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Chinese Journal of Chemistry 2023年第15期41卷 1823-1828页

作者： Maojian Lu rong-bin liang Can-Ming Zhu Qing-Xiao Tong Jian-Ji Zhong Department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province ShantouUniversityShantouGuangdong515063China Chemistry and Chemical Engineering Guangdong Laboratory ShantouGuangdong 515031China

Comprehensive Summary A visible-light mediated exclusively regioselective synthesis of 2,2-disubstituted thio-functionalized tetrahydrofurans,tetrahydro-pyrans and oxepanes has been described through an operationally simple and mild photoredox *** radical generated from N-phenylsulfenyl phthalimide by photoredox catalysis was proven to be the key reactive intermediate in this reaction.

关键词： Photoredox catalysis Cyclic ethers Thio-functionalization Thiyl radical Sulfenylating reagent N-Sulfenyl phthalimides Synthetic methods Cycloaddition Reaction mechanisms

Surgical correction of recurrent epiblepharon in Chinese children using modified skin re-draping epicanthoplasty

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International Journal of Ophthalmology(English edition) 2021年第2期14卷 217-222页

作者： Shou-Long Hu Wen-Qing Shi Ting Su Qian-Min Ge Qiu-Yu Li Biao Li rong-bin liang Pei-Wen Zhu Yi Shao National Center for Children’s Health MOE Key Laboratory of Major Diseases in ChildrenDepartment of OphthalmologyBeijing Children’s HospitalCapital Medical UniversityBeijing 100045China Department of Ophthalmology the First Affiliated Hospital of Nanchang UniversityJiangxi Province Clinical Ophthalmology InstituteNanchang 330006Jiangxi ProvinceChina Eye Institute of Xiamen University Fujian Provincial Key Laboratory of Ophthalmology and Visual ScienceSchool of MedicineXiamen UniversityXiamen 361102Fujian.ProvinceChina Department of Ophthalmology Massachusetts Eye and EarHarvard Medical School

AIM:To evaluate the clinical efficacy of the modified skin re-draping epicanthoplasty procedure for correction of recurrent lower lid epiblepharon in Chinese ***:From 2016 to 2018,18 children(10 males and 8 females,average age 6.2±1.7 y;30 eyes)with recurrent epiblepharon who attended Beijing Children’s Hospital were included in the *** the children had undergone lower eyelid surgery for *** design included using an additional incision along the upper palpebral margin,to avoid vertical scarring on the upper *** re-draping method was used to correct recurrent ***-up ranged from 3 to 24 *** surgical outcomes,complications,and subjective satisfaction were ***:Complete correction of cilia touching the cornea was observed in all patients during an average follow-up of 7.1 ***"dog ears"or obvious scars were formed after *** parents were satisfied with the cosmetic results and none *** astigmatism decreased from 2.39±0.79 diopter(D)preoperatively to 2.19±0.79 D at 6 mo after surgery;however,the difference was not ***-corrected visual acuity improved,although the change in mean visual acuity was not *** recurrence occurred during the follow-up ***:This surgical modified skin re-draping technique is effective and highly satisfactory for correction of recurrent *** approach is characterized by a simple design,a straightforward procedure,inconspicuous scarring,and good postoperative appearance.

关键词： recurrent epiblepharon modified skin redraping epicanthoplasty Chinese children

Decreased retinal microvasculature densities in pterygium

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International Journal of Ophthalmology(English edition) 2021年第12期14卷 1858-1867页

作者： Feng Wang Qian-Min Ge Hui-Ye Shu Xu-Lin Liao rong-bin liang Qiu-Yu Li Li-Juan Zhang Gui-Ping Gao Yi Shao Department of Ophthalmology Meizhou Pepole’s HospitalMeizhou 514000Guangdong ProvinceChina Department of Ophthalmology the First Affiliated Hospital of Nanchang UniversityJiangxi Centre of National Clinical Ophthalmology Research CentreNanchang 330006Jiangxi ProvinceChina Department of Ophthalmology and Visual Sciences the Chinese University of Hong KongShatinNew Territories 999077Hong KongChina

AIM:To investigate the retinal vascular network alterations in eyes of patients with ***:Totally 18 left eyes from 18 female pterygium patients and 18 left eyes from 18 female healthy control subjects were *** coherence tomography angiography(OCTA)images were generated of the superficial retinal layer and deeper retinal layer of the macular retina for each *** microvascular(MIR)and macrovascular(MAR)densities were calculated and MIR,MAR,and total microvascular(TMI)density was compared in the healthy control and pterygium ***:In pterygium group,in the superficial retinal layer,the vascular density in superficial MIR,superior right(SR),inferior right(IR),right(R),superficial central annuli(SC)1,SC2,and SC3 decreased significantly in the macular area(P0.05).CONCLUSION:OCTA findings suggest that pterygium patients present with decreased retinal MIR density,and the major vascular alterations occurr mainly on the bitamporal *** vascular density of the superficial SC1,SC2,SC3 adjacent to the foveal and deep layer of DC2,DC2 regions,significantly decreased.

关键词： retinal microvasculature density pterygium optical coherence tomography angiography

Altered spontaneous brain activity patterns in patients with hyperthyroidism exophthalmos using amplitude of low-frequency fluctuation:a resting-state fMRI study

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International Journal of Ophthalmology(English edition) 2021年第12期14卷 1957-1962页

作者： Ling Ling Wen-Feng Liu Yu Guo rong-bin liang Hui-Ye Shu Li-Juan Zhang Qiu-Yu Li Qian-Min Ge Yi-Cong Pan Yi Shao Affiliated Eye Hospital of Nanchang University Nanchang 330006Jiangxi ProvinceChina Department of Ophthalmology the First Affiliated Hospital of Nanchang UniversityJiangxi Province Clinical Ophthalmology InstituteNanchang 330006Jiangxi ProvinceChina Department of Hepatic Oncology Zhongshan HospitalFudan UniversityShanghai 200032China Department of Radiology the First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina

AIM:To assess changed spontaneous brain activity in hyperthyroid exophthalmos(HE)patients by the amplitude of the low-frequency fluctuation(ALFF)method,and to analyze the correlation between brain activity and ALFF values in these ***:Totally 18 HE and 18 hyperthyroid nonexophthalmos(HNE)patients were *** participants were tested by resting-state functional magnetic resonance imaging,and receiver operating characteristic(ROC)curves were generated to classify the ALFF values of the study ***’s correlation analysis was utilized to evaluate the relationship between the ALFF values obtained from different brain areas and clinical ***:Contrary to HNE patients,we observed lower ALFF values in the left calcarine fissure and surrounding cortex(LCFSC)in HE *** the ROC curve analysis of the LCFSC,the area under the curve reflected a high degree of *** addition,there was positive correlation between mean ALFF values of the LCFSC and the bestcorrected visual acuity of the affected ***:The study displays abnormal brain activity in LCFSC in patients with HE,which might suggest pathological mechanism of visual impairment of HE patients.

关键词： hyperthyroid exophthalmos amplitude of low-frequency fluctuation functional magnetic resonance imaging spontaneous brain activity

Altered spontaneous brain activity in patients with diabetic optic neuropathy:A resting-state functional magnetic resonance imaging study using regional homogeneity

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World Journal of Diabetes 2021年第3期12卷 278-291页

作者： Gui-Ying Guo Li-Juan Zhang Biao Li rong-bin liang Qian-Min Ge Hui-Ye Shu Qiu-Yu Li Yi-Cong Pan Chong-Gang Pei Yi Shao Department of Ophthalmology The First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina

BACKGROUND Diabetes is a common chronic *** the increasing incidence of diabetes,more individuals are affected by diabetic optic neuropathy(DON),which results in decreased *** DON leads to abnormalities of other visual systems,including the eye,the visual cortex,and other brain regions,remains *** To investigate the local characteristics of spontaneous brain activity using regional homogeneity(ReHo)in patients with *** We matched 22 patients with DON with 22 healthy controls(HCs).All subjects underwent resting-state functional magnetic resonance *** ReHo technique was used to record spontaneous changes in brain *** operating characteristic(ROC)curves were applied to differentiate between ReHo values for patients with DON and *** also assessed the correlation between Hospital Anxiety and Depression Scale scores and ReHo values in DON patients using Pearson correlation *** ReHo values of the right middle frontal gyrus(RMFG),left anterior cingulate(LAC),and superior frontal gyrus(SFG)/left frontal superior orbital gyrus(LFSO)were significantly lower in DON patients compared to *** these,the greatest difference was observed in the *** result of the ROC curves suggest that ReHo values in altered brain regions may help diagnose DON,and the RMFG and LAC ReHo values are more clinically relevant than SFG/*** also found that anxiety and depression scores of the DON group were extremely negatively correlated with the LAC ReHo values(r=-0.9336,P<0.0001 and r=-0.8453,P<0.0001,respectively).CONCLUSION Three different brain regions show ReHo changes in DON patients,and these changes could serve as diagnostic and/or prognostic biomarkers to further guide the prevention and treatment of DON patients.

关键词： Diabetes Diabetic optic neuropathy Regional homogeneity Resting state Functional magnetic resonance imaging Brain activity

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骨髓与脂肪间充质干细胞治疗眼病的研究进展

国际眼科杂志 2021年第1期21卷 62-65页

作者：于晨雨梁荣斌邵毅南昌大学第一附属医院眼科中国江西省南昌市330006

间充质干细胞(MSCs)具有很强的增殖能力,并且可以分化成不同类型的细胞,为动物个体发育中体细胞的更新提供了极大的可塑性。基于其独特的生物学特性,现在被用于治疗各种创伤性和退行性疾病,其临床应用潜能几乎是无限的。本文就骨髓和脂... 详细信息

间充质干细胞(MSCs)具有很强的增殖能力,并且可以分化成不同类型的细胞,为动物个体发育中体细胞的更新提供了极大的可塑性。基于其独特的生物学特性,现在被用于治疗各种创伤性和退行性疾病,其临床应用潜能几乎是无限的。本文就骨髓和脂肪组织来源的两种间充质干细胞(BMSCs和ADSCs),讨论了其应用于眼科各种疾病的临床治疗、给药方法及其获得途径和安全性的相关研究。

关键词：间充质干细胞干眼视网膜病变角膜损伤

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Sirtuins在眼科疾病中的研究进展

国际眼科杂志 2020年第5期20卷 831-833页

作者：梁荣斌吴康瑞邵毅南昌大学第一附属医院眼科中国江西省南昌市330006

在各种眼科疾病,如青光眼、黄斑变性等疾病的发生发展中,细胞氧化应激的发生非常常见,氧化应激可以使细胞受损而凋亡。Sirtuins家族(Ⅲ类组蛋白去乙酰化酶)作为一类多种细胞的调控因子,在人体各种器官中广泛表达。Sirtuins的同源基因(SI... 详细信息

在各种眼科疾病,如青光眼、黄斑变性等疾病的发生发展中,细胞氧化应激的发生非常常见,氧化应激可以使细胞受损而凋亡。Sirtuins家族(Ⅲ类组蛋白去乙酰化酶)作为一类多种细胞的调控因子,在人体各种器官中广泛表达。Sirtuins的同源基因(SIRT1)在眼部也广泛表达,其表达与激活可以起到抗氧化应激的作用,防止细胞衰老及损伤,进而防止疾病的进展。本文就Sirtuins家族在青光眼、年龄相关性黄斑变性、视神经炎、年龄相关性白内障中的作用机制与表达进行论述。

关键词： Sirtuins SIRT1 视网膜神经节细胞氧化应激

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持续性角膜上皮缺损的治疗进展

国际眼科杂志 2020年第10期20卷 1726-1729页

作者：梁荣斌吴世楠邵毅南昌大学第一附属医院眼科中国江西省南昌市330006

持续性角膜上皮缺损(PED/PCEDs)是指角膜损伤后10~14d内,在接受了相应治疗后,角膜也未能迅速重新形成上皮并闭合而导致的一种角膜疾病。角膜上皮的破坏和基质层的损伤容易使眼部受到感染、发生基质溃疡、穿孔、瘢痕,甚至丧失视力。就目... 详细信息

持续性角膜上皮缺损(PED/PCEDs)是指角膜损伤后10~14d内,在接受了相应治疗后,角膜也未能迅速重新形成上皮并闭合而导致的一种角膜疾病。角膜上皮的破坏和基质层的损伤容易使眼部受到感染、发生基质溃疡、穿孔、瘢痕,甚至丧失视力。就目前而言,临床医生对PED的治疗仍然面临相当大的挑战。标准的治疗方法包括配戴绷带隐形眼镜和使用人工泪液治疗,而新开发的药物则可以通过促进各类生长因子的生成使角膜重新形成上皮,进一步配合相应外科手术为角膜提供神经支配,以此达到治疗的效果。此外,确诊PED后应尽早接受治疗,以避免继发性并发症。本文就PED的流行病学、病因学、诊断与临床表现、治疗方法及预后进行综述。

关键词：持续性角膜上皮缺损角膜眼部疾病角膜缘干细胞表皮生长因子羊膜移植

Al_2O_3涂覆PE膜制备锂离子电池的高倍率性能

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电池 2018年第5期48卷 341-343页

作者：雷京朱丹容亮斌张国恒深圳市沃特玛电池有限公司广东深圳518118

采用三氧化二铝(Al_2O_3)单面涂覆聚乙烯隔膜(涂覆层厚度3μm,聚乙烯层厚度9μm),将涂覆层分别面对正极和负极,制作32700型6 Ah磷酸铁锂锂离子电池,并与使用9μm和12μm厚聚乙烯隔膜的对比。对电芯进行内阻、容量、倍率性能、循环性能... 详细信息

采用三氧化二铝(Al_2O_3)单面涂覆聚乙烯隔膜(涂覆层厚度3μm,聚乙烯层厚度9μm),将涂覆层分别面对正极和负极,制作32700型6 Ah磷酸铁锂锂离子电池,并与使用9μm和12μm厚聚乙烯隔膜的对比。对电芯进行内阻、容量、倍率性能、循环性能和循环伏安测试。使用陶瓷隔膜的电芯与使用未涂覆隔膜的电芯相比,内阻均降低0. 2 mΩ,6. 00 C充电恒流比提升2%左右,以6. 00 C在2. 00~3. 65 V循环566次的容量保持率提高8%,涂覆层面对负极的电芯与使用未涂覆隔膜的相比,6. 00 C放电温升可降低约3℃。使用陶瓷隔膜还可降低极化电压。

关键词：三氧化二铝(Al2O3) 磷酸铁锂(LiFePO4) 锂离子电池电化学性能隔膜

A promising approach for quantifying focal stroke modeling and assessing stroke progression:optical resolution photoacoustic microscopy photothrombosis

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Neural Regeneration Research 2025年第7期20卷 2029-2037页

作者： Xiao liang Xingping Quan Xiaorui Geng Yujing Huang Yonghua Zhao Lei Xi Zhen Yuan Ping Wang bin Liu Faculty of Health Sciences University of MacaoMacao Special Administrative RegionChina Center for Cognitive and Brain Sciences University of MacaoMacao Special Administrative RegionChina Department of Biomedical Engineering Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of Emergency Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

To investigate the mechanisms underlying the onset and progression of ischemic stroke,some methods have been proposed that can simultaneously monitor and create embolisms in the animal cerebral ***,these methods often require complex systems and the effect of age on cerebral embolism has not been adequately studied,although ischemic stroke is strongly *** this study,we propose an optical-resolution photoacoustic microscopy-based visualized photothrombosis methodology to create and monitor ischemic stroke in mice simultaneously using a 532 nm pulsed *** observed the molding process in mice of different ages and presented age-dependent vascular embolism ***,we integrated optical coherence tomography angiography to investigate age-associated trends in cerebrovascular variability following a *** imaging data and quantitative analyses underscore the differential cerebrovascular responses to stroke in mice of different ages,thereby highlighting the technique's potential for evaluating cerebrovascular health and unraveling age-related mechanisms involved in ischemic strokes.

关键词： age-dependent cerebral cortex ischemic stroke mouse model optical coherence tomography angiography photoacoustic microscopy photothrombosis vascular imaging