检索结果-南通市图书馆

Emerging roles of lncRNAs in the post-transcriptional regulation in cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genes & Diseases 2019年第1期6卷 6-15页

作者： rong-zhang he Di-Xian Luo Yin-Yuan Mo Department of Clinical Pharmacology Xiangya HospitalCentral South UniversityChangsha410078 HunanChina Translational Medicine Institute National&Local Joint Engineering Laboratory for High-through Molecular Diagnosis TechnologyCollaborative Research Center for Post-doctoral Mobile Stations of Central South UniversityAffiliated the First People’s Hospital of Chenzhou of University of South ChinaChenzhou432000China Department of Pharmacology/Toxicology and Cancer InstituteUniversity of Mississippi Medical CenterJacksonMSUSA

Accumulating evidence indicates that long non-coding RNAs(lncRNAs)can play a pivotal role in regulation of diverse cellular *** particular,lncRNAs can serve as master gene regulators at transcriptional and posttranscriptional levels,leading to *** this review,we discuss latest developments in lncRNA-meditated gene expression at the post-transcriptional level,including gene splicing,mRNA stability,protein stability and nuclear trafficking.

关键词： Alternative splicing LncRNA Posttranscriptional regulation Protein stability RNA binding proteins RNA stability

M6A modification of circNSUN2 promotes colorectal liver metastasis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genes & Diseases 2021年第1期8卷 6-7页

作者： rong-zhang he Jing Jiang Di-Xian Luo Department of Clinical Pharmacology Xiangya HospitalCentral South UniversityChangshaHunan410078PR China Translational Medicine Institute National&Local Joint Engineering Laboratory for High-through Molecular Diagnosis TechnologyCollaborative Research Center for Post-doctoral Mobile Stations of Central South UniversityAffiliated the First People’s Hospital of ChenzhouUniversity of South ChinaChenzhouHunan423000PR China Center for Clinical Pathology The First People’s Hospital of ChenzhouUniversity of South ChinaChenzhouHunan423000PR China

Circular RNAs(circRNAs)are playing emerging role in the pathogenesis of cancers,but the mechanisms still *** the recent issue of the Nature Communications,Chen and colleagues have demonstrated that YTHDC1 facilitates N6-methyladenosine modified circNSUN2 cytoplasmic export and the circNSUN2/IGF2BP2/HMGA2 complex stabilizes HMGA2 to promote colorectal liver *** discoveries not only expand our understanding of circRNAs biology in tumor,but also demonstrate that m6A modification plays a key role for circRNAs in RNA ***,these findings indicate that circRNAs may be a new approach for therapeutic target of cancers.

关键词： CircRNAs Colorectal carcinoma IGF2BP2 Metastasis N6-methyladenosine

Effects of angiotensin-converting enzyme inhibitors and angiotensin II type 1 receptor blockers on lymphangiogenesis of gastric cancer in a nude mouse model

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2008年第21期121卷 2167-2171页

作者： WANG Liang CAI Shi-rong zhang Chang-hua he Yu-long ZHAN Wen-hua WU Hui PENG Jian-jun Department of Gastroenteropancreatic Surgery First Affiliated Hospital Center of Gastric Cancer Sun Yat-sen University Guangzhou Guangdong 510080 China

Background Angiotensin-converting enzyme inhibitors （ACEI） and angiotensin II type 1 receptor blockers （ARB） can inhibit tumor growth by inhibition of angiogenesis. This study was designed to study the anticancer effects of ACEI and ARB on tumor growth and lymphangiogenesis in an implanted gastric cancer mouse model. Methods A model of gastric cancer was established by subcutaneously inoculating human gastric cancer cell line SGC-7901 into 60 nude mice. One week later, all mice were randomly divided into 5 groups. A control group received physiologic saline once daily for 21 days. Mice in the 4 treatment groups received one of the following agents by gavage once daily for 21 days： perindopril, 2 mg/kg; captopril, 5 mg/kg; Iosartan, 50 mg/kg; or valsartan, 40 mg/kg. Twenty-one days after treatment, all the mice were sacrificed and the tumors were removed. Tumor sections were processed, and immunohistochemical methods were used to observe the expressions of vascular endothelial growth factor C （VEGF-C）, matrix metalloproteinase 7 （MMP-7）, and lymphatic microvessel density （LMVD）. Results Tumor volume was significantly inhibited in all ACEI and ARB groups, compared with the control group （all P 〈0,01）. LMVD in the ACEI and ARB groups was also significantly lower than that of the control group （all P 〈0.01）. In the ACEI groups, the expressions of VEGF-C and MMP-7 were both significantly decreased, compared with the control group （all P 〈0.05）. In the ARB groups, expression of VEGF-C was significantly decreased compared with the control group （all P 〈0.05）. However, no significant difference was found in the expression of MMP-7 between ARB groups and the control group. Conclusion In a mouse model, ACEI and ARB might inhibit gastric cancer tumor growth by suppressing lymphangiogenesis.

关键词： stomach neoplasms angiotensin-converting enzyme inhibitor angiotensin Ⅱ type Ⅰ receptor blocker lymphangiogenesis

Regulating the conductance of tungsten diselenide by oxygen plasma and improving its electrical stability by encapsulation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2024年第4期17卷 3253-3260页

作者： Zhaofang Cheng Shaodan he Shimin zhang Shijun Duan Min Wang Ziyu Liu rong zhang Wenya Qiang Xudong zhang Minggang Xia MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter School of PhysicsXi’an Jiaotong UniversityXi’an 710049China Department of Applied Physics School of PhysicsXi’an Jiaotong UniversityXi’an 710049China Shaanxi Province Key Laboratory of Quantum Information and Optoelectronic Quantum Devices School of PhysicsXi’an Jiaotong UniversityXi’an 710049China

Two-dimensional(2D)tungsten selenide(WSe_(2))is promising candidate material for future electronic applications,owing to its potential for ultimate device *** improving the electronic performance of WSe_(2)-based field-effect transistors(FETs),the modification of surface properties is *** this study,the seamless structural phase transition in WSe_(2) lattice is achieved by soft oxygen plasma,regulating the electrical conductance of WSe_(2)-based *** found that during the soft oxygen plasma treatment with optimal processing time,the generated oxygen ions can substitute some selenium atoms and thus locally modify the bond length,inducing 2H→1T phase transition in WSe_(2) with seamless *** mosaic structures have been proven to tailor the electronic structure and increase the hole carrier concentration inside WSe_(2),significantly increasing the channel conductance of WSe_(2) *** the further increase of the oxygen plasma treatment time,the creation of more selenium vacancy defects leads to the electronic doping,resulting in the reduction of *** from the hexagonal boron nitride(h-BN)encapsulation to interrupt the partial structural relaxation from 1T to 2H phase,our WSe_(2) FET exhibits high electronic stability with conductance of 6.8×10^(-4) S,which is about four orders of magnitude higher than 2H WSe_(2)(5.8×10^(-8) S).This study could further broaden the WSe_(2) FETs in applications for functionalization and integration in electronics.

关键词： tungsten selenide(WSe2) structural phase transition oxygen plasma conductance hexagonal boron nitride(h-BN)encapsulation

Surface water resource attenuation attribution and patterns in Hai River Basin

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Earth Sciences 2024年第5期67卷 1545-1560页

作者： Qingming WANG Yong ZHAO Hao WANG Jiaqi ZHAI Yue zhang Fan he rong LIU Mengyang MA State Key Laboratory of Simulation and Regulation of Water Cycle in River Basin China Institute of Water Resources and Hydropower Research(IWHR)Beijing 100038China Key Laboratory of Water Safety for Beijing-Tianjin-hebei Region of Ministry of Water Resources Beijing 100038China General Institute of Water Resources and Hydropower Planning and Design Ministry of Water ResourcesBeijing 100120China

From 1956 to 2016,Hai River Basin suffered the most severe surface water resource attenuation among the 10 first-class river basins in *** on the surface water circulation process,and evolving characteristics of precipitation and underlying surface in Hai River Basin,this study attributed the causes of surface water resource attenuation to six primary impact factors,analyzed each factor's quantitative contribution,and revealed four patterns of surface water resource attenuation in Hai River *** pattern of the dominant factor:comparing the 1980–2000 period with the 1956–1979period,the variation of precipitation is the dominant factor of which contribution is 7 billion m^(3),accounting for 59%of total11.7 billion m^(3);comparing the 2001–2016 period with the 1956–1979 period,the increasing of vegetation cover in mountainous area is the dominant factor of which contribution is 2.78 billion m3,accounting for 51%of total 4.9 billion m^(3).The pattern of spatial distributions:comparing the 2001–2016 period with the 1956–1979 period,mountainous areas were more affected by increasing vegetation cover which for example contributed 42%in Luan River Basin mountainous;the plains were more impacted by farmland ridge interception which for example contributed 51%in Beisi River Basin *** pattern of attenuation trend:comparing the 2001–2016 period with the 1980–2000 period,surface water resources in mountainous areas continued to decline,owing to the increasing water consumption of large-scale vegetation restoration,while the influence of the underlying surface changes on surface water resources in plains areas tended to remain *** pattern of reversible change:among factors led to surface water resource attenuation,the human activity,including vegetation cover increase,farmland ridge interception,and urbanization expansion,contributed 36%of the attenuation,which resulted in the variation of precipitation-runoff *** study improved the traditiona

关键词： Hai River Basin Surface water resources Contribution decomposition Quantitative contribution Attenuation patterns

Enhancing immunotherapy efficacy against MHC-I deficient triple-negative breast cancer using LCL161-loaded macrophage membranedecorated nanoparticles

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第7期14卷 3218-3231页

作者： Wen zhang Yihui Zhai Ying Cai Xiang Gong Yunxuan Jiang rong rong Chao Zheng Binyu Zhu helen he Zhu Hao Wang Yaping Li Pengcheng zhang China State Institute of Pharmaceutical Industry Shanghai 201203China State Key Laboratory of Drug Research&Center of Pharmaceutics Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China School of Biomedical Engineering&State Key Laboratory of Advanced Medical Materials and Devices ShanghaiTech UniversityShanghai 201210China School of Chinese Materia Medica Nanjing University of Chinese MedicineNanjing 210023China Yantai Institute of Materia Medica Shandong 264000China State Key Laboratory of Oncogenes and Related Genes Renji-Med-X Stem Cell Research CenterDepartment of UrologyRen Ji HospitalSchool of Medicine and School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghai 200127China University of Chinese Academy of Sciences Beijing 100049China

Current cytotoxic T lymphocyte(CTL)activating immunotherapy requires a major histocompatibility complex I(MHC-I)-mediated presentation of tumor-associated antigens,which malfunctions in around half of patients with triple-negative breast cancer(TNBC).here,we create a LCL161-loaded macrophage membrane decorated nanoparticle(LMN)for immunotherapy of MHC-I-deficient *** on the macrophage membrane helps LMNs recognize CD47-expressing cancer cells for targeted delivery of LCL161,which induces the release of high mobility group protein 1 and proinflammatory cytokines from cancer *** released cytokines and high mobility group protein 1 activate antitumor immunity by increasing the intratumoral density of the phagocytic macrophage subtype by 15 times and elevating the intratumoral concentration of CTL lymphotoxin by 4.6 *** also block CD47-mediated phagocytosis *** inhibit the growth of MHC-I-deficient TNBC tumors,as well as those resistant to combined therapy of anti-PDL1 antibody and albumin-bound paclitaxel,and prolong the survival of animals,during which process CTLs also play important *** macrophage membrane-decorated nanoparticle presents a generalizable platform for increasing macrophagemediated antitumor immunity for effective immunotherapy of MHC-I-deficient cancers.

关键词： MHC-I deficiency Macrophage CD47 Immunotherapy Triple-negative breast cancer Phagocytosis Immune checkpoint Innate immunity

U-Net Models for Representing Wind Stress Anomalies over the Tropical Pacific and Their Integrations with an Intermediate Coupled Model for ENSO Studies

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Atmospheric Sciences 2024年第7期41卷 1403-1416页

作者： Shuangying Du rong-Hua zhang Key Laboratory of Ocean Circulation and Waves Institute of OceanologyChinese Academy of SciencesQingdao266071China School of Marine Sciences Nanjing University of Information Science and TechnologyNanjing210044China Laosan Laboratory Qingdao266237China University of Chinese Academy of Sciences Beijing100049China

El Niño-Southern Oscillation(ENSO)is the strongest interannual climate mode influencing the coupled ocean-atmosphere system in the tropical Pacific,and numerous dynamical and statistical models have been developed to simulate and predict *** some simplified coupled ocean-atmosphere models,the relationship between sea surface temperature(SST)anomalies and wind stress(τ)anomalies can be constructed by statistical methods,such as singular value decomposition(SVD).In recent years,the applications of artificial intelligence(AI)to climate modeling have shown promising prospects,and the integrations of AI-based models with dynamical models are active areas of *** study constructs U-Net models for representing the relationship between SSTAs andτanomalies in the tropical Pacific;the UNet-derivedτmodel,denoted asτUNet,is then used to replace the original SVD-basedτmodel of an intermediate coupled model(ICM),forming a newly AI-integrated ICM,referred to as *** simulation results obtained from ICM-UNet demonstrate their ability to represent the spatiotemporal variability of oceanic and atmospheric anomaly fields in the equatorial *** the ocean-only case study,theτUNet-derived wind stress anomaly fields are used to force the ocean component of the ICM,the results of which also indicate reasonable simulations of typical ENSO *** results demonstrate the feasibility of integrating an AI-derived model with a physics-based dynamical model for ENSO modeling ***,the successful integration of the dynamical ocean models with the AI-based atmospheric wind model provides a novel approach to ocean-atmosphere interaction modeling studies.

关键词： U-Net models wind stress anomalies ICM integration of AI and physical components

Self-Triggered Set Stabilization of Boolean Control Networks and Its Applications

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

IEEE/CAA Journal of Automatica Sinica 2024年第7期11卷 1631-1642页

作者： rong Zhao Jun-e Feng Dawei zhang the School of Mathematics Shandong UniversityShandong UniversityJinan 250100China

Set stabilization is one of the essential problems in engineering systems, and self-triggered control(STC) can save the storage space for interactive information, and can be successfully applied in networked control systems with limited communication resources. In this study, the set stabilization problem and STC design of Boolean control networks are investigated via the semi-tensor product technique. On the one hand, the largest control invariant subset is calculated in terms of the strongly connected components of the state transition graph, by which a graph-theoretical condition for set stabilization is derived. On the other hand, a characteristic function is exploited to determine the triggering mechanism and feasible controls. Based on this, the minimum-time and minimum-triggering open-loop, state-feedback and output-feedback STCs for set stabilization are designed,respectively. As classic applications of self-triggered set stabilization, self-triggered synchronization, self-triggered output tracking and self-triggered output regulation are discussed as well. Additionally, several practical examples are given to illustrate the effectiveness of theoretical results.

关键词： Boolean control networks(BCNs) output regulation self-triggered control semi-tensor product of matrices set stabilization synchronization

Coupled dynamic response analysis of multi-column floating offshore wind turbine with low center of gravity

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Ocean Engineering and Science 2024年第1期9卷 25-39页

作者： Jie Yang Yan-ping he Yong-sheng Zhao Xiao-yan Yang Guo-rong zhang State Key Laboratory of Ocean Engineering Shanghai Jiao Tong UniversityShanghai 200240China Collaborative Innovation Center for Advanced Ship and Deep-Sea Exploration(CISSE) Shanghai Jiao Tong UniversityShanghai 200240China School of Naval Architecture Ocean&Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China Faculty of Maritime and Transportation Ningbo UniversityNingbo 315211China

To realize the application of the floating offshore wind turbine(FOWT)from deep to relatively shallow waters,a new concept of multi-column floating wind turbine platform with low center of gravity(CG)is designed and *** multi-column low CG platform is designed to support a 6MW wind turbine class and operated at a water depth of 50m in the South China *** frequency domain software WADAM and time domain software NREL-FAST are used to simulate coupled dynamic responses of the floating wind turbine system with second-order wave loads *** dynamic behaviors of multi-column low CG FOWT system under normal operation and parked conditions are *** influence of second-order wave force on the motion responses of the multi-column platform,fore-aft force and moment of the tower base and mooring force are researched *** results demonstrate that the coupled dynamic responses at rated operating condition and extreme condition meet the normal operating requirements and extreme survival requirements of FOWT system in the shallow water(50m)of South China *** addition,it is found that,the wave frequency response gradually replaces the second-order low frequency response as the main influencing factor of the coupled dynamic response of the FOWT system with the increasing severity of the sea ***,in general,the magnitude of second-order low frequency response increases with the increasing severity of the design load ***,in the subsequent design of the shallow water FOWT system,the second-order effects should be paid enough attention.

关键词： Floating offshore wind turbine Multi-column platform Second-order wave force Concept design Coupled dynamic response