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Prevalences and causes of vision impairment in elderly Chinese: a socioeconomic perspective of a comparative report nested in Jiangsu Eye Study

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International Journal of Ophthalmology(English edition) 2016年第7期9卷 1051-1056页

作者： rong-rong zhu Jian Shi Mei Yang Huai-Jin Guan Eye Institute Affiliated Hospital of Nantong University

AIM：To survey the prevalence and causes of visual impairment/blindness among elderly Chinese from different socioeconomic status in community-based design.METHODS：Cluster-sampling randomly selected residents from Binhu and Funing District,two areas representing different socioeconomic levels in China with Binhu in an advanced status and Funing in lessdeveloped area.The participants subjected to ophthalmic examination.The presenting visual acuity（PVA） and best-corrected visual acuity（BCVA） were recorded.Visual impairment and blindness were defined according to World Health Organization criteria.The causes of visual impairment/blindness were identified by ophthalmic examination and/or questionnaire.The socioeconomic status included the per capita gross domestic product,numbers of hospital with ophthalmic service and the number of ophthalmologists per 1 million residents.RESULTS：We successfully included 12 867 participants form 2 areas in this study.The prevalence of PVA impairment（〈20/63 to ≥20/400） in the better eye was 5.4% in Binhu and 23.6% in Funing,while the prevalence of blindness（〈20/400） was 0.9% in Binhu and 2.3% in Funing.With BCVA,the prevalence of visual impairment was 2.4% in Binhu and 6.4% in Funing,while the prevalence of blindness was 0.8% in Binhu and 1.6% in Funing.The participants with older age and female gender had higher prevalence in visual impairment and blindness.The highest prevalences of vision impairment and blindness evaluated by BCVA at 〉80y age group reached 20.4% and 6.3% respectively.The prevalences of vision impairment and blindness evaluated by BCVA were 3.5% and 1.0% in male and 5.0% and 1.3% in female.The above differences were statistically significant（P〈0.05）.The predominant causes of visual impairment and blindness were cataract,retinal disorders and uncorrected refractive error in both areas.The socioeconomic status was associated with visual impairment and blindness.CONCLUSION：This community-based study build a sufficient sample size for an ophthalmic survey.Our data show

关键词： blindness vision impairment prevalence community-based socioeconomic development

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Solid lipid nanoparticles loading with curcumin and dexanabinol to treat major depressive disorder

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Neural Regeneration Research 2021年第3期16卷 537-542页

作者： Xiao-Lie He Li Yang Zhao-Jie Wang Rui-Qi Huang rong-rong zhu Li-Ming Cheng Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education Department of OrthopedicsTongji HospitalSchool of Life Science and TechnologyTongji UniversityShanghaiChina

Dexanabinol(HU-211)is an artificially synthesized cannabinoid derivative that exerts neuroprotective effects through anti-inflammatory and antioxidant effects.Curcumin exhibits antidepressant effects in the treatment of major depressive disorder.To investigate the antidepressant effects of solid lipid nanoparticles loaded with both curcumin and dexanabinol,and the underlying mechanisms associated with this combination,we established wild-type(CBR1~(+/+))and cannabinoid receptor 1(CBR1)knockout(CBR1~(–/–))mouse models of major depressive disorder,through the intraperitoneal injection of corticosterone,for 3 successive days,followed by treatment with intraperitoneal injections of solid lipid nanoparticles loading with curcumin(20 mg/kg)and dexanabinol(0.85 mg/kg),for 2 successive days.Our results revealed that solid lipid nanoparticle loading with curcumin and dexanabinol increased the m RNA and protein expression levels of the mature neuronal markers neuronal nuclei,mitogen-activated protein 2,and neuron-specific beta-tubulin III,promoted the release of dopamine and norepinephrine,and increased the m RNA expression of CBR1 and the downstream genes Rasgef1c and Egr1,and simultaneously improved rat locomotor function.However,solid lipid nanoparticles loaded with curcumin and dexanabinol had no antidepressant effects on the CBR1~(–/–)mouse models of major depressive disorder.This study was approved by the Institutional Ethics Committee of Tongji Hospital of Tongji University,China(approval No.2017-DW-020)on May 24,2017.

关键词： biocompatibility curcumin depression dexanabinol dopamine nanoparticles norepinephrine

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Effect of femtosecond laser-assisted steepest-meridian clear corneal incisions on preexisting corneal regular astigmatism at the time of cataract surgery

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International Journal of Ophthalmology(English edition) 2020年第12期13卷 1895-1900页

作者： Wei Chen Min Ji Jian Wu Yong Wang Jing Zhou rong-rong zhu Hong Lu Huai-Jin Guan Department of Ophthalmology Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina

AIM:To investigate the clinical efficacy and safety of femtosecond laser-assisted steepest-meridian clear corneal incisions for correcting preexisting corneal astigmatism performed at the time of cataract surgery.METHODS:This prospective case series study comprised consecutive age-related cataract patients with corneal regular astigmatism(range:+0.75 to+2.50 D)who had femtosecond laser-assisted steepest-meridian clear corneal incisions(single or paired).Corneal astigmatism was performed with the Pentacam preoperatively and 3 mo postoperatively.Total corneal astigmatism and steepestmeridian measured in the 3-mm central zone were used to guide the location,size and number of clear corneal incision.The vector analysis of astigmatic change was performed using the Alpins method.RESULTS:Totally 138 eyes of 138 patients were included.The mean preoperative corneal astigmatism was 1.31±0.41 D,and was significantly reduced to 0.69±0.34 D(equivalent to difference vector)after surgery(P<0.01).The surgically-induced astigmatism was 1.02±0.54 D.The correction index(ratio of target induced astigmatism and surgically-induced astigmatism:0.72±0.36)as well as the magnitude of error(difference between surgically-induced astigmatism and target induced astigmatism:-0.29±0.51)represented a slight under correction.For angle of error,the arithmetic mean was 1.11±13.70,indicating no significant systematic alignment errors.CONCLUSION:Femtosecond-assisted steepest-meridian clear corneal incision is a fast,customizable,adjustable,precise,and safe technique for the reduction of low to moderate corneal astigmatism during cataract surgery.

关键词： astigmatism cataract surgery femtosecond laser clear corneal incision

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An antiempirical strategy:sacrificing aromatic moieties in the polymer precursor for improving the properties of the derived N-doped porous carbons

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Green Chemical Engineering 2020年第1期1卷 70-76页

作者： Shi-Chao Qi Ding-Ming Xue Guo-Xing Yu rong-rong zhu Xiao-Qin Liu Lin-Bing Sun State Key Laboratory of Materials-Oriented Chemical Engineering Jiangsu National Synergetic Innovation Center for Advanced Material(SICAM)College of Chemical EngineeringNanjing Tech UniversityNanjing211816China

With the carbonization at an elevated temperature,high aromaticity of a precursor for porous carbons was traditionally thought to be crucial for the resultant perfect textural properties and ideal application performances of the porous carbons.Thus,many efforts have been done to search or to artificially prepare the polymer precursors with higher aromaticity to generate more satisfying porous carbons.However,an antiempirical case was found in this study.The copolymerization between 1,3,5-tris(chloromethyl)-2,4,6-trimethylbenzene(TCM)and cyclohexane-1,4-diamine was successfully implemented to get a polymer code-named NUT-40,in which half of the ring structures are nonaromatic,while N-doped porous carbons(NDPCs)with better textural properties(e.g.,SBET=1363 m^(2)g^(-1)for NDPC-600)and competitive CO_(2)capture abilities(e.g.,CO_(2)capacity=4.3 mmol g^(-1)at 25℃and 1 bar for NDPC-600)were generated from the NUT-40,compared with the NDPC counterparts derived from the NUT-4 in a previous study(e.g.,SBET=958 m^(2)g^(-1)and CO_(2)capacity=3.8 mmol g^(-1)at 25℃and 1 bar for NDPC-600),in which TCM and ursol were employed as the monomers instead,and thus the ring structures in the NUT-4 was fully aromatic.With first-principle and molecular dynamics simulations,it was demonstrated that the embryo pore structure in the NUT-40 molecule can be more easily maintained during the carbonization than that of the NUT-4,which finally improves the surface area and porosity of the NUT-40 generated NDPCs.

关键词： Copolymer Aromaticity Pyrolysis Carbon capture N-doped porous carbon

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Maximal operators of pseudo-differential operators with rough symbols

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Applied Mathematics(A Journal of Chinese Universities) 2024年第1期39卷 174-180页

作者： Ramla Benhamoud zhu Xiang-rong School of Mathematical Sciences Zhejiang Normal UniversityJinhua 321004China

Consider a pseudo-differential operator T_(a)f(x)=∫_(R^(n))e^(ix,ζ)a(x,ζ)f(ζ)dζwhere the symbol a is in the rough Hormander class L^(∞)S_(ρ)^(m)with m∈R andρ∈[0,1].In this note,when 1≤p≤2,if n(ρ-1)/p and a∈L^(∞)S_(ρ)^(m),then for any f∈S(R^(n))and x∈R^(n),we prove that M(T_(a)f)(x)≤C(M(|f|^(p))(x))^(1/p) where M is the Hardy-Littlewood maximal operator.Our theorem improves the known results and the bound on m is sharp,in the sense that n(ρ-1)/p can not be replaced by a larger constant.

关键词： pseudo-differential operator rough Hormander class H-L maximal operator

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Advanced cervix cancer patient with chemotherapy-induced grade IV myelosuppression achieved complete remission with cadonilimab:A case report

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World Journal of Clinical Cases 2024年第8期12卷 1510-1516页

作者： Rui zhu Tian-Ze Chen Meng-Ting Sun Chun-rong zhu Department of Oncology The First Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Urology The First Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina

BACKGROUND The prognosis for patients with advanced metastatic cervix cancer(MCC)is poor,and this disease continues to pose a considerable therapeutic challenge.Despite the administration of first-line regimens consisting of cisplatin,paclitaxel,and bevacizumab,survival rates for patients with metastasis remain poor.The emergence of bispecific antibodies(BsAbs)offers a novel treatment option for patients diagnosed with MCC.CASE SUMMARY In this report,we present a patient with MCC who was treated with cadonilimab monotherapy at a dose of 6 mg/kg every two weeks after chemotherapy was proven to be intolerable.The patient exhibited a sustained complete response for a duration of 6 months,demonstrating an optimistic outlook.CONCLUSION This case illustrates the considerable efficacy of cadonilimab for treating advanced MCC.Therefore,BsAb therapy is a promising strategy for effectively treating patients with advanced MCC and should be considered as an option when patients are intolerant to standard chemotherapy.

关键词： Cadonilimab Complete response Bispecific antibodies Recurrent or metastatic cervical cancer Programmed death protein 1 Cytotoxic T-lymphocyteassociated antigen-4 Case report

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Carbon-based interface engineering and architecture design for high-performance lithium metal anodes

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Carbon Energy 2024年第1期6卷 207-235页

作者： Na zhu Yuxiang Yang Yu Li Ying Bai Junfeng rong Chuan Wu SINOPEC Research Institute of Petroleum Processing Co. Ltd.BeijingChina Beijing Key Laboratory of Environmental Science and Engineering School of Materials Science and EngineeringBeijing Institute of TechnologyBeijingChina Yangtze Delta Region Academy of Beijing Institute of Technology JiaxingChina

Metallic lithium(Li)is considered the“Holy Grail”anode material for the nextgeneration of Li batteries with high energy density owing to the extraordinary theoretical specific capacity and the lowest negative electrochemical potential.However,owing to inhomogeneous Li-ion flux,Li anodes undergo uncontrollable Li deposition,leading to limited power output and practical applications.Carbon materials and their composites with controllable structures and properties have received extensive attention to guide the homogeneous growth of Li to achieve high-performance Li anodes.In this review,the correlation between the behavior of Li anode and the properties of carbon materials is proposed.Subsequently,we review emerging strategies for rationally designing high-performance Li anodes with carbon materials,including interface engineering(stabilizing solid electrolyte interphase layer and other functionalized interfacial layer)and architecture design of host carbon(constructing three-dimension structure,preparing hollow structure,introducing lithiophilic sites,optimizing geometric effects,and compositing with Li).Based on the insights,some prospects on critical challenges and possible future research directions in this field are concluded.It is anticipated that further innovative works on the fundamental chemistry and theoretical research of Li anodes are needed.

关键词： carbon materials dendrites hosts interfacial layers Li metal anodes

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Constructing core@shell structured photothermal nanosphere with thin carbon layer confined Co-Mn bimetals for pollutant degradation and solar interfacial water evaporation

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Rare Metals 2024年第4期43卷 1686-1701页

作者： Hong-Yang zhu Meng-Ting Liu Gang Wang rong-rong Du Hong-Yao Zhao Hao Lu Shi-Qi Yang Sheng Tang Zeng-Jing Guo Jun Yang Cheng-Zhang zhu Fu Yang School of Environmental and Chemical Engineering Jiangsu University of Science and Technology School of Chemistry and Chemical Engineering Liaocheng University School of Material Science and Engineering Jiangsu University of Science and Technology School of Environmental Science and Engineering Nanjing Tech University

Photothermal material applied in environmental governance has attracted growing attention.By combining the Stober method and dopamine-triggered coating strategy,Co-Mn precursor was in situ incorporated into the poly dopamine（PDA） layer over the surface of silica cores.Afterwards,a unique photothermal nanosphere with SiO2core and thin carbon layer and dual Co-Mn oxides shell was allowed to form by sequential heat treatment in the inert atmosphere（SiO2@CoMn/C）.The bimetallic fraction of Co/Mn in the carbon layer and post-treatment calcination temperature was comprehensively tuned to optimize the peroxymonosulfate（PMS） activation performance of the catalyst.The state of bimetallic species was studied including their physical distribution,chemical valence,and interplay by various characterizations.Impressively,Co oxides appear as dominant monodispersed nanoparticles（～ 10 nm）,while Mn with cluster-like morphology is observed to uniformly distribute over thin-layer carbon and adhered to the surface of SiO2nanospheres（～ 250 nm）.The calcined temperature could tune the oxidized state of Co species,leading to the optimization of the catalytic performance of introduced dual metal species.As a result,this obtained optimal catalyst integrated the advantages of exposed bimetallic CoMn species and N-doped thin carbon to deliver excellent catalytic PMS activation performance and photothermal synergetic catalytic mineralization ability for diversiform pollutants.Further reactions condition controls and anion interference studies were conducted to identify the adaptability of the optimal catalyst.Moreover,the application of solar-driven interfacial water evaporation using optimal SiO2@Co3Mn1/C-600 catalyst was explored,showing a high water evaporation rate of 1.48 kg·m-2·h-1and an efficiency of 95.2%,further revealing a comprehensive governance functionality of obtained material in the complex pollution condition.

关键词： Photothermal Peroxymonosulfate (PMS) activation Bimetallic synergy Water evaporation Advanced oxidation process

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Single-atom alloys prepared by two-step thermal evaporation

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Nano Research 2024年第4期17卷 2808-2813页

作者： Honglin Wang Jing Li Meirong Huang Jizhe Cui Zhiying Cheng rong Yu Hongwei zhu State Key Lab of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China State Key Lab of Solid Waste Reuse for Building Materials Beijing Building Materials Academy of Science ResearchBeijing 100041China

Single-atom alloys(SAAs)have gained significant attention due to their remarkable atomic utilization efficiency,interactions between single atoms(SAs)and metal supports,and free-atom-like electronic structure of dopant elements.In this work,we observed the formation of SAs in pre-deposited metal particles by a two-step thermal evaporation technique,thereby establishing the first instance of discovering SAAs by thermal evaporation.The discovery of SAAs by thermal evaporation extends the range of SAAs preparation methods to include this traditional synthetic technique,which offers convenience,cost-efficiency,and universality.The formation mechanism of SAAs prepared using this technique was elucidated by density functional theory calculations.It was demonstrated that thermal evaporation can be utilized to prepare SAAs with multiple SAs,further highlighting its universal applicability.

关键词： single-atom alloys thermal evaporation density functional theory

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Efficacy and safety of Y- 2 sublingual tablet for patients with acute ischaemic stroke: protocol of a phase III randomised double- blind placebo- controlled multicentre trial

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Stroke & Vascular Neurology 2024年第1期9卷 90-95页

作者： Yu Fu Renhong Tang rong Chen Anxin Wang Jinsheng Ren Shunwei zhu Xiaofei Feng Dongsheng Fan Deparment of Neurology Peking University Third HospitalBeijingChina State Key Laboratory of Neurology and Oncology Drug Development NanjingJiangsuChina Simcere Pharmaceutical Group Limited NanjingJiangsuChina Neurodawn Pharmaceutical Co. LtdNanjingJiangsuChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina

Background and purpose Clinical studies have demonstrated that edaravone dexborneol can improve the functional outcomes in patients with acute ischaemic stroke(AIS).The present clinical trial aimed at testing the efficacy and safety of Y-2 sublingual tablet on 90-day functional outcome in patients with AIS.Methods and design This is a randomised,double-blind,placebo-controlled,multicentre,parallel-group trial of Y-2 sublingual tablet on patients with AIS.An estimated 914 patients at age of 18–80 years with AIS within 48 hours after symptom onset from 40 hospitals will be randomly assigned to receive Y-2 sublingual tablet or placebo for 14 days.Patients are at score 6–20 points on National Institutes of Health Stroke Scale(NIHSS)and had a modified Rankin Scale(mRS)≤1 before this stroke,except mechanical thrombectomy and neuroprotective agents treatment.Study outcomes The primary outcome is the proportion of patients with mRS≤1 on day 90 after randomisation.Secondary efficacy outcomes include mRS score on day 90,the proportion of patients with mRS≤2 on day 90;the change of NIHSS score from baseline to day 14 and the proportion of patients with NIHSS score≤1 at the days 14,30 and 90.Discussion This trial will provide valuable evidence for the efficacy and safety of Y-2 sublingual table for improving 90 days the functional outcomes in patients with AIS.Trial registration number NCT04950920.

关键词： patients protective centre

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