检索结果-南通市图书馆

Recent Advances in Artificial Sensory Neurons:Biological Fundamentals,Devices,Applications,and Challenges

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第3期17卷 168-216页

作者： Shuai Zhong Lirou Su Mingkun Xu Desmond Loke Bin Yu Yishu Zhang rong Zhao Guangdong Institute of Intelligence Science and Technology HengqinZhuhai 519031People’s Republic of China College of Integrated Circuits Zhejiang UniversityHangzhou 3112000People’s Republic of China ZJU-Hangzhou Global Scientific and Technological Innovation Center Hangzhou 310027People’s Republic of China Department of Science Mathematics and TechnologySingapore University of Technology and DesignSingapore 487372Singapore Department of Precision Instruments Tsinghua UniversityBeijing 100084People’s Republic of China Center for Brain‑Inspired Computing Research Tsinghua UniversityBeijing 100084People’s Republic of China IDG/McGovern Institute for Brain Research Tsinghua UniversityBeijing 100084People’s Republic of China

Spike-based neural networks,which use spikes or action potentialsto represent information,have gained a lot of attention because of their high energyefficiency and low power *** fully leverage its advantages,convertingthe external analog signals to spikes is an essential *** including analog-to-digital converters or ring oscillators,and sensorssuffer from high power and area *** efforts are devoted to constructingartificial sensory neurons based on emerging devices inspired by the biologicalsensory *** can simultaneously perform sensing and spike conversion,overcoming the deficiencies of traditional sensory *** review summarizesand benchmarks the recent progress of artificial sensory *** starts with thepresentation of various mechanisms of biological signal transduction,followed bythe systematic introduction of the emerging devices employed for artificial ***,the implementations with different perceptual capabilitiesare briefly outlined and the key metrics and potential applications are also ***,we highlight the challenges and perspectives for the future development of artificial sensory neurons.

关键词： Artificial intelligence Emerging devices Artificial sensory neurons Spiking neural networks Neuromorphic sensing

Inhibiting ceramide synthase 5 expression in microglia decreases neuroinflammation after spinal cord injury

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第10期20卷 2955-2968页

作者： Wei Zhang Yubao Lu Ruoqi Shen Yingjie Wu Chenrui Liu Xingxing Fang Liangming Zhang Bin Liu Limin rong Department of Spine Surgery The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina National Medical Products Administration(NMPA)Key Laboratory for Quality Research and Evaluation of Cell Products GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Quality Control of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Engineering and Technology Research of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina

Microglia,the resident monocyte of the central nervous system,play a crucial role in the response to spinal cord ***,the precise mechanism remains *** investigate the molecular mechanisms by which microglia regulate the neuroinflammatory response to spinal cord injury,we performed single-cell RNA sequencing dataset analysis,focusing on changes in microglial *** found that the MG1 subpopulation emerged in the acute/subacute phase of spinal cord injury and expressed genes related to cell pyroptosis,sphingomyelin metabolism,and neuroinflammation at high ***,we established a mouse model of contusive injury and performed intrathecal injection of siRNA and molecular inhibitors to validate the role of ceramide synthase 5 in the neuroinflammatory responses and pyroptosis after spinal cord ***,we established a PC12-BV2 cell co-culture system and found that ceramide synthase 5 and pyroptosis-associated proteins were highly expressed to induce the apoptosis of neuron *** ceramide synthase 5 expression in a mouse model of spinal cord injury effectively reduced ***,ceramide synthase 5-induced pyroptosis was dependent on activation of the NLRP3 signaling *** ceramide synthase 5 expression in microglia in vivo reduced neuronal apoptosis and promoted recovery of neurological ***2g7 formed a“bridge”between sphingolipid metabolism and ceramide synthase 5-mediated cell death by inhibiting the NLRP3 signaling ***,these findings suggest that inhibiting ceramide synthase 5 expression in microglia after spinal cord injury effectively suppressed microglial pyroptosis mediated by NLRP3,thereby exerting neuroprotective effects.

关键词： ceramide synthase 5 gasdermin D microglia neuroinflammation NLRP3 nuclear factor kappa B Pla2g7 pyroptosis sphingomyelin metabolism spinal cord injury

维普期刊数据库

Direct and rapid detection of serum amino acid and monoamine neurotransmitters to assist the diagnosis of panic disorder

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2025年第01期 377-384页

作者： Shiwen Liu Xuerui Wan Meng Zhao Jiaqi Wang Weilan Wu Linlin You Yonggui Yuan Qian Xu rong Gao Key Laboratory of Environmental Medicine Engineering Ministry of Education School of Public Health Southeast University Key Laboratory of Modern Toxicology of Ministry of Education Department of Hygienic Analysis and Detection School of Public HealthNanjing Medical University Department of Psychosomatics and Psychiatry Zhongda Hospital School of Medicine Southeast University

The measurement of amino acid and monoamine neurotransmitters（NTs） in serum plays a central role in the identification and monitoring of clinical panic disorder（PD）. However, the strong polarity and chemical heterogeneity of NTs make direct extraction and rapid detection extremely challenging. Herein, we developed a strategy that integrated solid phase extraction based on magnetic Fe3O4coated with polydopamine（Fe3O4@PDA） and direct analysis of mass spectrometry in real time（DART-MS） for quantification of 10 NTs. We systematically investigated the optimal conditions of this strategy to achieve good accuracy and precision. Compared with existing magnetic solid phase extraction methods for NTs detection in biological samples, this strategy could adsorb more targets while having similar adsorption efficiencies, and the total process time was reduced by an average of 69.42%. We rapidly determined the metabolic abnormality of 6 types of NTs in the serum of PD patients and demonstrated their diagnostic accuracy. In addition, an outstanding feature of PD in which tryptophan was more metabolized by the KYN pathway and the 5-hydroxytryptamine pathway was inhibited could be elucidated by this strategy. Our results highlighted the potential ability of Fe3O4@PDA coupled with DART-MS to assist in the clinical diagnosis of PD.

关键词：

同方期刊数据库

Code Transform Model Producing High-Performance Program

在线全文

学校读者我要写书评

暂无评论

Computer Modeling in Engineering & Sciences 2021年第10期129卷 253-277页

作者： Bao rong Chang Hsiu-Fen tsai Po-Wen Su Department of Computer Science and Information Engineering National University of KaohsiungKaohsiungTaiwan Department of Fragrance and Cosmetic Science Kaohsiung Medical UniversityKaohsiungTaiwan

This paper introduces a novel transform method to produce the newly generated programs through code transform model called the second generation of Generative Pre-trained Transformer(GPT-2)reasonably,improving the program execution performance ***,a theoretical estimation in statistics has given the minimum number of generated programs as required,which guarantees to find the best one within *** proposed approach can help the voice assistant machine resolve the problem of inefficient execution of application *** addition to GPT-2,this study develops the variational Simhash algorithm to check the code similarity between sample program and newly generated program,and conceives the piecewise longest common subsequence algorithm to examine the execution’s conformity from the two programs mentioned *** code similarity check deducts the redundant generated programs,and the output conformity check finds the best-performing generative *** addition to texts,the proposed approach can also prove the other media,including images,sounds,and *** a result,the newly generated program outperforms the sample program significantly because the number of code lines reduces 27.21%,and the program execution time shortens 24.62%.

关键词： Newly generated programs GPT-2 predetermined generative programs variational Simhash algorithm piecewise longest common subsequence

Recent advances in RNA-targeting therapy for neurological diseases

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2023年第12期18卷 2663-2664页

作者： Satheesh Kumar guei-Sheung Liu Center for Eye Research Australia Royal Victorian Eye and Ear HospitalEast MelbourneVICAustralia Menzies Institute for Medical Research University of TasmaniaHobartTASAustralia Ophthalmology Department of SurgeryUniversity of MelbourneEast MelbourneVICAustralia Aier Eye Institute ChangshaHunan ProvinceChina

Advances in sequencing and molecular technology now allow us to understand the genetic underpinnings of complex diseases such as neurological *** variations(or mutations) in the DNA sequence of single genes have been implicated in neurological diseases such as Huntington's disease and spinal muscular *** a result,the development of gene therapies for neurological diseases is now a feasible endeavor.

关键词： diseases neurological Huntington

维普期刊数据库

Implementation of Rapid Code Transformation Process Using Deep Learning Approaches

在线全文

学校读者我要写书评

暂无评论

Computer Modeling in Engineering & Sciences 2023年第7期136卷 107-134页

作者： Bao rong Chang Hsiu-Fen tsai Han-Lin Chou Department of Computer Science and Information Engineering National University of KaohsiungKaohsiung811Taiwan Department of Fragrance and Cosmetic Science Kaohsiung Medical UniversityKaohsiung811Taiwan

Our previous work has introduced the newly generated program using the code transformation model GPT-2,verifying the generated programming codes through simhash(SH)and longest common subsequence(LCS)***,the entire code transformation process has encountered a time-consuming ***,the objective of this study is to speed up the code transformation process signi􀀀*** paper has proposed deep learning approaches for modifying SH using a variational simhash(VSH)algorithm and replacing LCS with a piecewise longest common subsequence(PLCS)algorithm to faster the veri􀀀cation process in the test *** the code transformation model GPT-2,this study has also introduced MicrosoMASS and Facebook BART for a comparative analysis of their ***,the explainable AI technique using local interpretable model-agnostic explanations(LIME)can also interpret the decision-making *** experimental results show that VSH can reduce the number of quali􀀀ed programs by 22.11%,and PLCS can reduce the execution time of selected pocket programs by 32.39%.As a result,the proposed approaches can signi􀀀cantly speed up the entire code transformation process by 1.38 times on average compared with our previous work.

关键词： Code transformation model variational simhash piecewise longest common subsequence explainable AI LIME

Optimizing Big Data Retrieval and Job Scheduling Using Deep Learning Approaches

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computer Modeling in Engineering & Sciences 2023年第2期134卷 783-815页

作者： Bao rong Chang Hsiu-Fen tsai Yu-Chieh Lin Department of Computer Science and Information Engineering National University of KaohsiungKaohsiungTaiwan Department of Fragrance and Cosmetic Science Kaohsiung Medical UniversityKaohsiungTaiwan

Big data analytics in business intelligence do not provide effective data retrieval methods and job scheduling that will cause execution inefficiency and low system *** paper aims to enhance the capability of data retrieval and job scheduling to speed up the operation of big data analytics to overcome inefficiency and low throughput ***,integrating stacked sparse autoencoder and Elasticsearch indexing explored fast data searching and distributed indexing,which reduces the search scope of the database and dramatically speeds up data ***,exploiting a deep neural network to predict the approximate execution time of a job gives prioritized job scheduling based on the shortest job first,which reduces the average waiting time of job *** a result,the proposed data retrieval approach outperforms the previous method using a deep autoencoder and Solr indexing,significantly improving the speed of data retrieval up to 53%and increasing system throughput by 53%.On the other hand,the proposed job scheduling algorithmdefeats both first-in-first-out andmemory-sensitive heterogeneous early finish time scheduling algorithms,effectively shortening the average waiting time up to 5%and average weighted turnaround time by 19%,respectively.

关键词： Stacked sparse autoencoder Elasticsearch distributed indexing data retrieval deep neural network job scheduling

Near-infrared organic photosensitizers with aggregation-induced emission and switchable fluorescence for fungal infection therapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2025年

作者： Xinzhe Yang Zixuan Huang Keke Ding Huili Yang Lirong Wang Qing Xia rong Hu Guang Shi Bingjia Xu Anjun Qin School of Chemistry South China Normal University State Key Laboratory of Luminescent Materials and Devices Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates Center for Aggregation-Induced Emission AIE Institute South China University of Technology Department of Urology The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College) School of Chemistry and Chemical Engineering University of South China

The development of near-infrared (NIR) photosensitizers with aggregation-induced emission (AIE) properties,switchable luminescence colors,and satisfactory photodynamic therapy (PDT) effects on the treatment of fungal infection is of great importance but very ***,two ionic organic luminogens are constructed by employing diphenylamine,diphenylacrylonitrile/1,2-diphenylethene,and methylated quinoline cation as building *** is found that the resulting compounds TCQF and TQF show apparent AIE properties and produce intense fluorescence with high photoluminescence quantum yields of up to 31.2%in the solid *** the meantime,their emission colors can be switched between red and NIR and in the NIR region by mechanical force and solvent vapor,respectively,thereby enabling remarkable and reversible mechanochromism with emission variations of up to 104 *** excitingly,TCQF and TQF can efficiently generate ROS under the illumination of white light and show excellent antimicrobial activities and satisfactory PDT *** by the unique anti-fungus properties,TCQF is employed as a biocompatible NIR photosensitizer for treating wound infection with ***,and apparent PDT effects are *** work provides a new direction for the development of multifunctional NIR materials with AIE properties.

关键词：

An Analytical Solution for Wave Transformation Over Axi-Symmetric Topography

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

China Ocean Engineering 2019年第6期33卷 694-703页

作者： CUONG San Sieu CHANG Jen-Yi tsai Chia-Cheng CHOU Wan-rong aInstitute of Oceanography National Taiwan UniversityTaipei 10617China Tainan University of Technology Tainan 71002China Department of Marine Environmental Engineering National Kaohsiung University of Science and TechnologyKaohsiung 81164China Department of Marine Environment and Engineering National Sun Yat-Sen UniversityKaohsiung 80424China Department of Hydraulic and Ocean Engineering National Cheng Kung UniversityTainan 701China

The present study considers wave scattering phenomena around a cylindrical island mounted on a general axisymmetric topography or a general submerged truncated axi-symmetric shoal based on the mild-slope equation. The method of separation of variables and Taylor series expansion are invoked to find the approximate solution to the variable water depth region which varies proportionally to an arbitrary power of radial distance. Validations against the solutions for the combined wave refraction and diffraction around a cylindrical island mounted on a paraboloidal shoal of Liu et al. in 2004 and the scattering and trapping of wave energy by a submerged truncated paraboloidal shoal of Lin and Liu in 2007 show excellent agreements as the power of radial distance being equal to two. For the solutions of wave refraction and diffraction around a cylindrical island mounted on a shoal with depth proportionally to an arbitrary power of radial distance, good agreements with Zhai et al.’s(2013) solutions are demonstrated. Since the robustness of the assumption of a general axi-symmetric geometry based on an arbitrary power variability of the radial distance, the present solution can be very conveniently employed to investigate the effects of bottom topography on wave scattering and trapping patterns.

关键词： general axi-symmetric topography mild-slope equation submerged truncated shoal wave refraction wave diffraction

维普期刊数据库