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Inhibition of hepatitis B virus via selective apoptosis modulation by Chinese patent medicine Liuweiwuling Tablet

World Journal of Gastroenterology 2024年第13期30卷 1911-1925页

作者： fei-Lin Ge Yan Yang Lan-Lan Si Yuan-Hua Li Meng-Zhen cao Jun Wang Zhao-Fang Bai Zhi-Gang Ren Xiao-He Xiao Yan Liu Department of Chinese Medicine State Key Laboratory of Antiviral DrugsThe First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina The Fifth Medical Center of Chinese PLA General Hospital Beijing 100039China College of Traditional Chinese Medicine Chongqing Medical UniversityChongqing 400010China Beijing Key Laboratory of Emerging Infectious Diseases Peking University Ditan Teaching HospitalBeijing 100015China Department of Infectious Diseases State Key Laboratory of Antiviral Drugsthe First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina

BACKGROUND Liuweiwuling Tablet(LWWL)is a Chinese patent medicine approved for the treatment of chronic inflammation caused by hepatitis B virus(HBV)*** studies have indicated an anti-HBV effect of LWWL,specifically in terms of antigen inhibition,but the underlying mechanism remains *** To investigate the potential mechanism of action of LWWL against *** In vitro experiments utilized three HBV-replicating and three non-HBV-replicating cell *** in vivo experiment involved a hydrodynamic injectionmediated mouse model with HBV *** and metabolomics were used to investigate the underlying mechanisms of action of *** In HepG2.1403F cells,LWWL(0.8 mg/mL)exhibited inhibitory effects on HBV DNA,hepatitis B surface antigen and pregenomic RNA(pgRNA)at rates of 51.36%,24.74%and 50.74%,*** inhibition rates of LWWL(0.8mg/mL)on pgRNA/covalently closed circular DNA in HepG2.1403F,HepG2.2.15 and HepG2.A64 cells were 47.78%,39.51%and 46.74%,*** of transcriptomics and metabolomics showed that the anti-HBV effect of LWWL was primarily linked to pathways related to apoptosis(PI3K-AKT,CASP8-CASP3 and P53 pathways).Apoptosis flow analysis revealed that the apoptosis rate in the LWWL-treated group was significantly higher than in the control group(CG)among HBV-replicating cell lines,including HepG2.2.15(2.92%±1.01%vs 6.68%±2.04%,P0.05),L02 cells(5.49%±0.80%vs 5.48%±1.01%,P>0.05)and LX2 cells(6.29%±1.54%vs 6.29%±0.88%,P>0.05).TUNEL staining revealed a significantly higher apoptosis rate in the LWWL-treated group than in the CG in the HBVreplicating mouse model,while no noticeable difference in apoptosis rates between the two groups

关键词： Hepatitis B virus Chinese patent medicine Antiviral activity Antiviral mechanism Selective apoptosis

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Correlating the crystal structure and facet of indium oxides with their activities for CO_(2)electroreduction

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Fundamental Research 2024年第3期4卷 635-641页

作者： Jiajun Wang Guangjin Wang Han Wu fei Liu Xixi Ren Yidu Wang Yanhui cao Qi Lu Xuerong Zheng Xiaopeng Han Yida Deng Wenbin Hu School of Materials Science and Engineering Key Laboratory of Advanced Ceramics and Machining Technology of Ministry of EducationTianjin UniversityTianjin 300072China School of Materials Science and Energy Engineering Foshan UniversityFoshan 528000China State Key Laboratory of Marine Resource Utilization in South China Sea School of Materials Science and EngineeringHainan UniversityHaikou 570228China Joint School of National University of Singapore and Tianjin University International Campus of Tianjin UniversityBinhai New CityFuzhou 350207China

Constructing structure-function relationships is critical for the rational design and development of efficient catalysts for CO_(2) electroreduction reaction(CO_(2)RR).In_(2)O_(3) is well-known for its specific ability to produce formic ***,how the crystal phase and surface affect the CO_(2)RR activity is still unclear,making it difficult to further improve the intrinsic activity and screen for the most active *** this work,cubic and hexagonal In_(2)O_(3) with different stable surfaces((111)and(110)for cubic,(120)and(104)for hexagonal)are investigated for CO_(2)*** results demonstrate that the adsorption of reactants on cubic In_(2)O_(3) is stronger than that on hexagonal In_(2)O_(3),with the cubic(111)surface being the most active for CO_(2)*** experiments,synthesized cubic In_(2)O_(3) nanosheets with predominantly exposed(111)surfaces exhibited a high HCOO^(-)Faradaic efficiency(87.5%)and HCOO^(–)current density(–16.7 mA cm^(-2))at–0.9 V vs *** addition,an aqueous Zn-CO_(2) battery based on a cubic In2O3 cathode was *** work correlates the phases and surfaces with the CO_(2)RR activity,and provides a fundamental understanding of the structure-function relationship of In_(2)O_(3),thereby contributing to further improvements in its CO_(2)RR ***,the results provide a principle for the directional preparation of materials with optimal phases and surfaces for efficient electrocatalysis.

关键词： Structure-function relationship CO_(2)electroreduction Indium oxide Reactionmechanism Catalyst design

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Dendrite-free Zn deposition initiated by nanoscale inorganic-organic coating-modified 3D host for stable Zn-ion battery

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SusMat 2024年第2期4卷 13-27页

作者： Jiaming Dong Junwen Duan Ruirui cao Wang Zhang Kangkang Fang Hao Yang Ying Liu Zhitao Shen Fumin Li rong Liu Mengqi Jin Longhui Lei Huilin Li Chong Chen Henan Key Laboratory of Photovoltaic Materials College of Future TechnologyHenan UniversityKaifengChina College of Optoelectronic Engineering Shenzhen UniversityShenzhenChina Institute of Solid-State Physics Chinese Academy of SciencesHefeiChina

A 3D nanostructured scaffold as the host for zinc enables effective inhibition of anodic dendrite ***,the increased electrode/electrolyte interface area provided by using 3D matrices exacerbates the passivation and localized corrosion of the Zn anode,ultimately bringing about the degradation of the electrochemical ***,a nanoscale coating of inorganic-organic hybrid(α-In_(2)Se_(3)-Nafion)onto a flexible carbon nanotubes(CNTs)framework(ISNF@CNTs)is designed as a Zn plating/stripping scaffold to ensure uniform Zn nucleation,thus achieving a dendrite-free and durable Zn *** intro-duced inorganic-organic interfacial layer is dense and sturdy,which hinders the direct exposure of deposited Zn to electrolytes and mitigates the side ***,the zincophilic nature of ISNF can largely reduce the nucleation energy barrier and promote the ion-diffusion ***,the ISNF@CNTs@Zn electrode exhibits a low-voltage hysteresis and a superior cycling life(over 1500 h),with dendrite-free Zn-plating behaviors in a typical symmetrical cell ***,the superior feature of ISNF@CNTs@Zn anode is further demonstrated by Zn-MnO_(2)cells in both coin and flexible quasi-solid-state *** work puts forward an inspired remedy for advanced Zn-ion batteries.

关键词： 2D/3D configuration dendrite-free inorganic-organic layer interfacial protection Zn-ion batteries

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Pit density reduction for AlN epilayers grown by molecular beam epitaxy using Al modulation method

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Chinese Physics B 2024年第10期33卷 95-101页

作者： Huan Liu Peng-fei Shao Song-Lin Chen Tao Tao Yu Yan Zi-Li Xie Bin Liu Dun-Jun Chen Hai Lu rong Zhang Ke Wang Jiangsu Provincial Key Laboratory of Advanced Photonic and Electronic Materials School of Electronic Science and EngineeringNanjing UniversityNanjing 210093China Hefei National Laboratory Hefei 230088China Xiamen University Xiamen 361005China

We have investigated homoepitaxy of AlN films grown by molecular beam epitaxy on AlN/sapphire templates byadopting both the continuous growth method and the Al modulation epitaxy(AME)growth *** continuous growthmethod encounters significant challenges in controlling the growth *** the precise Al/N=1.0 ratio is difficult toachieve,either the excessive Al-rich or N-rich growth mode *** contrast,by adopting the AME growth method,sucha difficulty has been effectively *** manipulating the supply time of the Al and nitrogen sources,we were able toproduce AlN films with much improved surface *** first step of the AME method,only supplying Al atoms,is important to wet the surface and the Al adatoms can act as a *** of the initial Al supply time caneffectively reduce the pit density on the grown AlN *** pits density dropped from 12 pits/μm^(2)to 1 pit/μm^(2)andthe surface roughness reduced from 0.72 nm to 0.3 nm in a 2×2μm^(2)area for the AME AlN film homoepitaxially grownon an AlN template.

关键词： Al modulation epitaxy molecular beam epitaxy AlN pits

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Three-dimensional visualization technology for guiding one-step percutaneous transhepatic cholangioscopic lithotripsy for the treatment of complex hepatolithiasis

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World Journal of Gastroenterology 2024年第28期30卷 3393-3402页

作者： Yong-Qing Ye Ya-Wen cao rong-Qi Li En-Ze Li Lei Yan Zhao-Wei Ding Jin-Ming Fan Ping Wang Yi-Xiang Wu Department of Hepatobiliary Surgery The Second People’s Hospital of FoshanFoshan 528000Guangdong ProvinceChina Department of Emergency Medicine Biomedical Innovation CenterThe Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655Guangdong ProvinceChina Department of Hepatobiliary Surgery Foshan Hospital of Traditional Chinese MedicineFoshan 528000Guangdong ProvinceChina Department of Hepatobiliary Surgery The First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510282Guangdong ProvinceChina Department of Gastrointestinal Surgery The First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510120Guangdong ProvinceChina

BACKGROUND Biliary stone disease is a highly prevalent condition and a leading cause of hospitalization *** with associated strictures has high residual and recurrence rates after traditional multisession percutaneous transhepatic cholangioscopic lithotripsy(PTCSL).AIM To study one-step PTCSL using the percutaneous transhepatic one-step biliary fistulation(PTOBF)technique guided by three-dimensional(3D)*** This was a retrospective,single-center study analyzing,140 patients who,between October 2016 and October 2023,underwent one-step PTCSL for *** patients were divided into two groups:The 3D-PTOBF group and the PTOBF *** clearance on choledochoscopy,complications,and long-term clearance and recurrence rates were *** Age,total bilirubin,direct bilirubin,Child-Pugh class,and stone location were similar between the 2 groups,but there was a significant difference in bile duct strictures,with biliary strictures more common in the 3D-PTOBF group(P=0.001).The median follow-up time was 55.0(55.0,512.0)*** immediate stone clearance ratio(88.6%vs 27.1%,P=0.000)and stricture resolution ratio(97.1%vs 78.6%,P=0.001)in the 3D-PTOBF group were significantly greater than those in the PTOBF *** complication(8.6%vs 41.4%,P=0.000)and stone recurrence rates(7.1%vs 38.6%,P=0.000)were significantly lower in the 3D-PTOBF *** Three-dimensional visualization helps make one-step PTCSL a safe,effective,and promising treatment for patients with complicated primary *** perioperative and long-term outcomes are satisfactory for patients with complicated primary *** minimally invasive method has the potential to be used as a substitute for hepatobiliary surgery.

关键词： Hepatolithiasis One-step percutaneous transhepatic cholangioscopic lithotripsy Biliary disease Three-dimensional visualization Clinical efficacy

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预压缩镁板的冲压成形性能

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塑性工程学报 2024年第6期31卷 15-22页

作者：曹苗赵崇斐太原科技大学材料科学与工程学院山西太原030024 富士康并州智能制造研究院山西太原030000

对AZ31镁合金薄板沿不同方向预压缩相同变形量引入{1012}拉伸孪晶:第1组镁合金板沿轧向(RD)分别预压缩1%、3%和5%后再沿横向(TD)预压缩2%(命名为RT镁板:R1T2、R3T2和R5T2);第2组镁合金板沿TD预压缩2%后再沿RD预压缩1%、3%和5%(命名为TR... 详细信息

对AZ31镁合金薄板沿不同方向预压缩相同变形量引入{1012}拉伸孪晶:第1组镁合金板沿轧向(RD)分别预压缩1%、3%和5%后再沿横向(TD)预压缩2%(命名为RT镁板:R1T2、R3T2和R5T2);第2组镁合金板沿TD预压缩2%后再沿RD预压缩1%、3%和5%(命名为TR镁板:T2R1、T2R3和T2R5)。对所有镁板在400℃下退火3 h,研究各预孪晶镁板的静态再结晶和冲压成形行为。结果表明:镁板预压缩变形量越大,孪晶越多;且在相同预压缩条件下,相比RT镁板,TR镁板中孪晶的体积分数更大。高温退火后,大预压缩程度的板材晶粒更加细小;且在相同预压缩条件下,相比RT镁板,TR镁板晶粒尺寸更加细小,分布更加均匀。随预压缩变形量的增加,镁板的屈服强度、极限抗拉强度和伸长率均增大;且相同预压缩条件下,相比RT镁板,TR镁板的屈服强度、极限抗拉强度和断裂伸长率更高。随着预压缩变形量的增加,镁板的杯突值显著增加;且相同预压缩条件下,相比RT镁板,TR镁板的杯突值更高,这很大程度上归因于其优异的延展性、较小的塑性应变比和较大的加工硬化指数。

关键词：预压缩拉伸孪晶静态再结晶冲压成形性能

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Immunosuppressive tumor microenvironment in gastric signet-ring cell carcinoma

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World Journal of Clinical Oncology 2024年第9期15卷 1126-1131页

作者： Yu-Qiong Xie Chun-Chun Li Mei-rong Yu Jiang cao Center for Basic and Translational Research the Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310009Zhejiang ProvinceChina

Gastric signet-ring cell carcinoma(GSRCC)is a subtype of gastric cancer with distinct phenotype and high risk of peritoneal *** have shown that early GSRCC has a good prognosis,while advanced GSRCC is insensitive to radiotherapy,chemotherapy or immune checkpoint blockade *** technological advancement of single-cell RNA sequencing analysis and cytometry by time of flight mass cytometry,more detailed atlas of tumor microenvironment(TME)in GSRCC and its association with prognosis could be investigated ***,two single-cell RNA sequencing studies revealed that GSRCC harbored a unique TME,manifested as highly immunosuppressive,leading to high immune *** TME of advanced GSRCC was enriched for immunosuppressive factors,including the loss of CXCL13+-cluster of differentiation 8+-Tex cells and declined clonal crosstalk among populations of T and B *** addition,GSRCC was mainly infiltrated by follicular B *** increased proportion of SRCC was accompanied by a decrease in mucosaassociated lymphoid tissue-derived B cells and a significant increase in follicular B cells,which may be one of the reasons for the poor prognosis of *** understanding the relationship between immunosuppressive TME and poor prognosis in GSRCC and the underlying mechanism,more effective immunotherapy strategies and improved treatment outcomes of GSRCC can be anticipated.

关键词： Gastric signet-ring cell carcinoma Single-cell RNA sequencing Immunosuppressive tumor microenvironment Immune checkpoint blockade therapy Prognosis

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咪唑鎓盐基材料电催化二氧化碳还原研究进展

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物理化学学报 2024年第4期40卷 131-145页

作者：张强黄远标曹荣中国科学院福建物质结构研究所结构化学国家重点实验室福州350002 中国福建光电信息科学与技术创新实验室福州350108 中国科学技术大学化学与材料科学学院化学系合肥230000 中国科学院大学北京100049

随着化石能源的使用日益增加,大气中CO_(2)的浓度不断上升,给环境带来了挑战。通过催化将CO_(2)转化为高附加值化学品为解决这些问题提供了一个机会,并为燃料合成开辟了一条新的途径,最终有助于减少CO_(2)排放并实现碳中和。在众多的方... 详细信息

随着化石能源的使用日益增加,大气中CO_(2)的浓度不断上升,给环境带来了挑战。通过催化将CO_(2)转化为高附加值化学品为解决这些问题提供了一个机会,并为燃料合成开辟了一条新的途径,最终有助于减少CO_(2)排放并实现碳中和。在众多的方法中,利用可再生清洁能源进行CO_(2)电还原反应(CO_(2)RR)以其反应条件温和、反应进度可控、环境友好以及可以产生大量的附加值产品而受到重视。在此背景下,咪唑鎓基材料及其衍生物已成为CO_(2)RR的有潜力的候选材料。这些材料对CO_(2)有很强的亲和力,并且在CO_(2)RR系统中作为电解质和电催化剂都有应用。所以它们的主要优点之一是能够在催化体系中富集CO_(2),有效地抑制析氢副反应(HER),并提高CO_(2)RR产物的选择性。了解电催化条件下咪唑鎓基离子液体(Im-ILs)与CO_(2)分子之间的相互作用机制对于从分子角度深入了解为什么添加Im-ILs可以改善CO_(2)RR性能至关重要。此外在非均相电催化剂中,Im-ILs作为表面修饰基团和捕集剂,可以显著改变催化剂的表面环境和疏水性,从而促进CO_(2)RR。值得注意的是,Lehn型和金属卟啉分子催化剂中的咪唑鎓基团已被发现对这些催化剂在CO_(2)RR中的性能有影响。N-杂环卡宾(NHC)基电催化剂作为咪唑鎓与CO_(2)相互作用的活性形式之一,表现出优异的CO_(2)RR性能。将NHC基电催化剂引入多孔多相催化剂和分子催化剂中,可以稳定金属纳米颗粒,提高捕获CO_(2)的能力,从而提高CO_(2)RR活性。总之,在CO_(2)RR中使用咪唑鎓基材料对于推进CO_(2)转化,实现可持续、有效合成高附加值化学品具有巨大的前景。

关键词： CO_(2)电还原离子液体咪唑鎓盐氮杂环卡宾金属纳米颗粒

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Application of multidisciplinary team-based integrated traditional Chinese medicine and Western medicine in rotator cuff injury patients undergoing arthroscopic surgery

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World Journal of Clinical Cases 2024年第19期12卷 3767-3775页

作者： Di-Ping cao Lei Yin Yi-fei Wang Bing-Li Liu Department of Orthopedics The Seventh People's Hospital of Shanghai University of Traditional Chinese MedicineShanghai 200137China

BACKGROUND Arthroscopic rotator cuff repair is a common surgical treatment for rotator cuff injuries(RCIs).Although this procedure has certain clinical advantages,it requires rehabilitation management interventions to ensure therapeutic *** To investigate the effect of integrated traditional Chinese medicine and Western medicine(TCM-WM)under the multidisciplinary team(MDT)model on the postoperative recovery of patients undergoing arthroscopic surgery for *** This study enrolled 100 patients who underwent arthroscopic rotator cuff repair for RCIs at the Seventh People’s Hospital of Shanghai University of Traditional Chinese Medicine between June 2021 and May *** were divided into a control group(n=48)that received routine rehabilitation treatment and an experimental group(n=52)that received TCM-WM under the MDT model(e.g.,acupuncture,TCM traumatology and orthopedics,and rehabilitation).The results of the Constant–Murley Shoulder Score(CMS),Visual Analogue Scale(VAS),Shoulder Pain and Disability Index(SPADI),muscular strength evaluation,and shoulder range of motion(ROM)assessments were *** After treatment,the experimental group showed significantly higher CMS scores in terms of pain,functional activity,shoulder joint mobility,and muscular strength than the baseline and those of the control *** experimental group also exhibited significantly lower VAS and SPADI scores than the baseline and those of the control *** addition,the experimental group showed significantly enhanced muscular strength(forward flexor and external and internal rotator muscles)and shoulder ROM(forward flexion,abduction,and lateral abduction)after treatment compared with the control *** TCM-WM under the MDT model improved shoulder joint function,relieved postoperative pain,promoted postoperative functional recovery,and facilitated the recovery of muscular strength and shoulder ROM in patients with RCIs who underwent arthroscopic rotator c

关键词： Multidisciplinary team model Integrated traditional Chinese medicine and Western medicine Rotator cuff injury Arthroscopy Arthroscopic surgery

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机器人胰腺手术国际共识指南(2023版)进展与思考

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中国普通外科杂志 2024年第9期33卷 1406-1413页

作者：曹雨张修平刘荣中国人民解放军总医院第一医学中心肝胆胰外科医学部北京100853 中国人民解放军医学院北京100853

随着机器人外科技术和应用的进步,其在胰腺手术领域的应用前景也愈加宽广。近年来研究表明,在部分方面上,机器人胰腺手术与开腹、腹腔镜手术方式相比存在其独特优势。国际微创外科领域呈现不断发展进步的态势,但机器人胰腺手术在临床上... 详细信息

随着机器人外科技术和应用的进步,其在胰腺手术领域的应用前景也愈加宽广。近年来研究表明,在部分方面上,机器人胰腺手术与开腹、腹腔镜手术方式相比存在其独特优势。国际微创外科领域呈现不断发展进步的态势,但机器人胰腺手术在临床上的全方面应用仍需要循证医学指导,笔者团队在2019年的《机器人胰腺手术国际共识声明》的基础上牵头更新并在Hepatobiliary Surgery and Nutrition杂志上发表了《机器人胰腺手术国际共识指南(2023版)》,汇聚来自美国、欧洲和大洋洲等国际的众多微创手术专家,采用世界卫生组织(WHO)《指南制定手册》、GRADE网格法、德尔菲投票法和AGREE-Ⅱ工具,就系统文献评价后纳入的176项研究进行分析,在机器人胰十二指肠切除术、机器人远端胰腺切除术、机器人胰腺中段切除术等话题上进行了详细阐述,经过专家评估和对证据质量及可信度的综合评判,提出了19个问题和14项建议,有望为我国及国际范围内的综合、专科医院安全、有效开展机器人胰腺手术推广应用提供依据。新版共识还就多个问题指出随机对照研究证据的重要性,这也是促进机器人胰腺手术安全、有效推广进一步努力的方向。

关键词：胰腺肿瘤机器人手术多数赞同

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