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Maskless Microscopic Lithography through Shaping Ultraviolet Laser with Digital Micro-mirror device

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Optics and Photonics Journal 2013年第2期3卷 227-231页

作者： Xiang-Yu Ding Yu-Xuan Ren rong-de lu 2Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences CAS Shanghai China 3National Center for Protein Sciences (Shanghai) Shanghai Institutes for Biological Sciences CAS Shanghai China department of Physics University of Science and Technology of China Hefei China

Laser shaping was introduced to maskless projection soft lithography by using digital micro-mirror device (DMD). The predesigned intensity pattern was imprinted onto the DMD and the input laser beam with a Gaussian or quasi-Gaussian distribution will carry the pattern on DMD to etch the resin. It provides a method of precise control of laser beam shapes and?photon-induced curing behavior of resin. This technology provides an accurate micro-fabrication of microstructures used for micro-systems. As a virtual mask generator and a binary-amplitude spatial light modulator, DMD is equivalent to the masks in the conventional exposure system. As the virtual masks and shaped laser beam can be achieved flexibly, it is a good method of precision soft lithography for 2D/3D microstructures.

关键词： Digital Micro-mirror device (DMD) Laser Shaping Maskless Projection Soft Lithography

Inhibiting ceramide synthase 5 expression in microglia decreases neuroinflammation after spinal cord injury

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Neural Regeneration Research 2025年第10期20卷 2955-2968页

作者： Wei Zhang Yubao lu Ruoqi Shen Yingjie Wu Chenrui Liu Xingxing Fang Liangming Zhang Bin Liu Limin rong department of Spine Surgery The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina National Medical Products Administration(NMPA)Key Laboratory for Quality Research and Evaluation of Cell Products GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Quality Control of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Engineering and Technology Research of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina

Microglia,the resident monocyte of the central nervous system,play a crucial role in the response to spinal cord ***,the precise mechanism remains *** investigate the molecular mechanisms by which microglia regulate the neuroinflammatory response to spinal cord injury,we performed single-cell RNA sequencing dataset analysis,focusing on changes in microglial *** found that the MG1 subpopulation emerged in the acute/subacute phase of spinal cord injury and expressed genes related to cell pyroptosis,sphingomyelin metabolism,and neuroinflammation at high ***,we established a mouse model of contusive injury and performed intrathecal injection of siRNA and molecular inhibitors to validate the role of ceramide synthase 5 in the neuroinflammatory responses and pyroptosis after spinal cord ***,we established a PC12-BV2 cell co-culture system and found that ceramide synthase 5 and pyroptosis-associated proteins were highly expressed to induce the apoptosis of neuron *** ceramide synthase 5 expression in a mouse model of spinal cord injury effectively reduced ***,ceramide synthase 5-induced pyroptosis was dependent on activation of the NLRP3 signaling *** ceramide synthase 5 expression in microglia in vivo reduced neuronal apoptosis and promoted recovery of neurological ***2g7 formed a“bridge”between sphingolipid metabolism and ceramide synthase 5-mediated cell death by inhibiting the NLRP3 signaling ***,these findings suggest that inhibiting ceramide synthase 5 expression in microglia after spinal cord injury effectively suppressed microglial pyroptosis mediated by NLRP3,thereby exerting neuroprotective effects.

关键词： ceramide synthase 5 gasdermin D microglia neuroinflammation NLRP3 nuclear factor kappa B Pla2g7 pyroptosis sphingomyelin metabolism spinal cord injury

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高分子修饰金纳米粒子的自组装研究进展

高分子学报 2018年第8期28卷 1033-1047页

作者：周加境吴迪卢德荣段宏伟南洋理工大学化学与生物医学工程学院新加坡637459 浙江大学化学系杭州310058

近年来,高分子修饰金纳米粒子的自组装行为逐渐成为新的研究热点.当金纳米粒子修饰上高分子后,在维持其自身光电特性的同时展现出了与高分子类似的自组装行为,从而能够在适当的条件下形成结构明确的零维、一维、二维和三维自组装结构.... 详细信息

近年来,高分子修饰金纳米粒子的自组装行为逐渐成为新的研究热点.当金纳米粒子修饰上高分子后,在维持其自身光电特性的同时展现出了与高分子类似的自组装行为,从而能够在适当的条件下形成结构明确的零维、一维、二维和三维自组装结构.这些自组装结构的出现不仅促进了金纳米粒子组装的基础研究,并且极大地丰富了金纳米粒子的应用潜力,为金/高分子纳米复合材料的发展开拓了新的方向.本文总结了金/高分子纳米复合粒子形成的不同维度组装体,着重讨论了金纳米粒子自组装构筑单元的设计、组装方法以及组装体的性质,分类讨论了相应的自组装材料在环境和生物医药中的应用,并展望了相关研究在未来发展的机遇与挑战.

关键词：高分子金纳米粒子自组装多维组装体

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氮肥对库布齐沙地柳枝稷目标产量的影响

北京林业大学学报 2017年第7期39卷 87-95页

作者：陶梦王铁梅苏德荣吕世海陈俊翰北京林业大学草地资源与生态研究中心中国环境科学研究院生态环境研究所亿利资源集团有限公司

柳枝稷是一种生物量高、防风固沙效果好,具有良好发展前景的草本能源植物。为了将暖季型的柳枝稷引种到库布齐沙地,以柳枝稷品种"BL-1"为试验材料,研究了库布齐沙地柳枝稷目标产量(生物量、粗蛋白产量、中性洗涤纤维产量、酸性洗涤纤维... 详细信息

柳枝稷是一种生物量高、防风固沙效果好,具有良好发展前景的草本能源植物。为了将暖季型的柳枝稷引种到库布齐沙地,以柳枝稷品种"BL-1"为试验材料,研究了库布齐沙地柳枝稷目标产量(生物量、粗蛋白产量、中性洗涤纤维产量、酸性洗涤纤维产量)对施用尿素和硫酸铵两种氮肥的响应。硫酸铵和尿素各设置4个施氮水平0、75、150和225 kg/hm2,每个处理设置3个重复,分别于苗期、分蘖期和拔节期施入各试验小区,施入量分别为施氮量的1/5、2/5和2/5。在柳枝稷的拔节期、孕穗期、初花期分别测定其株高、茎粗、叶面积、地上生物量。结果表明:硫酸铵和尿素的施用均可以显著提高柳枝稷的产量,施用硫酸铵后,柳枝稷的产量随着施氮量的增加而呈现逐渐增加的趋势;施用尿素后,柳枝稷的产量随着施氮量的增加出现先升高后降低的动态趋势,且产量最高点出现在施氮量为150 kg/hm2时。在施氮量为75和150 kg/hm2时硫酸铵和尿素两种肥料对柳枝稷的产量的增加程度差异不显著;在施氮量为225 kg/hm2时,硫酸铵对柳枝稷的产量提高程度显著高于尿素。柳枝稷个体大小与叶面积是影响柳枝稷产量的重要因素,氮肥的施用对于柳枝稷生长的促进作用在拔节期最明显;对于柳枝稷叶面积的促进作用在孕穗期最明显;对于柳枝稷增产的促进作用在初花期最明显。硫酸铵相较于尿素更有利于促进柳枝稷的增产。

关键词：柳枝稷产量尿素硫酸铵

Understanding the local structure and thermophysical behavior of Mg-La liquid alloys via machine learning potential

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 439-449页

作者： Jia Zhao Taixi Feng Guimin lu National Engineering Research Center for Integrated Utilization of Salt Lake Resource East China University of Science and TechnologyShanghai 200237China Joint International Laboratory for Potassium and Lithium Strategic Resources East China University of Science and TechnologyShanghai 200237China

The local structure and thermophysical behavior of Mg-La liquid alloys were in-depth understood using deep potential molecular dynamic(DPMD) simulation driven via machine learning to promote the development of Mg-La alloys. The robustness of the trained deep potential(DP) model was thoroughly evaluated through several aspects, including root-mean-square errors(RMSEs), energy and force data, and structural information comparison results;the results indicate the carefully trained DP model is reliable. The component and temperature dependence of the local structure in the Mg-La liquid alloy was analyzed. The effect of Mg content in the system on the first coordination shell of the atomic pairs is the same as that of temperature. The pre-peak demonstrated in the structure factor indicates the presence of a medium-range ordered structure in the Mg-La liquid alloy, which is particularly pronounced in the 80at% Mg system and disappears at elevated temperatures. The density, self-diffusion coefficient, and shear viscosity for the Mg-La liquid alloy were predicted via DPMD simulation, the evolution patterns with Mg content and temperature were subsequently discussed, and a database was established accordingly. Finally, the mixing enthalpy and elemental activity of the Mg-La liquid alloy at 1200 K were reliably evaluated,which provides new guidance for related studies.

关键词： magnesium-lanthanum liquid alloys local structure macroscopic properties thermodynamic behavior deep potential mo-lecular dynamic simulation

LiDAR-Visual SLAM with Integrated Semantic and Texture Information for Enhanced Ecological Monitoring Vehicle Localization

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Computers, Materials & Continua 2025年第1期82卷 1401-1416页

作者： Yiqing lu Liutao Zhao Qiankun Zhao Foreign Environmental Cooperation Center Ministry of Ecology and Environment of PRCBeijing100035China Beijing Computing Center Co. Ltd.Beijing Academy of Science and TechnologyBeijing100083China Beijing Guyu Interactive Artificial Intelligence Application Co. Ltd.Beijing100024China

Ecological monitoring vehicles are equipped with a range of sensors and monitoring devices designed to gather data on ecological and environmental *** vehicles are crucial in various fields,including environmental science research,ecological and environmental monitoring projects,disaster response,and emergency management.A key method employed in these vehicles for achieving high-precision positioning is LiDAR(lightlaser detection and ranging)-Visual Simultaneous Localization and Mapping(SLAM).However,maintaining highprecision localization in complex scenarios,such as degraded environments or when dynamic objects are present,remains a significant *** address this issue,we integrate both semantic and texture information from LiDAR and cameras to enhance the robustness and efficiency of data ***,semantic information simplifies the modeling of scene elements,reducing the reliance on dense point clouds,which can be less ***,visual texture information complements LiDAR-Visual localization by providing additional contextual *** incorporating semantic and texture details frompaired images and point clouds,we significantly improve the quality of data association,thereby increasing the success rate of *** approach not only enhances the operational capabilities of ecological monitoring vehicles in complex environments but also contributes to improving the overall efficiency and effectiveness of ecological monitoring and environmental protection efforts.

关键词： LiDAR-Visual simultaneous localization and mapping integrated semantic texture information

A quantum-search-based multi-classifier for image recognition

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 21-31页

作者： lu Liu Xingyu Wu lufan Zhang Chuan Wang School of Artificial Intelligence Beijing Normal University Applied Optics Beijing Area Major Laboratory Beijing Normal University

The multi-class classification of images is a pivotal challenge within the realm of image processing. As the volume of visual data continues to expand, there is a burgeoning interest in harnessing the unique capabilities of quantum computation to augment the efficiency of classification tasks. However, many existing methods for training quantum image multi-classifiers parallel classical machine learning techniques, where the requisite circuit measurements increase linearly with the volume of training data. This work introduces a novel approach for training a quantum image multi-classifier based on the quantum search algorithm. We have meticulously conducted rigorous experiments on a handwritten digit dataset, a classic benchmark in the field. The results have been meticulously compared with previous works, and the comparative analysis not only validates the efficiency of our proposed approach, requiring only O(N/b) measurements during training, but also highlights a significant quadratic speedup of the algorithm.

关键词： quantum computation image recognition quantum search algorithm

Unraveling the origins of PGY-sRNA-6,BZL-sRNA-20,and XKC-sRNA-h3

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Science China Life Sciences 2025年

作者： Shanfa lu State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Institute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences&Peking Union Medical College Engineering Research Center of Chinese Medicine Resource Ministry of Education

dear Editor,The regulatory role of herbal sRNAs in humans and animals is an interesting research ***,current evidence is insufficient to conclude that herbal sRNAs are novel precision medicines.I previously showed that HJT-sRNA-m1-HJT-sRNA-m8,identified as herbal sRNAs previously (Du et al.,2019),may be derived from humans and/or animals(lu,2023).To minimize errors during herbal sRNA analysis,I provided a list of matters needing special attention and proposed problem-solving solutions for researchers working on sRNA cross-kingdom regulation (lu,2023).

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Numerical Study of Flow and Heat Transfer Characteristics of Shell-and-Tube Molten Salt Electric Heater with Circularly Perforated Baffles

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Journal of Thermal Science 2025年第1期34卷 24-33页

作者： LIN Yongjie ZHANG Cancan WU Yuting ZHANG Yi lu Yuanwei Key Laboratory of Heat Transfer and Energy Conversion National User-Side Energy Storage Innovation Research and Development CenterBeijing University of Technology

Numerical simulations of the flow and heat transfer characteristics of four shell-and-tube molten salt electric heaters with different perforation rates was ***-and-tube electric heaters have the same geometry and tube arrangement,and all of them use single segmental baffles,but there exist four different baffle openings（φ）,i.e.,0%,2.52%,4.06%,and 6.31%.The results indicated that the reasonable baffle opening could significantly reduce the shell-side pressure drop,effectively decreasing the shell-side flow dead zone *** can eliminate the local high-temperature phenomenon on the surface of electric heating tubes,but the heat transfer coefficient is slightly *** perforated schemes significantly reduce shell-side pressure drop compared to the baseline solution without open *** particular,the φ=6.31% scheme exhibits the optimal performance among all the schemes,with a maximum reduction of up to 50.50% in shell-side pressure drop relative to the unopened holes *** heat transfer coefficient is the highest for φ=0%,exhibiting a range of5.26% to 5.73%,5.14% to 5.99%,and 7.31% to 8.54% higher than φ=2.52%,4.06%,and 6.31%,respectively,within the calculated *** composite index h/（Δp）1/3was higher for all open-hole solutions than that for the unopened-hole *** best overall performance was for φ=6.31%,which improved the composite index by15.29% to 17.18% over the unopened-hole solution.

关键词： molten salt electric heater perforated baffles heat transfer