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Hierarchical crystalline-amorphous nanocomposites with high strength and large deformability enabled by elemental diffusion

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Journal of Materials Science & Technology 2024年第4期171卷 150-161页

作者： Liqiang Wang Heyi Wang Xin zhou Huangliu Fu James Utama Surjadi Shuo Qu Xu Song rong Fan Yang Lu Department of Mechanical Engineering City University of Hong KongHong KongChina Nano-Manufacturing Laboratory(NML) Shenzhen Research Institute of City University of Hong KongShenzhen 518057China Chengdu Research Institute City University of Hong KongChengdu 610200China Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Department of Mechanical and Automation Engineering The Chinese University of Hong KongHong KongChina Department of Mechanical Engineering The University of Hong KongHong KongChina

Amorphous/nanocrystalline dual-phase structures have recently emerged as an effective way for over-coming the strength-ductility trade-offand breaking the limitation of the reverse Hall-Petch ***,we proposed a new strategy to develop a hierarchical and interconnected amorphous-crystalline nanocomposite arising from the nanoscale elemental interdiffusion and oxygen adsorption behavior dur-ing thermal treatment *** nanocomposite consisted of a three-dimensional(3D)hierarchical network structure where the crystalline phase(Cr-Co-Ni-Al)was embedded into the Al-O-based amor-phous phase network with critical feature sizes encompassing three orders of magnitude(from microm-eter to nanometer scale).It can achieve ultrahigh compression yield strength of-3.6 GPa with large homogeneous deformation of over 50%*** massive interstitial atoms induced lattice distortion and hierarchical amorphous phase boundary contributed to the strength *** situ Uniaxial compression inside a transmission electron microscope(TEM)revealed that the exceptional deformability of the nanocomposites resulted from the homogenous plastic flow of nano-sized amorphous phase and the plastic co-deformation behavior restricted by the nano-architected dual-phase *** proposed dual-phase synthesis approach can outperform conventional nanolaminates design strategies in terms of the mechanical properties achievable while providing a pathway to easily tune the microstructure of these nanolaminates.

关键词： Nanolaminates Dual-phase nanocomposites In situ transmission electron microscopy Multi-component alloy

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Metochalcone induces senescence-associated secretory phenotype via JAK2/STAT3 pathway in breast cancer

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Oncology Research 2024年第5期32卷 943-953页

作者： JIANBO zhou FENG WAN bin XIAO XIN LI CHENG PENG FU PENG Department of Pharmacology West China School of PharmacySichuan UniversityChengduChina State Key Laboratory of Southwestern Chinese Medicine Resources Chengdu University of Traditional Chinese MedicineChengduChina Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial TechnologySichuan UniversityChengduChina Chengdu No.1 Pharmaceutical Co. Ltd.PengzhouChina Chengdu Push Bio-Technology Co. Ltd.ChengduChina

Breast and lung cancers are the leading causes of mortality and most frequently diagnosed cancers in women and men,respectively,*** the antitumor activity of chalcones has been extensively studied,the molecular mechanisms of isoliquiritigenin analog 2',4',4-trihydroxychalcone(metochalcone;TEC)against carcinomas remain less well *** this study,we found that TEC inhibited cell proliferation of breast cancer BT549 cells and lung cancer A549 cells in a concentration-dependent *** induced cell cycle arrest in the S-phase,cell migration inhibition in vitro,and reduced tumor growth in ***,transcriptomic analysis revealed that TEC modulated the activity of the JAK2/STAT3 and P53 *** triggered the senescence-associated secretory phenotype(SASP)by repressing the JAK2/STAT3 *** mechanism of metochalcone against breast cancer depended on the induction of SASP via deactivation of the JAK2/STAT3 pathway,highlighting the potential of chalcone in senescence-inducing therapy against carcinomas.

关键词： Metochalcone Breast cancer Lung cancer SASP JAK2/STAT3

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Hemodialysis bilayer bionic blood vessels developed by the mechanical stimulation of hepatitis B viral X(HBX)genetransfected hepatic stellate cells

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第6期25卷 499-512页

作者： Hongyi LIU Yuanyuan zhou Peng GUO Xiongwei ZHENG Weibin CHEN Shichao ZHANG Yu FU Xu zhou Zheng WAN bin ZHAO Yilin ZHAO Department of Oncology and Vascular Interventional Radiology Zhongshan Hospital Affiliated to Xiamen UniversitySchool of MedicineXiamen UniversityXiamen 361004China School of Medicine Xiamen UniversityXiamen 361102China Xiamen Health and Medical Big Data Center Xiamen 361008China Fujian Provincial Key Laboratory of Chronic Liver Disease and Hepatocellular Carcinoma(Zhongshan Hospital Affiliated to Xiamen University) Xiamen 361004China Xiamen Key Laboratory of Cellular Intervention and Interventional Medical Materials Xiamen 361004China

Artificial vascular graft(AVG)fistula is widely used for hemodialysis treatment in patients with renal ***,it has poor elasticity and compliance,leading to stenosis and *** ideal artificial blood vessel for dialysis should replicate the structure and components of a real artery,which is primarily maintained by collagen in the extracellular matrix(ECM)of arterial *** have revealed that in hepatitis B virus(HBV)-induced liver fibrosis,hepatic stellate cells(HSCs)become hyperactive and produce excessive ECM ***,mechanical stimulation can encourage ECM secretion and remodeling of a fiber *** on the above factors,we transfected HSCs with the hepatitis B viral X(HBX)gene for simulating the process of HBV ***,these HBX-HSCs were implanted into a polycaprolactonepolyurethane(PCL-PU)bilayer scaffold in which the inner layer is dense and the outer layer consists of pores,which was mechanically stimulated to promote the secretion of collagen nanofiber from the HBX-HSCs and to facilitate crosslinking with the *** obtained an ECM-PCL-PU composite bionic blood vessel that could act as access for dialysis after ***,the vessel scaffold was implanted into a rabbit’s neck arteriovenous fistula *** exhibited strong tensile strength and smooth blood flow and formed autologous blood vessels in the rabbit’s *** study demonstrates the use of human cells to create biomimetic dialysis blood vessels,providing a novel approach for creating clinical vascular access for dialysis.

关键词： Composite bilayer bionic blood vessel Extracellular matrix(ECM) Hepatic stellate cells(HSCs) Hepatitis B viral X(HBX)gene Mechanical force

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Bismuth clusters pinned on TiO_(2) porous nanowires boosting charge transfer for CO_(2) photoreduction to CH_(4)

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Nano Research 2024年第3期17卷 1190-1198页

作者： Jiazhi Meng Kaiwen Wang Yang Wang Jiangping Ma Chaogang Ban Yajie Feng bin Zhang Kai zhou Liyong Gan Guang Han Danmei Yu Xiaoyuan zhou College of Physics and Institute of Advanced Interdisciplinary Studies Chongqing UniversityChongqing 401331China School of Chemistry and Chemical Engineering Chongqing UniversityChongqing 401331China College of Materials Science and Engineering Chongqing UniversityChongqing 400044China Beijing Key Lab of Microstructure and Properties of Advanced Materials Beijing University of TechnologyBeijing 100124China Analytical and Testing Center Chongqing UniversityChongqing 401331China

Artificial photosynthesis in carbon dioxide(CO_(2))conversion into value-added chemicals attracts considerable attention but suffers from the low activity induced by sluggish separation of photogenerated carriers and the kinetic bottleneck-induced unsatisfied ***,we prepare a new-style Bi/TiO_(2) catalyst formed by pinning bismuth clusters on TiO_(2) nanowires through being confined by pores,which exhibits high activity and selectivity towards photocatalytic production of CH_(4) from CO_(2).Boosted charge transfer from TiO_(2) through Bi to the reactants is revealed via in situ X-ray photon spectroscopy and time-resolved photoluminescence(PL).Further,in situ Fourier transform infrared results confirm that Bi/TiO_(2) not only overcomes the multi-electron kinetics challenge of CO_(2) to CH_(4) via boosting charge transfer,but also facilitates proton production and transfer as well as the intermediates*CHO and*CH_(3)O generation,ultimately achieving the tandem catalysis towards *** calculation also underlies that the more favorable reaction step from*CO to*CHO on Bi/TiO_(2) results in CH_(4) production with higher *** work brings new insights into rational design of photocatalysts with high performance and the formation mechanism of CO_(2) to CH_(4) for solar energy storage in future.

关键词： carbon dioxide(CO_(2))photoreduction charge transfer tandem catalysis methanation

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Natural killer cell membrane doped supramolecular nanoplatform with immuno-modulatory functions for immuno-enhanced tumor phototherapy

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Chinese Chemical Letters 2024年第10期35卷 205-212页

作者： Ying Gao rong zhou Qiwen Wang Shaolong Qi Yuanyuan Lv Shuang Liu Jie Shen Guocan Yu Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province School of MedicineHangzhou City UniversityHangzhou 310015 China Department of Cardiology The First Afiliated HospitalZhejiang University School of MedicineHangzhou 310003China MEKey Laboratoryof Bioorganic Phosphorus Chemistry Chemical Bology epartmentof ChemtryTsinghua UniversityBeijing04Chin Emergency Department State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100730China

Photodynamic therapy(PDT)has garnered significant attention as a promising approach to cancer therapy,harnessing the combined benefits of localized light treatment and the accompanying host immune *** this study,we engineered an immuno-enhanced PDT nanoplatform,denoted as HM@p-MOF(hybrid membrane@porphyrin-metal organic framework).The core porphyrin-MOF was cloaked with a hybrid membrane derived from B16F10 cancer cells and NK cells,resulting in enhanced *** both in vitro and in vivo experiments,our finding demonstrated that the hybrid membrane conferred dual targeting capabilities to the nanoplatform,leveraging the unique properties of the B16F10 membrane and NK membrane to augment immunogenic cell death(ICD)induced by photodynamic ***,in conjunction with the immunomodulatory functions of the NK cell membrane,we observed an expansion of in situ immune infiltration leading to a systemic immune *** HM@p-MOF nanoplatform exhibited the capacity to not only inhibit the growth of mouse melanoma but also suppress *** innovative HM@p-MOF nanoplatform present a viable strategy to enhance phototherapeutic efficacy for both localized and metastatic *** provides a direction for the fabrication of biomimetic nanomedicines possessing immuno-modulatory function.

关键词： Biomimetic Cell membrane Metal-organic framework Phototherapy Tumor targeting

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Investigation of formaldehyde sources and its relative emission intensity in shipping channel environment

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Journal of Environmental Sciences 2024年第8期142卷 142-154页

作者： Jiaqi Liu Shanshan Wang Yan Zhang Yuhao Yan Jian Zhu Sanbao Zhang Tianyu Wang Yibing Tan bin zhou Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention(LAP3) Department of Environmental Science and EngineeringFudan UniversityShanghai 200433China Institute of Eco-Chongming(IEC) No.20 Cuiniao RoadShanghai 202162China Institute of Atmospheric Sciences Fudan UniversityShanghai 200433China National Observations and Research Station for Wetland Ecosystems of the Yangtze Estuary Fudan UniversityShanghai 200438China Institute of Digitalized Sustainable Transformation Big Data InstituteFudan UniversityShanghai 200433China

Formaldehyde(HCHO)is considered one of the most abundant gas-phase carbonyl compounds in the atmosphere,which can be directly emitted through transportation ***-Path Differential Optical Absorption Spectroscopy(LP-DOAS)was used to observe HCHO in the river channel of Wusong Wharf in Shanghai,China for the whole year of *** to the impact of ship activity,the annual average HCHO level in the channel is about2.5 times higher than that in the nearby campus *** explain the sources of HCHO under different meteorological conditions,the tracer-pair of CO and O_(x)(NO_(2)+O_(3))was used on the clustered air *** results of the source appointment show that primary,secondary and background account for 24.14%(3.34±1.19 ppbv),44.78%(6.20±2.04ppbv)and 31.09%(4.31±2.33 ppbv)of the HCHO in the channel when the air masses were from the mixed direction of the city and channel,*** performing background station subtraction at times of high primary HCHO values and resolving the plume peaks,directly emitted HCHO/NO_(2)in the channel environment and plume were determined to be mainly distributed between 0.2 and *** cargo ships with higher sailing speeds or main engine powers tend to have higher HCHO/NO_(2)*** the knowledge of NO_(2)(or NO_(x))emission levels from ships,this study may provide data support for the establishment of HCHO emission factors.

关键词： HCHO LP-DOAS Channel environment Ship emissions

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Preferentially selective extraction of lithium from spent LiCoO_(2)cathodes by medium-temperature carbon reduction roasting

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International Journal of Minerals,Metallurgy and Materials 2024年第2期31卷 315-322页

作者： Daixiang Wei Wei Wang Longjin Jiang Zhidong Chang Hualei zhou bin Dong Dekun Gao Minghui Zhang Chaofan Wu School of Chemistry and Biological Engineering University of Science and Technology BeijingBeijing 100083China State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China Anhui Chaoyue Environmental Protection Technology Co. LtdChuzhou 239060China Anhui Huihong Technology Co. LtdChuzhou 239060China

Lithium recovery from spent lithium-ion batteries(LIBs)have attracted extensive attention due to the skyrocketing price of *** medium-temperature carbon reduction roasting was proposed to preferential selective extraction of lithium from spent Li-CoO_(2)(LCO)cathodes to overcome the incomplete recovery and loss of lithium during the recycling *** LCO layered structure was destroyed and lithium was completely converted into water-soluble Li2CO_(3)under a suitable temperature to control the reduced state of the cobalt *** Co metal agglomerates generated during medium-temperature carbon reduction roasting were broken by wet grinding and ultrasonic crushing to release the entrained *** results showed that 99.10%of the whole lithium could be recovered as Li2CO_(3)with a purity of 99.55%.This work provided a new perspective on the preferentially selective extraction of lithium from spent lithium batteries.

关键词： spent LiCoO_(2)cathodes medium-temperature carbon reduction lithium extraction priority crystal transformation macro-scopic transport resistance

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LbCas12a-nuclease-mediated tiling deletion for large-scale targeted editing of non-coding regions in rice

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Plant Communications 2024年第4期5卷 141-144页

作者： Guigen Ma Fang Yan bin Ren Zhenwan Lu Hao Xu Fangxi Wu Shaofang Li Daowen Wang Xueping zhou Huanbin zhou State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193China Key Laboratory of Gene Editing Technologies(Hainan) Ministry of Agricultural and Rural AffairsSanya 572024China Scientific Observing and Experimental Station of Crop Pests in Guilin Ministry of Agriculture and Rural AffairsGuilin 541399China Rice Research Institute Fujian Academy of Agricultural SciencesFuzhou 350019China State Key Laboratory of Vegetable Biobreeding National Engineering Research Center for VegetablesBeijing Vegetable Research CenterBeijing Academy of Agriculture and Forestry ScienceBeijing 100097China College of Agronomy State Key Laboratory of Wheat and Maize Crop Scienceand Center for Crop Genome EngineeringHenan Agricultural UniversityZhengzhou 450046China State Key Laboratory of Rice Biology Institute of BiotechnologyZhejiang UniversityHangzhou 310058China These authors contributed equally to this article

Dear Editor,This study reports a nuclease-mediated tiling deletion(NTD)method that uses LbCas12a nuclease with a tiling CRISPRderived RNA(crRNA)library to efficiently induce numerous nucleotide deletions in non-coding regulatory regions of endogenous rice *** method was applied to non-coding regions of the Green Revolution gene SD1,generating 6 mutants with quantitative variations in plant height,which were then used to investigate associations between genotype and *** is thus a promising tool for molecular rice breeding.

关键词： breeding. generating nuclease

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The source of lithium in Lakkor Co Salt Lake on Qinghai-Tibet Plateau,China:evidence from hydrochemical characteristics and boron isotope

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Acta Geochimica 2024年第5期43卷 933-946页

作者： Zheng Yan Li bin Kai Li Mao-Yong He Xue Qin Wen Jiang Di zhou Department of Geoscience and Technology Taiyuan University of TechnologyYingzexi StreetTaiyuan 030024Shanxi ProvinceChina State Key Laboratory of Loess and Quaternary Geology Institute of Earth EnvironmentChinese Academy of SciencesXi’an 710061China Qinghai Provincial Key Laboratory of Geology and Environment of Salt Lakes Qinghai Institute of Salt LakesChinese Academy of SciencesXining 810008QinghaiChina School of Earth Science and Resources Chang’an UniversityXi’an 710000ShaanxiChina Qinghai Normal University Academy of Plateau Science and SustainabilityXining 810016China

The availability of lithium resources is of great significance for the development of modern technologies,as well as for civil and military *** Qinghai-Tibet Plateau is a region known for its abundance of lithium-rich salt ***,the specific origin of lithium in these lakes is still unknown,which hinders the advancement of the lithium resource business in this *** research this issue,this study involved the collection of 20 samples from Lakkor Co Salt Lake on Qinghai-Tibet Plateau,encompassing samples of surface brine,cold springs,fresh lakes,and recharge *** composition of anions and cations in these samples was ***,the analysis extensivelyutilizedthePiperthree-linediagram,Gibbs model,and ion proportion *** findings of this study indicate that as the moves from the recharge water system to salt lake,there is a transition in water type from strong carbonate to moderate carbonate and weak carbonate,as well as Na *** research based on a similar source of both lithium and boron,utilized ion correlation analysis and boron isotope study in the Lakkor Co area,and analyzed the source and transporting process of *** main origin of lithium in Lakkor Co is the dissolution of lithiumrich rocks,recharge water systems,and deep hydrothermal *** findings are highly significant in enhancing the foundational data of lithium-rich brine resources in the Qinghai-Tibet Plateau and are beneficial for assessing the future development of such deposits.

关键词： Lithium Hydrochemical Li-rich Salt lake Boron isotope

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Analysis of lymph node metastasis and survival prognosis in early gastric cancer patients: A retrospective study

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1637-1646页

作者： Dong-Yuan Liu Jin-Jin Hu Yong-Quan zhou Ai-rong Tan Department of General Surgery The 971st Hospital of Chinese People's Liberation ArmyQingdao 266071Shandong ProvinceChina Department of Chest Surgery Feicheng People's HospitalFeicheng 271600Shandong ProvinceChina Department of Gastrointestinal Surgery Zhongshan Hospital of Fudan UniversityShanghai 200032China Department of Oncology Qingdao Municipal HospitalQingdao 266000Shandong ProvinceChina

BACKGROUND Early gastric cancer(EGC)is a common malignant tumor of the digestive system,and its lymph node metastasis and survival prognosis have been *** retrospectively analyzing the clinical data of EGC patients,we can better under-stand the status of lymph node metastasis and its impact on survival and *** To evaluate the prognosis of EGC patients and the factors that affect lymph node METHODS The clinicopathological data of 1011 patients with EGC admitted to our hospital between January 2015 and December 2023 were collected in a retrospective cohort *** were 561 males and 450 *** mean age was 58±11 *** patient underwent radical *** status of lymph node metastasis in each group was determined according to the pathological examination results of surgical *** outcomes were as follows:(1)Lymph node metastasis in EGC patients;(2)Analysis of influencing factors of lymph node metastasis in EGC;and(3)Analysis of prognostic factors in patients with *** distributed measurement data are expressed as mean±SD,and a t test was used for comparisons between *** data are expressed as absolute numbers or percentages,and the chi-square test was used for comparisons between *** data were compared using a nonparametric rank sum test.A log-rank test and a logistic regression model were used for univariate analysis.A logistic stepwise regression model and a Cox stepwise regression model were used for multivariate *** Kaplan-Meier method was used to calculate the survival rate and construct survival curves.A log-rank test was used for survival *** Analysis of influencing factors of lymph node metastasis in *** results of the multifactor analysis showed that tumor length and diameter,tumor site,tumor invasion depth,vascular thrombus,and tumor differentiation degree were independent influencing factors for lymph node metastasis in patients with EGC(odds ratios=1.80,1.49,2.6

关键词： Gastric neoplasms Lymph node metastasis Prognosis Influencing factor Retrospective study

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