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Chronic Kidney Disease Induces Cognitive Impairment in the Early Stage

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Current Medical Science 2023年第5期43卷 988-997页

作者： Yu WANG Kai CheN zi-xuan QIAO Xiao-rong BAO Department of Nephrology Jinshan HospitalFudan UniversityShanghai 201508China

Objective Previous research indicates a link between cognitive impairment and chronic kidney disease(CKD),but the underlying factors are not fully *** study aimed to investigate the progression of CKD-induced cognitive impairment and the involvement of cognition-related proteins by developing early-and late-stage CKD models in Sprague-Dawley *** The Morris water maze test and the step-down passive avoidance task were performed to evaluate the cognitive abilities of the rats at 24 weeks after *** examinations were conducted to examine renal and hippocampal ***-time PCR,Western blotting analysis,and immunohistochemical staining were carried out to determine the hippocampal expression of brain-derived neurotrophic factor(BDNF),choline acetyltransferase(ChAT),and synaptophysin(SYP).Results Compared with the control rats,the rats with early-stage CKD exhibited mild renal damage,while those with late-stage CKD showed significantly increased serum creatinine levels as well as apparent renal and brain *** rats with early-stage CKD also demonstrated significantly impaired learning abilities and memory compared with the control rats,with further deterioration observed in the rats with late-stage ***,we observed a significant downregulation of cognition-related proteins in the hippocampus of rats with early-stage CKD,which was further exacerbated with declining renal function as well as worsening brain and renal damage in rats with late-stage *** These results suggest the importance of early screening to identify CKD-induced cognitive dysfunction *** addition,the downregulation of cognition-related proteins may play a role in the progression of cognitive dysfunction.

关键词： chronic kidney disease cognitive impairment Morris water maze test brain-derived neurotrophic factor choline acetyltransferase synaptophysin

Novel assays for quality evaluation of XueBiJing:Quality variability of a Chinese herbal injection for sepsis management

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Journal of Pharmaceutical Analysis 2022年第4期12卷 664-682页

作者： xuan Yu Wei Niu Ya-Ya Wang Olajide E.Olaleye Jia-Nan Wang Meng-Yuan Duan Jun-Ling Yang rong-rong he.zi-xuan chu Kai Dong Gui-Ping Zhang Chang-Xiao Liu Chen Cheng chuan Li State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China School of Pharmacy University of Chinese Academy of SciencesBeijing100049China Graduate School Tianjin University of Traditional Chinese MedicineTianjin300193China Research Institute Tianjin Chasesun Pharmaceutical Co.Ltd.Tianjin301700China State Key Laboratory of Drug Delivery Technology and Pharmacokinetics and Tianjin Key Laboratory of Quality-Marker of Traditional Chinese Medicines Tianjin Institute of Pharmaceutical ResearchTianjin300193China

XueBiJing is an intravenous five-herb injection used to treat sepsis in *** study aimed to develop a liquid chromatography-tandem mass spectrometry(LC-MS/MS)-or liquid chromatography-ultraviolet(LC-UV)-based assay for quality evaluation of *** development involved identifying marker constituents to make the assay therapeutically relevant and building a reliable one-point calibrator for monitoring the various analytes in *** marker constituents from the five herbs were selected based on XueBiJing's chemical composition,pharmacokinetics,and pharmacodynamics.A selectivity test(for“similarity of response”)was developed to identify and minimize interference by nontarget ***,an intercept test was developed to fulfill“linearity through zero”for each analyte(absolute ratio of intercept to C response,he newly developed assays,we analyzed samples from 33 batches of XueBiJing,manufactured over three years,and found small batch-to-batch variability in contents of the marker constituents(4.1%-14.8%),except for senkyunolide I(26.5%).

关键词： XueBiJing Chinese herbal medicine Quality variability Quality marker One-point calibration

Wavelength tunable ultra-short pulses based on a flat broadband spectrum generated in a nonlinear ytterbium-doped fiber amplifier

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Chinese Physics B 2017年第1期26卷 220-223页

作者： Run-Qin Xu zi-Kai Dong Jin-rong Tian Ke-xuan Li Yan-rong Song College of Applied Sciences Beijing University of Technology Beijing 100124 China

We present a nonlinear ytterbium-doped fiber amplifier based on enhanced nonlinear effects that can produce a flat broadband spectrum ranging from 1050–1225 nm with a maximum average output power of 7.8 W at 14 W pump *** repetition rate is 89 MHz. Using a pair of gratings and two knife edges as a filter, wavelength tunable picosecond pulses of tens to hundreds of milliwatts can be obtained in the broadband spectrum range. The output power, pulse width, and spectrum（center wavelength and linewidth） are adjusted by tuning the distance of the grating pair and/or the knife *** the distance between the two gratings at 15 mm and keeping the output spectrum linewidth at approximately 20 nm,the shortest pulse width obtained is less than 1 ps centered at 1080 nm. The longest wavelength of the short pulses is around1200 nm, and its output power and pulse width are 40 m W and 5.79 ps, respectively. The generation of a flat broadband spectrum is also discussed in this paper.

关键词： tunable ultra-short pulse broadband spectrum nonlinear amplifier

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HTAP评测基准的评测能力综述

软件学报 2025年第1期36卷 424-445页

作者：翁思扬俞融王清帅胡梓锐倪葎张蓉周烜周傲英徐泉清杨传辉刘维杨攀飞华东师范大学数据科学与工程学院蚂蚁集团OceanBase 工业和信息化部电子第五研究所

对数据库系统即时修改数据的高效实时分析需求推动了数据库系统向同时支持OLTP业务和OLAP业务两种场景的HTAP数据库系统的快速发展.面对众多的HTAP数据库系统,为了推动HTAP数据库系统的公平比较和健康发展,定义和实现相应的评测基准来评... 详细信息

对数据库系统即时修改数据的高效实时分析需求推动了数据库系统向同时支持OLTP业务和OLAP业务两种场景的HTAP数据库系统的快速发展.面对众多的HTAP数据库系统,为了推动HTAP数据库系统的公平比较和健康发展,定义和实现相应的评测基准来评估HTAP数据库系统的新特性至关重要.首先,分析HTAP数据库系统的关键特征并抽象总结HTAP数据库系统实现的关键技术.然后,提炼出HTAP数据库系统的设计难点和构建HTAP评测基准的挑战,并基于此提出HTAP评测基准应考虑的设计维度,包括数据生成、负载生成、评价指标和一致性模型支持性.对比现有HTAP评测基准在设计维度和实现技术上的差异,总结评测基准在不同设计维度上的优劣.此外,运行已公开的典型评测基准,展示并分析它们对HTAP数据库系统关键特征的评测能力以及对不同HTAP数据库系统的横向对比的支持能力.最后,总结对HTAP评测基准的能力需求和未来的一些研究方向,指出语义一致的负载控制和新鲜数据访问度量是HTAP数据库系统评测基准定义的关键问题.

关键词： HTAP评测基准 HTAP数据库系统性能分析新鲜度

Modeling of irradiation-induced damage and failure behaviors of fuel foil/cladding interface in UMo/Zr monolithic fuel plates

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Nuclear Science and Techniques 2022年第5期33卷 16-29页

作者： Xiang-Zhe Kong Xiao-Bin Jian Feng Yan Chang-Bing Tang zi-xuan Guo Shu-rong Ding Yuan-Ming Li chun-Yu Yin Institute of Mechanics and Computational Engineering Department of Aeronautics and AstronauticsFudan UniversityShanghai 200433China Science and Technology On Reactor System Design Technology Laboratory Nuclear Power Institute of ChinaChengdu 610213China

Models to describe the damage and fracture behaviors of the interface between the fuel foil and cladding in UMo/Zr monolithic fuel plates were established and numerically *** effects of the interfacial cohesive strength and cohesive energy on the irradiationinduced thermal-mechanical behaviors of fuel plates were *** results indicated that for heterogeneously irradiated fuel plates:(1)interfacial damage and failure were predicted to be initiated near the fuel foil corner with higher fission densities,accompanied by the formation of a large gap after interface failure,which was consistent with some experimental observations;high tensile stresses in the fuel foil occurred near the edges of the failed interface,attributed to through-thickness cracking of the fuel foil,as found in some post-irradiation examinations;(2)the cohesive strength and cohesive energy of the interface both influenced the in-pile evolution behaviors of fuel plates;a lower cohesive strength or cohesive energy resulted in faster interfacial damage;(3)after interface fracture,the thickness of the whole plate increased to a greater degree(by~20%)than that of the samples without interfacial damage,which was attributed to the locally enhanced Mises stresses and the nearby creep deformations around the cracked *** study provided a theoretical basis for assessing failure in fuel elements.

关键词： UMo/Zr Irradiation-inducedthermo-mechanicalbehavior Numericalsimulation Cohesive model Interfacialfailure

Synthesis of High-purity Fe_(2)AlB_(2) and the Effect as Sintering Additive for ZrB_(2)

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Chinese Journal of Structural Chemistry 2021年第3期40卷 283-290,271页

作者： WANG Rui XU Wen-Tao QIN zi-xuan LING Jun-rong ZHOU You-Fu Fujian Normal University College of Chemistry and Materials ScienceFuzhou 350007China Key Laboratory of Optoelectronic Materials Chemistry and Physics Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China University of Chinese Academy of Sciences Beijing 100039China

Fe_(2)AlB_(2) powder material was prepared by the direct reaction of iron,aluminum and boron powders in a tubular *** effects of different Al contents,temperature and raw material pretreatment on the purity of product were *** mixed powder with the stoichiometric ratio of 1.5Al/2Fe/2B was processed by CIP (Cold Isostatic Pressing),and then calcined at 1150℃ for 120 *** product containing a small amount of impurities is treated with alkaline solution to obtain high-purity Fe_(2)Al B_(2) *** B_(2)-Fe_(2)Al B_(2) composite ceramic was successfully prepared at 1250℃ by hot pressing *** density,hardness and fracture toughness were 96.2%,22±0.3 GPa and 5.78±0.5 MPa·m^(1/2),respectively.

关键词： MAB phase ternary layered structure high purity ZrB_(2)

Co-infection of SARS-COV-2 and Influenza A Virus:A Case Series and Fast Review

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Current Medical Science 2021年第1期41卷 51-57页

作者： xuan XIANG zi-hao WANG Lin-lin YE Xin-liang he Xiao-shan WEI Yan-ling MA Hui LI Long CheN Xiao-rong WANG Qiong ZHOU Department of Respiratory and Critical Care Medicine Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Coronavirus disease 2019(COVID-19)occurs in the influenza season and has become a global *** present study aimed to examine severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)co-infection with influenza A virus(IAV)in an attempt to provide clues for the antiviral interventions of co-infected *** described two patients who were co-infected with SARS-CoV-2 and IAV treated at Wuhan Union Hospital,*** addition,we performed a review in PubMed,Web of Science and CNKI(from January 1 up to November 1,2020)with combinations of the following key words:“COVID-19,SARS-COV-2,influenza A and co-infection”.A total of 28 co-infected patients were enrolled in the *** the 28 patients,the median age was 54.5 years(IQR,34.25–67.5)and 14 cases(50.0%)were classified as severe *** most common symptoms were fever(85.71%),cough(82.14%)and dyspnea(60.71%).Sixteen patients had lymphocytopenia on admission and 23 patients exhibited abnormal radiological *** median time from symptom onset to hospital admission was 4 days(IQR,3–6),and the median time of hospital stay was 14 days(IQR,8.5–16.75).In conclusion,patients with SARSCOV-2 and IAV co-infection were similar to those infected with SARS-COV-2 alone in symptoms and radiological ***-COV-2 co-infection with IAV could lead to more severe clinical condition but did not experience longer hospital stay compared with patients infected with SARSCOV-2 alone.

关键词： co-infection COVID-19 influenza A SARS-COV-2

Therapeutic effect of Keap1-Nrf2-ARE pathway-related drugs on age-related eye diseases through anti-oxidative stress

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International Journal of Ophthalmology(English edition) 2021年第8期14卷 1260-1273页

作者： zi-Yan Cai Meng-Die Fu Ke Liu xuan-chu Duan Department of Ophthalmology the Second Xiangya Hospital of Central South UniversityChangsha 410011Hunan ProvinceChina Department of Ophthalmology Changsha Aier Eye HospitalChangsha 410011Hunan ProvinceChina

Age-related eye diseases,including cataract,glaucoma,diabetic retinopathy(DR),and age-related macular degeneration(AMD),are the leading causes of vision loss in the *** studies have shown that the occurrence and development of these diseases have an important relationship with oxidative stress in the *** Keap1-Nrf2-ARE pathway is a classical pathway that resists oxidative stress and inflammation in the *** pathway is also active in the development of age-related eye diseases.A variety of drugs have been shown to treat agerelated eye diseases through the Keap1-Nrf2-ARE(Kelch-like ECH-Associating protein 1-nuclear factor erythroid 2 related factor 2-antioxidant response element)*** review describes the role of oxidative stress in the development of age-related eye diseases,the function and regulation of the Keap1-Nrf2-ARE pathway,and the therapeutic effects of drugs associated with this pathway on age-related eye diseases.

关键词： oxidative stress Keap1-Nrf2-ARE pathway age-related eye diseases

How to estimate isotope fractionations of a Rayleigh-like but diffusion-limited disequilibrium process?

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Acta Geochimica 2023年第1期42卷 24-37页

作者： zi xuan Guan Yun Liu School of Earth and Space Science Peking UniversityBeijing 100871China State Key Laboratory of Ore Deposit Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China International Center for Planetary Science College of Earth ScienceChengdu University of TechnologyChengdu 610059China CAS Center for Excellence in Comparative Planetology Hefei 230026China

The Rayleigh distillation isotope fractionation(RDIF) model is one of the most popular methods used in isotope geochemistry. Numerous isotope signals observed in geologic processes have been interpreted with this model. The RDIF model provides a simple mathematic solution for the reservoir-limited equilibrium isotope fractionation effect. Due to the reservoir effect, tremendously large isotope fractionations will always be produced if the reservoir is close to being depleted. However, in real situations, many prerequisites assumed in the RDIF model are often difficult to meet. For instance, it requires the relocated materials, which are removed step by step from one reservoir to another with different isotope compositions(i.e., with isotope fractionation), to be isotopically equilibrated with materials in the first reservoir simultaneously. This ‘‘quick equilibrium requirement’’ is indeed hard to meet if the first reservoir is sufficiently large or the removal step is fast. The whole first reservoir will often fail to re-attain equilibrium in time before the next removal *** problem led the RDIF model to fail to interpret isotope signals of many real situations. here a diffusion-coupled and Rayleigh-like(i.e., reservoir-effect included) separation process is chosen to investigate this problem. We find that the final isotope fractionations are controlled by both the diffusion process and the reservoir effects via the disequilibrium separation process. Due to its complexity, we choose to use a numerical simulation method to solve this problem by developing specific computing codes for the working *** to our simulation results, the classical RDIF model only governs isotope fractionations correctly at the final stages of separation when the reservoir scale(or thickness of the system) is reduced to the order of magnitude of the quotient of the diffusivity and the separation rate. The RDIF model fails in other situations and the isotope fractionations

关键词： Isotope fractionation Reservoir isotope effect Rayleigh-like distillation process Diffusional isotope effect Numerical modeling Disequilibrium process