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Effect of Jianpi Shengxue Tablet on Iron Metabolism and Nutritional Status in Patients with Renal Anemia:A Prospective,Randomized,Open,Parallel Controlled and Multicenter Clinical Study

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Current Medical Science 2024年第3期44卷 603-610页

作者： Juan YANG Meng-yuan LIANG Yu LI Hao ZHANG Wei LI Jing LV Li-ping DONG Jing-song JIN Cheng YANG Qing-hong ZHANG Li LONG rong zou Yi GAO Dan SONG Chun-qin PAN Ying YAO Xiao-lin ZHAN Xiao-hui WANG Department of Nephrology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Nephrology The First People’s Hospital of GuiyangGuiyang550000China Department of Nephrology The Third Xiangya HospitalCentral South UniversityChangsha410000China Department of Nephrology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an710061China Department of Nephrology Wuhan No. 4 HospitalWuhan430033China Department of Nephrology Hubei Provincial Hospital of Traditional Chinese MedicineWuhan430060China Department of Nephrology Central Theater General Hospital of PLAWuhan430064China Department of Nephrology Taihe HospitalShiyan442000China Department of Nephrology Third People’s Hospital of Hubei ProvinceWuhan430033China Department of Nephrology Hubei Province Integrated Traditional Chinese and Western Medicine Hospital of Hubei provinceWuhan430024China Department of Nephrology Xi’an No.3 HospitalAffiliated Hospital of Northwest UniversityXi’an710000China Department of Nephrology Shenzhen Guangming District People’s HospitalShenzhen518000China Department of Nephrology Xiantao First People’s HospitalXiantao433000China Department of Nutrition Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Nephrology Huangshi Central HospitalHuangshi435000China Department of Nephrology The Fifth Hospital of WuhanWuhan430050China

Objective This study aimed to analyze the clinical efficacy of the Jianpi Shengxue tablet for treating renal anemia.Methods A total of 200 patients with renal anemia from December 2020 to December 2022 were enrolled and randomly divided into two groups.Patients in the control group were treated with polysaccharide-iron complex,and those in the experimental group were administered Jianpi Shengxue tablet.After 8 weeks of continuous treatment,the therapeutic outcomes regarding anemia were compared between the two groups.Results After treatment,the red blood cell(RBC)count,hematocrit(HCT),reticulocyte percentage(RET),ferritin(SF),serum iron(SI),transferrin saturation(TSAT),and serum albumin(ALB)all increased(P<0.01),and the clinical symptom score and total iron binding capacity decreased(P<0.01)in the experimental group.Moreover,the improvements in RBC,HCT,RET,SF,SI,TAST,ALB,and clinical symptoms(fatigue,anorexia,dull skin complexion,numbness of hands and feet)in the experimental group were significantly greater than those in the control group(P<0.05).The total effective rate for treating renal anemia was significantly higher in the experimental group than in the control group(P<0.01).Conclusion The Jianpi Shengxue tablet demonstrates efficacy in treating renal anemia,leading to significant improvements in the laboratory examination results and clinical symptoms of patients with renal anemia.

关键词： Jianpi Shengxue tablet renal anemia randomized open parallel control multicenter clinical study

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Pharmacotherapy of urethral stricture

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Asian Journal of Andrology 2024年第1期26卷 1-9页

作者： Hui Luo Ke-Cheng Lou Ling-Yu Xie Fei Zeng Jun-rong zou The First Clinical College Gannan Medical UniversityGanzhou 341000China Department of Urology The First Affiliated Hospital of Gannan Medical UniversityGanzhou 341000China Institute of Urology The First Affiliated Hospital of Gannan Medical UniversityGanzhou 341000China Jiangxi Engineering Technology Research Center of Calculi Prevention Ganzhou 341000China

Urethral stricture is characterized by the chronic formation of fibrous tissue,leading to the narrowing of the urethral lumen.Despite the availability of various endoscopic treatments,the recurrence of urethral strictures remains a common challenge.Postsurgery pharmacotherapy targeting tissue fibrosis is a promising option for reducing recurrence rates.Although drugs cannot replace surgery,they can be used as adjuvant therapies to improve outcomes.In this regard,many drugs have been proposed based on the mechanisms underlying the pathophysiology of urethral stricture.Ongoing studies have obtained substantial progress in treating urethral strictures,highlighting the potential for improved drug effectiveness through appropriate clinical delivery methods.Therefore,this review summarizes the latest researches on the mechanisms related to the pathophysiology of urethral stricture and the drugs to provide a theoretical basis and new insights for the effective use and future advancements in drug therapy for urethral stricture.

关键词： adjuvant therapy pathophysiology pharmacotherapy urethra urethral stricture

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Selenium-doped cathode materials with polyaniline skeleton for lithium-organosulfur batteries

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Journal of Energy Chemistry 2023年第4期79卷 148-157页

作者： rong zou Wenwu Liu Fen Ran State Key Laboratory of Advanced Processing and Recycling of Non-ferrous Metals School of Materials Science and EngineeringLanzhou University of TechnologyLanzhou 730050GansuChina

Sulfur-containing polymer(SCP)is considered as an outstanding cathode material for lithium-sulfur batteries.However,undesirable soluble polysulfides may shuttle in electrolyte,concluding long-chain Li_(2)S_(n)(n>4)and short-chain Li2Sn(n≤4),as well as the sluggish conversion kinetics are yet to be solved to enhance the performance of lithium-sulfur batteries.Here Se-doped sulfurized polyaniline with adjusted sulfur-chain-S_(x)-(x≤6)contribute to ensure the absence of long-chain polysulfides,and the skeleton with quinoid imine can endow strongly adsorption towards short-chain polysulfides by the reversible transition between deprotonated/protonated imine(-NH^(+)=and-N=),which offer double insurance against suppressing“shuttle effect”.Furthermore,Se atoms are doped into sulfurized polysulfides to accelerate the redox conversion and take a frontier orbital theory-oriented view into catalytic mechanism.Se-doped sulfurized polyaniline as active materials for lithium-organosulfur batteries delivers good electrochemical performance,including high rate,reversible specific capacity(680 mA h g^(-1)at 0.1 A g^(-1)),and lower capacity decay rate only of 0.15%with near 100%coulomb efficiency during long-term cycle.This work provides a valuable guiding ideology and promising solution for the chemistry-oriented structure design and practical application for lithium-organosulfur batteries.

关键词： Lithium-organosulfur batteries Selenium-doped Cathode materials Sulfur-containing polymer Frontier orbital theory

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Prognostic significance and relationship of SMAD3 phosphoisoforms and VEGFR-1 in gastric cancer:A clinicopathological study

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 118-132页

作者： Shi-Lin Lv Pei Guo Jun-rong zou Ren-Sheng Chen Ling-Yu Luo De-Qiang Huang Hospital of Gastroenterology Institute of Digestive DiseasesThe First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina Department of Pathology Shenzhen Hospital of Southern Medical UniversityShenzhen 518000Guangdong ProvinceChina Institute of Urology The First Affiliated Hospital of Gannan Medical UniversityGanzhou 341000Jiangxi ProvinceChina Department of Pathology The First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina

BACKGROUND The TGF-β/SMAD3 and VEGFR-1 signaling pathways play important roles in gastric cancer metastasis.SMAD3 phosphorylation is a crucial prognostic marker in gastric cancer.AIM To determine the prognostic value and relationship of SMAD3 phospho-isoforms and VEGFR-1 in gastric cancer.METHODS This was a single-center observational study which enrolled 98 gastric cancer patients and 82 adjacent normal gastric tissues from patients aged 32-84 years(median age 65)between July 2006 and April 2007.Patients were followed up until death or the study ended(median follow-up duration of 28.5 mo).The samples were used to generate tissue microarrays(TMAs)for immunohistochemical(IHC)staining.The expressions of TGF-β1,pSMAD3C(S423/425),pSMAD3L(S204),and VEGFR-1 in gastric cancer(GC)tumor tissue and normal tissue were measured by IHC staining using TMAs obtained from 98 GC patients.Prognosis and survival information of the patients was recorded by Outdo Biotech from May 2007 to July 2015.The relationship between TGF-β1,pSMAD3C(S423/425),pSMAD3L(S204),and VEGFR-1 protein expression levels was analyzed using Pearson's correlation coefficient.The relationship between protein expression levels and clinicopathological parameters was analyzed using the Chi-squared test.A survival curve was generated using the Kaplan-Meier survival analysis.RESULTS TGFβ-1 and VEGFR-1 expression was significantly upregulated in gastric cancer tissue compared to adjacent noncancerous tissue.The positive expression of phosphorylated isoforms of Smad3 varied depending on the phosphorylation site[pSMAD3C(S423/425):51.0%and pSMAD3L(S204):31.6%].High expression of pSMAD-3L(S204)was significantly correlated with larger tumors(P=0.038)and later N stages(P=0.035).Additionally,high expression of VEGFR-1 was closely correlated with tumor size(P=0.015)and pathological grading(P=0.013).High expression of both pSMAD3L(S204)and VEGFR-1 was associated with unfavorable outcomes in terms of overall survival(OS).Multivariate analysis indicated that high expression of

关键词： Gastric cancer pSMAD3L(S204) pSMAD3C(S423/425) Survival Transforming growth factor-β1 VEGFR-1

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Coseismic Slip Distribution of the 2021 Mw7.4 Maduo,Qinghai Earthquake Estimated from InSAR and GPS Measurements

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Journal of Earth Science 2022年第4期33卷 885-891页

作者： Lihan Xiao Rui Zheng rong zou Institute of Geophysics and Geomatics China University of GeosciencesWuhan 430074China

On 22 May 2021,the Maduo Earthquake occurred on a branch fault of the East Kunlun fault in the Bayan Har Block,which provides opportunity to constrain fault geometry and strain accumulation and release for assessment of earthquake hazards.We processed the Sentinal-1A/B SAR images acquired before and after the earthquake,with which we constrained a finite fault model to best fit to the combined data set of downsampled InSAR image and GPS displacements.The inversion indicates that the Maduo event ruptured a 160 km long section striking 286.5°and a dipping 81.39°with rake angle of 4.62°.The model suggests three compact rupture areas with the slip amplitude exceeding 4 m on the main rupture section and the largest slip region is in the east of the epicenter with a slip of approximately 4.6 m below the surface,in a good agreement with the field geological survey.The total geodetic moment is 1.67×10^(20) N·m equivalent to Mw7.44,slightly larger than estimate of the USGS.

关键词： Maduo Earthquake geodetic measurements coseismic displacements slip distribution focal mechanism earthquakes

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Sulfur-containing polymer cathode materials: From energy storage mechanism to energy density

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InfoMat 2022年第8期4卷 1-24页

作者： rong zou Wenwu Liu Fen Ran State Key Laboratory of Advanced Processing and Recycling of Non-ferrous Metals School of Material Science and EngineeringLanzhou University of TechnologyLanzhouP.R.China

Besides lithium-ion batteries, it is imperative to develop new battery energystorage system with high energy density. In conjunction with the developmentof Li-S batteries, emerging sulfur-containing polymers with tunable sulfur-chain length and organic groups gradually attract much attention as cathodematerials. This can avoid the problems that are impeding the development ofthe typical Li-S batteries, such as volume expansion, active material dissolu-tion, shuttle effect, and so on. This review aims to generalize the type ofsulfur-containing polymers and the working principles in Li-S batteries. Thesulfur-containing polymers (R-Sn-R) with different sulfur-chain length (n > 6,n ≤ 2, and 3 ≤ n ≤ 6) are summarized. It also discusses several organic groupssuch as phenyl rings, N-heterocycles, and unique structure with cross-linkednetworks and multi-micropores skeleton. This review also explores other strat-egies of sulfur-containing polymers in the rest of Li-S batteries, providing asummary of the advantages of sulfur-containing polymers, recent develop-ment, in-depth discussion of the mechanism in Li-S batteries, and organicgroup-structure-performance relationship. This review would have guidelinesfor future development of sulfur-containing polymers in Li-S batteries.

关键词： cathode materials energy density energy storage mechanism Li-S batteries sulfur-containing polymer

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Yes-associated protein promotes endothelial-tomesenchymal transition of endothelial cells in choroidal neovascularization fibrosis

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International Journal of Ophthalmology(English edition) 2022年第5期15卷 701-710页

作者： rong zou Yi-Fan Feng Ya-Hui Xu Min-Qian Shen Xi Zhang Yuan-Zhi Yuan Department of Ophthalmology Zhongshan HospitalFudan UniversityShanghaiChina Department of Ophthalmology Xiamen BranchZhongshan HospitalFudan UniversityXiamenFujian ProvinceChina

AIM:To reveal whether and how Yes-associated protein(YAP)promotes the occurrence of subretinal fibrosis in agerelated macular degeneration(AMD).METHODS:Cobalt chloride(Co Cl2)was used in primary human umbilical vein endothelial cells(HUVECs)to induce hypoxia in vitro.Eight-week-old male C57 BL/6 J mice weighing 19-25 g were used for a choroidal neovascularization(CNV)model induced by laser photocoagulation in vivo.Expression levels of YAP,phosphorylated YAP,mesenchymal markers[αsmooth muscle actin(α-SMA),vimentin,and Snail],and endothelial cell markers(CD31 and zonula occludens 1)were measured by Western blotting,quantitative real-time PCR,and immunofluorescence microscopy.Small molecules YC-1(Lificiguat,a specific inhibitor of hypoxia-inducible factor 1α),CA3(CIL56,an inhibitor of YAP),and XMU-MP-1(an inhibitor of Hippo kinase MST1/2,which activates YAP)were used to explore the underlying mechanism.RESULTS:Co Cl2 increased expression of mesenchymal markers,decreased expression of endothelial cell markers,and enhanced the ability of primary HUVECs to proliferate and migrate.YC-1 suppressed hypoxia-induced endothelialto-mesenchymal transition(End MT).Moreover,hypoxia promoted total expression,inhibited phosphorylation,and enhanced the transcriptional activity of YAP.XMU-MP-1 enhanced hypoxia-induced End MT,whereas CA3 elicited the opposite effect.Expression of YAP,α-SMA,and vimentin were upregulated in the laser-induced CNV model.However,silencing of YAP by vitreous injection of small interfering RNA targeting YAP could reverse these changes.CONCLUSION:The findings reveal a critical role of the hypoxia-inducible factor-1α(HIF-1α)/YAP signaling axis in End MT and provide a new therapeutic target for treatment of subretinal fibrosis in AMD.

关键词： endothelial-to-mesenchymal transition Yes-associated protein hypoxia-inducible factor-1α choroidal neovascularization age-related macular degeneration

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论发展不平衡视野下的乡村建设行动——兼议乡村转型的两种类型

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西北师大学报（社会科学版） 2024年第1期61卷 118-126页

作者：桂华邹蓉武汉大学社会学院湖北武汉430072

改革开放以来,我国乡村转型过程与社会发展的整体形态紧密相关。改革开放后乡村市场化程度逐步提高,农村人财物纳入到全国统一的市场体系中配置,乡村在消除贫困的同时出现了发展不平衡问题。我国东部地区率先启动工业化和城镇化,获得了... 详细信息

改革开放以来,我国乡村转型过程与社会发展的整体形态紧密相关。改革开放后乡村市场化程度逐步提高,农村人财物纳入到全国统一的市场体系中配置,乡村在消除贫困的同时出现了发展不平衡问题。我国东部地区率先启动工业化和城镇化,获得了优势积累,形成了城市经济带动的乡村持续发展;与此同时,中西部地区人财物大量流出,乡村不断收缩。由此,我国乡村现代化变迁过程中出现了中西部地区“收缩型”与东部地区“扩张型”两种基本形态。这种现代化不均衡格局及其带来的乡村转型地区差异,要求政府主导的乡村建设行动必须在做到因地制宜的同时,将乡村建设放在城乡关系动态演变这一框架下规划,在行动策略上将不平衡现状当作机遇,利用好城乡二元条件,努力推动发展并实现更高水平的平衡,为进一步实现中国式现代化作准备。

关键词：乡村转型发展不平衡收缩型扩张型乡村建设

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Dust collector localization in trouble of moving freight car detection system

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浙江大学学报C辑：计算机与电子（英文版） 2013年第2期14卷 98-106页

作者： Fu-qiang ZHOU rong zou He GAO School of Instrumentation Science and Optoelectronics Engineering Beihang University

For a long time,trouble detection and maintenance of freight cars have been completed manually by inspectors.To realize the transition from manual to computer-based detection and maintenance,we focus on dust collector localization under complex conditions in the trouble of moving freight car detection system.Using mid-level features which are also named flexible edge arrangement(FEA) features,we first build the edge-based 2D model of the dust collectors,and then match target objects by a weighted Hausdorff distance method.The difference is that the constructed weighting function is generated by the FEA features other than specified subjectively,which can truly reflect the most basic property regions of the 3D object.Experimental results indicate that the proposed algorithm has better robustness to variable lighting,different viewing angle,and complex texture,and it shows a stronger adaptive performance.The localization correct rate of the target object is over 90%,which completely meets the need of practical applications.

关键词：英文摘要编辑工作学术论文期刊

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大型煤化工项目低温甲醇装置工艺技术优化分析

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石化技术 2024年第2期31卷 37-39页

作者：邹荣陕西长青能源化工有限公司陕西宝鸡721405

以某大型煤化工厂的低温甲醇装置工艺技术优化改造项目为例,从甲醇消耗过高、冷量消耗过大、热再生系统多项指标偏离设计值、甲醇水塔运行稳定性偏低这几方面入手,详细说明了低温甲醇装置工艺问题与处理思路。在此基础上,对改造的经济... 详细信息

以某大型煤化工厂的低温甲醇装置工艺技术优化改造项目为例,从甲醇消耗过高、冷量消耗过大、热再生系统多项指标偏离设计值、甲醇水塔运行稳定性偏低这几方面入手,详细说明了低温甲醇装置工艺问题与处理思路。在此基础上,对改造的经济效果进行了分析与计算,结果证实本文所述改造策略有效,且取得的效果理想。

关键词：煤化工低温甲醇工艺优化

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