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Hydrogen Bond Effect in Nonlinear Optical Properties of Azobenzene Derivatives

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Chinese Journal of Chemical Physics 2015年第5期28卷 -页

作者： Da-qiao Hu Wen-jun wang rong-rong wang Bo Yang Bo Yu School of Chemistry and Chemical Engineering and Center for Atomic Engineering of Advanced Materials Anhui University Hefei 230039 China Key Laboratory of Soft Matter Chemistry Department of Polymer Science and Engineering Anhui Key Laboratory of Optoelectronic Science and Technology University of Science and Technology of China Hefei 230026 China

Three kinds of 4-hydroxyl azobenzene compouds with different substituents varied as -NO2, -H, -OCH3 in the para-position were synthesized and characterized. Their nonlinearoptical properties in tetrahydrofuran (THF) and chloroform (CHCl3) solution were determined using Z-scan technique. The results revealed that the nonlinear absorption (β) and nonlinear refraction (γ) values of three azobenzene compounds in THF solution were larger than those in CHCl3 solution. It was mainly due to the regular arrangement and effective π-conjugation of azobenzene molecules caused by the formation of hydrogen bonds between the hydroxyl groups of azobenzene molecules and the oxygen atom of the THF molecules. Among three kinds of azobenzene compounds, the 4-nitro-4′-hydroxyazobenzene (NAzoOH) had the largest coefficients of β and γ values in both THF and CHCl3 solution. It was mainly because that a push-pull (D-π-A) electron system was formed by the electron withdrawing nitro-substituent with electron donating hydroxyl-group in both extremities of azobenzene, resulting in a higher electron delocalization.

关键词： Azobenzene Nonlinear property Hydrogen bond Substituent Z-scan

Regularized least-squares migration of simultaneous-source seismic data with adaptive singular spectrum analysis

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Petroleum Science 2017年第1期14卷 61-74页

作者： Chuang Li Jian-Ping Huang Zhen-Chun Li rong-rong wang School of Geosciences China University of PetroleumQingdao 266580 Shandong China Hisense (Shandong) Refrigerator Co. Ltd HisenseQingdao 266580 Shandong China

Simultaneous-source acquisition has been recog- nized as an economic and efficient acquisition method, but the direct imaging of the simultaneous-source data produces migration artifacts because of the interference of adjacent sources. To overcome this problem, we propose the regularized least-squares reverse time migration method （RLSRTM） using the singular spectrum analysis technique that imposes sparseness constraints on the inverted model. Additionally, the difference spectrum theory of singular values is presented so that RLSRTM can be implemented adaptively to eliminate the migration artifacts. With numerical tests on a fiat layer model and a Marmousi model, we validate the superior imaging quality, efficiency and convergence of RLSRTM compared with LSRTM when dealing with simultaneoussource data, incomplete data and noisy data.

关键词： Least-squares migration Adaptive singularspectrum analysis Regularization Blended data

c-Jun N-terminal kinase 3 deficiency protects axotomized retinal ganglion cells via affecting mitochondria involved apoptosis pathway

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International Journal of Ophthalmology(English edition) 2019年第1期12卷 30-37页

作者： rong-rong wang Cheng-Fang Li De-Zu wang Cheng-Wu Zhang Gui-Xiang Liu Qingdao University Department of Ophthalmology Jimo Traditional Chinese Medicine Hospital Department of Ophthalmology Affiliated Qingdao Hiser Hospital of Qingdao University Institute of Advanced Materials Nanjing Tech University Department of Ophthalmology Affiliated Hospital of the Medical College of Qingdao University

AIM: To illustrate the isoform-specific role and mechanism of c-Jun N-terminal kinases(JNKs) in mouse optic nerve axotomy induced neurotrauma. METHODS: We firstly investigated the expression of JNK1, JNK2, and JNK3 in the retinal ganglion cells(RGCs) by double-immunofluorescent staining. Then we created optic nerve axotomy model in wild type as well as JNK1, JNK2, JNK3, isoform specific gene deficiency mice. With that, we checked the protein expression profile of JNKs and its active form, and quantified the survival RGCs number by immunofluorescence staining. We further explored the molecules underlying isoform specific protective effect by real-time polymerase chain reaction(PCR) and Western blotting assay. RESULTS: We found that all the three isoforms of JNKs were expressed in the RGCs. Deficiency of JNK3, but not JNK1 or JNK2, significantly alleviated optic nerve axotomyinduced RGCs apoptosis. We further established that expression of Noxa, a pro-apoptotic member of BH3 family, was significantly suppressed only in JNK3 gene deficiency mice. But tumor necrosis factor receptor 1(TNFR1) and Fas, two key modulators of death receptor mediated apoptosis pathway, did not display obvious change in the expression. CONCLUSION: It is suggested that mitochondria mediated apoptosis, but not death receptor mediated apoptosis got involved in the JNK3 gene deficiency induced RGCs protection. Our study provides a novel insight into the isoform-specific role of JNKs in neurotrauma and indicates some cues for its therapeutics.

关键词： retinal ganglion cells c-Jun N-terminal kinases optic nerve mitochondria Noxa neurotrauma

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Chinese Medical Sciences Journal 2008年第3期23卷 162-165页

作者： Chun-yan Zhang rong rong Xiao-ying wang Department of Radiology Peking University First Hospital Functional Imaging Center Advanced Academy of Interdisciplinary Sciences Peking University Beijing 100034

Objective To investigate the signal intensity and apparent diffusion coefficient (ADC) of bone marrow of normal adult man on diffusion weighted imaging (DWI). Methods Fifteen healthy volunteers and thirty-eight patients with benign prostatic hyperplasia or normal prostate were enrolled in this study, with age range 28-82 years old (mean 55.26 ± 18.05 years). All people were examined with large field DWI on a 3.0T magnetic resonance scanner, which ranges from the top of head to the lower limb. The signal-to-noise ratio (SNR) on the DWI and ADC of lumber vertebra at renal hilum level, left ilium and superior segment of left femur were measured. The measured SNR and ADC value of the above sites were compared by one way analysis of variance and their correlations with age were investigated by Pearson's correlation analysis. Results The SNR of lumber vertebra, left ilium and left femur showed no significant difference (F = 0.271, P = 0.763). The SNR of lumber vertebra (r = 0.309, P = 0.024) and left ilium (r = 0.359, P = 0.008) showed positive correlation with age, while the SNR of left femur showed no correlation with age (r = -0.163, P = 0.283). The ADC of lumber vertebra [(0.617 ± 0.177) ×10-3 mm2/s] was significantly higher than that of left ilium [(0.404 ± 0.112) ×10-3 mm2/s, P < 0.001] and left femur [(0.362 ± 0.092) ×10-3 mm2/s, P < 0.001], while the ADC of left ilium and left femur had no significant difference. The ADC of lumber vertebra, left ilium and left femur showed no correlation with age. Conclusion Understanding of age-related changes of normal adult bone marrow on DWI is very important to differentiate the normal bone marrow and abnormal lesions.

关键词： diffusion weighted imaging magnetic resonance imaging bone marrow

Thermal performance and reduction kinetic analysis of cold-bonded pellets with CO and H2 mixtures

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International Journal of Minerals,Metallurgy and Materials 2018年第7期25卷 752-761页

作者： rong-rong wang Jian-liang Zhang H-ran Liu An-yang Zheng Zheng-jian Liu Xing-le Liu Zhan-guo Li School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China School of Chemical Engineering University of New South WalesSydneyAustralia

Cold-bonded pellets, to which a new type of inorganic binder was applied, were reduced by H2~CO mixtures with different HJCO molar ratios （1：0, 5：2, 1：1, 2：5, and 0：1） under various temperatures （1023, 1123, 1223, 1323, and 1423 K） in a daermogravimetric analysis appaxatus. The effects of gas composition, temperature, and binder ratio on the reduction process were studied, and the microstxucture of re- duced pellets was observed by scanning electron microscopy-energy-dispersive spectrometry （SEM-EDS）. The SEM-EDS images show that binder particles exist in pellets in two forms, and the form that binder particles completely surround ore particles has a more significant hin- der effect on the reduction. The reduction equilibrium constant, effective diffusion coefficient, and the reaction rate constant were calculated on the basis of the unreacted core model, and the promotion effect of temperature on reduction was further analyzed. The results show that no sintering phenomenon occurred at low temperatures and that the increasing reaction rate constant and high gas diffusion coefficient could main- tain the promotion effect of temperature; however, when the sintering phenomenon occurs at high temperatures, gas diffusion is hindered and the promotion effect is diminished. The contribution of the overaJl equilibrium constant to the promotion effect depends on the gas composition.

关键词： cold-bonded pellets inorganic binder reduction fraction reduction kinetic model sintering phenomenon

Study of the mechanisms of streamline-adjustment-assisted heterogeneous combination flooding for enhanced oil recovery for post-polymer-flooded reservoirs

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Petroleum Science 2019年第3期16卷 606-618页

作者： Qing-Jun Du Guang-Ming Pan Jian Hou Lan-Lei Guo rong-rong wang Zhi-Zeng Xia Kang Zhou Key Laboratory of Unconventional Oil & Gas Development (China University of Petroleum (East China)) Ministry of Education Qingdao 266580 Shandong P. R. China School of Petroleum Engineering China University of Petroleum (East China) Qingdao 266580 Shandong P. R. China Bohai Petroleum Research Institution Tianjin Branch of CNOOC Ltd Tianjin 300452 P. R. China Research Institute of Exploration and Development Shengli Oilfield SINOPEC Dongying 257061 Shandong P. R.China

Streamline-adjustment-assisted heterogeneous combination flooding is a new technology for enhanced oil recovery for post-polymer-flooded *** this work,we first carried out a series of 2D visualization experiments for different chemical flooding scenarios after polymer ***,we explored the synergistic mechanisms of streamline-adjustment-assisted heterogeneous combination flooding for enhanced oil recovery and the contribution of each *** results show that for single heterogeneous combination flooding,the residual oil in the main streamline area after polymer flooding is ready to be driven,but it is difficult to be recovered in the non-main streamline *** to the effect of drainage and synergism,the streamline-adjustment-assisted heterogeneous combination flooding diverts the injected chemical agent from the main streamline area to the non-main streamline area,which consequently expands the active area of chemical *** on the results from the single-factor contribution of the quantitative analysis,the contribution of temporary plugging and profile control of branched preformed particle gels ranks in the first place and followed by the polymer profile control and the effect of streamline *** the contrary,the surfactant contributes the least to enhance the efficiency of oil displacement.

关键词： Plate sand-pack model Heterogeneous combination flooding Streamline adjustment Polymer flooding Displacement

Transcutaneous electrical acupoint stimulation benefits postoperative pain relief of oocyte retrieval:A randomized controlled trial

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Journal of Integrative Medicine 2024年第1期22卷 32-38页

作者： Li-ying Liu Yang Su rong-rong wang Yuan-yuan Lai Lei Huang Yi-ting Li Xin-yue Tao Meng-hua Su Xiao-yan Zheng Shi-chen Huang Yong-na Wu Si-yi Yu Fan-rong Liang Jie Yang Acupuncture and Tuina School Chengdu University of Traditional Chinese MedicineChengdu 610000Sichuan ProvinceChina Traditional Chinese Medicine Department Sichuan Jinxin Xi’nan Women's and Children's HospitalChengdu 610000Sichuan ProvinceChina

Background Transvaginal oocyte retrieval is frequently followed by adverse events related to anesthesia and the *** research showed that transcutaneous electrical acupoint stimulation(TEAS)can relieve intraoperative pain and postoperative *** This study examined whether TEAS can alleviate pain and relieve adverse symptoms after oocyte ***,setting,participants and interventions Altogether 128 patients were randomly divided into the TEAS group and the mock TEAS *** two groups received a 30-minute-long TEAS or mock TEAS treatment that began 30 min after oocyte *** outcome measures The primary outcome was the visual analog scale(VAS)pain *** outcomes were pressure pain threshold,McGill score,pain rating index(PRI),present pain intensity(PPI),VAS stress score,VAS anxiety score,and postoperative adverse *** The baseline characteristics of the two groups were comparable(P>0.05).The VAS pain scores of the TEAS group were lower than those of the mock TEAS group at 60 and 90 min after oocyte retrieval(P0.05).The TEAS group was superior to the mock TEAS group for relieving postoperative adverse symptoms(P<0.05).Conclusion TEAS treatment can relieve postoperative pain and postoperative adverse symptoms for patients undergoing oocyte retrieval.

关键词： Transcutaneous electrical acupoint stimulation Fertilization Embryo transfer Oocyte retrieval Pain Randomized controlled trial

Reduction of Tat-interacting Protein 30 Expression Could be a Prognostic Marker in Bladder Urothelial Cancer

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Chinese Medical Journal 2018年第2期131卷 188-193页

作者： Ye-Ping Li Jian-Fang Zhu Ka-TeHuang rong-rong wang Bing Cai Hui Xie Hong-De Chen Department of Urology The First Affiliated Hospital of Wenzhou Medical University Wenzhou Zhejiang 325000 China Department of Vascular Surgery The Second Hospital of Shaoxing City Shaoxing Zhejiang 312000 China Department of Pathology The First Affiliated Hospital of Wenzhou Medical University Wenzhou Zhejiang 325000 China

Background： Tat-interacting protein 30 （TIP30） has been reported to be a tumor suppressor, with reduced or absent expression in various tumors. However, its role in bladder urothelial cancer （BUC） has not been investigated. Therefore, herein, we investigated the expression of T1P30 protein in BUC and normal bladder mucosa and the clinical significance of TIP30 expression in the prognosis of BUC. Methods： We reviewed data from 79 cases of BUC and 15 adjacent tissue samples from 79 patients treated at our institution between 2004 and 2007. TIP30 expression was examined by immunohistochemistry. The relationship between TIP30 expression and tumor stage, histological grade, and survival was analyzed. Differences between groups were evaluated using the t-test or matched-pairs test, and differences in the survival rates were analyzed with the log-rank test. Results： TIP30 protein expression was significantly reduced in BUC tissue （t = -6.91, P 〈 0.05） compared with normal tissue samples, and in invasive bladder cancer （t = 10.89, P 〈 0.05） compared with superficial bladder cancer. TIP30 protein expression differed significantly among different differentiated groups classified either according to the World Health Organization （2004, F = 17.48, P 〈 0.01） or World Health Organization （1973, F = 10.68, P 〈 0.01）. TIP30 protein expression was significantly reduced in high-grade papillary urothelial carcinoma compared with papillary urothelial neoplasm of low malignant potential （P 〈 0.05） and low-grade papillary urothelial carcinoma （P 〈 0.05）. Meanwhile, TIP30 protein expression was significantly reduced in Grade 111 BUC, compared with Grade I （P 〈 0.05） and Grade 11 （P 〈 0.05）. Patients with low T1P30 expression showed a higher incidence of disease progression than those with high TIP30 expression （t - 2.63, P 〈 0.05）. Kaplan-Meier survival analysis showed a strong positive relationship between TIP30 expression and overall survival （OS）（x^2 = 17.29, P 〈 0.05）. Conclusions： T

关键词： Bladder Urothelial Cancer Overall Survival Time Tat-interacting Protein 30

A 3.06-Mb interstitial deletion on 12p11.22-12.1 caused brachydactyly type E combined with pectus carinatum

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Chinese Medical Journal 2019年第14期132卷 1681-1688页

作者： Jia Huang Hong-Yan Liu rong-rong wang Hai Xiao Dong Wu Tao Li Ying-Hai Jiang Xue Zhang The Research Center for Medical Genomics Key Laboratory of Medical Cell BiologyChinese Ministry of EducationCollege of Basic Medical ScienceChina Medical UniversityShenyangLiaoning 110122China Institute of Medical Genetics Henan Provincial People's HospitalPeople's Hospital of Zhengzhou UniversitySchool of Clinical MedicineHenan UniversityZhengzhouHenan 450003China McKusick-Zhang Center for Genetic Medicine State Key Laboratory of Medical Molecular BiologyInstitute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing 100005China

Background:Brachydactyly,a developmental disorder,refers to shortening of hands/feet due to small or missing metacarpals/ metatarsals and/or *** brachydactyly type E (BDE),characterized by shortened metacarpals and/or metatarsals,consists in a small proportion of patients with Homeobox D13 (HOXD13) or parathyroid-hormone-like hormone (PTHLH) *** is often accompanied by other anomalies that are parts of many congenital *** this study,we investigated a Chinese family presented with BDE combined with pectus carinatum and short ***:A four-generation Chinese family was recruited in June *** informed consent was obtained,venous blood was collected,and genomic DNA was extracted by standard ***-exome sequencing was performed to screen pathogenic mutation,array comparative genomic hybridization (Array-CGH) analysis was used to analyze copy number variations,and quantitative real-time polymerase chain reaction (PCR),stride over breakpoint PCR (gap-PCR),and Sanger sequencing were performed to confirm the candidate ***:A 3.06-Mb deletion (chr12:25473650-28536747) was identified and segregated with the phenotype in this *** deletion region encompasses 23 annotated genes,one of which is PTHLH which has been reported to be causative to the *** is an important regulator of endochondral bone *** affected individuals showed bilateral,severe,and generalized brachydactyly with short stature,pectus carinatum,and prematurely fusion of *** feature of pectus carinatum has not been described in the PTHLH-related BDE patients ***:The haploinsufficiency of PTHLH might be responsible for the disease in this *** study has expanded the knowledge on the phenotypic presentation of PTHLH variation.

关键词： Brachydactyly type E Parathyroid-hormone-like hormone Pectus carinatum Short stature Copy number variation