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Serum hyaluronic acid, procollagen type Ⅲ and Ⅳ in histological diagnosis of liver fibrosis

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Hepatobiliary & Pancreatic Diseases International 2003年第1期2卷 69-72页

作者： Shi-Bin Xie Ji-Lu Yao rong-qin Zheng Xiao-Mou Peng Zhi-Liang Gao the Department of Infectious Diseases, Third Affiliated Hospital, Zhongshan University, Guangzhou 510630, China , Department of Infectious Diseases Third Affiliated Hospital Zhongshan University Guangzhou 510630 China. xieshib@***

OBJECTIVE: To assess the significance of serum hyaluronic acid (HA), proeollagen type Ⅲ (PCⅢ), collagen type Ⅳ (CⅣ) in the histological diagnosis of liver fibrosis. METHODS: The concentrations of serum HA, PCⅢ, CⅣ in 253 patients with chronic liver diseases were measured by radioimmunoassay. Liver biopsies were performed in all patients at the same time. The liver was pathologically evaluated by a pathologist according to a scoring system. Combined with the results of liver pathological diagnosis, the accuracy of serum HA, PCⅢ, CⅣ in diagnosing patients with hepatic fibrosis (staging≥S_2) or cirrhosis (S_4) was assessed using the receiver operating curve (ROC). RESULTS: The cutoff values of serum HA, PCⅢ and CⅣ for identifying patients with hepatic fibrosis (≥S_2) or cirrhosis (S_4) were determined. The cutoff values of serum HA, PCⅢ and CⅣ for detecting patients with fibrosis (stage≥S_2) were 90μg/L, 90μg/L, 75μg/L, respectively; their sensitivity (Se) was 80.4%, 82%, 63.1%; their specificity (Spe) was 70.2%, 60.8%, 83.8%; their positive predictive values (PPV) were 86.7%, 83.5%, 90.4%; their negative predictive values (NPV) were 59.8%, 58.4%, 48.4%, respectively. The cutoff values for detecting patients with liver cirrhosis were 210μg/L for HA, 96.2% for Se, 85.3% for Spe, 65.4% for PPV, 98.8% for NPV; 150μg/L for PCⅢ, 76.4% for Se, 68.7% for Spe, 40.4% for PPV, 91.3% for NPV; 90μg/L for CⅣ, 80% for Se, 75.8% for Spe, 47.8% for PPV, 93.2% for NPV, respectively. CONCLUSIONS: Serum HA, PCⅢ and CⅣ can be determined for an accurate diagnosis of hepatic fibrosis in various stages. HA is the best for screening liver cirrhosis.

关键词： hyaluronic acid procollagen type Ⅲ collagen type Ⅳ hepatic fibrosis diagnosis liver histology

Unravelling biosynthesis and biodegradation potentials of microbial dark matters in hypersaline lakes

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Environmental Science and Ecotechnology 2024年第4期20卷 177-188页

作者： Zhiguang Qiu Yuanyuan Zhu qing Zhang Xuejiao Qiao rong Mu Zheng Xu Yan Yan Fan Wang Tong Zhang Wei-qin Zhuang Ke Yu School of Environment and Energy Peking University Shenzhen Graduate SchoolShenzhen518055China AI for Science(AI4S)-Preferred Program Peking UniversityShenzhen518055China Southern University of Sciences and Technology Yantian Hospital Shenzhen518081China Institute of Biomedicine and Biotechnology Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen518055China State Key Laboratory of Isotope Geochemistry CAS Center for Excellence in Deep Earth ScienceGuangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou510640China School of Atmospheric Sciences Sun Yat-sen UniversitySouthern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Zhuhai519082China Department of Civil Engineering University of Hong Kong999077Hong KongChina Department of Civil and Environmental Engineering Faculty of EngineeringUniversity of AucklandNew Zealand

Biosynthesis and biodegradation of microorganisms critically underpin the development of biotechnology,new drugs and therapies,and environmental ***,most uncultured microbial species along with their metabolic capacities in extreme environments,remain *** we unravel the metabolic potential of microbial dark matters(MDMs)in four deep-inland hypersaline lakes in Xinjiang,*** metagenomic binning,we uncovered a rich diversity of 3030 metagenomeassembled genomes(MAGs)across 82 phyla,revealing a substantial portion,2363 MAGs,as previously unclassified at the genus *** unknown MAGs displayed unique distribution patterns across different lakes,indicating a strong correlation with varied physicochemical *** analysis revealed an extensive array of 9635 biosynthesis gene clusters(BGCs),with a remarkable 9403 being novel,suggesting untapped biotechnological ***,some MAGs from potentially new phyla exhibited a high density of these *** biosynthesis,our study also identified novel biodegradation pathways,including dehalogenation,anaerobic ammonium oxidation(Anammox),and degradation of polycyclic aromatic hydrocarbons(PAHs)and plastics,in previously unknown microbial *** findings significantly enrich our understanding of biosynthesis and biodegradation processes and open new avenues for biotechnological innovation,emphasizing the untapped potential of microbial diversity in hypersaline environments.

关键词： Biosynthesis Biodegradation Hypersaline lakes Metagenome-assembled genomes Microbial dark matters

基于样条有限点法的变截面Euler梁横向自由振动分析

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振动与冲击 2016年第11期35卷 66-73页

作者：刘鹏刘红军林坤秦荣哈尔滨工业大学深圳研究生院广东深圳518055 广西大学土木建筑工程学院南宁530004

基于Bernoulli-Euler梁理论,采用样条有限点法建立考虑截面高宽度沿轴线性变化的变截面Euler梁振动分析的计算模型,通过沿梁轴线设置一定数量的样条节点对变截面梁样条离散化,采用三次B样条函数对梁的位移场进行插值,基于Hamilton原理... 详细信息

基于Bernoulli-Euler梁理论,采用样条有限点法建立考虑截面高宽度沿轴线性变化的变截面Euler梁振动分析的计算模型,通过沿梁轴线设置一定数量的样条节点对变截面梁样条离散化,采用三次B样条函数对梁的位移场进行插值,基于Hamilton原理导出变截面Euler梁的振动方程,推导考虑截面尺寸变化效应的总刚度和总质量矩阵的表达式,并编制计算程序,算例分析表明,模型的变截面梁的横向自振频率解答与文献解答吻合良好,计算精度和计算效率高,且模型边界处理简单,取样条离散节点数为15时,模型可以取得较高精度且解答趋于稳定。模型可适用于不同边界、不同截面变化率和不同截面类型的变截面Euler梁的自由振动分析。

关键词：欧拉梁理论变截面梁横向自由振动样条有限点法

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模糊综合评判在矿山地质环境中的应用

重庆大学学报（自然科学版） 2010年第5期33卷 145-150页

作者：唐建新徐宁霞康钦容重庆大学资源及环境科学学院重庆400044

针对丘陵山区复杂的地质情况,构建了矿山地质环境影响程度的模糊综合评判指标体系;并引入弱模糊一致矩阵结合层次分析法确定权重,解决了传统AHP很难满足一致性检验的问题;依据矿山特殊地质条件,将地质环境影响程度划分为三个等级构建模... 详细信息

针对丘陵山区复杂的地质情况,构建了矿山地质环境影响程度的模糊综合评判指标体系;并引入弱模糊一致矩阵结合层次分析法确定权重,解决了传统AHP很难满足一致性检验的问题;依据矿山特殊地质条件,将地质环境影响程度划分为三个等级构建模糊综合评判表,确定各影响因子的隶属度;运用模糊综合评判方法,建立矿山地质环境影响程度的二级模糊综合评判模型。通过该模型在实际矿山中的应用,模型评估结果与实际结果显示的滑坡、地面沉降等地质灾害影响程度吻合性较高。

关键词：地下采煤地质环境层次分析法弱模糊一致矩阵多级模糊综合评判

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考虑联络线暂态稳定性约束的最优潮流计算

电网技术 2005年第11期29卷 25-29页

作者：李林川李彬王荣琴天津大学电气与自动化工程学院天津市南开区300072

提出了一种考虑联络线暂态稳定性约束的最优潮流计算方法,利用等微增率准则及其近似线性的特性,通过寻找发电机有功出力变化量与联络线输送有功变化量之间的关系快速确定联络线输送功率的极限,并用此极限值作为最优潮流中的不等式约束... 详细信息

提出了一种考虑联络线暂态稳定性约束的最优潮流计算方法,利用等微增率准则及其近似线性的特性,通过寻找发电机有功出力变化量与联络线输送有功变化量之间的关系快速确定联络线输送功率的极限,并用此极限值作为最优潮流中的不等式约束。该方法较好地解决了考虑暂态稳定约束后计算负担过重的问题。在一个简化的系统上对文中提出的方法进行了验证,证明了其有效性。

关键词：暂态稳定性联络线最优潮流计算等微增率准则暂态稳定约束不等式约束计算方法输送功率快速确定变化量发电机极限值有功出力

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对经营风险导向审计的反思

审计与经济研究 2006年第3期21卷 3-7页

作者：秦荣生北京国家会计学院北京101312

本文对经营风险导向审计的理论和方法进行了较全面的分析,指出经营风险导向审计的理论与方法体系严重脱节,难以指导实践;经营风险导向审计作为一种技术方法,难以规避审计失败,改变了审计的本质特征。

关键词：经营风险导向审计审计风险审计失败审计本质

Global status and trends of metabolomics in diabetes: A literature visualization knowledge graph study

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World Journal of Diabetes 2024年第5期15卷 1021-1044页

作者： Hong Li Liu Li Qiu-qing Huang Si-Yao Yang Jun-Ju Zou Fan Xiao qin Xiang Xiu Liu rong Yu College of Chinese Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina College of International Education Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Department of Science and Technology Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Hunan Key Laboratory of TCM Prescription and Syndromes Translational Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina College of Graduate Hunan University of Chinese MedicineHunan ChangshaHunan ProvinceChina

BACKGROUND Diabetes is a metabolic disease characterized by hyperglycemia,which has increased the global medical burden and is also the main cause of death in most *** To understand the knowledge structure of global development status,research focus,and future trend of the relationship between diabetes and metabolomics in the past 20 *** The articles about the relationship between diabetes and metabolomics in the Web of Science Core Collection were retrieved from 2002 to October 23,2023,and the relevant information was analyzed using CiteSpace6.2.2R(CiteSpace),VOSviewer6.1.18(VOSviewer),and Bibliometrix software under R *** A total of 3123 publications were included from 2002 to *** the past two decades,the number of publications and citations in this field has continued to *** United States,China,Germany,the United Kingdom,and other relevant funds,institutions,and authors have significantly contributed to this *** Reports and PLoS One are the journals with the most publications and the most *** keyword co-occurrence and cluster analysis,the closely related keywords are"insulin resistance","risk","obesity","oxidative stress","metabolomics","metabolites"and"biomarkers".Keyword clustering included cardiovascular disease,gut microbiota,metabonomics,diabetic nephropathy,molecular docking,gestational diabetes mellitus,oxidative stress,and insulin *** detection analysis of keyword depicted that"Gene","microbiota","validation","kidney disease","antioxidant activity","untargeted metabolomics","management",and"accumulation"are knowledge frontiers in recent *** The relationship between metabolomics and diabetes is receiving extensive *** nephropathy,diabetic cardiovascular disease,and kidney disease are key diseases for future research in this *** microbiota,molecular docking,and untargeted metabolomics are key research directions in the *** a

关键词： Diabetes Metabolomics Bibliometric CiteSpace VOSviewer

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矿井照明设备的光伏蓄电池控制器的设计

煤炭技术 2014年第6期33卷 276-278页

作者：荣雪琴苏州工业职业技术学院江苏苏州215104

蓄电池作为矿工作业照明系统的主要构成部分,利用太阳能对其充电,有效控制充电过程,有利于提高矿工作业效率,降低生产成本。基于干扰观测技术,设计了一种用于矿井照明的光伏蓄电池控制器,深入探讨了蓄电池的充电策略,给出了光伏电池的M... 详细信息

蓄电池作为矿工作业照明系统的主要构成部分,利用太阳能对其充电,有效控制充电过程,有利于提高矿工作业效率,降低生产成本。基于干扰观测技术,设计了一种用于矿井照明的光伏蓄电池控制器,深入探讨了蓄电池的充电策略,给出了光伏电池的MPPT控制的实现方法。该控制器运行可靠,适合大范围推广。

关键词：太阳能 MPPT 蓄电池充电降压型电路

完善农村金融服务体系的研究——以哈尔滨市为例

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生产力研究 2010年第9期 46-47页

作者：张荣琴哈尔滨学院财经与管理学院黑龙江哈尔滨150086

农村金融服务体系改革是加快农村经济发展、建设社会主义新农村的关键一环。文章对哈尔滨市农村金融服务体系的状况进行了分析,认为哈尔滨市农村金融市场存在的主要问题是经营主体单一,农村资金外流现象比较严重,农村金融服务面狭窄,只... 详细信息

农村金融服务体系改革是加快农村经济发展、建设社会主义新农村的关键一环。文章对哈尔滨市农村金融服务体系的状况进行了分析,认为哈尔滨市农村金融市场存在的主要问题是经营主体单一,农村资金外流现象比较严重,农村金融服务面狭窄,只能满足部分小额贷款的需求,提出哈尔滨市农村金融服务体系建设应该加强农村金融服务结构设计、建立农村保险风险保障机制、积极尝试发展现代化农产品期货市场,从深层次上完善哈尔滨市农村金融服务体系。

关键词：农村金融农村保险农产品期货