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Transcutaneous electrical acupoint stimulation benefits postoperative pain relief of oocyte retrieval:A randomized controlled trial

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Journal of Integrative Medicine 2024年第1期22卷 32-38页

作者： Li-ying Liu Yang Su rong-rong Wang Yuan-yuan Lai Lei Huang Yi-ting Li Xin-yue Tao Meng-hua Su Xiao-yan Zheng Shi-chen Huang Yong-na Wu Si-yi Yu Fan-rong liang Jie Yang Acupuncture and Tuina School Chengdu University of Traditional Chinese MedicineChengdu 610000Sichuan ProvinceChina Traditional Chinese Medicine Department Sichuan Jinxin Xi’nan Women's and Children's HospitalChengdu 610000Sichuan ProvinceChina

Background Transvaginal oocyte retrieval is frequently followed by adverse events related to anesthesia and the *** research showed that transcutaneous electrical acupoint stimulation(TEAS)can relieve intraoperative pain and postoperative *** This study examined whether TEAS can alleviate pain and relieve adverse symptoms after oocyte ***,setting,participants and interventions Altogether 128 patients were randomly divided into the TEAS group and the mock TEAS *** two groups received a 30-minute-long TEAS or mock TEAS treatment that began 30 min after oocyte *** outcome measures The primary outcome was the visual analog scale(VAS)pain *** outcomes were pressure pain threshold,McGill score,pain rating index(PRI),present pain intensity(PPI),VAS stress score,VAS anxiety score,and postoperative adverse *** The baseline characteristics of the two groups were comparable(P>0.05).The VAS pain scores of the TEAS group were lower than those of the mock TEAS group at 60 and 90 min after oocyte retrieval(P0.05).The TEAS group was superior to the mock TEAS group for relieving postoperative adverse symptoms(P<0.05).Conclusion TEAS treatment can relieve postoperative pain and postoperative adverse symptoms for patients undergoing oocyte retrieval.

关键词： Transcutaneous electrical acupoint stimulation Fertilization Embryo transfer Oocyte retrieval Pain Randomized controlled trial

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Laparoscopic enucleation for pancreatic lipomatous hamartoma

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Hepatobiliary & Pancreatic Diseases International 2024年第5期23卷 541-544页

作者： Da-Long Wan rong-liang Tong Xin-Yu Tong Chen Hu Qing-Hong Ke Xu Yang Jian Wu Department of Hepatobiliary and Pancreatic Surgery the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Pathology the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

To the Editor : Pancreatic hamartoma is an extremely rare and benign disease and accounts for less than 1% of all pancreatic tumors [1]. Pancreatic lipomatous hamartoma(PLH), a distinct variant of pancreatic hamartoma, is always easily misdiagnosed as other pancreatic tumors with lipomatous components, including pancreatic lipoma, liposarcoma, teratoma and malignant tumors with fatty degeneration. Here, we report a case of laparoscopic enucleation for the pancreatic head lipomatous hamartoma and provide new treatment strategies for surgeons who encounter similar diseases in the future.

关键词： degeneration Laparoscopic diseases

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Achieving laparoscopic anatomic resection for hepatocellular carcinoma by fluorescence guided positive staining of hepatic cone unit

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Hepatobiliary & Pancreatic Diseases International 2024年第4期23卷 406-411页

作者： Jun-Fang Deng Chuan-Hui Peng Yu Zhang Xiao-Feng Xu rong-liang Tong Zheng-Long Zhai Di-Yu Chen Cheng Zhang Li-Ming Wu Jian Wu Division of Hepatobiliary Pancreatic Surgery the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Laparoscopic anatomical liver resection has been increasingly reported worldwide,but how to demarcate the resection planes is technically challenging[1].Positive staining technique with intraoperative indocyanine green(ICG)-fluorescence imaging has been introduced as an effective tool for real-time intraoperative guidance[2].Liver anatomy is ***,liver is composed of 9 segments,each is composed of two to three subsegments,and each subsegment contains several hepatic cone units.A hepatic cone unit is dominated by a tertiary or quaternary hepatic pedicles[3].

关键词： hepatic resection anatomy

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Integrated ribosome and proteome analyses reveal insights into sevoflurane-induced long-term social behavior and cognitive dysfunctions through ADNP inhibition in neonatal mice

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Zoological Research 2024年第3期45卷 663-678页

作者： Li-rong liang Bing Liu Shu-Hui Cao You-Yi Zhao Tian Zeng Mei-Ting Zhai Ze Fan Dan-Yi He San-Xin Ma Xiao-Tong Shi Yao Zhang Hui Zhang State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral DiseasesShaanxi Engineering Research Center for Dental Materials and Advanced ManufactureDepartment of AnesthesiologySchool of StomatologyAir Force Medical UniversityXi’anShaanxi 710032China Department of Anesthesiology 986th Air Force HospitalAir Force Medical UniversityXi’anShaanxi 710032China

A growing number of studies have demonstrated that repeated exposure to sevoflurane during development results in persistent social abnormalities and cognitive ***,an active fragment of the activity-dependent neuroprotective protein(ADNP),has been implicated in social and cognitive ***,the potential of davunetide to attenuate social deficits following sevoflurane exposure and the underlying developmental mechanisms remain poorly *** this study,ribosome and proteome profiles were analyzed to investigate the molecular basis of sevoflurane-induced social deficits in neonatal *** neuropathological basis was also explored using Golgi staining,morphological analysis,western blotting,electrophysiological analysis,and behavioral *** indicated that ADNP was significantly down-regulated following developmental exposure to *** adulthood,anterior cingulate cortex(ACC)neurons exposed to sevoflurane exhibited a decrease in dendrite number,total dendrite length,and spine ***,the expression levels of Homer,PSD95,synaptophysin,and vglut2 were significantly reduced in the sevoflurane ***-clamp recordings indicated reductions in both the frequency and amplitude of miniature excitatory postsynaptic currents(mEPSCs).Notably,davunetide significantly ameliorated the synaptic defects,social behavior deficits,and cognitive impairments induced by *** analysis revealed that loss of ADNP led to dysregulation of Ca^(2+)activity via the Wnt/β-catenin signaling,resulting in decreased expression of synaptic *** of Wnt signaling was restored in the davunetide-treated ***,ADNP was identified as a promising therapeutic target for the prevention and treatment of neurodevelopmental toxicity caused by general *** study provides important insights into the mechanisms underlying social and cognitive disturbances caused by sevoflurane exposure in neonatal

关键词： Davunetide Sevoflurane Abnormal social behaviors ADNP Neurotoxicity

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Chidamide plus prednisone,cyclophosphamide,and thalidomide for relapsed or refractory peripheral T-cell lymphoma:A multicenter phase II trial

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Chinese Medical Journal 2024年第13期137卷 1576-1582页

作者： Jinhua liang Li Wang Xiaodong Wang Guohui Cui Jianfeng Zhou Tongyao Xing Kaixin Du Jingyan Xu Luqun Wang rong liang Biyun Chen Jian Cheng Haorui Shen Jianyong Li Wei Xu Department of Hematology The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingJiangsu 210029China Key Laboratory of Hematology of Nanjing Medical University NanjingJiangsu 210029China Collaborative Innovation Center for Cancer Personalized Medicine NanjingJiangsu 210029China Department of Hematology Sichuan Academy of Medical Sciences&Sichuan Provincial People’s HospitalSchool of Medicine of University of Electronic Science and Technology of ChinaChengduSichuan 610000China Department of Hematology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Department of Hematology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China Department of Hematology Nanjing Drum Tower HospitalNanjing University Medical SchoolNanjingJiangsu 210008China Department of Hematology Qilu Hospital of Shandong UniversityJinanShandong 250000China Department of Hematology Xijing HospitalThe Fourth Military Medical UniversityXi’anShaanxi 710032China Department of Hematology Fujian Provincial HospitalFuzhouFujian 350001China Department of Hematology Zhongda HospitalMedical School of Southeast UniversityNanjingJiangsu 210009China

Background:Although the treatment of peripheral T-cell lymphoma(PTCL)has undergone advancements during the past several years,the response rate and long-term effects with respect to patients with PTCL remain unsatisfactory—particularly for relapsed or refractory(R/R)*** phase II trial was designed to explore the efficacy and safety of an all-oral regimen of chidamide plus prednisone,cyclophosphamide,and thalidomide(CPCT)for R/R PTCL patients who could not tolerate the standard chemotherapy for a variety of ***:We conducted a multicenter phase II clinical trial in which we combined chidamide(30 mg twice weekly)with prednisone(20 mg daily after breakfast),cyclophosphamide(50 mg daily after lunch),and thalidomide(100 mg daily at bedtime)(the CPCT regimen)for a total of fewer than 12 cycles as an induction-combined treatment period,and then applied chidamide as single-drug ***-five patients were ultimately enrolled from August 2016 to April 2021 with respect to Chinese patients at nine *** primary objective was to assess the overall response rate(ORR)after the treatment with ***:Of the 45 enrolled patients,the optimal ORR and complete response(CR)/CR unconfirmed(CRu)were 71.1%(32/45)and 28.9%(13/45),respectively,and after a median follow-up period of 56 months,the median progression-free survival(PFS)and overall survival(OS)were 8.5 months and 17.2 months,*** five-year PFS and OS rates were 21.2%(95%confidence interval[CI],7.9-34.5%)and 43.8%(95%CI,28.3-59.3%),*** most common adverse event was neutropenia(20/45,44.4%),but we observed no treatment-related ***:The all-oral CPCT regimen was an effective and safe regimen for R/R PTCL patients who could not tolerate standard chemotherapy for various *** Registration:***,NCT02879526.

关键词： Peripheral T-cell lymphoma Chidamide Prednisone Cyclophosphamide Thalidomide All-oral regimen

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中国城市PM_(2.5)和PM_(10)时空分布特征和影响因素分析

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环境科学 2024年第4期45卷 1938-1949页

作者：李江苏段良荣张天娇河南大学黄河文明与可持续发展研究中心暨黄河文明省部共建协同创新中心开封475001

PM_(2.5)和PM_(10)浓度超标引发的空气质量问题严重影响公众健康,研究PM_(2.5)和PM_(10)浓度对制定有效的污染防控和治理措施具有重要意义.运用时空分析法,分析2018年季度PM_(2.5)和PM_(10)浓度时空分布,并用GWR探究浓度差异的原因.结... 详细信息

PM_(2.5)和PM_(10)浓度超标引发的空气质量问题严重影响公众健康,研究PM_(2.5)和PM_(10)浓度对制定有效的污染防控和治理措施具有重要意义.运用时空分析法,分析2018年季度PM_(2.5)和PM_(10)浓度时空分布,并用GWR探究浓度差异的原因.结果表明:(1)PM_(2.5)和PM_(10)的浓度均呈冬春高、夏秋低的季节性规律;四季污染物浓度在胡焕庸线两侧存在显著差异,该线以东地区高浓度聚集在京津冀地区,该线以西地区高浓度聚集在新疆中南部.(2)PM_(2.5)和PM_(10)浓度的Moran's I在四季均为正,且均在冬季增至最大值;PM_(2.5)和PM_(10)的分布格局基本一致,“高-高”类和“低-低”类集中分布现象明显.(3)各因素对PM_(2.5)和PM_(10)浓度的影响存在较大空间异质性.温度和坡度对PM_(2.5)和PM_(10)浓度的影响均表现为南部地区呈负相关,北部地区呈正相关.降水和风速对大部分地区PM_(2.5)和PM_(10)浓度的影响呈负相关,且夏季负相关的范围均较小.人类活动强度、二产占比和能源消耗总量对地区PM_(2.5)和PM_(10)浓度的影响在大部分地区呈正相关,各季度的正相关高值区也存在差异.

关键词： PM_(2.5)浓度 PM_(10)浓度时空分布地理加权回归(GWR) 影响因素

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视觉跟踪多转子位移测量

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振动工程学报 2024年第1期37卷 113-125页

作者：杨荣良王森伍星柳小勤刘韬昆明理工大学机电工程学院云南昆明650500 云南机电职业技术学院云南昆明650023

针对当前传统振动传感器在测量旋转体位移时受限于安装和测点数量等问题,将高速工业相机作为采集媒介,在转子振动试验台上进行转子振动视频的采集,并利用基于多目标跟踪的视觉振动测量方法跟踪多个转子目标的全场振动位移。将注意力机... 详细信息

针对当前传统振动传感器在测量旋转体位移时受限于安装和测点数量等问题,将高速工业相机作为采集媒介,在转子振动试验台上进行转子振动视频的采集,并利用基于多目标跟踪的视觉振动测量方法跟踪多个转子目标的全场振动位移。将注意力机制引入残差神经网络,结合特征金字塔网络结构建立改进的特征提取骨干网络,并利用身份重新识别方法来强化相邻帧间目标位移的关联性,跟踪旋转体全场振动位移信号。在转子振动位移测量数据集上对不同网络模型进行定性和定量的比较。结果表明,本文构建的网络模型在边界框回归时能够获取更为紧密的贴合度;将采集的电涡流位移信号作为标准量进行两个转子位移信号的对比实验,结果表明,本文多目标跟踪算法拟合的波形和频谱噪声最小,且能与电涡流信号相匹配;在目标对象模糊情况下的实验也证明本文算法所具有的泛化性能,这也体现出视觉测量在旋转体振动位移跟踪领域的工程应用价值。

关键词：视觉测振深度学习多目标视觉跟踪模糊图像旋转体位移测量

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节段预制拼装波形钢腹板连续组合箱梁抗弯性能试验研究

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工程力学 2024年第9期41卷 191-200页

作者：赵品邵旭东荣学亮韩恒涛道路与铁道工程安全保障省部共建教育部重点实验室(石家庄铁道大学) 石家庄050043 石家庄铁道大学土木工程学院石家庄050043 湖南大学土木工程学院长沙410082 中铁第四勘察设计院集团有限公司武汉430063

为研究波形钢腹板连续组合箱梁在整体现浇和节段预制拼装施工工艺下抗弯性能的差异,对一片节段预制拼装变截面波形钢腹板连续箱梁和一片相同尺寸的整体式波形钢腹板连续箱梁进行了抗弯性能试验,分析了接缝的存在对节段预制波形钢腹板连... 详细信息

为研究波形钢腹板连续组合箱梁在整体现浇和节段预制拼装施工工艺下抗弯性能的差异,对一片节段预制拼装变截面波形钢腹板连续箱梁和一片相同尺寸的整体式波形钢腹板连续箱梁进行了抗弯性能试验,分析了接缝的存在对节段预制波形钢腹板连续梁不同特征截面上应变的分布、荷载-挠度曲线变化、预应力增量的影响,并对两片梁的破坏形态进行了分析,试验结果表明:加载初期,接缝的存在对试验梁刚度影响较小,两片梁的应变和变形接近。开裂后节段拼装梁节段接缝间的混凝土应变相对整体梁偏小,但接缝处的混凝土应变较大,接缝位置的塑性变形使得内力重分布现象更加明显;整体梁出现典型的弯曲裂缝,而节段拼装梁裂缝数量在整个过程中相对较少,集中出现在节段两侧接缝位置;在塑性阶段,节段梁变形主要发生在接缝位置,梁体变形相对较大,而边跨相对于中跨挠度变化较小。节段拼装梁的预应力筋相比于整体梁发挥了更大的作用,应力增长速率更快,且节段拼装梁有效高度变化小于整体梁。提出了节段预制拼装波形钢腹板连续箱梁抗弯承载力计算公式,且公式计算值与试验结果吻合程度较好。

关键词：桥梁工程抗弯性能节段预制拼装波形钢腹板连续梁变截面

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Global research trends in postoperative ileus from 2011 to 2023:A scientometric study

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World Journal of Gastrointestinal Surgery 2024年第9期16卷 3020-3031页

作者： Yan Zhou Zi-Han Yin Ming-Sheng Sun Yang-Yang Wang Chen Yang Shu-Hao Li Fan-rong liang Fang Liu Acupuncture and Tuina School Chengdu University of Traditional Chinese MedicineChengdu 610075Sichuan ProvinceChina Department of Integrated Chinese and Western Medicine Sichuan Clinical Research Center for CancerSichuan Cancer Hospital&InstituteSichuan Cancer CenterAffiliated Cancer Hospital of University of Electronic Science and Technology of ChinaChengdu 610041Sichuan ProvinceChina

BACKGROUND Postoperative ileus(POI)is a common complication after abdominal surgery with high morbidity,which hinders patient recovery,prolongs hospitalization,and increases healthcare ***,POI has become a global public health *** triggering is *** and hormonal mechanisms are generally involved in POI *** studies have shown that beta adrenergic signaling of enteric glia is a POI ***,the status quo,trends,and frontiers of global research on POI remain *** To explore the current status,trends,and frontiers of POI research from 2011 to the present based on bibliometric *** Publications published on POI research from 2011 to 2023 were retrieved on June 1,2023,from the Web of Science Core *** 6.2.R2 and VOSviewer were used to conduct bibliometric *** In total,778 POI records published from 2011 to 2023 were *** the past few decades,the annual cumulative number of related articles has linearly increased,with China and the United States of America contributing *** publications were from 59 countries and *** and the University of Bonn were the top contributing country and institution,***&Motility was the most prolific *** Journal of Gastrointestinal Surgery had the highest number of *** Sven was the most productive *** keywords(e.g.,colon,prolonged ileus,acupuncture,paralytic ileus,pathophysiology,rectal cancer,gastrointestinal function,risk)and a series of reference citation bursts provided evidence for the research frontiers in recent *** This study demonstrates trends in the published literature on POI and provides new insights for *** emphasizes the importance of multidisciplinary cooperation in the development of this field.

关键词： Postoperative ileus Scientometric analysis VOSviewer CiteSpace Visualization Trends

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酶解法制备阿胶蛋白肽工艺条件优化及抗氧化活性分析

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食品工业科技 2024年第10期45卷 217-224页

作者：梁荣徐乐樊琛曹乐乐郭兴峰聊城大学农学与农业工程学院山东聊城252000

目的:研究酶解法制备阿胶蛋白肽的工艺条件及阿胶蛋白肽的抗氧化活性。方法:以阿胶为原料,通过酶解实验优化碱性蛋白酶Alcalase 2.4L制备阿胶蛋白肽的酶解工艺条件。以酶解pH、酶与底物比、酶解温度作为考察因素,以阿胶的水解度为指标,... 详细信息

目的:研究酶解法制备阿胶蛋白肽的工艺条件及阿胶蛋白肽的抗氧化活性。方法:以阿胶为原料,通过酶解实验优化碱性蛋白酶Alcalase 2.4L制备阿胶蛋白肽的酶解工艺条件。以酶解pH、酶与底物比、酶解温度作为考察因素,以阿胶的水解度为指标,在单因素实验的基础上,通过正交试验确定最佳工艺条件;利用高效凝胶色谱法测定酶解前后阿胶溶液的分子量分布情况,并通过检测对ABTS+和DPPH自由基的清除率,考察酶解前后阿胶溶液的抗氧化活性,从而综合分析酶解效果;采用4种不同大小孔径的超滤膜分离阿胶蛋白肽液,研究经超滤膜分离后不同分子量阿胶蛋白肽的抗氧化活性。结果:阿胶溶液的最佳酶解条件为:pH10.5、酶与底物比9%、酶解温度63℃,此条件下测得阿胶酶解液的水解度为15.93%±1.32%;酶解后阿胶溶液的分子量大部分分布在5000 Da以下;当浓度为10 mg/mL时,未酶解和酶解后的阿胶蛋白肽溶液ABTS+自由基清除率分别为75.83%±0.32%和93.16%±0.21%,DPPH自由基清除率为16.93%±2.41%和39.95%±1.27%;经超滤处理获得五组不同分子量的阿胶蛋白肽(>30 kDa、10~30 kDa、3~10 kDa、1~3 kDa和<1 kDa),分析比较发现低分子量的阿胶蛋白肽抗氧化效果较好。结论:碱性蛋白酶Alcalase 2.4L能够有效制备阿胶蛋白肽,且阿胶蛋白肽具有良好的抗氧化活性。试验结果为后续开展阿胶蛋白肽的抗氧化机制研究提供科学依据。

关键词：阿胶蛋白肽碱性蛋白酶酶解工艺正交试验抗氧化活性

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