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Impact of nodular size on the predictive value of gray-scale,color-Doppler ultrasound and sonoelastography for assessment of thyroid nodules

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Impact of nodular size on the predictive value of gray-scale...

Inhibiting ceramide synthase 5 expression in microglia decreases neuroinflammation after spinal cord injury

2011年浙江省超声医学学术年会

作者： Department of ultrasound,Second Affiliated Hospital,Zhejiang University College of Medicine Yu-rong Hong Xue-ming liu Zhi-Yan Luo Ning-Bo Wu

Objective To define the role of gray-scale,color Doppler ultrasound and sonoelastography for the assessment of thyroid nodules to evaluate whether nodule size affects the differential diagnosis of benign and malignant. Methods A total of 243 consecutive patients(214 women,29 men) with 329 thyroid nodules were examined by gray-scale,color-Doppler ultrasound and sonoelastography in this prospective *** patients

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Neural Regeneration Research 2025年第10期20卷 2955-2968页

作者： Wei Zhang Yubao Lu Ruoqi Shen Yingjie Wu Chenrui liu Xingxing Fang Liangming Zhang Bin liu Limin rong Department of Spine Surgery The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina National Medical Products Administration(NMPA)Key Laboratory for Quality Research and Evaluation of Cell Products GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Quality Control of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Engineering and Technology Research of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina

Microglia,the resident monocyte of the central nervous system,play a crucial role in the response to spinal cord ***,the precise mechanism remains *** investigate the molecular mechanisms by which microglia regulate the neuroinflammatory response to spinal cord injury,we performed single-cell RNA sequencing dataset analysis,focusing on changes in microglial *** found that the MG1 subpopulation emerged in the acute/subacute phase of spinal cord injury and expressed genes related to cell pyroptosis,sphingomyelin metabolism,and neuroinflammation at high ***,we established a mouse model of contusive injury and performed intrathecal injection of siRNA and molecular inhibitors to validate the role of ceramide synthase 5 in the neuroinflammatory responses and pyroptosis after spinal cord ***,we established a PC12-BV2 cell co-culture system and found that ceramide synthase 5 and pyroptosis-associated proteins were highly expressed to induce the apoptosis of neuron *** ceramide synthase 5 expression in a mouse model of spinal cord injury effectively reduced ***,ceramide synthase 5-induced pyroptosis was dependent on activation of the NLRP3 signaling *** ceramide synthase 5 expression in microglia in vivo reduced neuronal apoptosis and promoted recovery of neurological ***2g7 formed a“bridge”between sphingolipid metabolism and ceramide synthase 5-mediated cell death by inhibiting the NLRP3 signaling ***,these findings suggest that inhibiting ceramide synthase 5 expression in microglia after spinal cord injury effectively suppressed microglial pyroptosis mediated by NLRP3,thereby exerting neuroprotective effects.

关键词： ceramide synthase 5 gasdermin D microglia neuroinflammation NLRP3 nuclear factor kappa B Pla2g7 pyroptosis sphingomyelin metabolism spinal cord injury

Investigation of bubbles escape behavior from low basicity mold flux for high-Mn high-Al steels using 3D X-ray microscope

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 102-110页

作者： Qiang liu Xiang Li Shen Du ming Gao Yanbin Yin Jiongming Zhang State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

During the continuous casting process of high-Mn high-Al steels,various types of gases such as Ar need to escape through the top of the *** which,the behavior of bubbles traversing the liquid slag serves as a restrictive link,closely associated with viscosity and the thickness of liquid *** contrast to two-dimensional surface observation,three-dimensional(3D)analysis method can offer a more intuitive,accurate,and comprehensive ***,this study employs a 3D X-ray microscope(3D-XRM)to obtained spatial distribution and 3D morphological characteristics of residual bubbles in mold flux under different basicity of liquid slag,different temperatures,and different holding *** results indicate that as basicity of slag increases from 0.52 to 1.03,temperature increases from 1423 to 1573 K,the viscosity of slag decreases,the floating rate of bubbles *** addition,when holding time increases from 10 to 30 s,the bubbles floating distance increases,and the volume fraction and average equivalent sphere diameter of the bubbles solidified in the mold flux gradually *** one word,increasing the basicity,temperature,and holding time leading to an increase in the removal rate of bubbles especially for the *** findings of bubbles escape behavior provide valuable insights into optimizing low basicity mold flux for high-Mn high-Al steels.

关键词： mold flux low basicity bubbles three-dimensional X-ray microscope viscosity

基于进化信息改进蛋白质定点突变稳定性预测准确率

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生物物理学报 2009年第5期25卷 343-348页

作者：刘建国刘建荣刘明闫蓬勃河北大学生命科学学院生物信息实验室河北保定071002

定点突变后蛋白质稳定性的增加还是降低,是分子生物学和蛋白质工程的核心问题之一,也是目前生物信息学研究的重要领域。基于蛋白质序列信息对蛋白质定点突变后的稳定性进行预测的方法,因其简易、适用面广而得到广泛的研究应用。通过对... 详细信息

定点突变后蛋白质稳定性的增加还是降低,是分子生物学和蛋白质工程的核心问题之一,也是目前生物信息学研究的重要领域。基于蛋白质序列信息对蛋白质定点突变后的稳定性进行预测的方法,因其简易、适用面广而得到广泛的研究应用。通过对编码策略(coding schemes)的探索,发现不同编码策略对预测准确率有较大影响,并发现基于进化信息的BLOSUM打分矩阵可以用于蛋白质定点突变稳定性预测,具有较高的预测准确率。应用基于BLOSUM62打分矩阵的神经网络(ANN)和支持向量机(SVM)算法,可以改进蛋白质定点突变后稳定性的预测,而且ANN+BLOSUM62在1623条序列的数据集上的实测结果优于目前国际通用的几款预测软件。

关键词：定点突变编码策略稳定性预测神经网络 SVM

Real-time ultrasound elastography:its potential role in assessment of thyroid microcarcinoma

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Real-time ultrasound elastography:its potential role in asse...

Determination of Renin-Angiotensin-Aldosterone System in Different Stages of Hemorrhagic Fever with Renal Syndrome and Its Clinical Significance

第二届长三角超声医学论坛暨2009年浙江省超声医学学术年会

作者： Departement of Ultrasound,The Second Affiliated Hospital,Zhejiang University College of Medicine Hangzhou 310009,China Yu-rong HONG Xue-ming liu Zhi-yan LUO Mei-feng CHEN Zhi-yu LI

Purpose To investigate the ultrasound elastographic finding of thyroid benign and malignant nodules measuring≤10 mm. Materials and Methods A total of 127 consecutive patients with thyroid nodules who were referred to surgical treatment were examined in this prospective *** hundred ninty-three nodules in these patients

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中国人民解放军军医大学学报(英文版) 1987年第2期 173-177页

作者：杨开祺阎荣刘明陈名声 Central Lab.Fourth Military Medical College Xi’an Central Lab.Fourth Military Medical College Xi’an

Serum renin-angiotensin-aldosterone(RAA)levels were determined on169 occations in 96 cases of hemorrhagic fever with renal syndrome(HFRS).Theresults reveal that RAA system levels rise in vaviable degrees in different stages ofHFRS,the highest value being in the hypotensive and oliguric stages and thenormal value,in the polyuric and convalescent *** elevation range iscorrelated with the severity of the *** closely related to the decrease ofblood volume before the bypotensive stage and to the“tubuloglomerular feedback”mechanism after the oliguric stage,the activation of RAA system may be one ofthe contributing factors of the acute renal failure in HFRS.

关键词： hemorrhagic fever with renal syndrome plasma renin activity angiotensin Ⅱ aldosterone acute renal failure

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土工格栅与膨胀土界面摩擦阻力系数试验研究

同济大学学报（自然科学版） 2004年第2期32卷 172-176页

作者：徐林荣凌建明刘宝琛中南大学铁道校区土木建筑学院湖南长沙410075 同济大学道路与交通工程教育部重点实验室上海200092

为满足土工合成材料在道路工程应用中的技术要求,开展了合理选取土工格栅与膨胀土界面摩擦阻力系数的研究.以正交设计原理为指导,选取筋土界面参数的4个影响因素(上覆压力、膨胀土体含水量、土工格栅尺寸和拉拔速度),进行了筋土界面摩... 详细信息

为满足土工合成材料在道路工程应用中的技术要求,开展了合理选取土工格栅与膨胀土界面摩擦阻力系数的研究.以正交设计原理为指导,选取筋土界面参数的4个影响因素(上覆压力、膨胀土体含水量、土工格栅尺寸和拉拔速度),进行了筋土界面摩擦阻力系数测试的拉拔试验.通过分析筋土界面各参数的影响因素,提出了当量拉拔位移的概念和筋土界面参数拉拔试验测试结果的过程分析方法,获取了各影响因素对摩擦阻力系数的影响程度及其在拉拔试验过程中的变化规律,并提出了拉拔试验的测试要求、步骤和结束标准.

关键词：拉拔试验筋土界面参数影响因素当量拉拔位移过程分析

Enhancement of motor functional recovery in thoracic spinal cord injury: voluntary wheel running versus forced treadmill exercise

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Neural Regeneration Research 2025年第3期20卷 836-844页

作者： Do-Hun Lee Dan Cao Younghye Moon Chen Chen Nai-Kui liu Xiao-ming Xu Wei Wu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteIndiana University School of MedicineIndianapolisINUSA Department of Neurological Surgery Indiana University School of MedicineIndianapolisINUSA Department of Neuroscience Baylor College of MedicineHoustonTXUSA

Spinal cord injury necessitates effective rehabilitation strategies, with exercise therapies showing promise in promoting recovery. This study investigated the impact of rehabilitation exercise on functional recovery and morphological changes following thoracic contusive spinal cord injury. After a 7-day recovery period after spinal cord injury, mice were assigned to either a trained group(10 weeks of voluntary running wheel or forced treadmill exercise) or an untrained group. Bi-weekly assessments revealed that the exercise-trained group, particularly the voluntary wheel exercise subgroup, displayed significantly improved locomotor recovery, more plasticity of dopaminergic and serotonin modulation compared with the untrained group. Additionally, exercise interventions led to gait pattern restoration and enhanced transcranial magnetic motor-evoked potentials. Despite consistent injury areas across groups, exercise training promoted terminal innervation of descending axons. In summary, voluntary wheel exercise shows promise for enhancing outcomes after thoracic contusive spinal cord injury, emphasizing the role of exercise modality in promoting recovery and morphological changes in spinal cord injuries. Our findings will influence future strategies for rehabilitation exercises, restoring functional movement after spinal cord injury.

关键词： behavioral assessment motor function neural plasticity running wheel exercise spinal cord injury treadmill exercise voluntary exercise

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锦氨棉无缝弹力针织内衣的染色工艺

染整技术 2003年第5期25卷 19-22页

作者：刘明荣张昌桂扬州华源彩虹针织有限公司江苏扬州225001 扬州印染厂江苏扬州225003

介绍了无缝内衣的染色工艺路线、染色方法、操作注意事项,并对该织物染色中的工艺难点作了研究分析,提出了解决问题的方法。

关键词：锦纶氨纶棉纤维弹力针织内衣染色工艺染色设备