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A Glycosylated and Catechol-crosslinkedε-Polylysine Hydrogel:Simple Preparation and Excellent Wound Hemostasis and Healing Properties

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Chinese Journal of Polymer Science 2022年第9期40卷 1110-1119页

作者： Lin Teng Zheng-Wei shao Yu-Shi He Jia-Yu Lu De-rong Zou Chuan-Liang Feng Chang-Ming Dong School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative MoleculesShanghai Key Laboratory of Electrical Insulation and Thermal AgingShanghai Jiao Tong UniversityShanghai 200240China Department of Stomatology Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai Jiao Tong UniversityShanghai 200233China School of Chemistry and Chemical Engineering Shanghai Electrochemical Energy Devices Research CenterShanghai Jiao Tong UniversityShanghai 200240China School of Materials Science and Engineering State Key Laboratory of Metal Matrix CompositesShanghai Jiao Tong UniversityShanghai 200240China

Commercial tissue adhesives have been widely applied in wound hemostats and dressings while enhancing the hemostasis and healing capabilities is challenging to meet clinical needs.Herein,we designed the glucose-and catechol-functionalized derivatives from commercialε-polylysine(EPL)and prepared the hydrogels by simple amidation and catechol-crosslinking reactions,which have larger swelling ratios of 220%–240%,suitable microporous size of about 6–8µm,and tissue adhesion strength of about 20–40 kPa.The hemolysis,cytotoxicity,and cellular double-staining assays indicate that those hydrogels had good biocompatibility and the H-3 hydrogel with higher glucose content gave a lower hemolysis ratio of 0.73%±0.14%.The blood-clotting index,blood cell attachment and adhesion studies showed those hydrogels had fast blood-coagulation,resulting in excellent hemostasis performance with a short hemostatic time of 38–46 s and less blood loss of 19%–34%in a liver hemorrhage model.A full-thickness rat-skin defect model further demonstrates that the H-3 hydrogel achieved fast wound healing with a wound closure of 70.0%±2.7%on postoperative day 7 and nearly full closure on day 14.Remarkably,the hydroproline level that denotes the collagen production reached a higher one of 7.24±0.55µg/mg comparable to that in normal skins on day 14,evidencing the wound healing was close to completion in the H-3 treatment.Consequently,this work provides a simple method to construct a glycosylated and catechol-functionalized hydrogel platform from commercial EPL,holding translational potentials in wound hemostats and dressings.

关键词： Polylysine hydrogel Glycosylation Mussel-mimetic Hemostasis Wound dressing

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集中带量采购背景下生物药产能保障影响因素研究

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中国医药工业杂志 2023年第12期54卷 1789-1793页

作者：杜怿蒋蓉章玲邵蓉中国药科大学药品监管科学研究院江苏南京211198 国家药品监督管理局药品监管创新与评价重点实验室江苏南京211198

在生物药集中带量采购的制度设计与落地过程中,可能存在中选生产企业产能保障问题。文章采用文献研究、企业调研,以及对生物药生产企业和生产质量管理等领域的专家进行访谈调研,从天然因素、设施设备因素、产业供应因素、政策管理因素4... 详细信息

在生物药集中带量采购的制度设计与落地过程中,可能存在中选生产企业产能保障问题。文章采用文献研究、企业调研,以及对生物药生产企业和生产质量管理等领域的专家进行访谈调研,从天然因素、设施设备因素、产业供应因素、政策管理因素4个方面分析了生物药产能保障的影响因素。文章在明确企业产能信息收集标准、根据产能信息确定协议采购量以及设置充分的采购执行期3个层面,为生物药集中带量采购的规则设定提出了建议,具有一定的参考意义。

关键词：生物药药品集中带量采购产能影响因素

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融合显著性模型和高斯网模型的视网膜血管分割方法（英文）

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Frontiers of Information Technology & Electronic Engineering 2019年第8期20卷 1075-1087页

作者： Lan-yan XUE Jia-wen LIN Xin-rong CAO shao-hua ZHENG Lun YU College of Physics and Information Engineering Fuzhou UniversityFuzhou350108China Institute of Computer and Information Fujian Agriculture and Forestry UniversityFuzhou350002China

视网膜血管分割是眼底图像分析的一个重要问题。本文提出一种融合显著性模型和高斯网(GNET)模型的新型深度学习结构分割视网膜血管。显著性图像替代原始图像作为GNET模型的输入。GNET模型具有双边对称结构。左边结构中,在第一层进行上... 详细信息

视网膜血管分割是眼底图像分析的一个重要问题。本文提出一种融合显著性模型和高斯网(GNET)模型的新型深度学习结构分割视网膜血管。显著性图像替代原始图像作为GNET模型的输入。GNET模型具有双边对称结构。左边结构中,在第一层进行上采样操作,在其他层进行最大池化操作;右边结构中,在第一层进行最大池化操作,在其他层进行上采样操作。利用DRIVE数据库对所提方法进行评估。实验结果表明,与UNET模型相比,GNET模型能获得更精确的特征和更精细的细节。本文所提算法能提取准确的血管网络,与其他深度学习方法相比具有更高精确度。视网膜血管分割有助于提取血管变化特征,为脑血管疾病筛查提供依据。

关键词：视网膜血管分割显著性模型高斯网模型(GNET) 特征学习

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Bowel mesentery(meso-appendix) microcystic/reticular schwannoma: Case report and literature review

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World Journal of Gastroenterology 2014年第5期20卷 1371-1376页

作者： shao-Xian Tang Yi-Hua Sun Xian-rong Zhou Jian Wang Department of Pathology Shanghai Cancer Center Fudan University Department of Oncology Shanghai Medical College Fudan University Department of Pathology Obstetrics and Gynecology Hospital Fudan University

Microcystic/reticular schwannoma is a recently described variant of schwannoma with a predilection for the gastrointestinal tract. Due to overlapping features with other tumors, unawareness of this tumor type may lead to diagnostic and therapeutic pitfalls. We here report a case of microcystic/reticular schwannoma arising in the meso-appendix of a 43-year-old woman. The tumor was incidentally discovered by computed tomography scan for unrelated reasons. A laparoscopic operation was performed shortly after admission. Histological examination revealed a circumscribed tumor with a striking microcystic and cribriform architecture. Immunohistochemically, the tumor cells were diffusely positive for S100 protein, glial fibrillary acid protein and protein gene product 9.5, which were consistent with a peripheral nerve sheath tumor. The patient remains well with no signs of recurrence at a 10-mo follow-up. To our knowledge, this is the first case of microcystic/reticular schwannoma arising in the meso-appendix. Albeit very rare, microcystic/reticular schwannoma should be included in the differential diagnosis of appendiceal tumors.

关键词： Laparoscopy Schwannoma Appendiceal neoplasms Immun

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基于行为概率和符号结构的行为管理制度设计

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系统工程理论与实践 2013年第10期33卷 2546-2554页

作者：孙绍荣上海理工大学管理学院上海200093

提出一种科学而实用的行为管理制度设计方法——符号结构化行为概率设计,提出了制度符号系统和结构图制图规则,提出了制度设计的三类优化问题:一是最小失效率问题;二是最小成本问题;三是最大效率问题.开发了最小失效率问题的求解方法:... 详细信息

提出一种科学而实用的行为管理制度设计方法——符号结构化行为概率设计,提出了制度符号系统和结构图制图规则,提出了制度设计的三类优化问题:一是最小失效率问题;二是最小成本问题;三是最大效率问题.开发了最小失效率问题的求解方法:边界法.这种方法的意义在于比一般的搜索法能够更快地找到制度设计的最优方案,而且无需建立解析函数即可求解,从而对使用条件的要求比较宽松,具有大面积的推广应用前景,是制度设计的科学且实用的方法.

关键词：行为管理制度设计行为概率符号结构

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突发公共卫生事件下我国医药产品应急审批制度研究

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中国医药工业杂志 2022年第1期53卷 140-147页

作者：王雅男蒋蓉邵蓉中国药科大学药品监管科学研究院国家药品监督管理局药品监管创新与评价重点实验室江苏南京211198

医药产品应急审批制度作为应对突发公共卫生事件的一项重要制度,包括药品特别审批、医疗器械应急审批和医疗机构制剂应急审批,在满足公众急需医药物资保障需求方面发挥了重要作用。本研究以新型冠状病毒肺炎疫情为研究背景,分析了国家... 详细信息

医药产品应急审批制度作为应对突发公共卫生事件的一项重要制度,包括药品特别审批、医疗器械应急审批和医疗机构制剂应急审批,在满足公众急需医药物资保障需求方面发挥了重要作用。本研究以新型冠状病毒肺炎疫情为研究背景,分析了国家和各省关于医药产品应急审批的政策、措施和实施情况,发现当前医药产品应急审批制度的法律依据有待更新、细化,各省存在应急审批程序启动时间、覆盖范围、注册批件有效期不一致,应急审批信息透明度不高等问题。对此,建议明确各级应急审批程序的启动与终止条件、建立应急审批产品纳入机制、科学设立应急注册批件有效期、规范应急审批信息公开管理等。

关键词：突发公共卫生事件医药产品应急审批省级药品监督管理局新型冠状病毒肺炎

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意大利研究型医院管理经验借鉴研究

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中国医院 2023年第12期27卷 47-50页

作者：吴艺蒋蓉邵蓉中国药科大学药品监管科学研究院·国家药品监督管理局药品监管创新与评价重点实验室江苏省南京市211198

借鉴意大利科研、住院及医疗保健研究所(IRCCS)机构管理方式,为研究型医院管理提供建议。利用文献研究法,结合国内研究型医院建设现状,提出健全医学科技创新体系、制定重点研究方向、定期滚动评价科研绩效等建议,推动研究型医院发展。

关键词：研究型医院公立医院意大利国际经验

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Structure and Raman scattering of Mg-doped ZnO nanoparticles prepared by sol-gel method

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Rare Metals 2018年第10期37卷 881-885页

作者： Zhonglyu Jiang Ke-rong Zhu Zhong-Qing Lin shao-Wei Jin Guang Li School of Physics and Materials Science Anhui UniversityHefei 230039 China Modern Experiment Technical Center Anhui University Hefei230039 China

Mg-doped ZnO （MgxZn1-xO, x=0-0.10） nanoparticles were prepared by sol-gel method. Structural characterization by X-ray diffraction （XRD） indicates that the lattice parameter a increases and c decreases linearly with the increase in Mg content （x） due to the substitution of Mg2＋ for Zn2＋ in ZnO lattice. The blueshift of Raman modes is observed, impling the increase in force constant of atom vibration in the MgxZn1-xO （MgZnO） nanoparticles. Resonant Raman spectra show longitudinal optical phonon overtones up to fifth order, revealing that the short part of the electron-phonon interaction is enhanced and long-range part is weakened by Mg doping.

关键词： ZnO nanoparticles Mg doping X-ray diffraction Raman scattering

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Protein conformation and electric attraction adsorption mechanisms on anodized magnesium alloy by molecular dynamics simulations

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Journal of Magnesium and Alloys 2022年第11期10卷 3143-3155页

作者： Zhao-Qi Zhang Hong-Yan Wang Li Wang Xiao-Bo Chen shao-Kang Guan Cun-Guo Lin rong-Chang Zeng Corrosion Laboratory for Light Metals College of Material Science and EngineeringShandong University of Science and TechnologyQingdao 266590China School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450002China State Key Laboratory for Marine Corrosion and Protection Luoyang Ship Material Research InstituteQingdao 266101China School of Engineering RMIT UniversityCarlton VIC 3053Australia

Protein adsorption preferentially occurs and significantly affects the physicochemical reactions once the biodegradable magnesium alloys as bone replacements have been implanted. To date, interactions mechanisms between Mg implants and proteins remain unclear at a molecular level. Thereby, a combination of molecular dynamic(MD) simulations and experimental exploration is used to investigate the adsorption behavior and conformational change of bovine serum albumin(BSA), a representative protein of blood plasma, upon the surface of microarc oxidation(MAO) coated Mg alloy AZ31. The influences of absorbed proteins on the cytocompatibility of MAO coating are evaluated by virtue of cytotoxicity assay. Results indicate that the negatively charged O atoms(BSA) exhibit strong interaction with Mg^(2+) ions of Mg(OH)_(2), revealing that BSA molecules are ionically adsorbed on the AZ31 surface. Interestingly, MD simulation reveals that MAO coating demonstrates superior ability to capture BSA molecules during the process of adsorption owing to strong electric attraction between the negatively charged O atoms in BSA molecules with Mg atoms of MgO in MAO coating. Moreover, the α-helix part of absorbed BSA molecules on AZ31 substrate and MAO coating markedly decreases with an increase in β-sheet, β-turn and unordered contents, which is attributed to the reduction in the number of hydrogen bonds in BSA molecules. Furthermore, the adsorbed BSA molecules improve the cytocompatibility of MAO coating since the positively charged-NH_(3)^(+) group and β-sheet content of absorbed BSA molecules mediate the cell adhesion by interacting with the negatively charged cell membrane.

关键词： Magnesium alloy Molecular dynamics simulations Protein Conformation Biomaterial

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Protection of carbon monoxide intraperitoneal administration from rat intestine injury induced by lipopolysaccharide

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Chinese Medical Journal 2010年第8期123卷 1039-1046页

作者： LIU shao-hua MA Ke XU Bing XU Xin-rong Intensive Care Unit First Affiliated Hospital of Nanjing Medicial University Nanjing Jiangsu 210029 China Department of Emergency Huashan Hospital Affiliated Fudan University Shanghai 200040 China Department of Emergency Sixth Hospital Affiliated Shanghai Jiao Tong University Shanghai 200233 China

Background Treatment with inhaled carbon monoxide （CO） has been shown to ameliorate intestinal injury in experimental animals induced by lipopolysaccharide （LPS） or ischemia-reperfusion. We hypothesized that CO intraperitoneal administration （i.p.） might provide similar protection to inhaled gas. This study aimed to investigate the effects of continuous 2 L/min of 250 ppm CO i.p. on rat intestine injury induced by LPS and to try to develop a more practical means of delivering the gas. Methods A total of 72 male Sprague-Dawley rats were randomly assigned to 4 groups： control group, CO i.p. group, LPS group and LPS＋CO i.p. group. One hour after intravenously received 5 mg/kg LPS, the rats in LPS group and LPS＋CO i.p. group were exposed to room air and 2 L/min of 250 ppm CO i.p., respectively, and the rats of control group and CO i.p. group intravenously received an equal volume of 0.9% NaCI and 1 hour later, were exposed to room air and 2 L/min of 250 ppm CO i.p., respectively. One, 3 and 6 hour of each group after treated with room air or CO i.p., the animals （n=-6 for each time point） were sacrificed and intestinal tissues were collected for determinating the levels of platelet activator factor （PAF） and intercellular adhesion molecule-1 （ICAM-1） with enzyme-lined immunosorbent assays. The maleic dialdehyde （MDA） content and the myeloperoxidase （MPO） activity were determined with a chemical method. The phosphorylated p38 mitogen activated protein kinase （MAPK） expression was assayed with Western blotting and the cell apoptotic rate with flow cytometery. The arterial oxygenation was measured by blood gas analysis, and the pathology determined by light microscope. Results After treatment with 2 L/min of 250 ppm CO i.p., the increase of PAF, ICAM-1, MDA, MPO, and cell apoptotic rate induced by LPS was markedly reduced （P 〈0.05 or 0.01）, and accompanied by ameliorating intestine injury. Western blotting showed that these effects of CO i.p. were mediated by p38 MAPK pathway. There were no significant differences in al

关键词： carbon monoxide intestine injury mitogen activated protein kinase

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