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Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosis in human tumor cells

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第1期14卷 8-24页

作者： Qin FU Chen he Zheng-rong MAO Department of Pathology and Pathophysiology School of Medicine Zhejiang University Hangzhou 310058 China

Epstein-Barr virus(EBV),a human gammaherpesvirus carried by more than 90% of the world's population,is associated with malignant tumors such as Burkitt's lymphoma(BL),Hodgkin lymphoma,post-transplant lymphoma,extra-nodal natural killer/T cell lymphoma,and nasopharyngeal and gastric carcinomas in immune-compromised patients.In the process of infection,EBV faces challenges:the host cell environment is harsh,and the survival and apoptosis of host cells are precisely regulated.Only when host cells receive sufficient survival signals may they immortalize.To establish efficiently a lytic or long-term latent infection,EBV must escape the host cell immunologic mechanism and resist host cell apoptosis by interfering with multiple signaling pathways.This review details the apoptotic pathway disrupted by EBV in EBV-infected cells and describes the interactions of EBV gene products with host cellular factors as well as the function of these factors,which decide the fate of the host cell.The relationships between other EBV-encoded genes and proteins of the B-cell leukemia/lymphoma(Bcl) family are unknown.Still,EBV seems to contribute to establishing its own latency and the formation of tumors by modifying events that impact cell survival and proliferation as well as the immune response of the infected host.We discuss potential therapeutic drugs to provide a foundation for further studies of tumor pathogenesis aimed at exploiting novel therapeutic strategies for EBV-associated diseases.

关键词：医学免疫学研究方法免疫生物学免疫遗传学

酸笋中微生物区系演替和风味物质形成机制的研究进展

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食品与发酵工业 2024年第4期50卷 315-321页

作者：薛冰洁胡荣吴良如杨金来李彬张甫生郑炯西南大学食品科学学院重庆400715 国家林业和草原局竹子研究开发中心浙江杭州310012 重庆市林业科学院重庆400036

酸笋是竹笋经微生物发酵作用而成的一种中国传统发酵蔬菜,目前常作为螺蛳粉、桂林米粉的配料,因其独特的风味深受广大消费者的喜爱。酸笋中微生物群落的构成及其代谢是酸笋生产的核心,酸笋中风味物质的含量和种类是决定酸笋品质的关键... 详细信息

酸笋是竹笋经微生物发酵作用而成的一种中国传统发酵蔬菜,目前常作为螺蛳粉、桂林米粉的配料,因其独特的风味深受广大消费者的喜爱。酸笋中微生物群落的构成及其代谢是酸笋生产的核心,酸笋中风味物质的含量和种类是决定酸笋品质的关键。而微生物是酸笋风味的主要来源,两者在发酵过程中密切相关。因此,该文总结了酸笋中微生物的构成及其演替规律,分析了影响酸笋微生物演替的因素,概述了酸笋中的风味物质,阐述了微生物诱导风味物质形成的机理,有助于进一步了解酸笋中复杂微生物群落和风味物质的互作效应,从而为酸笋的品质提升及质量控制提供理论依据。

关键词：酸笋微生物群落乳酸菌风味物质有机酸

“人类主体”:一种新型伦理主体的可能性——对“人类共同存在如何可能”白的前提性反思

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世界哲学 2024年第3期 83-92,F0003页

作者：贺来吉林大学哲学基础理论研究中心暨哲学社会学院

当代世界所面临的全球性风险和不确定性,内在要求哲学和伦理学为回答人类的“共同存在”何以可能的重大课题探求新的伦理根基。现代社会的“分离”和“脱嵌”机制,形成了现代人特殊的伦理境遇,为当代世界和人类的分裂与冲突埋下了深深... 详细信息

当代世界所面临的全球性风险和不确定性,内在要求哲学和伦理学为回答人类的“共同存在”何以可能的重大课题探求新的伦理根基。现代社会的“分离”和“脱嵌”机制,形成了现代人特殊的伦理境遇,为当代世界和人类的分裂与冲突埋下了深深的种子,它使“个人”以及与此内在相关的“民族共同体”被确立为两种最典型的伦理主体,使得人类的“共同存在”蕴藏着重大的危机。因此,要克服这一危机,一个重要前提是克服这两种伦理主体的局限性,并确立“人类主体”的伦理自觉。“人类主体”是一种把所有人作为内在统一的“类”予以考虑的伦理视野和立场,它要求在承认个人和民族国家的独立性的前提下,超越其界限和固化的区分,并以之为基础,寻求和生成一种新型的伦理思维、伦理原则和伦理价值理念。

关键词：人类共同存在个人主体民族国家主体人类主体

Radical innovation breakthroughs of biodegradation of plastics by insects:history,present and future perspectives

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Frontiers of Environmental Science & Engineering 2024年第6期18卷 127-165页

作者： Shan-Shan Yang Wei-Min Wu Federica Bertocchini Mark Eric Benbow Suja P.Devipriya Hyung Joon Cha Bo-Yu Peng Meng-Qi Ding Lei he Mei-Xi Li Chen-Hao Cui Shao-Nan Shi Han-Jun Sun Ji-Wei Pang Defu he Yalei Zhang Jun Yang Deyi Hou De-Feng Xing Nan-Qi Ren Jie Ding Craig S.Criddle State Key Laboratory of Urban Water Resource and Environment School of EnvironmentHarbin Institute of TechnologyHarbin 150090China Department of Civil and Environmental Engineering William&Cloy Codiga Resource Recovery CenterStanford UniversityStanfordCA 94305USA Plasticentropy rue Thiers 28Reims 51100France Department of Entomology and Department of Osteopathic Medical Specialties Michigan State UniversityEast LansingMI 48824USA School of Environmental Studies Cochin University of Science and TechnologyKochi 682022India Department of Chemical Engineering Pohang University of Science and TechnologyPohang 37673Republic of Korea School of Environmental Science and Engineering Tongji UniversityShanghai 200092China China Energy Conservation and Environmental Protection Group CECEP Talroad Technology Co.Ltd.Beijing 100096China School of Ecological and Environmental Sciences East China Normal UniversityShanghai 200241China Research Institute for Frontier Science Beihang UniversityBeijing 100191China School of Environment Tsinghua UniversityBeijing 100084China

Insects damaging and penetrating plastic packaged materials has been reported since the 1950s.Radical innovation breakthroughs of plastic biodegradation have been initiated since the discovery of biodegradation of plastics by Tenebrio molitor larvae in 2015 followed by Galleria mellonella in 2017.here we review updated studies on the insect-mediated biodegradation of plastics.Plastic biodegradation by insect larvae,mainly by some species of darkling beetles(Tenebrionidae)and pyralid moths(Pyralidae)is currently a highly active and potentially transformative area of research.Over the past eight years,publications have increased explosively,including discoveries of the ability of different insect species to biodegrade plastics,biodegradation performance,and the contribution of host and microbiomes,impacts of polymer types and their physic-chemical properties,and responsible enzymes secreted by the host and gut microbes.To date,almost all major plastics including polyethylene(PE),polypropylene(PP),polyvinyl chloride(PVC),polyethylene terephthalate(PET),polyurethane(PUR),and polystyrene(PS)can be biodegraded by T.molitor and ten other insect species representing the Tenebrionidae and Pyralidae families.The biodegradation processes are symbiotic reactions or performed by synergistic efforts of both host and gut-microbes to rapidly depolymerize and biodegrade plastics with hourly half-lives.The digestive ezymens and bioreagents screted by the insects play an essential role in plasatic biodegradation in certain species of Tenebrionidae and Pyralidae families.New research on the insect itself,gut microbiomes,transcriptomes,proteomes and metabolomes has evaluated the mechanisms of plastic biodegradation in insects.We conclude this review by discussing future research perspectives on insect-mediated biodegradation of plastics.

关键词： Plastics Biodegradation Insects Gut microbiomes Enzymes

“佛系”与“躺平”:网络亚文化叙事逻辑及扬弃路径

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湖北民族大学学报（哲学社会科学版） 2024年第2期42卷 66-79页

作者：何为西华大学马克思主义学院

网络亚文化“佛系”与“躺平”,渊薮于“丧文化”,其文化叙事症候具有深刻的社会根源,并在与“内卷”相互对抗的叙事框架中进行文化构境,影响了一部分青年群体的价值观念与生存样态,形成一道独特的对抗与转化的圈层景观。青年在“佛系... 详细信息

网络亚文化“佛系”与“躺平”,渊薮于“丧文化”,其文化叙事症候具有深刻的社会根源,并在与“内卷”相互对抗的叙事框架中进行文化构境,影响了一部分青年群体的价值观念与生存样态,形成一道独特的对抗与转化的圈层景观。青年在“佛系”与“躺平”文化叙事空间中能够实现一定的情绪宣泄、舒缓压力的需求,同时其叙事逻辑也潜藏着抵抗主流文化、消解主流价值、解构责任意识等多种对青年的慢性危害。面对亚文化症候负效应对主流价值的折冲,需要聚焦青年奋斗精神的培育,采取“文化根治—社会治理—破壁出圈”调适导向策略,系统性地扬弃亚文化带来的消极成分,从而引导青年保持昂扬的奋斗姿态。

关键词：佛系躺平内卷青年文化文化治理

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社交网络舆情多模态知识图谱构建框架研究

情报杂志 2024年第1期43卷 160-166页

作者：何巍中国人民警察大学廊坊065000

[研究目的]信息技术的发展丰富了社交媒体用户的沟通交流方式,研究社交网络舆情多模态知识图谱的构建对网络舆情治理具有重要的现实意义。[研究方法]基于多模态数据的语义互补,讨论了实体属性关联、图像(视频)文字描述、图像(视频)属性... 详细信息

[研究目的]信息技术的发展丰富了社交媒体用户的沟通交流方式,研究社交网络舆情多模态知识图谱的构建对网络舆情治理具有重要的现实意义。[研究方法]基于多模态数据的语义互补,讨论了实体属性关联、图像(视频)文字描述、图像(视频)属性、图像(视频)关联等多种异构数据融合方式。在此基础上,提出社交网络舆情多模态知识图谱的构建框架,并分析了在多模态语义理解、多模态实体对齐、多模态知识表示等方面存在的问题与挑战。[研究结论]提出基于多模态知识融合的社交网络舆情多模态知识图谱构建框架,为交互方式日趋丰富的社交网络舆情治理提供有益参考。

关键词：社交媒体多模态多模态知识图谱多模态数据网络舆情舆情治理情感分析

Macrophages and microglia in inflammation and neuroinflammation underlying different pain states

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Medical Review

Medical Review 2023年第5期3卷 381-407页

作者： Ouyang Chen Xin Luo Ru-rong Ji Department of Anesthesiology Center for Translational Pain MedicineDuke University Medical CenterDurhamNCUSA Department of Cell Biology Duke University Medical CenterDurhamNCUSA Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence Southern Medical UniversityGuangzhouGuangdong ProvinceChina Department of Anesthesiology Center for Translational Pain MedicineDuke University Medical CenterDurhamNC 27710USA Department of Cell Biology Duke University Medical CenterDurhamNC 27710USA

Pain is a main symptom in inflammation,and inflammation induces pain via inflammatory mediators acting on nociceptive neurons.Macrophages and microglia are distinct cell types,representing immune cells and glial cells,respectively,but they share similar roles in pain regulation.Macrophages are key regulators of inflammation and pain.Macrophage polarization plays different roles in inducing and resolving pain.Notably,macrophage polarization and phagocytosis can be induced by specialized pro-resolution mediators(SPMs).SPMs also potently inhibit inflammatory and neuropathic pain via immunomodulation and neuromodulation.In this review,we discuss macrophage signaling involved in pain induction and resolution,as well as in maintaining physiological pain.Microglia are macrophage-like cells in the central nervous system(CNS)and drive neuroinflammation and pathological pain in various inflammatory and neurological disorders.Microglia-produced inflammatory cytokines can potently regulate excitatory and inhibitory synaptic transmission as neuromodulators.We also highlight sex differences in macrophage and microglial signaling in inflammatory and neuropathic pain.Thus,targeting macrophage and microglial signaling in distinct locations via pharmacological approaches,including immunotherapies,and non-pharmacological approaches will help to control chronic inflammation and chronic pain.

关键词： inflammation macrophages microglia neuroinflammation pain

推拿对实验性结肠炎小鼠抗炎作用的蛋白质组学研究

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时珍国医国药 2024年第4期35卷 1009-1012页

作者：王厚融王湘宜张英琦于天源鲁梦倩北京中医药大学北京102488 北京医院针灸按摩科、国家老年医学中心、中国医学科学院老年医学研究院北京100730

目的探究推拿对实验性结肠炎小鼠的治疗作用及机制。方法将18只雄性BALA/c小鼠随机分为空白组、模型组和推拿组。模型组和推拿组通过葡聚糖硫酸钠(DSS)诱导实验性结肠炎模型。推拿组在造模后7 d进行干预,实验过程中记录体重、血便等一... 详细信息

目的探究推拿对实验性结肠炎小鼠的治疗作用及机制。方法将18只雄性BALA/c小鼠随机分为空白组、模型组和推拿组。模型组和推拿组通过葡聚糖硫酸钠(DSS)诱导实验性结肠炎模型。推拿组在造模后7 d进行干预,实验过程中记录体重、血便等一般情况,干预7次后,取结肠组织进行he染色和蛋白质组学研究。结果推拿干预后UC小鼠一般情况改善,he染色显示结肠组织病变程度减轻。蛋白质组学结果显示与推拿作用相关的差异蛋白共有216个,iPath分析得到402条代谢途径,KEGG富集分析到262条通路。结论推拿能够改善UC炎症表现,其作用机制可能与维生素消化吸收、花生四烯酸代谢、TRP通道的炎症介质调节有关。

关键词：推拿摩腹法溃疡性结肠炎蛋白组学结肠花生四烯酸瞬时感受器电位通道

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齿轮传动性能检测系统设计与试验

机械设计与制造 2024年第3期 176-180页

作者：王荣先武彪陈智勇马利民洛阳理工学院智能制造学院河南洛阳471023 中铁十七局集团有限公司铺架分公司山西太原030032 西北工业大学机电学院陕西西安710072

齿轮传动中的啮合角和重合度受制造精度、载荷、齿廓磨损、变形等因素影响会发生改变,导致传动的平稳性和连续性下降。为检测齿轮传动啮合参数,基于机器视觉技术设计了齿轮传动性能检测系统。该系统由轮系、传动装置、测量装置和图像分... 详细信息

齿轮传动中的啮合角和重合度受制造精度、载荷、齿廓磨损、变形等因素影响会发生改变,导致传动的平稳性和连续性下降。为检测齿轮传动啮合参数,基于机器视觉技术设计了齿轮传动性能检测系统。该系统由轮系、传动装置、测量装置和图像分析系统等组成。使用工业摄像机拍摄齿轮啮合运动图像,基于最小二乘法进行数据分析,检测齿轮节圆、啮合角、重合度等啮合参数。检测结果表明,实际啮合角和重合度值检测结果与设计值相对误差低于5%。该检测系统具有高效、实时、非接触等优点,为齿轮智能制造及检测提供技术支持。

关键词：齿轮节圆啮合角检测