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Facile Adjusting for Cells of Lightweight Isocyanate-based Polyimide Foam and Operable Combination between Different Distinctive Acoustic Foams for Higher Performance

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Chinese Journal of Polymer Science 2021年第2期39卷 237-248,I0008页

作者： Xiao-He Ren Gao-Hui Sun Lei-Chao Wang rong-rong chen Jun Wang Shi-Hui Han Key Laboratory of Superlight Material and Surface Technology of Ministry of Education Harbin Engineering UniversityHarbin 150001China College of Material Science and Chemical Engineering Harbin Engineering UniversityHarbin 150001China

New ambient sound absorption material,lightweight isocyanate-based polyimide foam(IBPIF),was fabricated by operable combination between different distinctive acoustic *** structure of IBPIF was facilely and obviously adjusted by increased slurry temperature corresponding to change in distinctive acoustic ***,density of all IBPIF kept at only 12-17 kg/*** increasing slurry temperature from 0℃to 40℃,cell size and window opening rate gradually increased from 553μm to 791μm and from 6.85%to 58.46%,*** this study,IBPIF generated by slurries at 0℃(marked as PIF-2)and 40℃(marked as PIF-6)showed best and distinctive acoustic behavior in 315-800 Hz and 800-6300 Hz regions,*** acoustic behavior study of combined IBPIF prepared by stitching combination between two distinctive acoustic IBPIFs,results showed that only when PIF-6 sheet used as sound receiving surface even though with thickness of only 10 mm could the combined IBPIF possess the best acoustic level in 800-6300 Hz region as ***,acoustic behavior in 315-800 Hz region could be significantly enhanced by increasing thickness of PIF-2 and could reach or close to the best acoustic level.

关键词： Isocyanate-based polyimide foam Slurry temperature Cellular structure Distinctive acoustic Combination style

Successful treatment of refractory lung adenocarcinoma harboring a germline BRCA2 mutation with olaparib:A case report

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World Journal of Clinical Cases 2021年第25期9卷 7498-7503页

作者： Li Zhang Jing Wang Ling-Zhi Cui Kai Wang Ming-Ming Yuan rong-rong chen Li-Jiao Zhang Department of Cadre Health Shanxi Provincial Cancer HospitalTaiyuan 030013Shanxi ProvinceChina Department of Medicine Geneplus-BeijingBeijing 102206China

BACKGROUND In recent years,targeted therapy and immunotherapy have become important treatment strategies for patients with non-small cell lung cancer(NSCLC).However,the clinical evidence for successful off-label use of targeted drugs for patients with NSCLC following progression on multiple lines of treatment is still *** SUMMARY We describe a 62-year-old male patient with a right lung adenocarcinoma who harbored an EGFR exon 19 deletion *** received gefitinib combined with six cycles of vinorelbine,cisplatin,and recombinant human endostatin as the first-line *** gefitinib was administered in combination with recombinant human endostatin as maintenance therapy,resulting in a progression-free survival(PFS)of 14 *** was added following progression(enlarged brain metastases)on maintenance ***,the brain lesions were highly refractory and progressed again after 15 mo,at which time next-generation sequencing(NGS)of 1021 cancer-related genes was performed using peripheral blood to identify potential actionable *** revealed that the patient harbored a BRCA2 germline mutation,the EGFR exon 19 deletion mutation disappeared,and no additional targetable genetic variant was ***,the patient received olaparib combined with gefitinib and recombinant human endostatin,with a rapid and long-lasting clinical response(PFS=13.5 mo).CONCLUSION This is a rare case of lung adenocarcinoma in a patient with a BRCA2 germline mutation who had long-term benefit from olaparib combination treatment,suggesting that NGS-based genetic testing may render the possibility of long-term survival in NSCLC patients after disease progression.

关键词： Non-small cell lung cancer Next-generation sequencing BRCA2 gene Poly(adenosine diphosphate-ribose)polymerase inhibitor Case report

Quadriceps strength assessed by magnetic stimulation of femoral nerve in patients with chronic obstructive pulmonary disease

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Chinese Medical Journal 2011年第15期124卷 2309-2315页

作者： JU Chun-rong chen rong-chang State Key Laboratory of Respiratory Disease Guangzhou Institute of Respiratory Disease First Affiliated Hospital of Guangzhou Medical College Guangzhou Guangdong 510012 China

Background Skeletal muscle dysfunction is one of important systemic manifestations of chronic obstructive pulmonary disease （COPD） and is associated with mortality in patients with COPD, thus quantifying its strength is of great clinical interest and of particular value. Quadriceps maximal volitional contraction （MVC） is often used for the routine measurements of this muscle＇s strength; while twitch tension （TwQ） evoked by magnetic stimulation of the femoral nerve has been employed for measurement of quadriceps strength non-volitionally. We aimed to investigate the prevalence and severity of skeletal muscle dysfunction in COPD patients by measurement of quadriceps strength with volitional and non-volitional techniques, and to probe into some methodological issues. Methods We recruited 71 COPD patients and 60 control subjects. Quadriceps strength was measured with both maximality of TwQ and MVC force. The reproducibility for TwQ and MVC was investigated using within-occasion variability from three repeated maneuvers. Results Maximal TwQ was achieved in 121 participants at a mean of 90% of the stimulator＇s maximum output. The mean maxmality of TwQ was decrease by about 44%-47% in COPD patients as compared with controls （P 〈0.05）, so was MVC. There was a significant correlation between quadriceps TwQ and MVC, and the mean ratio of TwQ/MVC was 0.29 in controls and 0.33 in patients. The coefficient of variation showed that TwQ yielded lower within-occasion variability than MVC in both groups. Conclusions Quadriceps strength is commonly and substantially impaired in patients with COPD, in terms of MVC as well as TwQ. The magnetic stimulation of the femoral nerve presents a higher reproducibility and is a better technique for measurement of quadriceps strength for the general population, especially for those who are too unwell to perform a full MVC; while it may not be applied to subjects who are over-weighted.

关键词： chronic obstructive pulmonary disease magnetic stimulation quadriceps twitch tension maximal volitional contraction

Reversal of idiopathic hypogonadotropic hypogonadism： a cohort study in Chinese patients

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Asian Journal of Andrology 2015年第3期17卷 497-502页

作者： Jiang-Feng Mao Hong-Li Xu Jin Duan rong-rong chen Li Li Bin Li Min Nie Le Min Hong-Bing Zhang Xue-Yan Wu Department of Endocrinology Peking Union Medical College Hospital Key Laboratory of Endocrinology Ministry of Health Beijing 100730 China Department of Physiology State Key Laboratory of Medical Molecular Biology Institute of Basic Medical Sciences and School of Basic Medicine Peking Union Medical College and Chinese Academy of Medical Sciences Beijing 100005 China Beijing Genomics Institute at Shenzhen Shenzhen 518083 China Division of Endocrinology Diabetes and Hypertension Brigham and Women's Hospital Harvard Medical School Boston MA 02115 USA

Although idiopathic hypogonadotropic hypogonadism （IHH） has traditionally been viewed as a life-long disease caused by a deficiency of gonadotropin-releasing hormone neurons, a portion of patients may gradually regain normal reproductive axis function during hormonal replacement therapy. The predictive factors for potential IHH reversal are largely unknown. The aim of our study was to investigate the incidence and clinical features of IHH male patients who had reversed reproductive axis function. In this retrospective cohort study, male IHH patients were classified into a reversal group （n = 18） and a nonreversal group （n = 336）. Concentration of gonadotropins and testosterone, as well as testicle sizes and sperm counts, were determined. Of 354 IHH patients, 18 （5.1%） acquired normal reproductive function during treatment. The median age for reversal was 24 years old （range 21-34 years）. Compared with the nonreversal group, the reversible group had higher basal luteinizing hormone （LH）（1,0±0.7 IU 1-1 vs 0.4±0.4 IU 1-1, P 〈 0.05） and stimulated LH （28.3 ± 22.6 IU 1-1 vs 1.9 ±1.1 IU 1-1, P 〈 0.01） levels, as well as larger testicle size （5.1 ±2.6 ml vs 1.5± 0.3 ml, P〈 0.01）, at the initial visit. In summary, larger testicle size and higher stimulated LH concentrations are favorite parameters for reversal. Our finding suggests that reversible patients may retain partially active reproductive axis function at initial diagnosis.

关键词： hypothalamic-pituitary-gonadal axis idiopathic hypogonadotropic hypogonadism reversal

Motion-Sensing Based Management System for Smart Context-Awareness Rehabilitation Healthcare

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Advances in Internet of Things 2013年第2期3卷 1-7页

作者： Tung-Hung Lu Hsing-chen Lin rong-rong chen Ya-Ling chen Service Systems Technology Center Industrial Technology Research Institute Hsinchu Taiwan

In this paper, a motion-sensing based management system for smart context-awareness rehabilitation healthcare including various balance exercise is built by the integration of the physiological sensing and feedback coaching. The home-end system can not only provide the exercise coaching instruction, the balance stability analysis, and the motion similarity analysis in real-time, but also simultaneously transmit the user image, exercise skeleton streaming, center of pressure (COP), center of gravity (COG) and physiological information to the telecare-end center. According to the combination of the home-end and the telecare-end as well as the real-time care management of one-to-multiple personal balance exercise monitor, this system can provide user various personalized balance exercise prescription and cardiac rehabilitation coaching in an effectiveness rehabilitation exercise environment. Therefore, via this tele-system, the spinocerebellar ataxia (SCA) patients in balance rehabilitation stage not only can be monitored execution status of the rehabilitation exercise prescription, but also can be long-term monitored and evaluated the predicted goal of the rehabilitation exercise balance stability in order to improve patient’s compliance.

关键词： Motion-sensing Rehabilitation Exercise System Care Service Platform Balance Rehabilitation

Synchronous diagnosis and treatment of acute myeloid leukemia and chronic lymphocytic leukemia:Two case reports

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World Journal of Clinical Cases 2021年第30期9卷 9144-9150页

作者： rong-rong chen Li-Xia Zhu Lu-Lu Wang Xue-Ying Li Jia-Nai Sun Mi-Xue Xie Jing-Jing Zhu De Zhou Jian-Hu Li Xin Huang Wan-Zhuo Xie Xiu-Jin Ye Department of Hematology The First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310003Zhejiang ProvinceChina

BACKGROUND The concurrence of acute myeloid leukemia(AML)and chronic lymphocytic leukemia(CLL)is *** reports of such cases have focused mainly on clinical diagnosis and characteristics,so the mechanism remains unclear,and therapy options have been poorly *** SUMMARY Here,we report two cases of synchronous AML and *** cytometry revealed two distinct abnormal cell populations(myeloblasts and lymphoid cells)according to scatter ***5-positive B cell lymphoma with myeloid leukemia invasion was observed on lymph node *** regimens indicated for both AML and CLL were used in our patients,and our patients achieved complete response after ***-generation sequencing of 88 genes was *** We conclude that early mutation and dysregulation at the hematopoietic stem cell stage and the accumulation of multiple rearrangements may cause the concurrence of CLL and *** treatment of infection and combination therapy aimed at the CLL component are significant in the management of patients with concurrent CLL and AML.

关键词： Acute myeloid leukemia Chronic lymphocytic leukemia B-cell lymphoma-2 inhibitors Therapy Ten-eleven translocation-2 Case report

Complete response of gallbladder cancer treated with gemcitabine and cisplatin chemotherapy combined with durvalumab:A case report and review of literature

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 226-232页

作者： Kai chen Xu Feng Yuan Shi Xin-Lin Li Zheng-rong Shi Xiang Lan Department of Hepatobiliary Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Gallbladder cancer(GBC)is the most common and aggressive subtype of biliary tract cancer(BTC)and has a poor prognosis.A newly developed regimen of gemcitabine,cisplatin,and durvalumab shows promise for the treatment of advanced ***,the efficacy of this treatment for GBC remains *** SUMMARY In this report,we present a case in which the triple-drug regimen exhibited marked effectiveness in treating locally advanced GBC,thus leading to a long-term survival benefit.A 68-year-old man was diagnosed with locally advanced GBC,which rendered him ineligible for curative *** three cycles of therapy,a partial response was *** one year of combined therapy,a clinical complete response was successfully *** maintenance therapy with durvalumab monotherapy resulted in a disease-free survival of 9 months for the *** patient experienced tolerable toxicities of reversible grade 2 nausea and *** adverse events were observed in the patient throughout the entirety of the *** The combination of gemcitabine and cisplatin chemotherapy with durvalumab was proven to be an effective treatment approach for advanced GBC,with manageable adverse *** research is warranted to substantiate the effectiveness of the combined regimen in the context of GBC.

关键词： Gallbladder cancer Chemotherapy Immunotherapy Durvalumab Complete response Case report

Serum myostatin levels and skeletal muscle wasting in chronic obstructive pulmonary disease

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Serum myostatin levels and skeletal muscle wasting in chroni...

胎儿侧脑室增宽的超声与MRI评估一致性分析

中华医学会呼吸病学年会——2011（第十二次全国呼吸病学学术会议）

作者： Chun-rong JU,rong-chang chen State Key Lab of the Respiratory Disease,First Affiliated Hospital of Guangzhou Medical College

Introduction It has been well confirmed that myostatin is a negative regulator of skeletal muscle mass and implicated in several diseases involved in muscle wasting and *** muscle wasting is an important systemic manifestation of chronic obstructive pulmonary disease (COPD),while the expression of circulating myostatin in COPD remains *** study was

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中国医学影像技术 2016年第12期32卷 1817-1821页

作者：容蓉陈倩王霄英陈俊雅叶锦棠北京大学第一医院医学影像科北京100034 北京大学第一医院妇产科北京100034

目的评价超声和MRI测量胎儿侧脑室宽度和诊断侧脑室增宽的一致性。方法回顾性分析200胎胎儿头颅轴位声像图和冠状位MRI测量的双侧侧脑室宽度,评价两种检查方法测量的一致性[采用组内相关系数(ICC)]和诊断侧脑室增宽的一致性(采用κ系数)... 详细信息

目的评价超声和MRI测量胎儿侧脑室宽度和诊断侧脑室增宽的一致性。方法回顾性分析200胎胎儿头颅轴位声像图和冠状位MRI测量的双侧侧脑室宽度,评价两种检查方法测量的一致性[采用组内相关系数(ICC)]和诊断侧脑室增宽的一致性(采用κ系数),评价不同MRI医师间测量侧脑室宽度的一致性(采用ICC)。结果超声和MRI测量侧脑室1(宽度较宽的侧脑室)、侧脑室2(宽度较窄的侧脑室)宽度的一致性很好(ICC=0.98、0.96),超声和MRI诊断侧脑室增宽的一致性很好(κ>0.8)。2名MRI医师测量侧脑室1、侧脑室2宽度的一致性很好(ICC=0.999、0.997)。结论超声与MRI测量侧脑室宽度和诊断侧脑室增宽具有很好的一致性。

关键词：胎儿侧脑室增宽超声检查磁共振成像一致性