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Seroprevalence of Neutralizing Antibodies against Six Human Adenovirus Types Indicates the Low Level of Herd Immunity in Young Children from Guangzhou, China

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Virologica Sinica 2021年第3期36卷 373-381页

作者： Xingui Tian Ye Fan Changbing Wang Zhenwei Liu Wenkuan Liu Yun Xu Chuncong Mo Aiping You Xiao Li Xia rong rong zhou State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory Diseasethe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangzhou 510182China Central Laboratory Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhou 510180China Institute of Clinical Blood Transfusion Guangzhou Blood CenterGuangzhou 510095China

Human adenoviruses(HAdVs) commonly cause many diseases such as respiratory diseases, gastroenteritis, cystitis worldwide. HAdV-3,-7,-4 and emergent HAdV-55 and HAdV-14 are the most important types causing severe respiratory diseases. There is no effective drug available for clinical treatment, and no vaccine available for the general population.Therefore, it is important to investigate the seroprevalence against HAdV for developing novel vaccines and vectors. In this study, we investigated the seroprevalence and titer levels of neutralizing antibodies(NAb) against HAdV-3,-4,-7,-14,-55,and-11 in total 278 healthy populations between 0 months and 49 years of age(228 children and 50 adults) from Guangzhou. In children under the age of 18 years, the seropositive rates were significantly increased against HAdV-3 at12.07%, 33.96%, and 64.29% and against HAdV-7 at 0%, 18.87%, and 19.05% in age groups of 1–2, 3–5, and 6–17 years,respectively. The seroprevalence was very low(0% - 8.1%) for all other four types. In adults aged between 18 and49 years, HAdV-3,-4, and-7(> 50.00%) were the most common types, followed by HAdV-14(38.00%),-55(34.00%),and-11(24.00%). Adults tended to have high NAb titers against HAdV-4 and-55. HAdV-55-seropositive donors tended to be HAdV-11-and HAdV-14-seropositive. These results indicated the low level of herd immunity against all six HAdV types in young children, and HAdV-14,-55,-11 in adults from Guangzhou City. Our findings demonstrate the importance of monitoring HAdV types and developing vaccines against HAdV for children and adults.

关键词： Human adenovirus(HAdV) Seroprevalence Neutralizing antibodies(NAb) Vaccination Vector Acute respiratory disease

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中国民族传统体育文化国际传播效果提升的影响因素与组态路径——基于YouTube热门视频的实证分析

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武汉体育学院学报 2024年第5期58卷 35-42页

作者：李乾丙王相飞周榕武汉体育学院新闻传播学院湖北武汉430079 武汉体育学院国家体育总局体育社会科学研究中心湖北武汉430079

采用定性比较与回归分析法,对YouTube平台中与民族传统体育文化相关的热门视频传播的影响因素及组态路径进行分析。研究发现,民族传统体育文化的传播内容、信息来源特征因素与传播效果存在显著相关性,并构成三种促进民族传统体育文化国... 详细信息

采用定性比较与回归分析法,对YouTube平台中与民族传统体育文化相关的热门视频传播的影响因素及组态路径进行分析。研究发现,民族传统体育文化的传播内容、信息来源特征因素与传播效果存在显著相关性,并构成三种促进民族传统体育文化国际传播的组态路径,分别表现为:以系列短视频创作为主的内容支撑型、以过往内容二次创作为主的专业解读型、以迷影叙事为主的个人创作型路径。对应组态路径,建议民族传统体育文化国际传播应:丰富系列视频的叙事题材,注重传统体育元素与人物日常细节刻画;发挥官方叙事者专业优势,深入挖掘传统体育的价值理念;扩大迷影群体规模,优化个体叙事者关于传统武侠的戏仿创作。

关键词：民族传统体育文化国际传播海外社交媒体传播效果组态分析

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中国存款保险费率体系

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上海经济研究 2024年第2期 111-128页

作者：苏育洲姚帅吴思斌周镕基澳门科技大学商学院中国澳门999078 美国得克萨斯大学大河谷分校商学院 78541 衡阳师范学院经济与管理学院 421002

道德风险是中国存款保险制度设计过程面临的核心难题,定价体系是解决道德风险问题的重要途径,但国内现有定价文献对中国现实问题关注不足。设计存款保险费率定价体系要从中国国情出发,重视中国独特的储蓄结构和社会体制现实。本文基于... 详细信息

道德风险是中国存款保险制度设计过程面临的核心难题,定价体系是解决道德风险问题的重要途径,但国内现有定价文献对中国现实问题关注不足。设计存款保险费率定价体系要从中国国情出发,重视中国独特的储蓄结构和社会体制现实。本文基于彭博违约风险模型和彭博估值定价模型设计出一个最新的存款保险定价表,并制定了一个融合量化矩阵体系和综合评价体系的银行评分表。结合定价约束和评分约束,提出一种新的存款保险费率定价体系,综合考虑银行风险承担、政府注资承诺、银行类型差异、信用评级范围、差别费率体系和惩戒机制。为验证新费率体系的合理性,基于累积正确率曲线对生成的差别费率结果进行评估,进一步推算出基金目标规模并进行充裕性测度验证。研究结果显示:新费率体系下国有大型商业银行适用0.005%~0.095%的差别费率区间,全国性商业银行适用0.020%~0.100%的差别费率区间,地区性商业银行适用级距鲜明的0.025%~0.200%的差别费率区间,这种新费率体系能够通过累积正确率曲线评估和基金充裕性验证。本文将弥补中国存款保险差别费率设计的部分理论缺陷,并为存款保险基金管理公司的政策制定提供实证支持。

关键词：存款保险道德风险风险浮动保费定价模型中国特色

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Cauterization technique for suture erosion in transscleral fixation of intraocular lenses

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International Journal of Ophthalmology(English edition) 2013年第6期6卷 892-894页

作者： Xu-Ting Hu Zong-Duan Zhang rong zhou Qin-Tuo Pan The Eye Hospital of Wenzhou Medical University

Transscleral suturing is a commonly applied technique to fix intraocular Implants in the sulcus.A major problem after transscleral implantation is suture erosion that normally happens in the late post-surgery period and may result In an Increased incidence of endophthalmitis.Here we describe an original cauterization method by using a glass rod to melt the exposed suture end without damaging the suture knot in the sclera to avoid suture exposure in sclera-fixed IOL implantation.This is a simple,quick and effective technique that can be performed without conjunctiva incisions and will help to reduce suture erosion related complications.

关键词： suture erosion cauterization technique intraocular lenses

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Focal choroidal excavation: a preliminary interpretation based on clinic and review

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International Journal of Ophthalmology(English edition) 2015年第3期8卷 513-521页

作者： Guang-Hui Liu Bing Lin Xin-Quan Sun Zi-Fang He Ji-rong Li rong zhou Xiao-Ling Liu School of Optometry and Ophthalmology and Eye Hospital Wenzhou Medical University Department of Ophthalmology Affiliated People's Hospital to Fujian University of Traditional Chinese Medicine Department of Ophthalmology China-Japan Friendship Hospital

AIM: To describe the clinical and imaging characteristics associated with focal choroidal excavation(FCE), analyze the possible complication, and interpret its probable etiopathogenesis.METHODS: Retrospective descriptive case series of 37 eyes of 32 patients with FCE. Findings of spectral-domain optical coherence tomography(SD-OCT),fluorescein angiography, indocyanine green angiography,and clinical features were analyzed. RESULTS: All patients were Chinese. Five patients(15.6%) were bilaterally involved. Patients’ ages ranged from 7 to 66 y. Refractive error ranged between +2.0 D and 11.0 D. Mean best-corrected visual acuity was 0.6(range, 0.1 to 1.2). Fundus examinations exhibited mild-moderate localized pigmentary disturbances in the corresponding area of 17 eyes. Fluorescein angiography performed in 18 patients showed varying degrees of hyperfluorescence and hypofluorescence related to a range of retinal pigment epithelium(RPE) alterations.Indocyanine green angiography performed in 7 patients showed hypofluorescence at the excavation. SD-OCT demonstrated choroidal excavation in all 37 eyes.Twenty-nine eyes showed a single lesion of FCE, and three eyes showed 2-3 separated lesions. Fifteen eyes showed separation between the photoreceptor tips andRPE consistent with nonconforming FCE. Central serous chorioretinopathy(CSC, n =1) and choroidal neovascularization(CNV, n =1) developed during follow-up.CONCLUSION: FCE could be interpreted as congenital focal choroidal dysplasia involving the RPE,choriocapillaris, and photoreceptor associated with the faulty anatomy. The abnormal anatomy of FCE was similar to anatomy at risk of CSC and CNV.

关键词： focal choroidal excavation dysplasia optical coherence tomography etiology

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基于TTC冲突风险的加速车道合流标线设置方法

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公路交通科技 2024年第1期41卷 152-159页

作者：高沛邵超逸周荣贵周建李欣交通运输部公路科学研究院北京100088 广州市高速公路有限公司广东广州510000

为了提高合流区域的安全性,分析了不同形式的交通设施对合流车辆的影响,研究了考虑速度离散性的加速车道安全合流设施设置方法。首先,以减小合流区的速度离散性为目的,基于车辆的实测加速与换道过程,分析了车辆在合流鼻后的运动过程。其... 详细信息

为了提高合流区域的安全性,分析了不同形式的交通设施对合流车辆的影响,研究了考虑速度离散性的加速车道安全合流设施设置方法。首先,以减小合流区的速度离散性为目的,基于车辆的实测加速与换道过程,分析了车辆在合流鼻后的运动过程。其次,基于驾驶员实际换道位置需求,构建了合流区禁止跨越同向车行道分界线(禁止跨越标线)长度计算模型,采用了重复仿真的方式确定最大值的要求。然后采用双向4车道作为仿真模型,对比分析了主线、匝道在不同流量、车速下的标线长度,总结了禁止跨越标线长度的演化规律。最后,基于实测数据搭建VISSIM仿真模型,以交通冲突为评价指标对设置效果进行了验证,分析在不同流量、主线速度、匝道速度组合下的禁止跨越标线设置必要性。结果表明:主线交通量增大,需设置的长度越长;主线与匝道速度差越大,标线长度越长;主线车速越大,标线长度越长,匝道车速越大,标线长度越短;主线流量在1级、2级上半段时的追尾与换道冲突明显减少,此时宜设置;在2级下半段之后时,换道冲突有所减少,但追尾冲突显著增加,需要结合最外侧车道车型比例等交通条件进行控制;在3级服务水平下,施画禁止跨越标线导致追尾冲突显著增加,换道冲突无显著变化,不建议设置。禁止跨越标线的设置能够进一步增加车辆加速空间,提高汇入速度,提升合流的安全性。

关键词：交通安全禁止跨越标线微观仿真交通冲突合流区

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2021年中国农业源氧化亚氮排放及减排的经济成本和社会收益研究

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环境科学学报 2024年第1期44卷 424-437页

作者：丰睿李震华周荣戚庄周浙江大学环境与资源学院杭州310058 浙江大学能源清洁利用国家重点实验室杭州310027 杭州市下城区学援科技工作室杭州310004 浙江省生态环境科学设计研究院杭州310007 中国科学院大学经济管理学院北京100190

氧化亚氮(N_(2)O)是对全球变暖贡献率第三大的温室气体,仅次于CO_(2)和CH_(4);N_(2)O是21世纪破坏臭氧层最多的物质.本研究估算了2021年我国各省级行政区农业源N_(2)O总排放以及各子行业和部门的排放,并计算了在现有技术框架下减排农业... 详细信息

氧化亚氮(N_(2)O)是对全球变暖贡献率第三大的温室气体,仅次于CO_(2)和CH_(4);N_(2)O是21世纪破坏臭氧层最多的物质.本研究估算了2021年我国各省级行政区农业源N_(2)O总排放以及各子行业和部门的排放,并计算了在现有技术框架下减排农业源各子行业N_(2)O的潜力、经济成本和所能获得的社会收益.结果表明,2021年我国农业源排放的N_(2)O总共为177.32×10^(4)(143.63×10^(4)~212.96×10^(4))t,其中化肥施用导致的N_(2)O排放为59.67×10^(4)(48.33~71.66×10^(4))t,动物粪便管理为26.82×10^(4)(21.72×10^(4)~32.21×10^(4))t,粪肥施用为32.73×10^(4)(26.51×10^(4)~39.31×10^(4))t,秸秆还田为32.09×10^(4)(25.99×10^(4)~38.54×10^(4))t,淋溶径流为12.95×10^(4)(10.49×10^(4)~15.55×10^(4))t,大气氮沉降为13.05×10^(4)(10.57×10^(4)~15.67×10^(4))t.各省级行政区平均农业源N_(2)O排放量为5.72×10^(4)t,中位数是5.73×10^(4)t(新疆).排放最多的5个省份为黑龙江、河南、吉林、四川和山东,分别约为12.58×10^(4)、11.85×10^(4)、11.71×10^(4)、10.74×10^(4)和10.14×10^(4)t,总计占比32.2%;排放最少的5个省级行政区为青海、宁夏、天津、上海和北京,总计排放为3.43×10^(4)t,占比1.9%.施用当前技术,不考虑不确定性,能使得2021年我国化肥、动物粪便管理、粪肥和秸秆还田的N_(2)O排放分别减少23.87×10^(4)、13.09×10^(4)、13.40×10^(4)和12.84×10^(4)t.采用“精准农业”减排化肥和秸秆还田排放N_(2)O的成本分别为387.5元·kg^(-1)和425.6元·kg^(-1),采用土壤微生物活性抑制剂减排粪肥排放N_(2)O的成本为46.6元·kg^(-1).减少1kg N_(2)O排放能使我国获得的货币化社会收益为13.4元.本文总结了目前可减少我国农业源N_(2)O排放的方案,并提出了改进现有的计算我国农业源N_(2)O排放方法的建议.

关键词：全球变暖臭氧层破坏省级排放清单减排经济成本减排社会收益

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Design of an air isolation and purification (AIP) desk for medical use and characterization of its efficacy in ambient air isolation and purification

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Biosafety and Health 2020年第3期2卷 169-176页

作者： Tiantian Liu Yubing Guo Mei Wang Xiaotang Hao Shicong He rong zhou School of Public Health Guangdong Pharmaceutical UniversityGuangzhou 510310China State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory HealthFirst Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangzhou 510180China

The incidences of nosocomial infections(NIs)are increasing throughout the world,especially for those airborne diseases caused by pathogens or air particulates that float in air.In this study,we designed and manufactured a desk for clinic consultation room air purification and air isolation between doctor and patient.The air isolation and purification(AIP)desk has a high efficiency particulate air(HEPA)filter on the tope and several primary efficiency filters on the sides for air purification.The air circulating between inlet and outlet forms a wind-curtain between doctor and patient.The Computational Fluid Dynamics(CFD)model was used to calculate the speed of the air flow and the angle of sampler.We tested the air purification function of the AIP desk in rooms sized about 3.6×2.8×2.8 m(L×W×H)and found that the AIP desk could significantly remove the tested air pollutants like smoke particulates and microorganisms like Staphylococcus albus(S.albus)and human adenovirus type 5(HAdV-5).The wind-curtain can significantly block the exhale air of patient being transmitted to the respiratory area of doctor setting in the opposite of AIP desk.Thus,the AIP desk can be used in hospital setting to reduce the risk of NIs and protect both doctors and patients.

关键词： Nosocomial infection Air isolation Air purification AIP desk Smoke particulate Airborne pathogen S.albus HAdV-5

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High Throughput Sequencing of circRNAs in Tomato Leaves Responding to Multiple Stresses of Drought and Heat

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Horticultural Plant Journal 2020年第1期6卷 34-38页

作者： rong zhou Xiaqing Yu Carl-Otto Ottosen Tongmin Zhao Department of Food Science Aarhus UniversityArslev DK-5792Denmark Laboratory for Genetic Improvement of High Efficiency Horticultural Crops in Jiangsu Province Institute of Vegetable CropJiangsu Province Academy of Agricultural SciencesNanjing 210014China National Key Laboratory of Crop Genetics and Germplasm Enhancement Nanjing Agricultural UniversityNanjing 210095China

Our aim is to study the roles of a new emerging group of non-coding RNAs, circRNAs, in tomato(Solanum lycopersicum L.) plants grown at the combination of drought and heat, two of the most usual stress conditions known to frequently happen in field. Tomato seedlings from cultivar‘Jinling Meiyu’ were treated without stresses(control), at water shortage, high temperature and subjected the multiple stresses. In total, 467 circRNAs were identified with 87.82% from exon using high throughput sequencing technology. Among the circRNAs, 70 were from chr1 with the range from 23 to 49 from the other chromosomes. In detail, 156 circRNAs were shared in the four libraries, while 21, 17 and 36 circRNAs were only shown in drought, heat and multiple stresses libraries, respectively. Through a differential expression analysis, four, seven and nine circRNAs were differentially regulated in tomato at drought, heat and multiple stresses as compared with control. These circRNAs played roles on photosynthesis, starch and sucrose metabolism, RNA transport, RNA degradation, spliceosome, ribosome, etc. Our study underlined the potential role of circRNAs involved in the abiotic stress response in tomato, which might pave the way for studying biological roles of circRNAs responding to multiple stresses in plants.

关键词： Solanum lycopersicum circRNAs High throughput sequencing High temperature Water shortage

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Design a pediatric isolation bed and characterization of its purification efficacy in ambient air

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Biosafety and Health 2021年第3期3卷 172-178页

作者： Tiantian Liu Xi Li Mengyuan Xu Yubing Guo rong zhou School of Public Health Guangdong Pharmaceutical UniversityGuangzhou 510310China State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory HealthFirst Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangzhou 510182China

Patients with acute infectious respiratory illness may emit bio‐aerosols containing pathogens to infect susceptible hosts,including other patients and healthcare workers.This study aimed to design the pediatric isolation(PI)bed and evaluate its purification effect on aerosols and microorganisms in the air in experiment rooms and verify the general wards'purification efficiency.The PI bed is connected to a purification device that surrounds the child's head to prevent contaminants'spread into the room.We test the purification effect of the PI bed in the experiment room and verified the purification effect of the PI bed in the hospital.The results showed that PI beds in the demonstration ward presented purifying effects on both smoke particulates and microorganisms like Staphylococcus albus(S.albus)and H1N1 virus.The Aerosol in the room in the hospital was then detected to validity the purification rate.Therefore,Isolation beds could be used in hospitals to reduce the risk of nosocomial infection to protect the health of doctors,patients,and visitors.

关键词： Pediatric isolation Purification effect Particulate Aerosol Bacteria H1N1 viruses

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