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Residual levels and health risk assessment of trace metals in Chinese resident diet

Journal of Environmental Sciences 2024年第2期136卷 451-459页

作者： Yubing Dai Shuai Sun rong Cao Haijun zhang Jiping Chen Ningbo Geng CAS Key Laboratory of Separation Science for Analytical Chemistry Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China Shenyang Pharmaceutical University Shenyang 110016China University of Chinese Academy of Sciences Beijing 100049China

Large-scale metal contamination across the food web is an intractable problem due to increasing pollutant emissions,atmospheric transport,and dry and wet deposition of *** present study focus on several trace metals that are rarely studied but have special toxicity,including tin(Sn),antimony(Sb),gold(Au),hafnium(Hf),palladium(Pd),platinum(Pt),ruthenium(Ru),tellurium(Te)and iridium(Ir).We investigated trace metals residues and distribution characteristics,and further evaluated the potential health risks from major daily food intakes in 33 cities in ***,Sb,Ir,Hf,and Au were frequently detected in food samples with the concentrations ranged from ND(not detected)to 24.78μg/kg ww(wet weight).Eggs exhibited the highest residual level of all detected metals(13.70±14.70μg/kg ww in sum),while the lowest concentrations were observed in vegetables(0.53±0.17μg/kg ww in sum).Sn accounting for more than 50%of the total trace metals concentration in both terrestrial and aquatic animal origin *** terrestrial plant origin foods,Sn and Ir were the most abundant *** and Au were the most abundant elements in egg *** addition,Sb and Ir showed a clear trophic dilution effect in terrestrial environments,while in aquatic ecosystems,Sn,Hf,and Au exhibited obvious trophic amplification *** calculated average estimated daily intake(EDI)via food consumption in five regions of China was 0.09μg/(kg·day),implying the health risk of aforementioned elements was acceptable.

关键词： Trace metals Accumulation characteristics Dietary exposure Estimated daily intake(EDI)

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Role of oxidative stress in the apoptosis of hepatocellular carcinoma induced by combination of arsenic trioxide and ascorbic acid

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Acta Pharmacologica Sinica 2006年第8期27卷 1078-1084页

作者： Jing-jing LI~2 Qiang TANG~2 Yuan LI ben-rong HU zhang-yin MING Qin FU~3 Jia-qing QIAN Ji-zhou XIANG~3 Department of Pharmacology,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China Department of Pharmacology Tongji Medical College Huazhong University of Science and Technology Wuhan China

Aim:The present study was designed to determine the possible pathway under-lying the enhancement of apoptosis induced by the combined use of arsenictrioxide(As2O3)and ascorbic acid(AA).Methods:The level of intracellular reac-tive oxygen species(ROS)was detected by means of flow cytometry analysis withan oxidation-sensitive fuorescent probe(6-carboxy-2′,7′dichlorodihydrofluoresceindiacetate)*** activity of glutathione(GSH),glutathione peroxidase(GPx),and superoxide dismutase(SOD)were detected by biochemical *** mitochondrial membrane potential was measured by flow cytometry analysiswith rhodamine 123 ***-2,Bax,and p17 subunit of caspase-3 were ana-lyzed using the Western blot *** apoptosis rate was determined by flowcytometry with annexin-V/propidium iodide ***:Compared withAs2O3(2.0 μmol/L)treated alone,As2O3(2.0 μmol/L)in combination with AA(100μmol/L)decreased intracellular GSH content from 101.30+5.76 to 81.91+3.12 mg/gprotein,and increased ROS level from 127.61+5.12 to 152.60+5.88,which was rep-resented by the 2,7-dichlorofluorescein *** loss of mitochondria mem-brane potential was increased from 1269.97±36.11 to 1540.52+52.63,which waspresented by fluorescence *** p17 subunit of caspase-3 expressionwas increased approximately ***,SOD and GPx depletion and theratio of Bcl-2 to Bax were equal to that of As2O3treated alone(P>0.05).When theROS scavenger,N-acetyl-L-cysteine,was added to As2O3and AA combined treat-ment group,the apoptosis rate decreased from 15.60%±1.14% to 9.48%±0.67%,and the ROS level decreased from 152.60±5.88 to 102.77±***:AApotentiated As2O3-induced apoptosis through the oxidative pathway by increas-ing the ROS *** may be the result of depleting intracellular *** mayinfluence the downstream cascade following ROS,including mitochondria depo-larization and caspase-3 ***,SOD and GPx depletion and theratio of Bcl-2 to Bax influenced by

关键词： arsenic trioxide ascorbic acid hepatocellular carcinoma apoptosis glutathione reactive oxygen species

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SYNTHESIS OF LADDERLIKE POLYHYDROXYPROPYLSILSESQUIOXANE

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Chinese Journal of Polymer Science 2000年第5期18卷 453-457页

作者： Huai-zhong Pan Chun-qing Liu Zhong Jin Ming Cao Jian-hua Luo Ping Xie rong-ben zhang Yu-hui Lin Neal Tai-sheng Chung Center for Molecular Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China Institute of Materials Research and Engineering, Singapore 117602, Singapore 中科院化学所北京 Istitute of Materials Research and Engineering Singapore 新加坡

Ladderlike polyhydroxypropylsilsesquioxane (HO-T) was synthesized by alcoholysis of ladderlike poly(3-propionyloxy-propyl)silsesquioxane. The HO-T was characterized by GPC, IR, NMR, DSC, TGA and X-ray diffraction methods. Through hydrogen-bonding interaction, ladderlike polymer (HO-T) can form a supramolecular complex with somewhat regular structure.

关键词： ladderlike polyhydroxypropylsilsesquioxane hydrogen-bond interaction supermolecular complex

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benefit-Risk Assessment of Chinese Medicine Injections for Primary Liver Cancer Based on Multi-criteria Decision Analysis

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Chinese Journal of Integrative Medicine 2024年第6期30卷 559-564页

作者： zhang rong-rong SHAO Ming-yi FU Yu ZHAO Rui-xia WANG Jing-wen FANG Yu-xuan The First Clinical Medical College of Henan University of Traditional Chinese Medicine Zhengzhou450046China Personal Department the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China Scientific Research Department the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China Digestive Department the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China

ObjectiveTo evaluate the benefit-risk of 3 commonly used Chinese medicine injections, Aidi Injection (ADI), Cinobufagin Injection (CINI) and Compound Kushen Injection (CKI), in the treatment of primary liver cancer (PLC), so as to provide a reference for clinical *** controlled trials (RCTs) of ADI, CINI and CKI in the treatment of PLC published in the databases of China National Knowledge Infrastructure, Wanfang, China Science and Technology Journal Database, SinoMed, PubMed, Cochrane Library, and Web of Science were retrieved from January 2020 to October 2022. The data of benefit and risk indicators were combined to obtain the effect value. The multi-criteria decision analysis (MCDA) model was applied to build the decision tree. The benefit value, risk value and benefit risk value of the 3 injections in PLC treatment were calculated. Monte Carlo simulation was carried out to calculate the 95% confidence interval and probability of differences among the 3 injections, so as to optimize the evaluation *** total of 71 RCTs were included. The benefit values of ADI, CINI and CKI combined with transcatheter arterial chemoembolization (TACE) were 42, 38 and 36, respectively. The risk values were 42, 25 and 37, respectively. The benefit risk values were 42, 31 and 37, respectively. The benefit risk differences of ADI vs. CINI, ADI vs. CKI, and CKI vs. CINI were 11 (−0.86, 17.75), 5 (−5.01, 11.09), and 6 (−1.87, 12.63), respectively. The probability that ADI superior to CINI, ADI superior to CKI, and CKI superior to CINI was 96.26%, 77.27%, and 92.62%, *** on the results of MCDA model, CINI combined with TACE has the greatest risk in the treatment of the PLC. Considering the efficacy and safety, the possible priority of the 3 Chinese medicine injections combined with TACE in the treatment of PLC is ADI, CKI and CINI.

关键词： multi-criteria decision analysis benefit-risk assessment Chinese medicine injections primary livercancer

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The superiority of nonconjugated structures in fluorescence:through-space ***-bond charge transfer

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Science China Chemistry 2024年第9期67卷 3121-3130页

作者： Weihao Tu Zuping Xiong Lei Wang Jianyu zhang Jing Zhi Sun Haoke zhang ben Zhong Tang MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310058China Zhejiang-Israel Joint Laboratory of Self-Assembling Functional Materials ZJU-Hangzhou Global Scientific and Technological Innovation CenterZhejiang UniversityHangzhou 311215China Centre of Healthcare Materials Shaoxing InstituteZhejiang UniversityShaoxing 312000China Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and ReconstructionThe Hong Kong University of Science and TechnologyHong Kong 999077China School of Science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhen(CUHK-Shenzhen)Guangzhou 518172China

Constructing charge transfer(CT)state by introducing donor(D)and acceptor(A)is an efficient strategy to regulate the photophysical properties of luminescent *** CT-type luminophores are built onπ-conjugated fused-ring structures,which always show hybrid CT/locally excited(LE)states and luminescence quenching effect in the aggregate *** this work,eight conjugated biphenyl(BP)and nonconjugated diphenylmethane(DPM)derivatives with different donors and acceptors are synthesized to investigate the CT *** photophysical characterization and theoretical calculation demonstrate that the through-space CT(TSCT)in nonconjugated DA-DPM exhibit superior photophysical performance than the conjugated DA-BP with through-bond CT(TBCT),the main manifestations are as follows:(1)TSCT luminophores produce longer maximum emission wavelength(λ_(em))than the corresponding TBCT *** example,the longest λ_(em)of DMA-CN-DPM(DMA,dimethylamino)is 621 nm but the corresponding λ_(em)of DMA-CN-BP is only 480 nm.(2)TSCT-based DA-DPM demonstrates more sensitive responsiveness to environmental stimuli such as temperature and polarity.(3)Complete separation of the the highest occupied molecular orbital(HOMO)and the lowest unoccupied molecular orbital(LUMO)distribution exists in all kinds of conformation of DA-DPM,which was hard to realize in conjugated DA-BP.

关键词： through-space charge transfer through-space conjugation clusteroluminescence diphenylmethane

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Application of sparse S transform network with knowledge distillation in seismic attenuation delineation

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Petroleum Science 2024年第4期21卷 2345-2355页

作者： Nai-Hao Liu Yu-Xin zhang Yang Yang rong-Chang Liu Jing-Huai Gao Nan zhang School of Information and Communications Engineering Xi'an Jiaotong University School of Software Engineering Xi'an Jiaotong University PetroChina Research Institute of Petroleum Exploration and Development (RIPED) CNPC Research Institute of Exploration and Development Yumen Oilfield Company CNPC

Time-frequency analysis is a successfully used tool for analyzing the local features of seismic ***, it suffers from several inevitable limitations, such as the restricted time-frequency resolution,the difficulty in selecting parameters, and the low computational efficiency. Inspired by deep learning,we suggest a deep learning-based workflow for seismic time-frequency analysis. The sparse S transform network(SSTNet) is first built to map the relationship between synthetic traces and sparse S transform spectra, which can be easily pre-trained by using synthetic traces and training labels. Next, we introduce knowledge distillation(KD) based transfer learning to re-train SSTNet by using a field data set without training labels, which is named the sparse S transform network with knowledge distillation(KD-SSTNet).In this way, we can effectively calculate the sparse time-frequency spectra of field data and avoid the use of field training labels. To test the availability of the suggested KD-SSTNet, we apply it to field data to estimate seismic attenuation for reservoir characterization and make detailed comparisons with the traditional time-frequency analysis methods.

关键词： S transform Deep learning Knowledge distillation Transfer learning Seismic attenuation delineation

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A Mass-Preserving Characteristic Finite Difference Method For Miscible Displacement Problem

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Advances in Applied Mathematics and Mechanics 2024年第1期16卷 164-180页

作者： Jiansong zhang Yue Yu rong Qin Zhaohui Liu Department of Applied Mathematics China University of PetroleumQingdaoShandong 266580China

In this article,a new characteristic finite difference method is developed for solving miscible displacement problem in porous *** new method combines the characteristic technique with mass-preserving interpolation,not only keeps mass balance but also is of second-order accuracy both in time and *** results are presented to confirm the convergence and the accuracy in time and space.

关键词： The method of characteristics mass-preserving finite difference miscible displacement problem

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Dynamic analysis of a latent HIV infection model with CTL immune and antibody responses

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International Journal of Biomathematics 2024年第3期17卷 289-316页

作者： Zhiqi zhang Yuming Chen Xia Wang Libin rong School of Mathematics and Statistics Xinyang Normal University XinyangHenan 464000P.R.China Department of Mathematics Wilfrid Laurier University WaterlooONN2L 3C5Canada Department of Mathematics University of Florida GainesvilleFL 32611USA

This paper develops a mathematical model to investigate the Human Immunodeficiency Virus(HIV)infection *** model includes two transmission modes(cell-to-cell and cell-free),two adaptive immune responses(cytotoxic T-lymphocyte(CTL)and antibody),a saturated CTL immune response,and latent HIV *** existence and local stability of equilibria are fully characterized by four reproduction *** sensitivity analyses,we assess the partial rank correlation coefficients of these reproduction numbers and identify that the infection rate via cell-to-cell transmission,the number of new viruses produced by each infected cell during its life cycle,the clearance rate of free virions,and immune parameters have the greatest impact on the reproduction ***,we compare the effects of immune stimulation and cell-to-cell spread on the model's *** findings highlight the significance of adaptive immune responses in increasing the population of uninfected cells and reducing the numbers of latent cells,infected cells,and ***,cell-to-cell transmission is identified as a facilitator of HIV *** analytical and numerical results presented in this study contribute to a better understanding of HIV dynamics and can potentially aid in improving HIV management strategies.

关键词： HIV infection cell-to-cell transmission adaptive immune response latent infection local stability

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Salinity effect-induced ENSO amplitude modulation in association with the interdecadal Pacific Oscillation

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Journal of Oceanology and Limnology 2024年第4期42卷 1019-1036页

作者： Hai ZHI Xiaokun WANG rong-Hua zhang Pengfei LIN Jifeng QI College of Atmospheric Sciences Nanjing University of Information Science and TechnologyNanjing 210044China School of Marine Sciences Nanjing University of Information Science and TechnologyNanjing 210044China Laoshan Laboratory Qingdao 266237China State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics(LASG) Institute of Atmospheric Physics(IAP)Chinese Academy of SciencesBeijing 100029China Key Laboratory of Ocean Circulation and Waves Institute of Oceanologyand Center for Ocean Mega-ScienceChinese Academy of SciencesQingdao 266071China

A 110-year ensemble simulation of an ocean general circulation model(OGCM)was analyzed to identify the modulation of salinity interdecadal variability on El Niño-Southern Oscillation(ENSO)amplitude in the tropical Pacific during *** simulating results show that sea surface salinity(SSS)variation in the region exhibits notable and coherent interdecadal variability signal,which is closely associated with the Interdecadal Pacific Oscillation(IPO).As salinity increases or reduces,the SSS modulations on ENSO amplitude during its warm/cold events vary asymmetrically with positive/negative IPO ***,salinity interdecadal variability can enhance or reduce ENSO-related conditions in upper-ocean stratification,contributing noticeably to ENSO *** anomalies associated with the mixed layer depth and barrier layer thickness can modulate ENSO amplitude during positive and negative IPO phases,resulting in the asymmetry of sea surface temperature(SST)anomaly in the tropical *** positive IPO phases,SSS interdecadal variability contributes positively to El Niño amplitude but negatively to La Niña amplitude by enhancing or reducing SSS interannual variability,and vice versa during negative IPO ***,the results indicate that the modulation of the ENSO amplitude by the SSS interdecadal variability is 15%-28%during negative IPO phases and 30%-20%during positive IPO phases,***,the SSS interdecadal variability associated with IPO and its modulation on ENSO amplitude in the tropical Pacific are among factors essentially contributing ENSO diversity.

关键词： El Niño-Southern Oscillation(ENSO)amplitude Interdecadal Pacific Oscillation(IPO) ocean salinity variability tropical Pacific upper-ocean stratification

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Regulating the conductance of tungsten diselenide by oxygen plasma and improving its electrical stability by encapsulation

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Nano Research 2024年第4期17卷 3253-3260页

作者： Zhaofang Cheng Shaodan He Shimin zhang Shijun Duan Min Wang Ziyu Liu rong zhang Wenya Qiang Xudong zhang Minggang Xia MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter School of PhysicsXi’an Jiaotong UniversityXi’an 710049China Department of Applied Physics School of PhysicsXi’an Jiaotong UniversityXi’an 710049China Shaanxi Province Key Laboratory of Quantum Information and Optoelectronic Quantum Devices School of PhysicsXi’an Jiaotong UniversityXi’an 710049China

Two-dimensional(2D)tungsten selenide(WSe_(2))is promising candidate material for future electronic applications,owing to its potential for ultimate device *** improving the electronic performance of WSe_(2)-based field-effect transistors(FETs),the modification of surface properties is *** this study,the seamless structural phase transition in WSe_(2) lattice is achieved by soft oxygen plasma,regulating the electrical conductance of WSe_(2)-based *** found that during the soft oxygen plasma treatment with optimal processing time,the generated oxygen ions can substitute some selenium atoms and thus locally modify the bond length,inducing 2H→1T phase transition in WSe_(2) with seamless *** mosaic structures have been proven to tailor the electronic structure and increase the hole carrier concentration inside WSe_(2),significantly increasing the channel conductance of WSe_(2) *** the further increase of the oxygen plasma treatment time,the creation of more selenium vacancy defects leads to the electronic doping,resulting in the reduction of *** from the hexagonal boron nitride(h-BN)encapsulation to interrupt the partial structural relaxation from 1T to 2H phase,our WSe_(2) FET exhibits high electronic stability with conductance of 6.8×10^(-4) S,which is about four orders of magnitude higher than 2H WSe_(2)(5.8×10^(-8) S).This study could further broaden the WSe_(2) FETs in applications for functionalization and integration in electronics.

关键词： tungsten selenide(WSe2) structural phase transition oxygen plasma conductance hexagonal boron nitride(h-BN)encapsulation

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