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Model test of the mechanism underpinning water-and-mud inrush disasters during tunnel excavation in sandstone and slate interbedded Presinian strata

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2022年第11期23卷 882-899页

作者： Peng XU Peng PENG Rong-hua WEI Zhi-qiang ZHANG School of Civil Engineering Southwest Jiaotong UniversityChengdu 610031China Key Laboratory of Transportation Tunnel Engineering Ministry of EducationSouthwest Jiaotong UniversityChengdu 610031China

Water-and-mud inrush disasters have become a major challenge in underground engineering for the construction of tunnels in sandstone and slate interbedded Presinian strata.Disaster prediction and prevention rely in part on realistic modeling and observation of the disaster process,as well as the identification and examination of the underlying mechanisms.Based on the geological conditions and the historical records of the Xinping Tunnel on the China–Laos Railway,an engineering geological model of the water-and-mud inrush was established.A physical model test that accurately reproduced water-and-mud inrush during tunnel excavation in sandstone and slate interbedded strata was also carried out.Then,testing was conducted that examined the stress and strain,seepage pressure,and high-leakage flow of the surrounding rock.The results indicated that the water-and-mud inrush proceeded through three stages:seepage stage,high-leakage flow stage,and attenuation stage.In essence,the disaster was a catastrophic process,during which the water-resistant stratum was reduced to a critical safety thickness,a water-inrush channel formed,and the water-resistant stratum gradually failed under the influence of excavation unloading and in situ stress–seepage coupling.Parameters such as the stress and strain,seepage pressure,and flow of the surrounding rock had evident stage-related features during water-and-mud inrush,and their variation indicated the formation,development,and evolution of the disaster.As the tunnel face advanced,the trend of the stress–strain curve of the surrounding rock shifted from sluggish to rapid in its speed of increase.The characteristics of strain energy density revealed the erosion and weakening effect of groundwater on the surrounding rock.The seepage pressure and the thickness of the water-resistant stratum had a positive linear relationship,and the flow and thickness a negative linear relationship.There was a pivotal point at which the seepage pressure changed from high to low and the flow shifted from low

关键词： Water-and-mud inrush Sandstone and slate interbedded Presinian strata Model test Evolution law Thickness of water-resistant stratum Inducing mechanism

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Metabolomics-based comparative analysis of the effects of host and environment on Viscum coloratum metabolites and antioxidative activities

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Journal of Pharmaceutical Analysis 2022年第2期12卷 243-252页

作者： Rui-Zhen Zhang Jing-Tao Zhao wei-Qing Wang rong-hua Fan rong rong Zhi-Guo Yu Yun-Li Zhao Department of Pharmaceutical Analysis School of PharmacyShenyang Pharmaceutical UniversityShenyang110016China School of Pharmacy University College London29-39 Brunswick SquareBloomsuryLondonWC1N 1AXUK Department of Sanitary Inspection School of Public HealthShenyang Medical CollegeShenyang110034China

Viscum coloratum(Kom.)Nakai is a well-known medicinal hemiparasite widely distributed in Asia.The synthesis and accumulation of its metabolites are affected by both environmental factors and the host plants,while the latter of which is usually overlooked.The purpose of this study was to comprehensively evaluate the effects of host and habitat on the metabolites in V.coloratum through multiple chemical and biological approaches.The metabolite profile of V.coloratum harvested from three different host plants in two habitats were determined by multiple chemical methods including high-performance liquid chromatography-ultraviolet(HPLC-UV),gas chromatography-flame ionization detector(GC-FID)and ultra-performance liquid chromatography quadrupole time of flight mass spectrometry(UPLC-QTOF/MS).The differences in antioxidant efficacy of V.coloratum were determined based on multiple in vitro models.The multivariate statistical analysis and data fusion strategy were applied to analyze the differences in metabolite profile and antioxidant activity of V.coloratum.Results indicated that the metabolite profile obtained by various chemical approaches was simultaneously affected by host and environment factors,and the environment plays a key role.Meanwhile,three main differential metabolites between two environment groups were identified.The results of antioxidant assay indicated that the environment has greater effects on the biological activity of V.coloratum than the host.Therefore,we conclude that the integration of various chemical and biological approaches combined with multivariate statistical and data fusion analysis,which can determine the influences of host plant and habitat on the metabolites,is a powerful strategy to control the quality of semi-parasitic herbal medicine.

关键词： Viscum coloratum Host Environment Plant metabolomics Multivariate statistical analysis Biological activity

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Vagus nerve stimulation is a potential treatment for ischemic stroke

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Neural Regeneration Research 2023年第4期18卷 825-831页

作者： Yi-Lin Liu San-rong Wang Jing-Xi Ma Le-hua Yu Gong-wei Jia Department of Rehabilitation The Second Affiliated Hospital of Chongqing Medical UniversityChongqingChina The Second Clinical College Chongqing Medical UniversityChongqingChina Department of Neurology Chongqing General HospitalChongqingChina Chongqing Key Laboratory of Neurodegenerative Diseases ChongqingChina

Microglia are the brain’s primary innate immune cells,and they are activated and affect pro-inflammatory phenotype or regulatory phenotype after ischemic stroke.Vagus nerve stimulation was shown to activate microglial phenotypic changes and exhibit neuroprotective effects in ischemia/reperfusion injury.In this study,we established rat models of ischemic stroke by occlusion of the middle cerebral artery and performed vagus nerve stimulation 30 minutes after modeling.We found that vagus nerve stimulation caused a shift from a pro-inflammatory phenotype to a regulatory phenotype in microglia in the ischemic penumbra.Vagus nerve stimulation decreased the levels of pro-inflammatory phenotype markers inducible nitric oxide synthase and tumor necrosis factorαand increased the expression of regulatory phenotype markers arginase 1 and transforming growth factorβthrough activatingα7 nicotinic acetylcholine receptor expression.Additionally,α7 nicotinic acetylcholine receptor blockade reduced the inhibition of Toll-like receptor 4/nuclear factor kappa-B pathwayassociated proteins,including Toll-like receptor 4,myeloid differentiation factor 88,I kappa B alpha,and phosphorylated-I kappa B alpha,and also weakened the neuroprotective effects of vagus nerve stimulation in ischemic stroke.Vagus nerve stimulation inhibited Toll-like receptor 4/nuclear factor kappa-B expression through activatingα7 nicotinic acetylcholine receptor and regulated microglial polarization after ischemic stroke,thereby playing a role in the treatment of ischemic stroke.Findings from this study confirm the mechanism underlying vagus nerve stimulation against ischemic stroke.

关键词： cerebral ischemia microglia neuroprotection nuclear factor kappa-B pro-inflammatory phenotype regulatory phenotype reperfusion Toll-like receptor 4 vagus nerve stimulation α7 nicotinic acetylcholine receptor

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Mesoscale wind stress-SST coupling induced feedback to the ocean in the western coast of South America

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Journal of Oceanology and Limnology 2021年第3期39卷 785-799页

作者： Chaoran CUI rong-hua ZHANG Yanzhou wei Hongna WANG Key Laboratory of Ocean Circulation and Waves Institute of Oceanologyand Center for Ocean Mega-ScienceChinese Academy of SciencesQingdao 266071China University of Chinese Academy of Sciences Beijing 100049China Qingdao National Laboratory for Marine Science and Technology Qingdao 266000China Center for Excellence in Quaternary Science and Global Change Chinese Academy of SciencesXi’an 710061China State Key Laboratory of Satellite Ocean Environment Dynamics Second Institute of OceanographyMinistry of Natural ResourcesHangzhou 310012China

The feedback induced by mesoscale wind stress-SST coupling to the ocean in the western coast of South America was studied using the Regional Ocean Modeling System(ROMS).To represent the feedback,an empirical mesoscale wind stress perturbation model was constructed from satellite observations,and was incorporated into the ocean model.Comparing two experiments with and without the mesoscale wind stress-SST coupling,it was found that SST in the mesoscale coupling experiment was reduced in the western coast of South America,with the maximum values of 0.5℃in the Peru Sea and 0.7℃in the Chile Sea.A mixed layer heat budget analysis indicates that horizontal advection is the main term that explains the reduction in SST.Specifically,the feedback induced by mesoscale wind stress-SST coupling to the ocean can enhance vertical velocity in the nearshore area through the Ekman pumping,which brings subsurface cold water to the sea surface.These results indicate that the feedback due to the mesoscale wind stress-SST coupling to the ocean has the potential for reducing the warm SST bias often seen in the large-scale climate model simulations in this region.

关键词： mesoscale air-sea coupling western coast of South America ocean model simulations cooling effect warm bias

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Representing surface wind stress response to mesoscale SST perturbations in western coast of South America using Tikhonov regularization method

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Journal of Oceanology and Limnology 2020年第3期38卷 679-694页

作者： CUI Chaoran ZHANG rong-hua WANG Hongna wei Yanzhou Key Laboratory of Ocean Circulation and Waves Institute of OceanologyChinese Academy of SciencesQingdao 266071China Center for Ocean Mega-Science Chinese Academy of SciencesQingdao 266071China University of Chinese Academy of Sciences Beijing 100049China Qingdao National Laboratory for Marine Science and Technology Qingdao 266000China State Key Laboratory of Satellite Ocean Environment Dynamics Second Institute of OceanographyMinistry of Natural ResourcesHangzhou 310012China

Interaction between mesoscale perturbations of sea surface temperature(SSTmeso)and wind stress(WSmeso)has great influences on the ocean upwelling system and turbulent mixing in the atmospheric boundary layer.Using daily Quik-SCAT wind speed data and AMSR-E SST data,SSTmeso and WSmeso fields in the western coast of South America are extracted by using a locally weighted regression method(LOESS).The spatial patterns of SSTmeso and WSmeso indicate strong mesoscale SST-wind stress coupling in the region.The coupling coefficient between SSTmeso and WSmeso is about 0.0095 N/(m^2·℃)in winter and 0.0082 N/(m^2·℃)in summer.Based on mesoscale coupling relationships,the mesoscale perturbations of wind stress divergence(Div(WSmeso))and curl(Curl(WSmeso))can be obtained from the SST gradient perturbations,which can be further used to derive wind stress vector perturbations using the Tikhonov regularization method.The computational examples are presented in the western coast of South America and the patterns of the reconstructed WS meso are highly consistent with SSTmeso,but the amplitude can be underestimated significantly.By matching the spatially averaged maximum standard deviations of reconstructed WSmeso magnitude and observations,a reasonable magnitude of WSmeso can be obtained when a rescaling factor of 2.2 is used.As current ocean models forced by prescribed wind cannot adequately capture the mesoscale wind stress response,the empirical wind stress perturbation model developed in this study can be used to take into account the feedback effects of the mesoscale wind stress-SST coupling in ocean modeling.Further applications are discussed for taking into account the feedback effects of the mesoscale coupling in largescale climate models and the uncoupled ocean models.

关键词： mesoscale air-sea coupling Tikhonov’s regularization method western coast of South America

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Patients with MMAF induced by novel biallelic CFAP43 mutations have good fertility outcomes after intracytoplasmic sperm injection

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Asian Journal of Andrology 2023年第5期25卷 564-571页

作者： Jing Ma Shun-hua Long Hai-Bing Yu Ye-Zhou Xiang Xiang-rong Tang Jia-Xun Li wei-wei Liu wei Han rong Jin Guo-Ning huang Ting-Ting Lin Center for Reproductive Medicine Women and Children's Hospital of Chongqing Medical UniversityChongqing 400010China Chongqing Health Center for Women and Children Chongqing 400010China Chongqing Key Laboratory of Human Embryo Engineering Chongqing 400010China

As a specific type of asthenoteratozoospermia,multiple morphological abnormalities of the sperm flagella(MMAF)is characterized by composite abnormalities,including absent,short,coiled,angulation,and irregular-caliber flagella.Mutations in cilia-and flagella-associated protein 43(CFAP43)are one of the main causative factors of MMAF established to date.To identify whether there are other CFAP43 mutations related to MMAF and to determine the clinical outcomes of assisted reproductive technology for patients with MMAF harboring different mutations,we recruited and screened 30 MMAF-affected Chinese men using a 22-gene next-generation sequencing panel.After systematic analysis,seven mutations in CFAP43,including five novel mutations and two previously reported mutations,were identified from four families and related to MMAF in an autosomal recessive pattern.Papanicolaou staining,immunofluorescence,and electronic microscopy further clarified the semen characteristics a nd abnormal sperm morphologies,including disorganized axonemal and peri-axonemal structures,of the CFAP43-deficient men.The female partners of two patients were pregnant after undergoing assisted reproductive technology through intracytoplasmic sperm injection,and one of them successfully gave birth to a healthy boy.This study significantly expands the mutant spectrum of CFAP43,and together with the available information regarding male infertility and MMAF,provides new information for the genetic diagnosis and counseling of MMAF in the future.

关键词： asthenoteratozoospermia CFAP43 intracytoplasmic sperm injection MMAF

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Traditional Chinese medicine network pharmacology study on exploring the mechanism of Xuebijing Injection in the treatment of coronavirus disease 2019

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Chinese Journal of Natural Medicines 2020年第12期18卷 941-951页

作者： XING Yan hua Ying-rong SHANG Jing GE wei-Hong LIAO Jun School of Science China Pharmaceutical UniversityNanjing 211198China School of Pharmacy China Pharmaceutical UniversityNanjing 211198China School of Traditional Chinese Pharmacy China Pharmaceutical UniversityNanjing 211198China Department of Pharmacy Nanjing Drum Tower HospitalNanjing 210008China

As a representative drug for the treatment of severe community-acquired pneumonia and sepsis,Xuebijing(XBJ)injection is also one of the recommended drugs for the prevention and treatment of coronavirus disease 2019(COVID-19),but its treatment mechanism for COVID-19 is still unclear.Therefore,this study aims to explore the potential mechanism of XBJ injection in the treatment of COVID-19 employing network pharmacology and molecular docking methods.The corresponding target genes of 45 main active ingredients in XBJ injection and COVID-19 were obtained by using multiple database retrieval and literature mining.102 overlapping targets of them were screened as the core targets for analysis.Then built the PPI network,TCM-compound-target-disease,and disease-target-pathway networks with the help of Cytoscape 3.6.1 software.After that,utilized DAVID to perform gene ontology(GO)function enrichment analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analysis to predict the action mechanism of overlapping targets.Finally,by applying molecular docking technology,all compounds were docked with COVID-193 CL protease(3 CLpro),spike protein(S protein),and angiotensin-converting enzyme II(ACE2).The results indicated that quercetin,luteolin,apigenin and other compounds in XBJ injection could affect TNF,MAPK1,IL6 and other overlapping targets.Meanwhile,anhydrosafflor yellow B(AHSYB),salvianolic acid B(SAB),and rutin could combine with COVID-19 crucial proteins,and then played the role of anti-inflammatory,antiviral and immune response to treat COVID-19.This study revealed the multiple active components,multiple targets,and multiple pathways of XBJ injection in the treatment of COVID-19,which provided a new perspective for the study of the mechanism of traditional Chinese medicine(TCM)in the treatment of COVID-19.

关键词： Network pharmacology Molecular docking Xuebijing injection COVID-19

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雌性GK糖尿病大鼠的核糖,AGEs和转酮酶变化

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生物化学与生物物理进展 2022年第5期49卷 949-952页

作者： CAO Xiao YU Le-Xiang wei Yan QU Mei-hua HE rong-Qiao College of Basic Medicine Southwest Medical UniversityLuzhou 646000China Institute of Biophysics Chinese Academy of SciencesBeijing 100101China Translational Medical Center Weifang Second People’s HospitalWeifang 261041China University of Chinese Academy of Sciences Beijing 100049China

Dear Editor,Type 2 diabetes is a chronic disease characterized by high glucose levels in the blood.Recently,it has been found that type 2 diabetic patients suffer from glucose and ribose dysmetabolism[1-3].The GotoKakizaki(GK)rat is a nonobese,nonhypertensive model of type 2 diabetes,which,like humans,shares a susceptibility locus on chromosome 10[4-5].

关键词： metabolism hypertensive diabetes

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Seasonal variability of the Kuroshio Current at the PN Section in the East China Sea based on in-situ observation from 1987 to 2010

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Acta Oceanologica Sinica 2015年第5期34卷 12-21页

作者： wei Yanzhou PEI Yuhua ZHANG rong-hua Key Laboratory of Ocean Circulation and Wave Institute of OceanologyChinese Academy of Sciences University of the Chinese Academy of Sciences State Key Laboratory of Satellite Ocean Environment Dynamics Second Institute of OceanographyState Oceanic Administration College of Physical and Environmental Oceanography Ocean University of China

As the spatio-temporal variability of the Kuroshio is highly influenced by mesoscale eddies, representing its seasonal variability characteristics requires sufficiently long term observations to reduce the uncertainties. Geostrophic velocity data estimated from hydrographic observation from 1987 to 2010 and the shipboard ADCP velocity data from 1993 to 2008 at the PN Section in the central East China Sea are collected to view the seasonal variability objectively. From both types of observation, it is found that the seasonal climatology mean of the Kuroshio Current exhibits significant difference in three areas, which are located at the Kuroshio Current core and its two flanks in a shallow layer less than 300 m, with the weakest northeast current at the core in autumn, the strongest counter current on the right flank in spring, and the strongest northeast current on the left flank in autumn, respectively. The seasonal variance of the Kuroshio Current also exhibits significant difference on the off- shore side of the Kuroshio, with larger variance in spring and summer while smaller variance in autumn and winter. For the current parallel to the PN Section, the ratio of the seasonal variability component to the intraseasonal variability component is relatively smaller than that for the current perpendicular to the PN Section. Further analyses indicate that the seasonal variability at the PN Section is tightly linked to the upstream and downstream current variability.

关键词： Kuroshio Current seasonal variability East China Sea significance test

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Differential Polymorphic Transformation Behavior of Polybutene-1 with Multiple Isotactic Sequences

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Chinese Journal of Polymer Science 2020年第2期38卷 164-173,I0007页

作者： Ya-Ping Ma wei-Ping Zheng Chen-Guang Liu hua-Feng Shao hua-rong Nie Ai-hua He Shandong Provincial Key Laboratory of Olefin Catalysis and Polymerization Key Laboratory of Rubber-Plastics (Ministry of Education) Qingdao University of Science and Technology

For the solid-solid transformation from form Ⅱ to form Ⅰ of isotactic polybutene-1(iPB),the temperature dependence of form Ⅰ nucleation and growth was deemed to control the transformation process.However,the relationship between formⅠ formation and form Ⅱ disappearance in the transformation process is not clear.In this work,the spontaneous crystal transformation from form Ⅱ to Ⅰ of iPB with 81 mol%mmmm sequence concentration is studied firstly by tracking the two processes,the decay of form Ⅱ and the yielding of form Ⅰ in a wide range of temperature spanning from 0℃ to 50℃ and in a long transformation time ranging from 5 min to 65 days with in situ FTIR and WAXD.Unlike the literature reports,the decay rate of form Ⅱ is firstly found to be lower than the yielding rate of form Ⅰ at all studied temperatures,especially at low transition temperature.This is attributed to the amorphous chains which locate near crystal lamella participating into the nucleation of form Ⅱ.The regular chain folding and growth of i PB form Ⅰ from amorphous chains containing short isotactic sequences also lead to an increase in crystallinity of form Ⅰ compared with that of initial form Ⅱ crystallized at 60℃.An increase in the annealing temperature results in decrease in crystallinity and increase in lamellae thickness of i PB formⅠ.

关键词： Polybutene-1 Polymorphic transformation Isotactic sequence Crystallinity Lamellae thickness

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