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Cell division cyclin 25C knockdown inhibits hepatocellular carcinoma development by inducing endoplasmic reticulum stress

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World Journal of Gastroenterology 2024年第19期30卷 2564-2574页

作者： Yan-Fei Li Fang-Yuan Zheng Xin-Yu Miao Hai-Long Liu Yao-Yao Zhang Nai-Xia Chao Fa-rong mo School of Basic Medical Sciences Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Key Laboratory of Biological molecular Medicine Research(Guangxi Medical University) Education Department of Guangxi Zhuang Autonomous RegionNanning 530021Guangxi Zhuang Autonomous RegionChina Key Laboratory of Human Development and Disease Research(Guangxi Medical University) Education Department of Guangxi Zhuang Autonomous RegionNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Cell division cyclin 25C(CDC25C)is a protein that plays a critical role in the cell cycle,specifically in the transition from the G2 phase to the M *** research has shown that CDC25C could be a potential therapeutic target for cancers,particularly for hepatocellular carcinoma(HCC).However,the specific regulatory mechanisms underlying the role of CDC25C in HCC tumorigenesis and development remain incompletely *** To explore the impact of CDC25C on cell proliferation and apoptosis,as well as its regulatory mechanisms in HCC *** Hepa1-6 and B16 cells were transduced with a lentiviral vector containing shRNA interference sequences(LV-CDC25C shRNA)to knock down ***,a xenograft mouse model was established by subcutaneously injecting transduced Hepa1-6 cells into C57BL/6 mice to assess the effects of CDC25C knockdown on HCC development in *** proliferation and migration were evaluated using a Cell Counting Kit-8 cell proliferation assays and wound healing assays,*** expression of endoplasmic reticulum(ER)stress-related molecules(glucose-regulated protein 78,X-box binding protein-1,and C/EBP homologous protein)was measured in both cells and subcutaneous xenografts using quantitative real-time PCR(qRT-PCR)and western ***,apoptosis was investigated using flow cytometry,qRT-PCR,and western *** CDC25C was stably suppressed in Hepa1-6 and B16 cells through LV-CDC25C shRNA transduction.A xenograft model with CDC25C knockdown was successfully established and that downregulation of CDC25C expression significantly inhibited HCC growth in ***25C knockdown not only inhibited cell proliferation and migration but also significantly increased the ER stress response,ultimately promoting ER stress-induced apoptosis in HCC *** The regulatory mechanism of CDC25C in HCC development may involve the activation of ER stress and the ER stress-induced apoptosis signali

关键词： Cell division cyclin 25C Hepatocellular carcinoma Endoplasmic reticulum stress Proliferation Apoptosis

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坚持就业优先促进高质量充分就业

劳动经济研究 2024年第4期12卷 3-8页

作者：莫荣殷宝明中国劳动和社会保障科学研究院

2024年5月27日,习近平总书记在中共中央政治局就促进高质量充分就业进行第十四次集体学习时,全面总结了新时代我国就业工作取得的宝贵经验,强调要坚持实施就业优先战略。中国共产党始终坚持全心全意为人民服务的根本宗旨,就业优先的思... 详细信息

2024年5月27日,习近平总书记在中共中央政治局就促进高质量充分就业进行第十四次集体学习时,全面总结了新时代我国就业工作取得的宝贵经验,强调要坚持实施就业优先战略。中国共产党始终坚持全心全意为人民服务的根本宗旨,就业优先的思想和理念根植已久。

关键词：就业优先高质量充分就业集体学习始终坚持全心全意为人民服务根本宗旨中国共产党习近平总书记

Integration of 1H-NMR-Based Metabolomics Approach with Traditional Chinese Pulse Diagnosis to Evaluate the Qi-Enhancing Activity of Herbal Tea

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Chinese Medicine 2024年第3期15卷 49-74页

作者： Chia-Hsin Lin Po-Jung Huang Chung-Hsuan Wang mo-rong Xu Sheng-Yang Wang Department of Forestry Chung Hsing University Taichung Fu Kang Traditional Chinese Medicine Clinic Nantou Special Crop and Metabolome Discipline Cluster Academy Circle Economy Chung Hsing University Taichung Agricultural Biotechnology Research Institute Academia Sinica Taipei City

Human metabolism is intricately linked to an individual’s health status. Regardless of living habits, it will be reflected in the metabolic characteristics of urine. The utilization of the 1H NMR-based metabolomics method has enabled examine the metabolomic changes in urine under various physiology conditions, providing valuable insights into metabolites. In this particular study, volunteers were divided into two groups based on the strength of their spleen pulses, using the pulse diagnosis method employed in traditional Chinese medicine. Subsequently, their urine samples were analyzed, revealing notable variances in urea, creatinine, citric acid, succinic acid, trimethylamine-N-oxide (TMAO), alanine, hippuric acid, and glycine between the two groups. Interestingly, individuals with weak spleen pulses showed significant improvements after consuming herbal tea. Furthermore, we conducted LC-MS analysis on herbal tea and performed adenosine triphosphate (ATP) activity tests on the C2C12 mouse skeletal muscle cell line. The results indicated that within a reasonable concentration range, exposure to herbal tea led to an increase in the mitochondrial ATP production capacity of C2C12 cells. These findings shed light on the relationship between traditional Chinese medicine pulse diagnosis and urine metabolites, highlighting their potential as non-invasive and straightforward health assessment indicators. They can aid in the preliminary determination of necessary dietary and lifestyle changes to enhance overall bodily health.

关键词： 1H-NMR Metabolomics Traditional Chinese Pulse Diagnosis Qi-Enhancing Herbal Tea

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瞿蜕园整理《文馆词林》初探

中国出版史研究 2024年第2期 150-156页

作者：戎默上海古籍出版社

上海古籍出版社新发现《文馆词林》整理本,虽无署名、前言、后记等,但正文内容首尾完整,校勘详细。根据前人提及掌故及该稿手迹等可以判断为文史名家、曾为上海古籍出版社特约编审的瞿蜕园先生的著作。该整理稿穷尽了当时可以搜集到的... 详细信息

上海古籍出版社新发现《文馆词林》整理本,虽无署名、前言、后记等,但正文内容首尾完整,校勘详细。根据前人提及掌故及该稿手迹等可以判断为文史名家、曾为上海古籍出版社特约编审的瞿蜕园先生的著作。该整理稿穷尽了当时可以搜集到的所有关于《文馆词林》残卷的文献,进行了精校,虽较之如今的整理成果尚有阙卷等问题,但仍有其独特的价值。

关键词：瞿蜕园《文馆词林》域外汉籍回流

Knotted Topological Phase Singularities of Electromagnetic Field

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Communications in Theoretical Physics 2008年第11期50卷 1071-1076页

作者： REN Ji-rong ZHU Tao mo Shu-Fan Institute of Theoretical Physics Lanzhou University Lanzhou 730000 China

In this paper,knotted objects (RS vortices) in the theory of topological phase singularity in electromagneticfield have been investigated in *** using the Duan's topological current theory,we rewrite the topological currentform of RS vortices and use this topological current we reveal that the Hopf invariant of RS vortices is just the sum ofthe linking and self-linking numbers of the knotted RS ***,the conservation of the Hopf invariant inthe splitting,the mergence and the intersection processes of knotted RS vortices is also discussed.

关键词： knotted optical vortex topological current phase singularity

Evolution of Spiral Waves in Excitable Systems

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Communications in Theoretical Physics 2009年第4期51卷 621-626页

作者： REN Ji-rong ZHU Tao mo Shu-Fan Institute of Theoretical Physics Lanzhou University Lanzhou 730000 China

Spiral waves, whose rotation center can be regarded as a point defect, widely exist in various two-dimensional excitable systems. In this paper, by making use of Duan＇s topological current theory, we obtain the charge density of spiral waves and the topological inner structure of its topological charge. The evolution of spiral wave is also studied from the topological properties of a two-dimensional vector field. The spiral waves are found generating or annihilating at the limit points and encountering, splitting, or merging at the bifurcation points of the two-dimensional vector field. Some applications of our theory are also discussed.

关键词： topological current spiral wave bifurcation theory of spiral wave

Branch Processes of Vortex Filaments and Hopf Invariant Constraint on Scroll Wave

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Communications in Theoretical Physics 2009年第12期52卷 1149-1156页

作者： ZHU Tao REN Ji-rong mo Shu-Fan Institute of Theoretical Physics Lanzhou University Lanzhou 730000 China

In this paper, by making use of Duan＇s topological current theory, the evolution of the vortex filaments in excitable media is discussed in detail. The vortex filaments are found generating or annihilating at the limit points and encountering, splitting, or merging at the bifurcation points of a complex function Z（x, t）. [t is also shown that the Hopf invariant of knotted scroll wave filaments is preserved in the branch processes （splitting, merging, or encountering） during the evolution of these knotted scroll wave filaments. Furthermore, it also revealed that the ＂exclusion principle＂ in some chemical media is just the special case of the Hopf invariant constraint, and during the branch processes the ＂exclusion principle＂ is also protected by topology.

关键词： scroll wave Hopf invariant topology of knot vortex filament

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非线性超谐共振时效系统弹簧设计方法的研究

机械设计与制造 2024年第8期402卷 23-27,32页

作者：莫荣献郭晓东赵丽芳李岩舟广西大学机械工程学院广西南宁530004

为解决难以获取满足非线性超谐共振时效系统所需要的非线性参数,以系统的核心元件—非线性弹簧为研究对象,提出了适用于此系统的不等节距圆柱螺旋弹簧结构参数设计的方法,从而实现系统所要达到的超谐共振。首先,依据工件振动时效所需的... 详细信息

为解决难以获取满足非线性超谐共振时效系统所需要的非线性参数,以系统的核心元件—非线性弹簧为研究对象,提出了适用于此系统的不等节距圆柱螺旋弹簧结构参数设计的方法,从而实现系统所要达到的超谐共振。首先,依据工件振动时效所需的弹簧力学特性曲线,计算得到符合该系统用不等节距圆柱螺旋弹簧的结构参数。其次,通过弹簧压缩试验证明了该弹簧设计方法的可行性。最后,以圆柱工件为试验对象,搭建非线性超谐振动台进行试验研究。结果表明:运用此方法设计的不等节距螺旋弹簧作用下的非线性超谐振动试验台能够产生超谐振动,且可产生高于200Hz的高次超谐频率,对推广非线性超谐式共振时效方法在消减高刚工件的残余应力方面具有重要的意义。

关键词：非线性超谐共振非线性弹簧弹簧设计振动时效

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基于LEC法涉铁桥梁施工安全风险评估

科技资讯 2024年第17期22卷 204-207页

作者：莫蓉刘绪王玉朱泽文江西省交通科学研究院有限公司江西交科交通工程有限公司江西南昌330200

涉铁桥梁的建设对既有铁路线路运营具有极大风险,因此,在涉铁桥梁施工前,必须对项目进行安全风险评估。首先,通过识别初始风险形成风险源清单,采用LEC法定性评估各风险发生概率并确定风险等级,进而制订相应防范方案和措施。其次,采用mid... 详细信息

涉铁桥梁的建设对既有铁路线路运营具有极大风险,因此,在涉铁桥梁施工前,必须对项目进行安全风险评估。首先,通过识别初始风险形成风险源清单,采用LEC法定性评估各风险发生概率并确定风险等级,进而制订相应防范方案和措施。其次,采用midas GTS NX对涉铁桥梁施工中引起的铁路路基位移进行计算,计算结果最大附加沉降位移为2.041 mm、最大附加水平位移为0.177 mm。综合定性和定量分析可知,涉铁桥梁工程施工及运营会对铁路路基变形产生一定影响,但影响值满足规范控制要求。

关键词：涉铁桥梁安全风险评估 LEC法位移