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Gastroenterology Report 2022年第1期10卷 653-655页

作者： jun-rong chen Lei Mai Jia-chen Sun Xiang Peng Min Zhang Min Zhi Department of General Practice The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdongP.R.China Department of Gastroenterology The Fifth Affiliated HospitalSun Yat-sen UniversityZhuhaiGuangdongP.R.China Department of Gastrointestinal Endoscopy The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdongP.R.China Department of Gastroenterology The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdongP.R.China

Introduction Inducing and maintaining clinical remission and mucosal healing is essential in the treatment of ulcerative colitis(UC),a nonspecific chronic recurrent inflammatory disorder[1].Mesalazine(5-ASA)is commonly prescribed as a first-line drug for *** the short-term efficacy of ciclosporin and infliximab,some patients may develop methylprednisolone resistance or dependence[2].

关键词： healing clinical treatment

A simple taurocholate-induced model of severe acute pancreatitis in rats

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World Journal of Gastroenterology 2009年第45期15卷 5732-5739页

作者： Zhong-Hui Liu jun-Sheng Peng Chu-jun Li Zu-Li Yang jun Xiang Hu Song Xiao-Bing Wu jun-rong chen De-Chang Diao Department of Gastrointestinal Surgery the Sixth Affiliated Hospital of Sun Yat-sen University 26 Yuanchun Erheng Road Guangzhou 510655 Guangdong Province China Department of Gastroenterology the Sixth Affiliated Hospital (Gastrointestinal & Anal Hospital) of Sun Yat-sen University 26 Yuanchun Erheng Road Guangzhou 510655 Guangdong Province China

AIM: To investigate gut barrier damage and intestinal bacteria translocation in severe acute pancreatitis (SAP), a simple rat model of SAP was induced and ***: Pancreatitis was induced by uniformly distributed injection of 3.8% Na taurocholate (1 mL/kg) beneath the pancreatic capsule. Rats in the control group were injected with normal saline in the identical location. RESULTS: Serum amylase, plasma endotoxin, intestinal permeability, and pancreatitis pathology scores were all markedly higher in the pancreatitis group than in the control group (P junction, as shown by electron microscopy. CONCLUSION: Significant gut barrier damage and intestinal bacterial translocation were def initely observed with few potential study confounders in this SAP rat model, suggesting that it may be an appropriate animal model for study of gut barrier damage and bacterial translocation in SAP.

关键词： Acute pancreatitis Bacterial translocation Inflammation Real-time polymerase chain reaction

Protective effect of indomethacin in renal ischemia-reperfusion injury in mice

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2014年第8期15卷 735-742页

作者： Sheng-hong ZHU Li-jia ZHOU Hong JIANG rong-jun chen Chuan LIN Shi FENG Juan JIN Jiang-hua chen Jian-yong WU Kidney Disease Center the First Affiliated Hospital School of Medicine Zhejiang University Kidney Disease Center Shaoxing Second Hospital

Objective： To evaluate the renoprotection effects of non-steroidal anti-inflammatory drugs （NSAIDs） in renal ischemia-reperfusion injury （IRI） and the cyclooxygenase （COX）-1/2 blockade association by indomethacin （IMT） in the mice model. Methods： After the left renal pedicle of mice was clamped, IMT was administrated by intraperitoneal injection with four doses： 1, 3, 5, and 7 mg/kg. Blood and kidney samples were collected 24 h after IRI. The renal functions were assayed by the cytokines and serum creatinine （SCr） using enzyme-linked immunosorbent assay （ELISA） kits. Kidney samples were analyzed by hematoxylin and eosin （H＆E） and immunohistochemistry stainings. Results： The mice administered with 5 mg/kg IMT had a marked reduction in SCr and significantly less tubular damage The tumor necrosis factor a （TNF-α） activity in renal homogenates and interleukin 6 （IL-6） activity in serum had a marked reduction at doses of 5 and 7 mg/kg IMT. The administration of 3 and 5 mg/kg IMT had a marked reduction in the ratio of thromboxane B2 to 6-keto-prostaglandin F1α. COX-1 and COX-2 stainings were weaker in 5 mg/kg IMT groups than that in the other groups. Conclusions： There was a dose response in the IMT function of renal IRI in mice, and IMT had a protective effect in a certain dose range. The effect of IMT on mice IRI was related to COX-1/2 blockades.

关键词： Non-steroidal anti-inflammatory drug (NSAID) Indomethacin (IMT) Ischemia-reperfusion injury (IRI) Dosage Protective effect

Structural Properties of Ions and Polyelectrolytes in Aqueous Solutions under External Electric Fields:The Sign Effect

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Chinese Journal of Polymer Science 2024年第9期42卷 1341-1352,I0007页

作者： cheng-Jiang Lin jun-jun Wang Yuan Jiang Shu-Li chen Hong-Fei Li Wen-Han Zhao Qing-rong Huang Chang-Ru rong Xiao-Zheng Duan State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei230026China National Key Laboratory of Advanced Vehicle Integration and Control China FAW Group Co.Ltd.Changchun130013China State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai200438China Department of Food Science Rutgers University65 Dudley RoadNew BrunswickNew Jersey08901USA

We utilize molecular dynamics simulations to investigate the microstructures of ions and polyelectrolytes in aqueous solutions under external electric *** focusing on the multi-body interactions between ionic components and H_(2)O molecules,as well as their responses to the external electric fields,we clarify several nontrivial molecular features of the ionic and polyelectrolyte solutions,such as the solvations of cations and anions,clustering of the ions,and dispersions/aggregations of polyelectrolyte chains,as well as the corresponding responses of H_(2)O molecules in these *** simulations illustrate the variations in structures of ionic solutions caused by reversing the charge sign of the ions,and elucidate the disparity in structures between anionic and cationic polyelectrolyte solutions in the presence of the external electric *** work clarifies the mechanism for the alternations in complex multi-body interactions in aqueous solutions caused by the application electric field,which can contribute to the fundamental understanding of the physical and chemical natures of ion-containing and charged polymeric systems.

关键词： Polyelectrolyte Ions Aqueous solutions External electric fields Asymmetric dipole

Self-Triggered Set Stabilization of Boolean Control Networks and Its Applications

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IEEE/CAA Journal of Automatica Sinica 2024年第7期11卷 1631-1642页

作者： rong Zhao jun-e Feng Dawei Zhang the School of Mathematics Shandong UniversityShandong UniversityJinan 250100China

Set stabilization is one of the essential problems in engineering systems, and self-triggered control(STC) can save the storage space for interactive information, and can be successfully applied in networked control systems with limited communication resources. In this study, the set stabilization problem and STC design of Boolean control networks are investigated via the semi-tensor product technique. On the one hand, the largest control invariant subset is calculated in terms of the strongly connected components of the state transition graph, by which a graph-theoretical condition for set stabilization is derived. On the other hand, a characteristic function is exploited to determine the triggering mechanism and feasible controls. Based on this, the minimum-time and minimum-triggering open-loop, state-feedback and output-feedback STCs for set stabilization are designed,respectively. As classic applications of self-triggered set stabilization, self-triggered synchronization, self-triggered output tracking and self-triggered output regulation are discussed as well. Additionally, several practical examples are given to illustrate the effectiveness of theoretical results.

关键词： Boolean control networks(BCNs) output regulation self-triggered control semi-tensor product of matrices set stabilization synchronization

Petrogenesis and Tectonic Significance of Shenxianshui Alkaline Granite in Gejiu,Yunnan Province,China

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Acta Geologica Sinica(English Edition) 2024年第2期98卷 368-385页

作者： YANG rong chen Yongqing School of Earth Sciences and Resources China University of GeosciencesBeijing 100083China

The Shenxianshui granites in the western Gejiu area were formed in the Late *** ablation inductively coupled plasma mass spectrometry indicates zircon U-Pb ages ranging from 90.67±0.7 to 85.97±0.6 *** intrusive rocks are peraluminous(A/CNK=1.03 to 1.33)and calc-alkaline,showing an affinity towards I-type *** ion lithophilic elements are enriched in K and Rb,while high field strength elements are ***,light rare earth elements are significantly enriched,showing a slight negative Eu anomaly(Eu/Eu^(*)=0.39 to 0.58).Shenxianshui granite has a relatively high initial Sr isotope ratio(^(87)Sr/^(86)Sr)_(i)(0.7098-0.7105),negative ε_(Nd)(t)values(−7.99 to−7.44)and negative ε_(Hf)(t)values(−8.37 to−2.58).Combined with previous studies,these characteristics suggest that the Shenxianshui alkaline granites were formed in a post-collision extensional *** alkaline granitic magma possibly originated from the partial melting of the lower crust during the Mesoproterozoic era and may have contained mantle source *** alkaline granite was formed from mixed magma with a high degree of crystal *** abundance of ore-forming elements indicates that Shenxianshui granite has the potential to mineralize key metals and rare earth elements.

关键词： I-type granite zircon U-Pb geochronology Sr-Nd-Pb isotopes Hf isotope Gejiu

Learning in games:a systematic review

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Science China(Information Sciences) 2024年第7期67卷 133-159页

作者： rong-jun QIN Yang YU National Key Laboratory for Novel Software Technology Nanjing University Polixir Technologies

Game theory studies the mathematical models for self-interested individuals. Nash equilibrium is arguably the most central solution in game theory. While finding the Nash equilibrium in general is known as polynomial parity arguments on directed graphs(PPAD)-complete, learning in games provides an alternative to approximate Nash equilibrium, which iteratively updates the player's strategy through interactions with other players. Rules and models have been developed for learning in games, such as fictitious play and no-regret learning. Particularly, with recent advances in online learning and deep reinforcement learning,techniques from these fields greatly boost the breakthroughs in learning in games from theory to *** a result, we have witnessed many superhuman game AI systems. The techniques used in these systems evolve from conventional search and learning to purely reinforcement learning(RL)-style learning methods,gradually getting rid of the domain knowledge. In this article, we systematically review the above techniques,discuss the trend of basic learning rules towards a unified framework, and recap applications in large ***, we discuss some future directions and make the prospect of future game AI systems. We hope this article will give some insights into designing novel approaches.

关键词： non-cooperative games learning in games no-regret learning reinforcement learning superhuman AI

Recent advancements in hydrometallurgical recycling technologies of spent lithium-ion battery cathode materials

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Rare Metals 2024年第3期43卷 879-899页

作者： Juan Wu Li Xiao Li Shen Jian-jun Ran Hui Zhong Yi-rong Zhu Han chen College of Materials and Advanced Manufacturing Hunan University of TechnologyZhuzhou412007China School of Resources Processing and Bioengineering Central South UniversityChangsha410083China Guangdong JiaNa Energy Technology Company Qingyuan513000China

The rapidly increasing production of lithium-ion batteries(LIBs)and their limited service time increases the number of spent LIBs,eventually causing serious environmental issues and resource *** the perspectives of clean production and the development of the LIB industry,the effective recovery and recycling of spent LIBs require urgent *** study provides an overview of the current hydrometallurgical processes employed in the recycling of spent cathode materials,focusing on the leaching of valuable metals and their *** particular,this research reviews the various leaching systems(inorganic acid,organic acid,and ammonia)and the separation of valuable metals,and then,recommendations for subsequent study are offered in an attempt to contribute to the development of highly efficient methods for recycling spent cathode *** addition,a range of existing technologies,such as solvent extraction,chemical precipitation,electrochemical deposition,and regeneration,for the postprocessing of leaching solutions are ***,the promising technologies,existing challenges and suggestions with respect to the development of effective and environmentally friendly recycling methods for handling spent cathode materials are identified.

关键词： Spent lithium-ion batteries(LIBs) Cathode material Hydrometallurgy Leaching Recycling

Risk factors,prognostic factors,and nomograms for distant metastasis in patients with diagnosed duodenal cancer:A population-based study

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1384-1420页

作者： Jia-rong Shang chen-Yi Xu Xiao-Xue Zhai Zhe Xu jun Qian Department of Oncology Jiangsu Province Hospital of Chinese MedicineThe Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210000Jiangsu ProvinceChina Department of Proctology Nanjing Hospital of Chinese MedicineNanjing 210000Jiangsu ProvinceChina Department of Digestive Cancer Surgery Jiangsu Province Hospital of Chinese MedicineThe Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210000Jiangsu ProvinceChina

BACKGROUND Duodenal cancer is one of the most common subtypes of small intestinal cancer,and distant metastasis(DM)in this type of cancer still leads to poor *** nomograms have recently been used in tumor areas,no studies have focused on the diagnostic and prognostic evaluation of DM in patients with primary duodenal *** To develop and evaluate nomograms for predicting the risk of DM and person-alized prognosis in patients with duodenal *** Data on duodenal cancer patients diagnosed between 2010 and 2019 were extracted from the Surveillance,Epidemiology,and End Results *** and multivariate logistic regression analyses were used to identify independent risk factors for DM in patients with duodenal cancer,and univariate and multivariate Cox proportional hazards regression analyses were used to determine independent prognostic factors in duodenal cancer patients with *** novel nomograms were established,and the results were evaluated by receiver operating characteristic(ROC)curves,calibration curves,and decision curve analysis(DCA).RESULTS A total of 2603 patients with duodenal cancer were included,of whom 457 cases(17.56%)had DM at the time of *** analysis revealed independent risk factors for DM in duodenal cancer patients,including gender,grade,tumor size,T stage,and N stage(P<0.05).Univariate and multivariate COX analyses further identified independent prognostic factors for duodenal cancer patients with DM,including age,histological type,T stage,tumor grade,tumor size,bone metastasis,chemotherapy,and surgery(P<0.05).The accuracy of the nomograms was validated in the training set,validation set,and expanded testing set using ROC curves,calibration curves,and DCA *** results of Kaplan-Meier survival curves(P<0.001)indicated that both nomograms accurately predicted the occurrence and prognosis of DM in patients with duodenal *** The two nomograms are expected as effective tools fo

关键词： Duodenal cancer Distant metastasis Nomogram Risk factors Prognostic factors

Development of lithium-free P2-type high-sodium content cathode materials with enhanced cycle and air stability for sodium-ion batteries

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Rare Metals 2024年第1期43卷 113-123页

作者： Jin-Lv Tian Lin-rong Wu Hai-jun Zhao Shou-Dong Xu Liang chen Ding Zhang Xiao-Chuan Duan College of Chemical Engineering and Technology Taiyuan University of TechnologyTaiyuan 030024China College of Chemistry Taiyuan University of TechnologyTaiyuan 030024China School of Chemical Engineering and Pharmacy Wuhan Institute of TechnologyWuhan 430205China

The effect of partial substitution of Mg for Ni on a high-sodium and lithium-free layered P2-type Na_(45/54)Mg_(6)/_(54)Ni_(12/54)Mn_(34/54)O_(2) cathode with high initial Coulombic efficiency and excellent cyclic stability has been investigated in this *** on the crystal structural analysis,the Mg doping can retain the P2 structure up to 4.3 V,thus restraining the detrimental phase transformation of P2-02during the Na-ion intercalation/deintercalation ***,the obtained Mg-doped P2-type cathode exhibits a reversible specific capacity of 109 mAh·g^(-1) at 0.1C between 2.0 and 4.3 V and a retention rate of 81.5% after 200cycles at *** addition,the full cell consisting of Mg-doped P2-type cathode and hard carbon anode shows a capacity retention rate of 85.6% after 100 *** study provides new insight into the development of durable cathode materials for sodium-ion batteries.

关键词： Sodium-ion batteries Cathode material High sodium content Air stability