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Hierarchical Porous Polymer Beads Prepared by Polymerization-induced Phase Separation and Emulsion-template in a Microfluidic Device

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Chinese Journal of Polymer Science 2014年第12期32卷 1646-1654页

作者： Wei-cai Wang Yan-xiong pan kai Shi Chao Peng 姬相玲 State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences University of Chinese Academy of Sciences

Porous polymer beads（PPBs） containing hierarchical bimodal pore structure with gigapores and meso-macropores were prepared by polymerization-induced phase separation（PIPS） and emulsion-template technique in a glass capillary microfluidic device（GCMD）. Fabrication procedure involved the preparation of water-in-oil emulsion by emulsifying aqueous solution into the monomer solution that contains porogen. The emulsion was added into the GCMD to fabricate the（water-in-oil）-in-water double emulsion droplets. The flow rate of the carrier continuous phase strongly influenced the formation mechanism and size of droplets. Formation mechanism transformed from dripping to jetting and size of droplets decreased from 550 μm to 250 μm with the increase in flow rate of the carrier continuous phase. The prepared droplets were initiated for polymerization by on-line UV-irradiation to form PPBs. The meso-macropores in these beads were generated by PIPS because of the presence of porogen and gigapores obtained from the emulsion-template. The pore morphology and pore size distribution of the PPBs were investigated extensively by scanning electron microscopy and mercury intrusion porosimetry（MIP）. New pore morphology was formed at the edge of the beads different from traditional theory because of different osmolarities between the water phase of the emulsion and the carrier continuous phase. The morphology and proportion of bimodal pore structure can be tuned by changing the kind and amount of porogen.

关键词： Porous polymer beads Hierarchical Polymerization-induced phase separation Emulsion-template Microfluidic device.

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SET8 Inhibition Potentiates Radiotherapy by Suppressing DNA Damage Repair in Carcinomas

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Biomedical and Environmental Sciences 2022年第3期35卷 194-205页

作者： pan Dong DU Ya rong LI rong SHEN Ai Hua LIU Xiao Dong LI Chuan Yuan HU Bu rong Department of Radiological Health and Radiation Medicine School of Public Health and ManagementWenzhou Medical UniversityWenzhou 325035ZhejiangChina Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences&Key laboratory of Space Radiobiology of Gansu province Institute of Modern PhysicsChinese Academy of SciencesLanzhou 730000GansuChina Department of Dermatology Duke University Medical CenterDurhamNC27710USA

Objective SET8 is a member of the SET domain-containing family and the only known lysine methyltransferase(KMT)that monomethylates lysine 20 of histone H4(H4 K20 me1).SET8 has been implicated in many essential cellular processes,including cell cycle regulation,DNA replication,DNA damage response,and *** is no conclusive evidence,however,regarding the effect of SET8 on *** the current study we determined the efficacy of SET8 inhibition on radiotherapy of tumors and the underlying *** First,we explored the radiotherapy benefit of the SET8 expression signature by analyzing clinical ***,we measured a series of biological endpoints,including the xenograft tumor growth in mice and apoptosis,frequency of micronuclei,and foci of 53 BP1 andγ-H2 AX in cells to detect the SET8 effects on *** sequencing and subsequent experiments were exploited to verify the mechanism underlying the SET8 effects on *** Low expression of SET8 predicted a better benefit to radiotherapy in lung adenocarcinoma(LUAD)and invasive breast carcinoma(BRCA)***,genetic deletion of SET8 significantly enhanced radiation treatment efficacy in a murine tumor model,and A549 and MCF7 cells;SET8 overexpression decreased the ***8 inhibition induced more apoptosis,the frequency of micronuclei,and blocked the kinetics process of DNA damage repair as 53 BP1 andγ-H2 AX foci remained in ***,RNF8 was positively correlated with the SET8 impact on DNA damage *** Our results demonstrated that SET8 inhibition enhanced radiosensitivity by suppressing DNA damage repair,thus suggesting that SET8 potentiated radiotherapy of *** new inhibitors of SET8 are synthesized and tested in preclinical and clinical settings,combining SET8 inhibitors with radiation warrants consideration for precise radiotherapy.

关键词： SET8 Histone methylation DNA repair Radiotherapy Carcinoma

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Intelligent Fast Cell Association Scheme Based on Deep Q-Learning in Ultra-Dense Cellular Networks

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China Communications 2021年第2期18卷 259-270页

作者： Jinhua pan Lusheng Wang Hai Lin Zhiheng Zha Caihong kai Key Laboratory of Knowledge Engineering with Big Data Ministry of Education.School of Computer Science and Information EngineeringHefei University of TechnologyHefei 230601China Anhui Province Key Laboratory of Industry Safety and Emergency Technology Hefei 230601China Key Laboratory of Aerospace Information Security and Trusted Computing Ministry of Education.School of Cyber Science and EngineeringWuhan UniversityWuhan 430072China

To support dramatically increased traffic loads,communication networks become *** cell association(CA)schemes are timeconsuming,forcing researchers to seek fast *** paper proposes a deep Q-learning based scheme,whose main idea is to train a deep neural network(DNN)to calculate the Q values of all the state-action pairs and the cell holding the maximum Q value is *** the training stage,the intelligent agent continuously generates samples through the trial-anderror method to train the DNN until *** the application stage,state vectors of all the users are inputted to the trained DNN to quickly obtain a satisfied CA result of a scenario with the same BS locations and user *** demonstrate that the proposed scheme provides satisfied CA results in a computational time several orders of magnitudes shorter than traditional ***,performance metrics,such as capacity and fairness,can be guaranteed.

关键词： ultra-dense cellular networks(UDCN) cell association(CA) deep Q-learning proportional fairness Q-learning

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A Decoupling-Type Strategy for the Allen-Cahn Equation on Curved Surfaces

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Journal of Mathematical Research with Applications 2025年第1期 73-83页

作者： Xiaoman XIE Qing pan School of Computer and Communication Engineering Changsha University of Science & Technology

In this paper, we construct an efficient decoupling-type strategy for solving the Allen-Cahn equation on curved surfaces. It is based on an FEM-EIEQ(Finite Element Method and explicit-Invariant Energy Quadratization) fully discrete scheme with unconditional energy stability. Spatially the FEM is adopted, using a triangular mesh discretization strategy that can be adapted to complex regions. Temporally, the EIEQ approach is considered, which not only linearizes the nonlinear potential but also gives a new variable that we combine with the nonlocal splitting method to achieve the fully decoupled computation. The strategy can successfully transform the Allen-Cahn system into some completely independent algebraic equations and linear elliptic equations with constant coefficients, we only need to solve these simple equations at each time step. Moreover, we conducted some numerical experiments to demonstrate the effectiveness of the strategy.

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Bulk CsPbCl_(x)Br_(3-x)(1≤x≤3)perovskite nanocrystals/polystyrene nanocomposites with controlled Rayleigh scattering for light guide plate

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Light(Science & Applications) 2023年第11期12卷 2468-2479页

作者： Chongming Liu Zhicheng Zhu kaibo pan Yuan Fu kai Zhang Bai Yang State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin University130012 ChangchunChina

Perovskite nanocrystals(PNCs)/polymer nanocomposites can combine the advantages of each other,but extremely few works can achieve the fabrication of PNCs/polymer nanocomposites by bulk *** originally adopt a two-type ligand strategy to fabricate bulk PNCs/polystyrene(PS)nanocomposites,including a new type of synthetic polymerizable *** CsPbCl_(3)PNCs/PS nanocomposites show extremely high transparency even the doping content up to 5 wt%.The high transparency can be ascribed to the Rayleigh scattering as the PNCs distribute uniformly without obvious *** on this behavior,we first exploit the potential of PNCs to serve as scatters inside light guided plate(LGP),whose surface illuminance and uniformity can be improved,and this new kind of LGP is compatible with the advanced liquid crystal display *** to the facile composition adjustment of CsPbCl_(x)Br_(3-x)(1≤x≤3)PNCs,the Rayleigh scattering behavior can also be adjusted so as to the performance of *** best-performing 5.0-inch LGP based on CsPbCl_(2.5)Br_(0.5)PNCs/PS nanocomposites shows 20.5 times higher illuminance and 1.8 times higher uniformity in display than the *** LGP based on PNCs/PS nanocomposite exhibits an enormous potential in commercialization no matter based on itself or combined with the LGP-related technology.

关键词： scattering plate nanocomposites

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Bullous pemphigoid associated with acquired hemophilia A: A case report

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World Journal of Clinical Cases 2025年第4期13卷 28-33页

作者： Su-Ye Hu Meng-Can Li Zi-Jia Hao Xu-Ya Chai Pei-Sai Li Yang Liu Li-Xia Liu Ying Xu pan-pan Yang Ling-E Li Department of Dermatology Shijiazhuang Traditional Chinese Medicine HospitalShijiazhuang 050051Hebei ProvinceChina Graduate School Hebei University of Traditional Chinese MedicineShijiazhuang 050051Hebei ProvinceChina Department of Pathology Shijiazhuang Traditional Chinese Medicine HospitalShijiazhuang 050051Hebei ProvinceChina

BACKGROUND Acquired hemophilia A (AHA) is a rare and potentially severe bleeding disordercaused by circulating autoantibodies against factor Ⅷ (FⅧ). In approximately50% of the patients, the condition is associated with autoimmune diseases,cancers, medication use, pregnancy, and the post-partum period. Bullous pemphigoid(BP) is a chronic autoimmune subepidermal blistering disease associatedwith tissue-bound and circulating autoantibodies against BP antigens 180 (BP180)and 230 (BP230). AHA-associated BP has a high mortality rate;hence, the understandingof this disease must *** SUMMARY A 69-year-old man presented with erythema, blisters, blood blisters, and crustsaccompanied by severe pruritus for more than 20 days, and ecchymosis andswelling on his left upper arm for 3 days. Pathological examination revealed asubepidermal blister that contained eosinophils. Laboratory tests showed that theBP180 autoantibody levels had increased, isolated activated partial thromboplastintime was notably prolonged (115.6 s), and coagulation FⅧ activity wasextremely low (< 1.0%). Furthermore, the FⅧ inhibitor titer had greatlyincreased (59.2 Bethesda units). Therefore, the patient was diagnosed as having BP associated with AHA, prescribed 0.05% topical halometasone cream, and transferred to a higher-level hospitalfor effective treatment;however, he died after 2 *** AHA associated BP is rare, dangerous, and has a high mortality rate. Therefore, its timely diagnosis and effectivetreatment are necessary.

关键词： Bullous pemphigoid Acquired hemophilia A Acquired hemophilia A FactorⅧ Case report

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Recent developments in selective laser processes for wearable devices

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Bio-Design and Manufacturing 2024年第4期7卷 517-547页

作者： Youngchan Kim Eunseung Hwang Chang kai kaichen Xu Heng pan Sukjoon Hong Optical Nanoprocessing Lab Department of Mechanical EngineeringBK21 FOUR ERICA-ACE CenterHanyang University55 Hanyangdaehak-RoSangnok-GuAnsan 15588Republic of Korea Multiscale Manufacturing Lab J.Mike Walker’66 Department of Mechanical EngineeringTexas A&M UniversityCollege StationTX 77843USA State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310058China

Recently,the increasing interest in wearable technology for personal healthcare and smart virtual/augmented reality applications has led to the development of facile fabrication *** have long been used to develop original solutions to such challenging technological problems due to their remote,sterile,rapid,and site-selective processing of *** this review,recent developments in relevant laser processes are summarized under two separate ***,transformative approaches,such as for laser-induced graphene,are *** addition to design optimization and the alteration of a native substrate,the latest advances under a transformative approach now enable more complex material compositions and multilayer device configurations through the simultaneous transformation of heterogeneous precursors,or the sequential addition of functional layers coupled with other electronic *** addition,the more conventional laser techniques,such as ablation,sintering,and synthesis,can still be used to enhance the functionality of an entire system through the expansion of applicable materials and the adoption of new ***,various wearable device components developed through the corresponding laser processes are discussed,with an emphasis on chemical/physical sensors and energy *** addition,special attention is given to applications that use multiple laser sources or processes,which lay the foundation for the all-laser fabrication of wearable devices.

关键词： Selective laser process Wearable device Transformative approach Laser-induced graphene Ablation Sintering Synthesis

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One-step synthesis of hollow PEI-NaBiF4:Yb^3+/Er^3+upconversion nanoparticles for water-responsive luminescent probe

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Journal of Rare Earths 2020年第4期38卷 362-368页

作者： Zaifa pan Yingting Wen Tao Wang kai Wang Yuanjie Teng Kang Shao College of Chemical Engineering Zhejiang University of TechnologyHangzhou 310000China

Novel PEI-modified NaBiF4:Yb3+/Er3+upconversion nanoparticles(UCNPs)with hollow structure were prepared by a surface modification free one-step solvothermal method and applied as a luminescent probe to determinate water content in organic ***,SEM and HRTEM results demonstrate that the obtained PEI-NaBiF4:Yb3+/Er3+UCNPs are pure hexagonal phase with uniform *** successful modification of PEI on the UCNPs surface was evidenced byζ-potential test,XPS and TG *** synthesized UCNPs are disintegrated into smaller nanoparticles in the presence of water and thus result in a surface quenching effect,which show the features of 0-100%wide range water response in various organic *** sensing performance towards real samples was validated by the water content determination in beer,rum and white ***,the luminescence intensity variation of the PEI-modified NaBiF4:Yb3+/Er3+enable the test visualization and ease of portability.

关键词： Luminescent probe Upconversion nanoparticles Water detection Organic solvents Rare earths

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Multi-layer quasi-zero-stiffness meta-structure for high-efficiency vibration isolation at low frequency

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Applied Mathematics and Mechanics(English Edition) 2024年第7期45卷 1189-1208页

作者： Jiahao ZHOU Jiaxi ZHOU Hongbin pan kai WANG Changqi CAI Guilin WEN College of Mechanical and Vehicle Engineering Hunan UniversityChangsha410082China State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body The Ministry of Science and TechnologyChangsha410082China School of Mechanical Engineering Zhejiang Sci-Tech UniversityHangzhou310018China School of Mechanical Engineering Yanshan UniversityQinhuangdao066004Hebei ProvinceChina

An easily stackable multi-layer quasi-zero-stiffness(ML-QZS)meta-structure is proposed to achieve highly efficient vibration isolation performance at low ***,the distributed shape optimization method is used to design the unit cel,i.e.,the single-layer QZS(SL-QZS)***,the stiffness feature of the unit cell is investigated and verified through static ***,the unit cells are stacked one by one along the direction of vibration isolation,and thus the ML-QZS meta-structure is ***,the dynamic modeling of the ML-QZS vibration isolation metastructure is conducted,and the dynamic responses are obtained from the equations of motion,and verified by finite element(FE)***,a prototype of the ML-QZS vibration isolation meta-structure is fabricated by additive manufacturing,and the vibration isolation performance is evaluated *** results show that the vibration isolation performance substantially enhances when the number of unit cells *** importantly,the ML-QZS meta-structure can be easily extended in the direction of vibration isolation when the unit cells are properly ***,the ML-FQZS vibration isolation meta-structure should be a fascinating solution for highly efficient vibration isolation performance at low frequency.

关键词： quasi-zero stiffness(QZS) meta-structure high efficiency low frequency vibration isolation

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Post-salpingectomy interstitial heterotopic pregnancy after in vitro fertilization and embryo transfer:A case report

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World Journal of Clinical Cases 2021年第23期9卷 6950-6955页

作者： Qiao Wang Xiao-Ling pan Xiao-rong Qi Department of Gynecology and Obstetrics West China Second HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Heterotopic pregnancy(HP)refers to the coexistence of ectopic pregnancy and intrauterine *** is proposed as a pretreatment before in vitro fertilization and embryo transfer(IVF-ET)to reduce the risk of *** after IVF-ET occurs in women who had already underwent bilateral salpingectomy,even though it is extremely *** SUMMARY A case of a 29-year-old woman with recurrent interstitial HP after IVF-ET following salpingectomy is *** main symptom was a sudden and worsening pelvic *** examinations revealed signs of peritoneal bleeding and irritation with stable vital *** ultrasound showed a live intrauterine pregnancy and another live embryo with cardiac activity in the left cornu extending beyond the lateral edge of the *** hemoglobin concentration was 8.0 g/dL,and serum human chorionic gonadotropin value was 171116.9 mIU/*** the diagnosis of ruptured HP with internal bleeding,an emergency laparoscopic resection of left cornu was *** interstitial pregnancy was removed with caution to protect the intrauterine *** the surgical treatment,the intrauterine pregnancy continued with no complications.A healthy baby was delivered by caesarean section at 39 *** of another three cases are further *** Post-salpingectomy HP is a rare but challenging *** treatment is preferred in the case with a viable intrauterine pregnancy.

关键词： Heterotopic pregnancy In vitro fertilization and embryo transfer Salpingectomy Surgery Case report

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