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Anticipation,anti-glaucoma drug treatment response and phenotype of a Chinese family with glaucoma caused by the Pro370Leu myocilin mutation

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International Journal of Ophthalmology(English edition) 2014年第1期7卷 44-50页

作者： Chun-Mei Li Yue-Hong Zhang rong-hua ye Chang-Xian Yi Yi-Min Zhong Dan Cao Xing Liu State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen University First Municipal People's Hospital of Guangzhou

AIM: To describe the anticipation and anti-glaucoma drugs response of a Chinese family with juvenile-onset open angle glaucoma(JOAG) caused by the Pro370Leu myocilin(MYOC) mutation. ·METHODS: Fifteen members of a three-generation Chinese family with JOAG were recruited to this study. They all underwent ophthalmic common examinations. Patients suspected to have JOAG got an assessment of visual field and optical coherence tomography. Intraocular pressures(IOPs) of four patients were measured at 8,10,12,14,17 o’clock respectively after using anti-glaucoma drugs. Mutation screening of all MYOC gene coding exons of the participants was performed by using direct sequencing of PCR products. ·RESULTS: Clinical examinations and pedigree analysis revealed eight family members were suffered from JOAG. Apparent genetics anticipation phenomenon was observed in this family. Their clinical features included elevated IOP of 35-55mmHg,loss of visual field,thinning of retinal nerve fiber layer,and glaucomatous optic disc damage. Noticeably,their intraocular pressure levels could be controlled within normal range at 8 and 10 o’clock by anti-glaucoma drugs,but their IOPs would elevate >21mmHg after 12 o’clock. Seven patients received trabeculectomy produced thin-walled,pale,and saccate filtering blebs maintaining lower intraocular pressure efficiently. Mutation screening indentified aheterozygous C→T missense mutation in the MYOC gene at position 1 109 in exon 3,corresponding to a substitution of a highly conserved proline to leucine at codon 370 in the olfactomedin domain of MYOC. ·CONCLUSION: The clinical characteristics of JOAG in this family were 1) genetics anticipation; 2) high IOP; 3) temporay response to anti-glaucoma drugs; 4) filtering surgery produced thin-walled and saccate filtering blebs,helping maintain lower IOP.

关键词： phenotype anticipation anti-glaucoma drugs myocilin

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Neuroprotective potential for mitigating ischemia-reperfusion-induced damage

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Neural Regeneration Research 2025年第8期20卷 2199-2217页

作者： Zi ye Runqing Liu Hangxing Wang Aizhen Zuo Cen Jin Nan Wang Huiqi Sun Luqian Feng hua Yang The Clinical Medical College Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Division of Infectious Diseases Department of Internal MedicinePeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina School of Medical Imaging Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Division of Gastroenterology First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina The Second Clinical Medical College Lanzhou UniversityLanzhouGansu ProvinceChina Department of Neurosurgery Affiliated Hospital of Guizhou Medical UniversityGuiyangGuizhou ProvinceChina

Reperfusion following cerebral ischemia causes both structural and functional damage to brain tissue and could aggravate a patient's condition;this phenomenon is known as cerebral ischemia-reperfusion *** studies have elucidated the neuroprotective role of the sirtuin protein family(Sirtuins)in modulating cerebral ischemia-reperfusion ***,the potential of utilizing it as a novel intervention target to influence the prognosis of cerebral ischemia-reperfusion injury requires additional *** this review,the origin and research progress of Sirtuins are summarized,suggesting the involvement of Sirtuins in diverse mechanisms that affect cerebral ischemia-reperfusion injury,including inflammation,oxidative stress,blood-brain barrier damage,apoptosis,pyroptosis,and *** therapeutic avenues related to Sirtuins that may improve the prognosis of cerebral ischemia-reperfusion injury were also investigated by modulating Sirtuins expression and affecting representative pathways,such as nuclear factor-kappa B signaling,oxidative stress mediated by adenosine monophosphate-activated protein kinase,and the forkhead box *** review also summarizes the potential of endogenous substances,such as RNA and hormones,drugs,dietary supplements,and emerging therapies that regulate Sirtuins *** review also reveals that regulating Sirtuins mitigates cerebral ischemia-reperfusion injury when combined with other risk *** Sirtuins show promise as a potential target for the treatment of cerebral ischemiareperfusion injury,most recent studies are based on rodent models with circadian rhythms that are distinct from those of humans,potentially influencing the efficacy of Sirtuinstargeting drug ***,this review provides new insights into the role of Sirtuins in the pathology and treatment of cerebral ischemia-reperfusion injury.

关键词： apoptosis autophagy blood-brain barrier dietary supplements drug hormones inflammation neuroprotection oxidative stress prognosis pyroptosis reperfusion injury risk factors RNA therapeutics

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学校的社会水平与改进模型——大同中学学校特色项目建设研究

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教育教学论坛 2017年第12期 51-54页

作者：姜荣华李伟叶教育部人文社会科学重点研究基地中国农村教育发展研究院东北师范大学吉林长春130024

Zaltman等根据时间和社会水平两个维度划分出六种类型的改变。个体的短期改变﹑个体的长期改变﹑群体的短期改变﹑群体的长期改变﹑社会的短期改变﹑社会的长期改变。本文通过使用该模型维度分析学校改进,以学校特色为切入点,对大同中... 详细信息

Zaltman等根据时间和社会水平两个维度划分出六种类型的改变。个体的短期改变﹑个体的长期改变﹑群体的短期改变﹑群体的长期改变﹑社会的短期改变﹑社会的长期改变。本文通过使用该模型维度分析学校改进,以学校特色为切入点,对大同中学诗之校特色进行了研究,提出学校改进的一些本土经验,成长与发展的建议。

关键词：学校改进社会水平改进模型学校特色诗之校

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中国上市公司增长的行业特征

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上海管理科学 2004年第2期26卷 54-55,64页

作者：丁培嵘马晔华上海交通大学管理学院

本文使用 1998- 2 0 0 1年数据 ,通过假设检验和回归分析对中国上市公司增长的行业特征进行了实证分析。研究结果表明 :中国不同行业上市公司的增长具有显著差异 ,但差异程度随时间的推移而逐渐降低 ;仅有少部分行业的增长与其它行业显... 详细信息

本文使用 1998- 2 0 0 1年数据 ,通过假设检验和回归分析对中国上市公司增长的行业特征进行了实证分析。研究结果表明 :中国不同行业上市公司的增长具有显著差异 ,但差异程度随时间的推移而逐渐降低 ;仅有少部分行业的增长与其它行业显著不同 ,大部分行业的增长率之间并无显著差异 ;不同时期增长率异常的行业也不相同。

关键词：中国上市公司行业特征增长率研究指标研究方法数据样本行业差异回归分析

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Influence of Shengmai Capsule(生脉胶囊) on Recovery of Living Capacity in Patients after Myocardial Infarction

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Chinese Journal of Integrative Medicine 2009年第5期15卷 333-336页

作者：张亚臣陈瑞明吕宝经赵美华荣烨之 Department of Cardiology Xinhua Hospital Affiliated to the Medical College of Shanghai Jiao Tong University Department of Laboratory Ruijin Hospital Affiliated to the Medical College of Shanghai Jiao Tong University

ABSTRACT Objective： To observe the effect of long-term application of Shengmai Capsule （生脉胶囊, SMC） on recovery of patients after myocardial infarction. Methods： A total of 120 myocardial infarction patients were assigned into two groups. Changes of angina pectoris, electrocardiogram （ECG）, living capacity and heart function in patients were observed after 6-month treatment. Results： The total effective rate in alleviating angina pectods was 90.0% and that in improving ECG figure was 93.3% in the treatment group, both were significantly higher than those in the control group, 73.4% and 70.0% respectively （P〈0.05）. The Karnofsky Performance Status scores of heart function were increased and the Activity of Daily Living scores in living capacity decreased in both groups, but the improvements were better in the treatment group （P〈0.01 and P〈0.05）. The parameters of cardiac function, including cardiac output, stroke volume, cardiac index and ejection fraction, were increased in both groups, but the increments in the treatment group were more significant （P〈0.01 or P〈0.05）. Conclusion： Long-term application of SMC could effectively prevent and treat angina pectoris, improve the living capacity and accelerate the recovery of heart function in patients after myocardial infarction.

关键词： Shengmai Capsule myocardial infarction living capacity heart function

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Effects of Rare Earth,Titanium,and Magnesium Additions on Microstructures and Properties of High-boron Medium-carbon Alloy

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Journal of Iron and Steel Research International 2016年第11期23卷 1226-1233页

作者： Xiao-li SHI ye-hua JIANG rong ZHOU Faculty of Materials Science and Engineering Kunming University of Science and Technology

In order to improve the toughness and wear resistance of high-boron medium-carbon alloy （HBMCA）, a novel wear-resistant HBMCA comprising granular borocarbide was obtained by titanium, magnesium, and rare earth modifications. These modifications gave rise to greatly refined as-cast eutectic borocarbide structures and a less interconnected continuous borocarbide network. Heat treatment mostly produced broken and spheriodized borocarbides that tended to exist as isolated particles in modified HBMCA. The heat treated modified HBMCA exhibited enhanced hardness than pristine and impact toughness was improved significantly to 12.5 J/cm^2. In addition, it displayed 2.39 and 1.7 times greater wear resistance than high-speed steel （HSS） and high nickel-chromium alloy steel （Cr25） at high temperature （500℃）, respectively. Here, the modification mechanisms involving Re2O3, TiN, and MgO/ MgS heterogeneous nuclei were discussed.

关键词： modification eutectic borocarbide spheroidization toughness wear resistance

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Using air curtains to reduce short-range infection risk in consulting ward: A numerical investigation

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Building Simulation 2021年第2期14卷 325-335页

作者： Jin ye hua Qian Jianchao Ma rong Zhou Xiaohong Zheng School of Energy and Environment Southeast UniversityNanjing210096China Engineering Research Center of BEEE Ministry of Education of ChinaNanjing210096China First Affiliated Hospital of Guangzhou Medical University Guangzhou510000China Guangzhou Angel Biosafety Co. LtdGuangzhou510000China Jiangsu Provincial Key Laboratory of Solar Energy Science and Technology Nanjing210096China

Air curtains is promising in reducing the short-range infection risk in *** quantitatively evaluate its performance,this paper explores air curtains equipped on normal consulting desk to avoid doctor’s direct exposure to the patient exhaled pollutants.A numerical investigation is conducted to evaluate the effects of supply air velocity and angle on cutting off *** results show that the average mass fraction of exhaled pollutants decreases significantly(70%–90%)in the consulting ward,indicating satisfying performance of air *** supply air velocity is demonstrated to be conducive in forming full air curtains,whereas an excessively high supply air velocity may be of adverse effects by entraining exhaled ***,the supply air angle is also critical due to its coupling with supply air *** is found that larger angle(0°–40°)is better where velocity is less than 3 m/s,otherwise a small angle(20°)is preferable where velocity is larger than 3 m/*** flow could be well suppressed at the supply air angle 20°but moves over air curtains at 40°.This study can provide effective and intuitive guidance in applying air curtains in consulting wards.

关键词： air curtains consulting ward cutting off performance numerical investigation

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伤害监测系统中口腔科门急诊病例特征分析

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临床口腔医学杂志 2017年第9期33卷 556-559页

作者：李莹崔春玉祁森荣华琳郭晔首都医科大学附属北京口腔医院儿童口腔科北京100050 北京市房山区第一医院门诊办北京102400 首都医科大学附属北京口腔医院放射科北京100050 首都医科大学数学与生物信息教研室北京100069

目的:了解北京市房山区颌面部伤害病例的分布特征。方法:利用2016年全国伤害监测系统(NISS)数据,对首次在NISS监测点医院北京房山第一医院口腔科门/急诊室就诊的伤害病例进行分析,了解其人口学、伤害事件和临床特征。结果:2016年房山第... 详细信息

目的:了解北京市房山区颌面部伤害病例的分布特征。方法:利用2016年全国伤害监测系统(NISS)数据,对首次在NISS监测点医院北京房山第一医院口腔科门/急诊室就诊的伤害病例进行分析,了解其人口学、伤害事件和临床特征。结果:2016年房山第一医院NISS共收集颌面部伤害病例1085例,男719人,占66.3%,女366人,占33.7%。病因第一位是跌倒/坠落(53.9%),其次是机动车车祸(14.0%)。伤害性质首位是锐器伤/咬伤/开放伤(57.1%),其次是擦伤/挫伤(35.3%)。1~5岁年龄组在家中发生伤害占比最高;6~17岁年龄组在学习与公共场所发生伤害占比最高;18~59岁在公路/街道发生伤害占比最高;60岁以上人群在家中发生伤害占比最高。结论:可从建立安全社区等多个方面介入减少颌面部伤害的发生。

关键词：颌面部伤害监测安全社区

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Relationship between Migration and HIV Risky Behavior: a Comparative Study of Returning Migrants and Non Migrants Based on Rural Out-of-school Youth in Jilin, China

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Biomedical and Environmental Sciences 2015年第6期28卷 429-436页

作者： ZHU Guang rong JI Cheng ye YANG Xing hua Institute of Child and Adolescent Health School of Public HealthPeking University Health Science Center Department of Epidemiology and Health Statistics School of Public HealthCapital Medical University

Objective To estimate the relationship between migration and HIV risky behavior when controlling for gender, age, and educational levels and to evaluate the gender differences in migration, HIV knowledge, and HIV risky behaviors among rural youth in China. Methods A cross-sectional, anonymous, investigative questionnaire for 1710 unmarried, out-of-school rural youth, aged between 15 and 24 years, was handed out in Gongzhuling county of Jilin province, China. Results 58.5% of participants had a history of migration, irrespective of gender. There were gender differences observed in other factors such as drug abuse（4.3% for males and 5.5% for females, P〈0.01）, multiple sexual partners（24.1% for males and 44.1% for females, P〈0.01）, and HIV knowledge rate（35.2% for males and 25.5% for females, P〈0.001）. While controlling for gender, age, and educational levels, the relationships between migration and drug abuse, selling sex, and non usage of condoms during last instance of sexual activity were found to be significant. The cases of premarital sex and multiple sexual partners were both not found to be related to migration. Conclusion Among rural youth, the HIV risky behavior such as drug abuse, selling sex, and lack of condom use, is significantly related to migration, while premarital sex and multiple sexual partners seem unrelated to migration.

关键词： Migration Rural out-of-school youth HIV risky behavior China

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小麦赤霉病的生物防治研究——Ⅱ .拮抗芽孢杆菌在麦穗上的消长动态及生物学特性

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四川农业大学学报 2002年第4期20卷 324-327页

作者：余桂容叶华智张敏秦芸四川农业大学农学院四川雅安625014

报导了对小麦赤霉病有良好防效的枯草芽孢杆菌(Bacillussutilis)B4和B6菌株在麦穗上的定殖和生长的动态以及它们的主要生物学特性。结果是:B4和B6菌株能定殖和生长在麦穗上,并维持较高的种群量达十余天;最适于二菌株生长的条件是YSP培... 详细信息

报导了对小麦赤霉病有良好防效的枯草芽孢杆菌(Bacillussutilis)B4和B6菌株在麦穗上的定殖和生长的动态以及它们的主要生物学特性。结果是:B4和B6菌株能定殖和生长在麦穗上,并维持较高的种群量达十余天;最适于二菌株生长的条件是YSP培养基、pH7、28℃和充足的氧气。B4和B6的最高生长量分别在培养36h和44h。供试的10种化学农药中有4种对B4和B6菌株生长有抑制作用。

关键词：消长动态麦穗生物学特性枯草芽孢杆菌生物防治小麦赤霉病定殖

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