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Levodopa methyl ester increases nerve growth factor expression in visual cortex area 17 in a feline model of strabismic amblyopia

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Neural Regeneration Research 2011年第26期6卷 2026-2031页

作者： Yongwen li Xing lin Shijun Zhang rong li Weizhe jiang Renbin Huang Department of Pharmacology Guangxi Medical University Nanning 530021 Guangxi Zhuang Autonomous Region China

In the present study, a feline model of strabismic amblyopia was established during a sensitive developmental period, and the influence of levodopa methyl ester and levodopa on nerve growth factor expression in the visual cortex （area 17） was compared. Pattern visual-evoked potential and immunohistochemistry results showed that levodopa methyl ester and levodopa treatment shortened P10o wave latency, increased Pleo amplitude, and increased the number of endogenous nerve growth factor-positive cells in visual cortex levels. In particular, the effects of levodopa methyl ester were superior to levodopa treatment.

关键词： levodopa methyl ester nerve growth factor strabismic amblyopia visual cortex neural regeneration

Influence of Helicobacter pylori infection on ghrelin levels in children

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World Journal of Gastroenterology 2012年第36期18卷 5096-5100页

作者： Zhao-Hui Deng Bo Chu Ya-Zhen Xu Bin Zhang li-rong jiang Department of Pediatrics Shanghai Children's Medi-cal CenterShanghai Jiaotong University School of MedicineShanghai 200127China

AIM:To compare ghrelin levels in plasma and gastric mucosa before and after Helicobacter pylori(***) treatment in children with ***-associated functional ***:Children with ***-associated functional dyspepsia were enrolled in this *** infection was confirmed by positive bacterial culture *** of the children received triple *** eradication therapy(a 2 wk course of omeprazole,amoxicillin,and clarithromycin).The children were divided into two groups based on the success of the *** treatment:group 1(eradicated)-patients who had a negative 13C-urea breath test 2 mo after the end of therapy;and group 2(non-eradicated)-patients who had a positive 13C-urea breath *** ghrelin,gastric ghrelin mRNA,and the body mass index were evaluated in both groups before and after the *** *** plasma ghrelin levels were measured by a *** expression of gastric ghrelin mRNA was determined by real-time reverse transcription polymerase chain ***:A total of 50 children with ***-associated functional dyspepsia were treated with triple *** eradication *** mean age of the children was 5.52 ± 0.83 years,and there were 28 males and 22 *** the 50 ***-positive children,30 successfully achieved eradication,and 20 did *** mean plasma ghrelin levels of group 1 were 22.17 ± 1.73 ng/L and 26.59 ± 2.05 ng/L before and after the treatment,respectively,which was a significant increase(P = 0.001).However,the mean plasma ghrelin level of group 2 before and after the *** treatment was 21.34 ± 2.40 ng/L and 22.24 ± 2.10 ng/L(P = 0.785).The plasma ghrelin levels increased substantially after treatment in group 1 but showed only minor changes in group ***,the gastric ghrelin mRNA expression in group 1 before treatment was 2.84 ± *** treatment,the level was 3.11 ± 0.65,which was significantly different(P = 0.023).The gastric ghrelin mRNA expression in g

关键词： Helicobacter pylori Functional dyspepsia Ghrelin Eradication Children

Genetic Diversity of Recurrent Selection Populations with Ms2 Gene Assessed by Gliadins in Common Wheat (Triticum aestivum L.)

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Agricultural Sciences in China 2010年第5期9卷 615-625页

作者： jiang Hui, GAO Qing-rong, li Luo-jiang, KONG ling-rang, ZHANG Wei-dong, WU Shi-wen and YANG Ya-li State Key Laboratory of Crop Biology, Department of Agronomy, Shandong Agricultural University, Tai’an 271018, P.R.China State Key Laboratory of Crop Biology Department of Agronomy Shandong Agricultural University Tai'an 271018 P.R.China

The male-sterile lines with Ms2 gene were highly evaluated in recurrent selection in wheat （Triticum aestivum L.）. Three populations C6 （population after six cycles of selection）, C7 （population after seven cycles of selection）, and C8 （population after eight cycles of selection） were constructed through recurrent selection with 12 parental materials （P）. Acid polyacrymide gel electrophoresis （A-PAGE） analysis was used to identify gliadin patterns and evaluate the genetic diversity in 12 parents and three populations. A total of 63 bands were identified, of which 17 polymorphic bands and 7 unique bands were present in populations and seven polymorphic bands and four unique bands were present in parents. The number of polymorphic and unique bands decreased gradually from C6 to C8, especially for to- and y-gliadins. The genetic distances in C6, C7, and C8 were calculated. The distributions of genetic distance were different in three recurrent selection populations. From C6 to C8, the genetic distance was 0.2687, 0.2652 and 0.1987, respectively. Statistically significant differences were detected between C7 and C8 with the T value of 37.9718. The result of cluster analysis based on genetic similarity matrix of three populations fitted well to those of principle coordinates analysis （PCoA）. Compared with 12 parents, almost all individuals of three populations are new genotypes. Most of the individuals from C6 and C7 could be divided into two groups, while most individuals of C8 were in one cluster. In conclusion, the results indicated that the genetic diversity was decreased severely according to the information revealed by A-PAGE, although some variations could be created in the recurrent selection. It was necessary to introduce diverse germplasm based on the genetic database of recurrent population to maintain and improve the breeding efficiency in the further program.

关键词： genetic diversity recurrent selection gliadins Ms2 gene Triticum aestivum L

Constraints on holographic QCD phase transitions from PTA observations

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 71-78页

作者： Song He li li Sai Wang Shao-jiang Wang Center for Theoretical Physics and College of Physics Jilin University School of Physical Science and Technology Ningbo University Max Planck Institute for Gravitational Physics (Albert Einstein Institute) CAS Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences (UCAS) School of Physical Sciences University of Chinese Academy of Sciences (UCAS) Theoretical Physics Division Institute of High Energy Physics Chinese Academy of Sciences

The underlying physics of QCD phase transition in the early Universe remains largely unknown due to its strong-coupling nature during the quark-gluon plasma/hadron gas transition, yet a holographic model has been proposed to quantitatively fit the lattice QCD data while with its duration of the first-order phase transition(FoPT) left undetermined. At specific baryon chemical potential, the first-order QCD phase transition agrees with the observational constraint of baryon asymmetry. It, therefore, provides a scenario for phase transition gravitational waves(GWs) within the standard model of particle physics. If these background GWs could contribute dominantly to the recently claimed common-spectrum red noise from pulsar timing array(PTA) observations, the duration of this FoPT can be well constrained, and the associated primordial black holes are still allowed by current observations.

关键词： pulsar timing array QCD phase transition gravitational waves primordial black holes

Effect of lamellarization on the microstructure and mechanical properties of marine 10Ni5CrMoV steel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 402-413页

作者： Tao Zou Yanwu Dong Zhouhua jiang Shuyang Du Yushuo li School of Metallurgy Northeastern UniversityShenyang 110819China Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819China Key Laboratory for Ecological Metallurgy of Multimetallic Ores(Ministry of Education) Northeastern UniversityShenyang 110819China

Multistage heat treatment involving quenching(Q),lamellarizing(L),and tempering(T)is applied to marine 10Ni5CrMoV *** microstructure and mechanical properties were studied by multiscale characterizations,and the kinetics of reverse austenite transformation,strain hardening behavior,and toughening mechanism were further *** lamellarized specimens possess low yield strength but high toughness,especially cryogenic *** leads to the development of film-like reversed austenite at the martensite block and lath boundaries,refining the martensite structure and lowering the equivalent grain *** analysis of austenite reversion based on the JMAK model shows that the isothermal transformation is dominated by the growth of reversed austenite,and the maximum transformation of reversed austenite is reached at the peak temperature(750℃).The strain hardening behavior based on the modified Crussard-Jaoul analysis indicates that the reversed austenite obtained from lamellarization reduces the proportion of martensite,significantly hindering crack propagation via martensitic transformation during the *** a consequence,the QLT specimens exhibit high machinability and low yield *** with the QT specimen,the ductile-brittle transition temperature of the QLT specimens decreases from-116 to-130℃due to the low equivalent grain size and reversed austenite,which increases the cleavage force required for crack propagation and absorbs the energy of external load,*** work provides an idea to improve the cryogenic toughness of marine 10Ni5CrMoV steel and lays a theoretical foundation for its industrial application and comprehensive performance improvement.

关键词： 10Ni5CrMoV steel lamellarizing reversed austenite cryogenic toughness ductile-brittle transition temperature

Microstructural evolution during the progressive transformation-induced plasticity effect in a Fe-0.1C-5Mnmedium manganese steel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 369-379页

作者： Mei Zhang Wenhao li Yangfei Chen Yang jiang Xiaofei Guo Han Dong School of Materials Science and Engineering Shanghai UniversityShanghai 200444China State Key Laboratory of Advanced Special Steel Shanghai UniversityShanghai 200444China

The microstructural evolution of a cold-rolled and intercritical annealed medium-Mn steel(Fe-0.10C-5Mn)was investigated during uniaxial tensile ***-situ observations under scanning electron microscopy,transmission electron microscopy,and X-ray diffraction analysis were conducted to characterize the progressive transformation-induced plasticity process and associated fracture initiation *** findings were discussed with the local strain measurements via digital image *** results indicated that Lüders band formation in the steel was limited to 1.5%strain,which was mainly due to the early-stage martensitic phase transformation of a very small amount of the less stable large-sized retained austenite(RA),which led to localized stress concentrations and strain hardening and further retardation of *** small-sized RA exhibited high stability and progressively transformed into martensite and contributed to a stably extended Portevin-Le Chatelier *** volume fraction of RA gradually decreased from 26.8%to 8.2%prior to *** the late deformation stage,fracture initiation primarily occurred at the austenite/martensite and ferrite/martensite interfaces and the ferrite phase.

关键词： medium-Mn steel retained austenite progressive transformation-induced plasticity effect local strain fracture initiation

MOOCs:新建本科院校辅导员素质提升的新途径

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教育理论与实践 2017年第30期37卷 38-39页

作者：李荣江成永红山西医科大学汾阳学院山西汾阳032200

MOOCs是数字化时代的在线教育新技术,可不受时空和地域限制,为学员在线提供中外免费优质教育资源。新建本科院校由于软硬件所限以及长期的专科管理运行模式,影响了其辅导员素质的提升,不能满足升本后大学生健康成长和学校持续发展的需... 详细信息

MOOCs是数字化时代的在线教育新技术,可不受时空和地域限制,为学员在线提供中外免费优质教育资源。新建本科院校由于软硬件所限以及长期的专科管理运行模式,影响了其辅导员素质的提升,不能满足升本后大学生健康成长和学校持续发展的需要。新建本科院校可充分利用MOOCs在线免费优质教育,借助MOOCs技术平台,加强辅导员队伍建设。

关键词： MOOCs 新建本科院校辅导员素质

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UV使用适用性三元状态指标体系构建方法

船海工程 2017年第A2期46卷 289-292页

作者：李荣修江莲王鑫 92001部队山东青岛266003 92337部队辽宁大连116023

针对水下航行器使用适用性试验验收中存在的指标体系综合集成和动态量化难点问题，提出基于统计模式识别的三元状态指标体系构建方法，将性能稳定性、功能随动性、故障鲁棒性三类动态性指标通过组内约简、组间聚合处理，集成为综合性指... 详细信息

针对水下航行器使用适用性试验验收中存在的指标体系综合集成和动态量化难点问题，提出基于统计模式识别的三元状态指标体系构建方法，将性能稳定性、功能随动性、故障鲁棒性三类动态性指标通过组内约简、组间聚合处理，集成为综合性指标。采用统计模式识别方法识别出使用适用性的良好、不稳定、异常3种典型状态，以较高正确率判别出水下航行器的状态，并且在不稳定状态检出率方面表现突出，判断错误率较低。通过3组试验验证该指标体系的理论正确性及工程可行性。

关键词：水下航行器使用适用性指标体系统计模式识别

响应面法优化微波辅助ESR-5树脂固定化胰蛋白酶

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食品工业科技 2017年第6期38卷 217-222,228页

作者：刘伟华李荣姜子涛天津商业大学生物技术与食品科学学院天津市食品生物技术重点实验室天津300134

研究了ESR-5伯氨树脂为固定化载体,微波辅助固定化胰蛋白酶的条件。通过单因素实验和响应面分析法确定了固定化胰蛋白酶的最佳条件是:微波温度35℃、加酶量1050 U、戊二醛质量分数0.53%、p H9.1,微波时间5 min,在此条件下制备的固定化... 详细信息

研究了ESR-5伯氨树脂为固定化载体,微波辅助固定化胰蛋白酶的条件。通过单因素实验和响应面分析法确定了固定化胰蛋白酶的最佳条件是:微波温度35℃、加酶量1050 U、戊二醛质量分数0.53%、p H9.1,微波时间5 min,在此条件下制备的固定化胰蛋白酶的活力为390.77 U·g^(-1)树脂。相比传统固定化方法需要几个小时,此固定化方法大大缩短了制备固定化酶的时间。制备的固定化胰蛋白酶在25~45℃的温度范围内、在p H8.5~10的碱性范围内都较稳定;重复使用11批次后,仍保留了86.7%的初始酶活力;在4℃储藏5周后仍保留了63.7%的初始酶活力,具有较好的稳定性。可见利用微波辅助固定化酶是一种值得尝试的高效方法。

关键词：胰蛋白酶固定化酶微波辅助 ESR-5伯氨树脂响应面法