combination of Cur(200 mg/kg per day)and TG(104 mg/kg per day or 520 mg/kg per day),or 5-fluorouracil combined with cisplatin as a positive control for 21 *** volume was measured and the protein expression of programmed cell death 1 and programmed cell death 1 ligand 1(PD-L1),inflammatory indicators Toll like receptor 4(TLR4)and nuclear factor-κB(NF-κB),and vascular growth-related factors nitric oxide synthases(iNOS)and matrix metalloproteinase 9 were analyzed by Western blot ***4+CD25+Foxp3+regulatory T cells(Tregs)were counted by flow *** The combination therapy of Cur and TG significantly inhibited the growth of liver cancer,as compared to vehicle-treated animals,and TG showed dose *** combined with TG-520 markedly decreased the protein expression of PD-L1(P<0.0001),while CD4+CD25+Foxp3+Tregs regulated by the PD-L1 signaling pathway exhibited a positive correlation with *** combined with TG-520 also inhibited the cascade action mediated by NF-κB(P<0.0001),thus inhibiting the TLR4/NF-κB signalling pathway(

关键词： Total ginsenosides Curcumin Liver cancer Immune Inflammation Programmed cell death 1 ligand 1

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Transcriptome and Metabolome Analyses of Sea Cucumbers Apostichopus japonicus in Southern China During the Summer Aestivation Period

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Journal of Ocean University of China 2021年第1期20卷 198-212页

作者： YANG Qiuhua ZHANG Xusheng LU Zhen HUANG Ruifang TRAN Ngoc Tuan wu Jianshao YANG Fuyuan GE Hui ZHONG Chenhui SUN qian ZHOU Chen LIN Qi Key Laboratory of Cultivation and High-Value Utilization of Marine Organisms in Fujian Province Fisheries Research Institute of FujianXiamen 361013China Guangdong Provincial Key Laboratory of Marine Biology Marine Biology InstituteShantou UniversityShantou 515063China

Aestivation is a common strategy of sea cucumbers(Apostichopus japonicus)in response to high-temperature *** studies have individually investigated the immune and physiological alterations at the aestivation ***,these studies have not evaluated the relationship between immunity and *** this study,we explored the transcriptome and metabolome of *** during the aestivation stage to study the *** transcriptome analysis of dormant(aestivation)and revived *** generated 2368 differentially expressed genes,including 927 downregulated genes and 1441 upregulated *** on Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses,the downregulated genes in the dormant group were found to be involved in DNA replication,RNA metabolic process,and protein metabolism,which results in the inhibition of motility,skeletal development,neural activity,cell proliferation,and development of *** contrast,the upregulated genes were found to be associated with fatty acid metabolism,carbohydrate hydrolysis,and *** the metabolome analysis,the downregulated metabolites were found to be associated with fatty acid metabolism,starch and sucrose metabolism,and TCA *** indicates that dormant sea cucumbers consume reserved carbohydrates and fatty acids to maintain low levels of energy *** protein-protein interaction network analysis further revealed that carbohydrate hydrolysis promoted phagocytosis activity in the dormant *** study provides new insights into potential molecular mechanisms of sea cucumber survival in high-temperature conditions,which is critical in aquaculture of sea cucumbers.

关键词： aestivation Apostichopus japonicus hypometabolism fatty acid metabolism carbohydrate hydrolysis phagocytosis

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The advanced development of molecular targeted therapy for hepatocellular carcinoma

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Cancer Biology & Medicine 2022年第6期19卷 802-817页

作者： Tao Yan Lingxiang Yu Ning Zhang Caiyun Peng Guodong Su Yi Jing Linzhi Zhang Tong wu Jiamin Cheng qian Guo Xiaoliang Shi Yinying Lu Comprehensive Liver Cancer Center the 5th Medical Center of Chinese PLA General HospitalBeijing 100039China The Second School of Clinical Medicine Southern Medical UniversityGuangzhou 510515China The Second Department of Hepatobiliary Surgery Senior Department of Hepatologythe 5th Medical Center of Chinese PLA General HospitalBeijing 100039China Shanghai OrigiMed Co. Ltd.Shanghai 201112China National Clinical Medical Research Center for Infectious Diseases the 5th Medical Center of Chinese PLA General HospitalBeijing 100039China

Hepatocellular carcinoma(HCC),one of the most common malignant tumors in China,severely threatens the life and health of *** recent years,precision medicine,clinical diagnoses,treatments,and innovative research have led to important breakthroughs in HCC *** discovery of new biomarkers and the promotion of liquid biopsy technologies have greatly facilitated the early diagnosis and treatment of *** in targeted therapy and immunotherapy has provided more choices for precise HCC *** technologies,such as genomics,transcriptomics,and metabolomics,have enabled deeper understanding of the occurrence and development mechanisms,heterogeneity,and genetic mutation characteristics of *** continued promotion and accurate typing of HCC,accurate guidance of treatment,and accurate prognostication have provided more treatment opportunities and prolonged survival timelines for patients with *** HCC research providing an in-depth understanding of the biological characteristics of HCC will be translated into accurate clinical practices for the diagnosis and treatment of HCC.

关键词： Hepatocellular carci no ma precision medicine liquid biopsy targeted therapy immunotherapy

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Application of Near Infrared Diffuse Reflectance Spectroscopy with Radial Basis Function Neural Network to Determination of Rifampincin Isoniazid and Pyrazinamide Tablets

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Chemical Research in Chinese Universities 2007年第5期23卷 518-523页

作者： DU Lin-na wu Li-hang LU Jia-hui GUO Wei-liang MENG Qing-fan JIANG Chao-jun SHEN Si-le TENG Li-rong College of Life Science College of Animal Science and Veterinary Medicine College of Chemistry Jilin University Changchun 130012 P. R. China

Partial least squares（PLS）,back-propagation neural network（BPNN）and radial basis function neural network（RBFNN）were respectively used for estalishing quantative analysis models with near infrared（NIR）diffuse reflectance spectra for determining the contents of rifampincin（RMP）,isoniazid（INH）and pyrazinamide（PZA）in rifampicin isoniazid and pyrazinamide ***-Golay smoothing,first derivative,second derivative,fast Fourier transform（FFT）and standard normal variate（SNV）transformation methods were applied to pretreating raw NIR diffuse reflectance *** raw and pretreated spectra were divided into several regions,depending on the average spectrum and RSD *** component analysis（PCA）method was used for analyzing the raw and pretreated spectra in different regions in order to reduce the dimensions of input *** optimum spectral regions and the models＇ parameters were chosen by comparing the root mean square error of cross-validation（RMSECV）values which were obtained by leave-one-out cross-validation *** RMSECV values of the RBFNN models for determining the contents of RMP,INH and PZA were 0.00288,0.00226 and 0.00341,*** these models for predicting the contents of INH,RMP and PZA in prediction set,the RMSEP values were 0.00266,0.00227 and 0.00411,*** results are better than those obtained from PLS models and BPNN *** additional advantages of fast calculation speed and less dependence on the initial conditions,RBFNN is a suitable tool to model complex systems.

关键词： Rifampicin isoniazid and pyrazinamide tablets NIR diffuse reflectance spectroscopy Partial least square Back-propagation neural network Radial basis function neural network

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基于质谱代谢组学分析冠状动脉狭窄和钙化对循环代谢物的影响

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昆明理工大学学报（自然科学版） 2024年第3期49卷 229-238页

作者：易伦朝李慧敏吴昊王瑞云顾颖杨柱林付光辉赵燕壮可任达兵王茜张宏昆明理工大学食品科学与工程学院云南昆明650500 昆明理工大学化学工程学院云南昆明650500 昆明理工大学附属医院云南昆明650032 云南省第一人民医院心血管内科云南昆明650032 昆明理工大学理学院云南昆明650500

冠心病是一种常见的心血管疾病,严重威胁人类健康.冠状动脉钙化在冠心病患者中非常普遍,钙化的进展与不良心血管疾病预后息息相关.本研究共召集164位患者,91名冠心病患者中钙化人群比例为68.13%,其中62人发生了冠脉钙化,29人无钙化.通... 详细信息

冠心病是一种常见的心血管疾病,严重威胁人类健康.冠状动脉钙化在冠心病患者中非常普遍,钙化的进展与不良心血管疾病预后息息相关.本研究共召集164位患者,91名冠心病患者中钙化人群比例为68.13%,其中62人发生了冠脉钙化,29人无钙化.通过对召集的患者进行年龄、性别、身体质量指数匹配,最终共入组68位患者进行血浆代谢组学研究,包括非冠心病(n=29)和冠心病(n=29)患者以及冠心病中血管钙化(n=12)和无钙化患者(n=12),以探究冠状动脉狭窄和钙化对循环代谢物的影响.超高效液相色谱-高分辨质谱联用技术共鉴定出血浆中的101个内源性代谢物,t检验结果表明,冠心病与非冠心病患者中含量有显著性差异的代谢物有12个,钙化与非钙化患者中含量有显著性差异的代谢物有2个.将基于稀疏正则化的子抽样-支持向量机方法所筛选到的代谢物和t检验中含量具有显著性差异的代谢物一起进行富集分析和代谢通路分析,结果表明,冠状动脉狭窄是影响循环代谢的主要因素,主要影响丙氨酸、天冬氨酸和谷氨酸代谢为主的氨基酸代谢、亚麻酸代谢、甘油磷脂代谢和三羧酸循环;冠状动脉狭窄基础上的血管钙化对循环代谢影响较小,只有溶血磷脂酰乙醇胺(18∶2)在钙化组中显著上调.

关键词：代谢组学冠心病冠状动脉钙化超高效液相色谱-高分辨质谱联用技术支持向量机

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