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Disturbed Yin-Yang balance:stress increases the susceptibility to primary and recurrent infections of herpes simplex virus type 1

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Acta Pharmaceutica Sinica B 2020年第3期10卷 383-398页

作者： Chang Yan Zhuo Luo Wen Li Xue Li Robert Dallmann Hiroshi Kurihara Yi-Fang Li rong-rong he Guangdong Engineering Research Center of Chinese Medicine&Disease Susceptibility Jinan University Guangzhou 510632China International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education(MOE) School of PharmacyJinan UniversityGuangzhou 510632China Institute of Atmospheric Environmental Safety and Pollution Control Jinan UniversityGuangzhou 510632China Warwick Medical School University of WarwickCoventry CV47ALUK

herpes simplex virus type 1(HSV-1),a neurotropic herpes virus,is able to establish a lifelong latent infection in the human host.Following primary replication in mucosal epithelial cells,the virus can enter sensory neurons innervating peripheral tissues via nerve termini.The viral genome is then transported to the nucleus where it can be maintained without producing infectious progeny,and thus latency is established in the cell.Yin-Yang balance is an essential concept in traditional Chinese medicine(TCM)theory.Yin represents stable and inhibitory factors,and Yang represents the active and aggressive factors.When the organism is exposed to stress,especially psychological stress caused by emotional stimulation,the Yin-Yang balance is disturbed and the virus can re-engage in productive replication,resulting in recurrent diseases.Therefore,a better understanding of the stress-induced susceptibility to HSV-1 primary infection and reactivation is needed and will provide helpful insights into the effective control and treatment of HSV-1.here we reviewed the recent advances in the studies of HSV-1 susceptibility,latency and reactivation.We included mechanisms involved in primary infection and the regulation of latency and described how stress-induced changes increase the susceptibility to primary and recurrent infections.

关键词： herpes simplex virus type 1 HSV-1 Susceptibility Latency Reactivation Stress

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Inhibitory effects of baicalein against herpes simplex virus type 1

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Acta Pharmaceutica Sinica B 2020年第12期10卷 2323-2338页

作者： Zhuo Luo Xiu-Ping Kuang Qing-Qing Zhou Chang-Yu Yan Wen Li Hai-Biao Gong Hiroshi Kurihara Wei-Xi Li Yi-Fang Li rong-rong he Guangdong Engineering Research Center of Chinese Medicine&Disease Susceptibility College of PharmacyCollege of PharmacyJinan UniversityGuangzhou 612505China International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education(MOE) College of PharmacyJinan UniversityGuangzhou 612505China Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research College of PharmacyJinan UniversityGuangzhou 612505China Yunnan University of Traditional Chinese Medicine Kunming 650550China

herpes simplex virus type 1(HSV-1)is a ubiquitous and widespread human pathogen,which gives rise to a range of diseases,including cold sores,corneal blindness,and encephalitis.Currently,the use of nucleoside analogs,such as acyclovir and penciclovir,in treating HSV-1 infection often presents limitation due to their side effects and low efficacy for drug-resistance strains.Therefore,new anti-herpetic drugs and strategies should be urgently developed.here,we reported that baicalein,a naturally derived compound widely used in Asian countries,strongly inhibited HSV-1 replication in several models.Baicalein was effective against the replication of both HSV-1/F and HSV-1/Blue(an acyclovir-resistant strain)in vitro.In the ocular inoculation mice model,baicalein markedly reduced in vivo HSV-1/F replication,receded inflammatory storm and attenuated histological changes in the cornea.Consistently,baicalein was found to reduce the mortality of mice,viral loads both in nose and trigeminal ganglia in HSV-1 intranasal infection model.Moreover,an ex vivo HSV-1-EGFP infection model established in isolated murine epidermal sheets confirmed that baicalein suppressed HSV-1 replication.Further investigations unraveled that dual mechanisms,inactivating viral particles and inhibiting IκB kinase beta(IKK-β)phosphorylation,were involved in the anti-HSV-1 effect of baicalein.Collectively,our findings identified baicalein as a promising therapy candidate against the infection of HSV-1,especially acyclovir-resistant strain.

关键词： Anti-HSV-1 Baicalein Viral inactivation IKK-βphosphorylation NF-kβactivation HSV-1 infection

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Four New Dicaffeoylspermidine Derivatives From Lycium barbarum

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World Journal of Traditional Chinese Medicine 2016年第4期2卷 1-5页

作者： Zheng-Qun Zhou Hong-Xia Fan rong-rong he Wan-Yang Sun Jia Xiao Xue-Feng Bao Kwok-Fai So Xin-Sheng Yao Hao Gao Institute of Traditional Chinese Medicine and Natural Products College of Pharmacy Jinan University Guangzhou 510632People's Republic of China Department of Immunobiology Institute of Tissue Transplantation and Immunology College of Life Science and Technology Jinan UniversityGuangzhou 510632 People's Republic of China Guangdong Medical Key Laboratory of Brain Function and Diseases GMH Institute of Central Nervous System Regeneration Jinan UniversityGuangzhou 510632 People's Republic of China

Four new dicaffeoylspermidine derivatives, lycibarbarspermidines P–S(1–4), were isolated from the fruit of Lycium barbarum(wolfberry).The structures were determined by extensive spectroscopic(HRESIMS, 1 D NMR, and 2 D NMR) analyses and chemical methods.Dicaffeoylspermidine derivatives are a kind of major bioactive and characteristic constituents in wolfberry, and the discovery of 1–4 added new members of this family.

关键词： Lycium barbarum Wolfberry Dicaffeoylspermidine derivatives Lycibarbarspermidines

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Novel insights into stress-induced susceptibility to influenza:corticosterone impacts interferon-βresponses by Mfn2-mediated ubiquitin degradation of MAVS

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Signal Transduction and Targeted Therapy 2020年第1期5卷 782-793页

作者： Zhuo Luo Li-Fang Liu Ying-Nan Jiang Lu-Ping Tang Wen Li Shu-Hua Ouyang Long-Fang Tu Yan-Ping Wu Hai-Biao Gong Chang-Yu Yan Shan Jiang Yu-Hui Lu Tongzheng Liu Zhenyou Jiang Hiroshi Kurihara Yang Yu Xin-Sheng Yao Yi-Fang Li rong-rong he Guangdong Engineering Research Center of Chinese Medicine&Disease Susceptibility Jinan UniversityGuangzhou 510632China International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education(MOE) College of PharmacyJinan UniversityGuangzhou 510632China Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research College of PharmacyJinan UniversityGuangzhou 510632China School of Traditional Chinese Materia Medica Shenyang Pharmaceutical UniversityShenyang 110016China Institute of Tumor Pharmacology College of PharmacyJinan UniversityGuangzhou 510632China Department of Microbiology and Immunology Basic Medicine CollegeJinan UniversityGuangZhou 510632China

Although stress has been known to increase the susceptibility of pathogen infection,the underlying mechanism remains elusive.In this study,we reported that restraint stress dramatically enhanced the morbidity and mortality of mice infected with the influenza virus(H1N1)and obviously aggravated lung inflammation.Corticosterone(CORT),a main type of glucocorticoids in rodents,was secreted in the plasma of stressed mice.We further found that this stress hormone significantly boosted virus replication by restricting mitochondrial antiviral signaling(MAVS)protein-transduced IFN-βproduction without affecting its mRNA level,while the deficiency of MAVS abrogated stress/CORT-induced viral susceptibility in mice.Mechanistically,the effect of CORT was mediated by proteasome-dependent degradation of MAVS,thereby resulting in the impediment of MAVS-transduced IFN-βgeneration in vivo and in vitro.Furthermore,RNA-seq assay results indicated the involvement of Mitofusin 2(Mfn2)in this process.Gain-and loss-offunction experiments indicated that Mfn2 interacted with MAVS and recruited E3 ligase SYVN1 to promote the polyubiquitination of MAVS.Co-immunoprecipitation experiments clarified an interaction between any two regions of Mfn2(HR1),MAVS(C-terminal/TM)and SYVN1(TM).Collectively,our findings define the Mfn2-SYVN1 axis as a new signaling cascade for proteasome-dependent degradation of MAVS and a‘fine tuning’of antiviral innate immunity in response to influenza infection under stress.

关键词： influenza ubiquitin MAVS

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The Protective Effect of Jiujiuguiyi, a Medicine and Food Homologous Formula, on Acute Alcohol Poisoning Mice

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TMR Modern herbal Medicine 2019年第3期2卷 121-130页

作者： Yang-Fan Zhou Tian-Ze Zhang Si-Qi Deng Meng Zhang Yu-Jiao Zhan Yi-Fang Li rong-rong he Guangdong Province Research and Development Center for Chinese Medicine in Disease Susceptibility College of PharmacyJinan UniversityGuangzhou 510632China International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE) College of PharmacyJinan UniversityGuangzhou 510632China Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research College of PharmacyJinan UniversityGuangzhou 510632China

急性酒精中毒已成为当代中国的第三大社会问题,而目前市面上的主流解酒产品主要是单一机制,通过提高与酒精代谢有关的酶活性来加速酒精代谢。因此,我们研发了一款可以同时做到保肝、减缓中枢异常兴奋、改善肌肉松弛的新型解酒配方——... 详细信息

急性酒精中毒已成为当代中国的第三大社会问题,而目前市面上的主流解酒产品主要是单一机制,通过提高与酒精代谢有关的酶活性来加速酒精代谢。因此,我们研发了一款可以同时做到保肝、减缓中枢异常兴奋、改善肌肉松弛的新型解酒配方——九酒归一。方法:给予0.12ml/10g50%乙醇灌胃,建立小鼠急性酒精中毒模型。连续20天给予九酒归一灌胃。接着,将小鼠随机分成8组,每组8只,分别为对照组(CON)、模型组(M)、海王金樽阳性对照组(HWJZ)、实验组(AL,AH,BL,BH,AB)。检测各组小鼠的步态、转棒爬行时间、肝脏和血清中的AST、ALT、SOD活性、血清中的MDA活性、肝脏中的ADH、ALDH、GSH-PX活性以及肝脏切片。结果:与模型组相比,九酒归一使肝脏和血清中的AST、ALT活性、血清中的MDA活性明显降低,同时使肝脏中的ADH、ALDH以及肝脏和血清中的SOD活性明显升高,显示肝脏代谢酒精能力增强、肝损伤降低。he染色同样证明了九酒归一可以减少干细胞损伤,并且先药后酒组效果更好。而且,九酒归一明显延长了急性酒精中毒小鼠的转棒爬行时间,改善了急性酒精中毒小鼠的步态。结论:本研究证明,九酒归一可以有效保肝、减缓中枢异常兴奋、改善肌肉松弛。其作用机制主要是调节酒精代谢酶和抗氧化酶活性.

关键词：九酒归一急性酒精中毒小鼠药食同源行为学检测

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Antioxidative and antiapoptotic effects of （＋）-clausenamide on acetaminophen-induced nephrotoxicity in mice

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TMR Modern herbal Medicine 2018年第3期1卷 127-135页

作者： Hong-Min Yu Min Wang Zong-Chao Yu Yi-Fang Li Chun-Xin Huang Fang-Xuan Han Fan-Na Liu rong-rong he Anti-stress and health Research Center and Guangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility Guangdong China College of Pharmacy Jinan University Guangdong China Department of Pharmacy Hainan General Hospital Hainan China Department of Nephrology the First Affiliated Hospital of Jinan University Guangdong China

目的：（＋）-黄皮酰胺（（＋）-CLA）是从黄皮叶中分离得到的-种黄皮活性成分,我们旨在评价（＋）-黄皮酰胺在对乙酰氨基酚（APAP）诱导小鼠肾损伤中的保护作用.方法：小鼠分成正常组、APAP组以及高低剂量（＋）-CLA组,连续5天给予（＋... 详细信息

目的：（＋）-黄皮酰胺（（＋）-CLA）是从黄皮叶中分离得到的-种黄皮活性成分,我们旨在评价（＋）-黄皮酰胺在对乙酰氨基酚（APAP）诱导小鼠肾损伤中的保护作用.方法：小鼠分成正常组、APAP组以及高低剂量（＋）-CLA组,连续5天给予（＋）-CLA（50和100mg/kg）进行预处理,末次给药后,小鼠腹腔注射单剂量APAP（600mg/kg）.通过苏木素-伊红染色观察肾组织病理学特征,用相应试剂盒检测丙二醛（MDA）和谷胱甘肽（GSH）的水平以及过氧化氢酶（CAT）和超氧化物歧化酶（SOD）的活性,免疫印迹法分析肾组织中凋亡相关蛋白的表达.结果：与正常组相比,APAP组的血清肌酐和尿素氮水平上升.MDA水平的增加,GSH的耗竭以及CAT和SOD活性的降低表明APAP诱导的肾损伤由氧化应激调控.Bax,caspase-3,cleavagecaspase-3以及细胞浆细胞色素c表达上调,而Bcl-2和线粒体细胞色素c表达下调,这些说明APAP诱导的肾损伤明显增加肾细胞的凋亡.（＋）-CLA能逆转上述大多数参数并恢复肾的正常结构.结论：氧化应激与凋亡被认为是APAP肾毒性的潜在机制.（＋）-CLA的抗氧化和抗凋亡作用可能是对APAP急性肾损伤的-个有前景的解毒剂.

关键词： (+)-黄皮酰胺对乙酰氨基酚肾损伤氧化应激凋亡通路

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Photoinduced bismuth vanadate-catalyzed C(sp^(2))-H functionalization

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Chinese Chemical Letters 2024年第3期35卷 1-2页

作者： rong-Nan Yi Wei-Min he Key Laboratory of Food&Environment&Drug Monitoring and Testing of Universities in Hunan Province Hunan Police AcademyChangsha 410138China School of Chemistry and Chemical Engineering University of South ChinaHengyang 421001China

Visible light-induced organic reactions have gained much attention in recent years due to their mild conditions and high efficiency[1,2].In this context,many efficient photocatalysts including transition metal complex... 详细信息

关键词： bismuth catalyzed gained

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Shiqi herbal tea reduces the susceptibility to H1N1 influenza virus in stressed mice

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TMR Modern herbal Medicine 2021年第1期4卷 44-52页

作者： Guo Xie Zhuo Luo Lu-Ping Tang Li-Hang Zhang Li-Hua Peng Ling Jin Hiroshi Kurihara Jin-Le Cheng Yi-Fang Li rong-rong he Zhongshan Institute University of Electronic Science and Technology of ChinaZhongshan 528402GuangdongChina International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education(MOE) College of PharmacyJinan UniversityGuangdongChina Key Laboratory of Technology and Application of Ultrafine Granulated Powder of Traditional Chinese Medicine State Administration of Traditional Chinese Medicine of the People's Republic of ChinaZhongshan 528437GuangdongChina Guangdong Province Research and Development Center for Chinese Medicine in Disease Susceptibility College of PharmacyJinan UniversityGuangdongChina Department of Traditional Chinese Medicine The First Affiliated HospitalJinan UniversityGuangdongChina

Objective:It is well known that stress plays a critical role in immune response and susceptibility to diseases.Among many stressors,restraint stress has been shown to suppress immune function and increase susceptibility to infections.In this study,we employed a restraint-mouse model to investigate the effect and preliminary mechanism of ShiQi herbal tea(SQHT),a traditional Chinese medicine,on H1N1 virus infection.Methods:Mice were exposed to restraint stress and infected with H1N1 influenza virus by intranasal inoculation.SQHT(936 and 1872 mg/kg/d)was orally administrated to mice for 7 days from the first day of restraint stress.The survival rate of mice in each group was monitored daily for 21 days.Histopathological changes,inflammatory cells infiltration,and virus titer in lungs were examined.For the study of mechanisms,we investigated whether SQHT could promote interferon-β(IFN-β)generation and interferon stimulated genes(ISG)expression.Results:Our results suggested that SQHT(936 mg/kg/d)significantly reduced H1N1-induced mortality,the level of complement C5a and lung tissue inflammation,and viral replication in restraint-stressed mice.Further results revealed that in restraint-stressed mice model,SQHT(936 mg/kg/d)administration markedly improved IFN-βgeneration,and increased MX1 and IFITM3 gene expression.Conclusion:Our study demonstrates that SQHT reduces restraint stress-induced susceptibility to H1N1 infection via improving IFN-βantiviral pathway,which provides a certain basis for the clinical use of SQHT to treat H1N1 infection.

关键词： ShiQi herbal tea Restraint stress H1N1 virus C5a Interferon-β Susceptibility

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Two-photon polymerization-based 4D printing and its applications

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International Journal of Extreme Manufacturing 2024年第1期6卷 1-25页

作者： Bingcong Jian Honggeng Li Xiangnan he rong Wang Hui Ying Yang Qi Ge Shenzhen Key Laboratory of Soft Mechanics&Smart Manufacturing Southern University of Science and TechnologyShenzhen 518055People’s Republic of China Department of Mechanical and Energy Engineering Southern University of Science and TechnologyShenzhen 518055People’s Republic of China Pillar of Engineering Product Development Singapore University of Technology and Design8 Somapah RoadSingapore 487372Singapore

Two-photon polymerization(TPP)is a cutting-edge micro/nanoscale three-dimensional(3D)printing technology based on the principle of two-photon absorption.TPP surpasses the diffraction limit in achieving feature sizes and excels in fabricating intricate 3D micro/nanostructures with exceptional resolution.The concept of 4D entails the fabrication of structures utilizing smart materials capable of undergoing shape,property,or functional changes in response to external stimuli over time.The integration of TPP and 4D printing introduces the possibility of producing responsive structures with micro/nanoscale accuracy,thereby enhancing the capabilities and potential applications of both technologies.This paper comprehensively reviews TPP-based 4D printing technology and its diverse applications.First,the working principles of TPP and its recent advancements are introduced.Second,the optional4D printing materials suitable for fabrication with TPP are discussed.Finally,this review paper highlights several noteworthy applications of TPP-based 4D printing,including domains such as biomedical microrobots,bioinspired microactuators,autonomous mobile microrobots,transformable devices and robots,as well as anti-counterfeiting microdevices.In conclusion,this paper provides valuable insights into the current status and future prospects of TPP-based4D printing technology,thereby serving as a guide for researchers and practitioners.

关键词： two-photonpolymerization 4D printing nano/micro fabrication microrobot

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Transcriptional regulation in the development and dysfunction of neocortical projection neurons

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Neural Regeneration Research 2024年第2期19卷 246-254页

作者： Ningxin Wang rong Wan Ke Tang Precise Genome Engineering Center School of Life SciencesGuangzhou UniversityGuangzhouGuangdong ProvinceChina

Glutamatergic projection neurons generate sophisticated excitatory circuits to integrate and transmit information among different cortical areas,and between the neocortex and other regions of the brain and spinal cord.Appropriate development of cortical projection neurons is regulated by certain essential events such as neural fate determination,proliferation,specification,differentiation,migration,survival,axonogenesis,and synaptogenesis.These processes are precisely regulated in a tempo-spatial manner by intrinsic factors,extrinsic signals,and neural activities.The generation of correct subtypes and precise connections of projection neurons is imperative not only to support the basic cortical functions(such as sensory information integration,motor coordination,and cognition)but also to prevent the onset and progression of neurodevelopmental disorders(such as intellectual disability,autism spectrum disorders,anxiety,and depression).This review mainly focuses on the recent progress of transcriptional regulations on the development and diversity of neocortical projection neurons and the clinical relevance of the failure of transcriptional modulations.

关键词： autism spectrum disorders cognition differentiation excitatory circuits intellectual disability neocortex neurodevelopmental disorders projection neuron specification transcriptional regulation

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