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Bioinspired nanomaterials for the treatment of bacterial infections

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Nano Research 2024年第2期17卷 691-714页

作者： Xiaojing Ma Wenjing Tang Rong Yang Robert F.Smith School of Chemical&Biomolecular Engineering Cornell UniversityIthacaNY 14853USA

Infectious diseases pose a serious threat to global health.Although immunizations can control most viral infections,bacterial infections,particularly those caused by drug-resistant strains,continue to cause high rates of illness and death.Unfortunately,the creation of new antibiotics has come to a grinding halt in the last ten years.In response to this crisis,nanotechnology has emerged as a hopeful solution to tackle drug resistance and enhance treatment results.A large variety of biomimetic nanomaterials,termed nanozymes,have demonstrated strong antimicrobial efficacy.While the inherent toxicity of nanomaterials is a concern,recent studies have harnessed the stimuli-responsiveness of nanomaterials to enable local and/or targeted delivery to reduce the treatment side effects.Indeed,the physicochemical versatility of nanomaterials affords many degrees of freedom that enable rational design of smart or autonomous therapeutics,which cannot be achieved using conventional antibiotics.The design straddles the fields of catalysis,nanoscience,microbiology,and translational medicine.To provide an overview of this interdisciplinary landscape,this review is organized based on composition into lipid,metal,metal oxide,and non-metallic nanomaterials.Liposomes as a delivery vehicle enhance bioavailability and reduce toxicity.Metal-and metal oxide-based nanomaterials inhibit bacterial growth by mimicking natural enzymatic activities such as peroxidase(POD)and oxidase.Furthermore,carbon-,polymer-,and cell membrane-based nanomaterials are combined into a discussion on non-metallic materials.At the end of this review,potentially fruitful directions for future bioinspired nanomaterials in infectious disease treatment are included.

关键词： bioinspired nanomaterial bacteria infectious disease antimicrobial liposome nanozyme

Emerging single-atom nanozymes for catalytic biomedical uses

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Nano Research 2023年第12期16卷 13056-13076页

作者： Shuangfei Cai Wei Zhang Rong Yang CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety Center of Materials Science and Optoelectronics EngineeringCAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyUniversity of Chinese Academy of SciencesBeijing 100190China Sino-Danish College Sino-Danish Center for Education and ResearchUniversity of Chinese Academy of SciencesBeijing 100049China Institute of Applied Physics and Computational Mathematics Beijing 100088China

The past four years have witnessed booming progress in single-atom nanozymes(SANs),one of the newest generations of nanozymes with atomically dispersed metal sites for catalytic biomedical uses.They show distinct advantages over their nanoparticle-based counterparts,such as well-defined electronic/geometric structures and complete atomic utilization efficiency,thus offering opportunities to develop advanced nanozymes for practical uses.The atomically dispersed active centers in SANs could also facilitate the precise regulation of catalytic performance,while probing structure–activity relationship for in-depth understanding of mechanism.In this review,we first introduce the synthetic approaches,surface engineering,and characterization techniques of SANs.Subsequently,we discuss the enzyme-like properties of SANs,including some strategies for boosting their catalytic activities.Furthermore,we present their biomedical applications,ranging from biosensors,antibacterial uses,antioxidants,to therapeutics.Finally,the challenges and opportunities of SANs are prospected.

关键词： single atom metal nanozyme enzyme-like catalysis biomedical

On Fridman Invariants and Generalized Squeezing Functions

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Chinese Annals of Mathematics,Series B 2022年第2期43卷 161-174页

作者： Feng rong Shichao yang School of Mathematical Sciences Shanghai Jiao Tong UniversityShanghai 200240China Corresponding author.School of Mathematics and Statistics Huizhou UniversityHuizhou 516007GuangdongChina

In this paper,the authors introduce the notion of generalized squeezing function and study the basic properties of generalized squeezing functions and Fridman invariants.They also study the comparison of these two inv... 详细信息

关键词： Fridman invariant Squeezing function Quotient invariant

A DISCRETIZING LEVENBERG-MARQUARDT SCHEME FOR SOLVING NONLIEAR ILL-POSED INTEGRAL EQUATIONS

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Journal of Computational Mathematics 2022年第5期40卷 686-710页

作者： rong Zhang Hongqi yang School of Mathematics and Computer Science Gannan Normal UniversityGanzhou 341004China Guangdong Province Key Laboratory of Computational Science School of Computer Science and EngineeringSun Yat-sen UniversityGuangzhou 510275China

To reduce the computational cost,we propose a regularizing modified LevenbergMarquardt scheme via multiscale Galerkin method for solving nonlinear ill-posed problems.Convergence results for the regularizing modified Levenberg-Marquardt scheme for the solution of nonlinear ill-posed problems have been proved.Based on these results,we propose a modified heuristic parameter choice rule to terminate the regularizing modified Levenberg-Marquardt scheme.By imposing certain conditions on the noise,we derive optimal convergence rates on the approximate solution under special source conditions.Numerical results are presented to illustrate the performance of the regularizing modified Levenberg-Marquardt scheme under the modified heuristic parameter choice.

关键词： The regularizing Levenberg-Marquardt scheme Multiscale Galerkin methods Nonlinear ill-posed problems Heuristic parameter choice rule Optimal convergence rate.

Atomically thin transition metal dichalcogenides for the hydrogen evolution reaction

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ChemPhysMater 2022年第2期1卷 102-111页

作者： Jianqi Zhu Rong Yang Guangyu Zhang Laboratory of Micro-Nano Optics School of Physics and Electronic EngineeringSichuan Normal UniversityChengdu 610101China Institute of Physics Chinese Academy of SciencesBeijing 100190China Songshan Lake Materials Laboratory Dongguan 523808China

Hydrogen is a sustainable and environmentally friendly fuel produced by electrolytic water splitting.This re-quires efficient and easily accessible electrocatalysts to minimize energy consumption.Recently,as a substitute to the conventional noble-metal-based catalysts,two-dimensional transition metal dichalcogenides(TMDs)have demonstrated their potential as inexpensive catalysts for the hydrogen evolution reaction(HER).In this review,we offer an overview of recent progresses in the development of layered TMDs for the HER.The improvements in TMD catalytic activity in terms of nanostructuring,defect and boundary engineering,heteroatom doping,and interaction with the supporting material are presented.We summarize with a perspective on the challenges for the future development of highly effective TMD catalysts for the HER.

关键词： Transition metal dichalcogenides Hydrogen evolution reaction Electrocatalysts Catalytic performance Two-dimensional materials Nanostructures

Rb_(5)Ba_(2)(B_(10)O_(17))_(2)(BO_(2)):The formation of unusual functional [BO_(2)]^(-) in borates with deep-ultraviolet transmission window

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Science China Chemistry 2022年第4期65卷 719-725页

作者： Yanhui Zhang Fuming Li Rong Yang Yun yang Fangfang Zhang Zhihua yang Shilie Pan CAS Key Laboratory of Functional Materials and Devices for Special Environments Xinjiang Technical Institute of Physics&ChemistryChinese Academy of SciencesXinjiang Key Laboratory of Electronic Information Materials and DevicesUrumqi 830011China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

The design and synthesis of new deep-ultraviolet(DUV)optical materials are important but challenging.It is well known that the polarizability anisotropy of linear[BO_(2)]^(−)is larger than those of[BO_(3)]^(3−)and[BO_(4)]^(5−),which is the better choice for exploring excellent optical materials.Here,we search for such crystals in borate systems based on the unusual fundamental structural unit[BO_(2)]^(−).By combining the linear[BO_(2)]^(−)with the traditional triangular[BO_(3)]^(3−)and tetrahedral[BO_(4)]^(5−)units,a new mixed metal borate,Rb_(5)Ba_(2)(B_(10)O_(17))_(2)(BO_(2))was obtained via high-temperature solution method.It exhibits excellent optical properties including a DUV transmission window(188 nm)and suitable birefringence(0.06).It also has good thermal stability and its crystal plates can be prepared easily.Furthermore,the strategies of designing borates with[BO_(2)]^(−)units have been proposed from the transformation of crystal framework and the preparation method.

关键词： isolate BO_(2) borate crystal deep-ultraviolet transmission birefringence

Numerical Study on the Linear and Nonlinear Behavior of A Fluid-Filled Piezoelectric Membrane Under Gravity Waves

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China Ocean Engineering 2023年第5期37卷 768-780页

作者： LIU Chun-rong yang Wen-yu School of Civil Engineering and Architecture Xiamen University of TechnologyXiamen 361024China

This study integrated piezoelectric layers in a flexible membrane to form a piezoelectric membrane.A fluid-filled piezoelectric membrane,which can be used as breakwater and wave energy converter simultaneously,was presented.The mathematical models to describe the interactions of the waves with the piezoelectric membrane were given.The dimensionless parameters to control the behavior of the piezoelectric membrane were obtained.The mixed EulerianLagrangian method was employed to simulate the mathematical models.The simulation code was verified.Based on the simulation results,the effects of dimensionless elastic modulus of the membrane E^(*),tension of the membrane T_(0)^(*)and the resistance of the load R^(*)on the behavior of the piezoelectric membrane were discussed.As E^(*)is small(E^(*)0.0001),the response of the piezoelectric membrane can be considered as linear.For linear response,the minimum transmission coefficient and maximum output electric power of the piezoelectric membrane can be achieved simultaneously by adjusting T_(0)^(*)and R^(*).For larger E^(*),nonlinear behavior of the piezoelectric membrane is observed.At some larger values of E^(*),working frequency of piezoelectric elements can reach eight times the wave frequency.In these cases,higher output electric power can be achieved for smaller strain of the membrane.

关键词： wave energy breakwater piezoelectric membrane nonlinear

The 2010–2020 National Natural Science Foundation of China:Radiation Therapy

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Current Medical Science 2022年第2期42卷 453-461页

作者： Jun LIU yang LI rong SHI Division VII Department of Health SciencesNational Natural Science Foundation of ChinaBeijing100085China Department of Thoracic Surgery Zhongnan Hospital of Wuhan UniversityWuhan430062China Department of Genetics School of Life ScienceAnhui Medical UniversityHefei230031China

Objective This study explains the application number and funding rate of oncology projects undertaken by the National Natural Science Foundation of China(NSFC),with focus on tumor radiotherapy-related research over the past 11 years.Methods A stratified analysis was carried out on the application and funding status of tumor radiotherapy studies in different NSFC project categories,different research areas,and different tumor types.Research areas that required specific focus,such as immunology-related radiotherapy,multimodality imaging and radiomics,and post-radiotherapy organ injury,were separately analyzed.Results The status and development trends of various related research fields were studied,and the research results were presented with the support of the NSFC,in order to provide reference for future applications and funding allocations.Conclusion The number of applications for funding increases every year.Although the total number of funded projects has also increased every year,the funding rate has decreased year by year.Projects on radiotherapy and immunization have been at the forefront in recent years,and the funding rate for these projects increases yearly.

关键词： National Natural Science Foundation of China radiation therapy funding rate

Applications of magnetic nanoparticles in surface-enhanced Raman scattering(SERS)detection of environmental pollutants

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Journal of Environmental Sciences 2019年第6期31卷 14-34页

作者： Dan Song Rong Yang Feng Long Anna Zhu School of Environment and Natural Resources Renmin University of China Research Institute of Chemical Defense Academy of Military Sciences PLA China State Key Laboratory of NBC Protection FOR Civilian

Environmental pollution, a major problem worldwide, poses considerable threat to human health and ecological environment. Efficient and reliable detection technologies, which focus on the appearance of emerging environmental and trace pollutants, are urgently needed. Surface-enhanced Raman scattering(SERS) has become an attractive analytical tool for sensing trace targets in environmental field because of its inherent molecular fingerprint specificity and high sensitivity. In this review, we focused on the recent developments in the integration of magnetic nanoparticles(MNPs) with SERS for facilitating sensitive detection of environmental pollutants. An overview and classification of different types of MNPs for SERS detection were initially provided, enabling us to categorize the huge amount of literature that was available in the interdisciplinary research field of MNPs based SERS technology. Then, the basic working principles and applications of MNPs in SERS detection were presented. Subsequently, the detection technologies integrating MNPs with SERS that eventually were used for the detection of various environmental pollutions were reviewed. Finally, the advantages of MNP-basedSERS detection technology for environmental pollutants were concluded, and the current challenges and future outlook of this technology in practical applications were highlighted. The application of the MNPsbasedSERS techniques for environmental analysis will be significantly advanced with the great progresses of the nanotechnologies, optics, and materials.

关键词： Magnetic nanoparticles Surface-enhanced Raman scattering SERS substrates Environmental pollutant detection