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Correlations of the expression of Cx43,SCFFBXW7,p-cyclin E1(Ser73),p-cyclin E1(Thr77)and p-cyclin E1(Thr395)in colon cancer tissues

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 207-213页

作者： rong-Gang luan Ming-Da Liu Zi-Feng Deng Cong-Lan lu Mei-Ling Yu Ming-Yu Zhang rong Liu Ran An You-Liang Yao Dong-Bei Guo Yong-Xing Zhang Lei Zhao Department of Gastrointestinal Surgery Air Force Hospital of Eastern TheaterAnhui Medical UniversityNanjing 230032Jiangsu ProvinceChina State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics School of Public HealthXiamen UniversityXiamen 361102Fujian ProvinceChina Trauma Surgery Air Force Hospital of Eastern TheaterAnhui Medical UniversityNanjing 230032Jiangsu ProvinceChina Department of Orthopaedics Air Force Hospital of Eastern TheaterAnhui Medical UniversityNanjing 230032Jiangsu ProvinceChina

BACKGROUND Previous cellular studies have demonstrated that elevated expression of Cx43 promotes the degradation of cyclin E1 and inhibits cell proliferation through ***,reduced expression results in a loss of this capacity to facilitate cyclin E *** ubiquitination and degradation of cyclin E1 may be associated with phosphorylation at specific sites on the protein,with Cx43 potentially enhancing this process by facilitating the phosphorylation of these critical *** To investigate the correlation between expression of Cx43,SKP1/Cullin1/F-box(SCF)FBXW7,p-cyclin E1(ser73,thr77,thr395)and clinicopathological indexes in colon *** Expression levels of Cx43,SCFFBXW7,p-cyclin E1(ser73,thr77,thr395)in 38 clinical colon cancer samples were detected by immunohistochemistry and were analyzed by statistical methods to discuss their *** Positive rate of Cx43,SCFFBXW7,p-cyclin E1(Ser73),p-cyclin E1(Thr77)and p-cyclin E1(Thr395)in detected samples were 76.32%,76.32%,65.79%,5.26%and 55.26%*** expressions of these proteins were not related to the tissue type,degree of tissue differentiation or lymph node ***43 and SCFFBXW7(r=0.749),p-cyclin E1(Ser73)(r=0.667)and p-cyclin E1(Thr395)(r=0.457),SCFFBXW7 and p-cyclin E1(Ser73)(r=0.703)and p-cyclin E1(Thr395)(0.415)were correlated in colon cancer(Pluencing the ubiquitination and degradation of cyclin E1.

关键词： Colon cancer Cx43 SCFFBXW7 Phosphorylation of cyclin E1 Sites of cyclin E1 Correlation analysis

Inhibiting ceramide synthase 5 expression in microglia decreases neuroinflammation after spinal cord injury

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Neural Regeneration Research 2025年第10期20卷 2955-2968页

作者： Wei Zhang Yubao lu Ruoqi Shen Yingjie Wu Chenrui Liu Xingxing Fang Liangming Zhang Bin Liu Limin rong Department of Spine Surgery The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina National Medical Products Administration(NMPA)Key Laboratory for Quality Research and Evaluation of Cell Products GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Quality Control of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Engineering and Technology Research of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina

Microglia,the resident monocyte of the central nervous system,play a crucial role in the response to spinal cord ***,the precise mechanism remains *** investigate the molecular mechanisms by which microglia regulate the neuroinflammatory response to spinal cord injury,we performed single-cell RNA sequencing dataset analysis,focusing on changes in microglial *** found that the MG1 subpopulation emerged in the acute/subacute phase of spinal cord injury and expressed genes related to cell pyroptosis,sphingomyelin metabolism,and neuroinflammation at high ***,we established a mouse model of contusive injury and performed intrathecal injection of siRNA and molecular inhibitors to validate the role of ceramide synthase 5 in the neuroinflammatory responses and pyroptosis after spinal cord ***,we established a PC12-BV2 cell co-culture system and found that ceramide synthase 5 and pyroptosis-associated proteins were highly expressed to induce the apoptosis of neuron *** ceramide synthase 5 expression in a mouse model of spinal cord injury effectively reduced ***,ceramide synthase 5-induced pyroptosis was dependent on activation of the NLRP3 signaling *** ceramide synthase 5 expression in microglia in vivo reduced neuronal apoptosis and promoted recovery of neurological ***2g7 formed a“bridge”between sphingolipid metabolism and ceramide synthase 5-mediated cell death by inhibiting the NLRP3 signaling ***,these findings suggest that inhibiting ceramide synthase 5 expression in microglia after spinal cord injury effectively suppressed microglial pyroptosis mediated by NLRP3,thereby exerting neuroprotective effects.

关键词： ceramide synthase 5 gasdermin D microglia neuroinflammation NLRP3 nuclear factor kappa B Pla2g7 pyroptosis sphingomyelin metabolism spinal cord injury

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Predictive value of a constructed artificial neural network model for microvascular invasion in hepatocellular carcinoma:A retrospective study

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 88-100页

作者： Hai-Yang Nong Yong-Yi Cen Shan-Jin lu Rui-Sui Huang Qiong Chen Li-Feng Huang Jian-Ning Huang Xue Wei Man-rong Liu Lin Li Ke Ding Department of Radiology The Third Affiliated Hospital of Guangxi Medical UniversityNanning 530031Guangxi Zhuang Autonomous RegionChina Department of Radiology Affiliated Hospital of Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Guangxi Clinical Medical Research Center for Hepatobiliary Diseases Affiliated Hospital of Youiiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Ultrasound The Third Affiliated Hospital of Guangxi Medical UniversityNanning 530031Guangxi Zhuang Autonomous RegionChina Department of Hepatobiliary Surgery The Third Affiliated Hospital of Guangxi Medical UniversityNanning 530031Guangxi Zhuang Autonomous RegionChina

BACKGROUND Microvascular invasion(MVI)is a significant risk factor for recurrence and metastasis following hepatocellular carcinoma(HCC)***,there is a paucity of preoperative evaluation approaches for *** To investigate the predictive value of texture features and radiological signs based on multiparametric magnetic resonance imaging in the non-invasive preoperative prediction of MVI in *** Clinical data from 97 HCC patients were retrospectively collected from January 2019 to July 2022 at our *** were classified into two groups:MVI-positive(n=57)and MVI-negative(n=40),based on postoperative pathological *** correlation between relevant radiological signs and MVI status was ***4.6 software and the mutual information method were employed to identify the top 10 dominant texture features,which were combined with radiological signs to construct artificial neural network(ANN)models for MVI *** predictive performance of the ANN models was evaluated using area under the curve,sensitivity,and *** models with relatively high predictive performance were screened using the DeLong test,and the regression model of multilayer feedforward ANN with backpropagation and error backpropagation learning method was used to evaluate the models’*** The absence of a pseudocapsule,an incomplete pseudocapsule,and the presence of tumor blood vessels were identified as independent predictors of HCC *** ANN model constructed using the dominant features of the combined group(pseudocapsule status+tumor blood vessels+arterial phase+venous phase)demonstrated the best predictive performance for MVI status and was found to be automated,highly operable,and very *** The ANN model constructed using the dominant features of the combined group can be recommended as a noninvasive method for preoperative prediction of HCC MVI status.

关键词： Hepatocellular carcinoma Texture analysis Magnetic resonance imaging Microvascular invasion Pseudocapsule Tumor blood vessels

FUZZY SYNTHETIC EVAluATION ON RESIDENT'S PERCEPTIONS OF TOURISM IMPACTS——Case of Jiuzhaigou National Park, Sichuan Province, China

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Chinese Geographical Science 2006年第1期16卷 87-94页

作者： lu Xiao-li WU Chun-you XIAO gui-rong School of Management Dalian University of Technology Dalian 116024 P.R.China Eaculty of Geography Environmental Studies University of Waterlao Ontaria Canada N2L 3G1

Tourism can have both positive and negative outcomes for residents in tourism destinations, It is a good method to analyze the status of tourism impact by means of investigating residents＇ perceptions of it. Various methods have been used in previous authoritative studies. However, owing to inherent imprecision, difficulties always exist in some conventional methodologies when describing the interpretation of linguistic or measured uncertainties for real-world randoln phenomena. The purpose of this research is to present the fuzzy synthetic evaluation method to investigate residents＇ perceptions of tourisln impacts. At first, basic attributes and a hierarchical framework of tourism impacts are defined and formed. Secondly, the weighted vectors are determined according to the knowledge and experience of experts. Thirdly, the weighted evaluation matrices are aggregated to get the fuzzy sets of tourism impacts. In the last stage, the final fuzzy sets are defuzzified to get the rank of the residents＇ perceptions of tourism impacts. A case study in Jiuzhaigou National Park of China is provided to demonstrate the application of this method.

关键词： residents' perceptions tourism impacts fuzzy synthetic evaluation Jiuzhaigou National Park

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乳剂颗粒表面上碘离子的减敏作用

感光科学与光化学 1984年第2期 9-13页

作者：战师荣吴桂兰吕光荣刘敦程虎民中国科学院感光化学研究所北京大学化学系

本文表明双注法乳剂颗粒表面上的碘离子与处在颗粒内部的碘离子相比,前者有三种作用:(1)使颗粒的离子电导率增高;(2)使颗粒表面上的硫加金敏化反应受到抑制,而这又进一步同样使颗粒的离子电导率增高;(3)使乳剂的光敏度降低,由此推测,乳... 详细信息

本文表明双注法乳剂颗粒表面上的碘离子与处在颗粒内部的碘离子相比,前者有三种作用:(1)使颗粒的离子电导率增高;(2)使颗粒表面上的硫加金敏化反应受到抑制,而这又进一步同样使颗粒的离子电导率增高;(3)使乳剂的光敏度降低,由此推测,乳剂颗粒表面上的碘离子对颗粒的减敏作用是与某种使颗粒的离子电导率增高的过程有连系的。

关键词：乳剂光敏度碘离子阴离子颗粒表面减敏

Multi-Stage-Based Siamese Neural Network for Seal Image Recognition

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 405-423页

作者： Jianfeng lu Xiangye Huang Caijin Li Renlin Xin Shanqing Zhang Mahmoud Emam School of Computer Science and Technology Hangzhou Dianzi UniversityHangzhou310018China Shangyu Institute of Science and Engineering Hangzhou Dianzi UniversityShaoxing312300China Faculty of Artificial Intelligence Menoufia UniversityShebin El-Koom32511Egypt

Seal authentication is an important task for verifying the authenticity of stamped seals used in various domains to protect legal documents from tampering and *** seal inspection is commonly audited manually to ensure document ***,manual assessment of seal images is tedious and laborintensive due to human errors,inconsistent placement,and completeness of the *** image recognition systems are inadequate enough to identify seal types accurately,necessitating a neural network-based method for seal image ***,neural network-based classification algorithms,such as Residual Networks(ResNet)andVisualGeometryGroup with 16 layers(VGG16)yield suboptimal recognition rates on stamp ***,the fixed training data categories make handling new categories to be a challenging *** paper proposes amulti-stage seal recognition algorithmbased on Siamese network to overcome these ***,the seal image is pre-processed by applying an image rotation correction module based on Histogram of Oriented Gradients(HOG).Secondly,the similarity between input seal image pairs is measured by utilizing a similarity comparison module based on the Siamese ***,we compare the results with the pre-stored standard seal template images in the database to obtain the seal *** evaluate the performance of the proposed method,we further create a new seal image dataset that contains two subsets with 210,000 valid labeled pairs in *** proposed work has a practical significance in industries where automatic seal authentication is essential as in legal,financial,and governmental sectors,where automatic seal recognition can enhance document security and streamline validation ***,the experimental results show that the proposed multi-stage method for seal image recognition outperforms state-of-the-art methods on the two established datasets.

关键词： Seal recognition seal authentication document tampering siamese network spatial transformer network similarity comparison network

Variational quantum algorithm for node embedding

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Fundamental Research 2024年第4期4卷 845-850页

作者： Zeng-rong Zhou Hang Li gui-lu Long Research Center for Quantum Sensing Zhejiang LabHangzhou 311121China Bejing Academy of Quantum Information Sciences Beijing 100193China State Key Laboratory of Low-Dimensional Quantum Physics and Department of Physics Tsinghua UniversityBeijing 100084China

Quantum machine learning has made remarkable progress in many important ***,the gate complexity of the initial state preparation is seldom considered in lots of quantum machine learning algorithms,making them ***,we propose a quantum algorithm for the node embedding problem that maps a node graph's topological structure to embedding *** resulting quantum embedding state can be used as an input for other quantum machine learning *** O(log(N))qubits to store the information of N nodes,our algorithm will not lose quantum advantage for the subsequent quantum information ***,owing to the use of a parameterized quantum circuit with O(poly(log(N)))depth,the resulting state can serve as an efficient quantum *** addition,we explored the measurement complexity of the quantum node embedding algorithm,which is the main issue in training parameters,and extended the algorithm to capture high-order neighborhood information between ***,we experimentally demonstrated our algorithm on an nuclear magnetic resonance quantum processor to solve a graph model.

关键词： Quantum machine learning Quantum computation Node embedding Variational quantum algorithm Nuclear magnetic resonance

Characterization and mapping of a novel light-dependent lesion mimic mutant lmm6 in rice(Oryza sativa L.)

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Journal of Integrative Agriculture 2015年第9期14卷 1687-1696页

作者： XIAO gui-qing ZHANG Hai-wen lu Xiang-yang HUANG rong-feng College of Bioscience and Biotechnology Hunan Agricultural University Hunan Agricultural Bioengineering Research Institute Biotechnology Research Institute Chinese Academy of Agricultural Sciences

A novel rice lesion mimic mutant (LMM) was isolated from an ethane methyl sulfonate (EMS)-induced 02428 mutant bank. The mutant, tentatively designated as lmm6, develops necrotic lesions in the whole growth period along with changes in several important agronomic traits. We found that the initiation of the lesions was induced by light and cel death occurred in lmm6 accompanied with accumulation of reactive oxygen species (ROS). The lower chlorophyl content, soluble protein content and superoxide dismutase (SOD) activity, the higher malondialdehyde (MDA) content were detected in lmm6 than in the wild type (WT). Moreover, the observation by transmission electronic microscope (TEM) demonstrated that some organel es were damaged and the stroma lamel a of chloroplast was irregular and loose in mesophyl cel of lmm6. In addition, lmm6 was more resistant than WT to rice blast fungus Magnaporthe grisea infection, which was consistent with increased expression of four genes involved in the defense-related reaction. Genetic analysis showed that mutant trait of lmm6 is inherited as a monogenic recessive nuclear gene located on the long arm of chromosome 6. Using simple sequence repeat (SSR) markers, the target gene was ifnal y delimited to an interval of 80.8 kb between markers MM2359 and MM2370, containing 7 annotated genes. Taken together, our results provide the information to identify a new gene involved in rice lesion mimic, which wil be helpful in clarifying the mechanism of cel death and disease resistance in rice.

关键词： rice lesion mimic mutant gene mapping ROS blast resistance

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B(E2) Saturation in the Rare-Earth Region

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Chinese Physics Letters 1997年第5期14卷 340-343页

作者： LONG gui-lu Department of Physics Tsinghua UniversityBeijing 100084 Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100080

The quadrupole interactions between neutrons and protons are calculated using Nilsson+BCS model for the neutron-rich even-even rare-earth *** is used to study the saturation of B(E2)'s in this mass *** neutron numbers at which saturation of B(E2)occurs are calculated for each isotopic *** particular,the calculation suggests that B(E2)saturation may occur in the 2nd half of the 82-126 major shell in erbium and ytterbium.

关键词： B(E2) saturation Rare