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Electro-chemo-mechanical design of polymer matrix in composited LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2) cathode endows solid-state batteries with superior performance

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Journal of Energy Chemistry 2023年第3期78卷 277-282,I0009页

作者： Haolong Jiang Xieyu Xu Qingpeng Guo hui Wang Jiayi zheng Yuhao Zhu huize Jiang Olesya O.Kapitanova Valentyn S.Volkov Jialin Wang Yaqi Chen Yongjing Wang Yu Han Chunman zheng Kai Xie Shizhao Xiong Yangyang Liu Xingxing Jiao College of Aerospace Science and Engineering National University of Defense TechnologyChangsha 410073HunanChina Department of Materials Science Lomonosov Moscow State UniversityLeninskie gory 1Moscow 119991Russia Center for Photonics and 2D Materials Moscow Institute of Physics and Technology9 Institutskiy per.DolgoprudnyMoscow Region 141701Russia State Key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi’an 710049ShaanxiChina

Nickel-rich LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)(NCM811) cathode material has been widely concerned due to its high voltage,high specific capacity and excellent rate performance,which is considered as one of the most promising cathode materials for the next generation of high-energy-density solid-state lithium ***,serious electro-chemo-mechanical degradation of Nickel-rich cathode during cycling,especially at a high voltage(over 4.5 V),constrains their large-scale ***,using the multiphysical simulation,highly-conductive polymer matrix with spontaneous stress-buffering effect was uncovered theoretically for reinforcing the electrochemical performance of composited NCM81 1 cathode through the visualization of uniform concentration distribution of Li-ion coupled with improved stress field inside NCM811 ***,polyacrylonitrile(PAN) and soft polyvinylidene fluoride(PVDF) were selected as the polymer matrix to fabricate the composited NCM811 cathode(PVDFPAN@NCM811) for improving the electrochemical performance of the solid-state NMC811|Li full cells,which can maintain high capacity over 146.2 mA h g^(-1)after 200 cycles at a high voltage of 4.5 ***,designing a multifunctional polymer matrix with high ionic conductivity and mechanical property can buffer the stress and maintain the integrity of the structure,which can be regarded as the door-opening avenue to realize the high electrochemical performance of Ni-rich cathode for solidstate batteries.

关键词： Ni-rich cathode Solid-state batteries Interfacial modiﬁcation in electro-chemo-mechanics Multi-physical simulation

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Detection and Genetic Characterization of Rabies Virus from Human Patients

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中国病毒学 2007年第4期22卷 307-315页

作者： Wen-rong YAO Guo-qiang PAN Cheng-long XIONG Qian-fu ZHOU Qi-you XIAO Ming-hui LI Yong-zhen ZHANG Department of Hemorrhagic Fever Institute for Communicable Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing 102206 China The Affiliated Hospital of Wenzhou Medical College Wenzhou 325000 China Xinning Center for Disease Control and Prevention Xinning 422700 China Hunan Center for Disease Control and Prevention Changsha 410005 China

Saliva and blood were collected from two patients who had not received post exposure prophylaxis in the cities of Wenzhou and Xinning respectively. Both patients were confirmed as positive for rabies by detection of rabies virus specific nucleoprotein antibodies in the sera by Western Blot. However, rabies virus specific RNA was only identified in the saliva collected from the patient in Wenzhou. Furthermore, the isolate Zhejiang Wz0 (H) was obtained by inoculating one-day-old suckling mice. Both nucleoprotein (N) and glycoprotein (G) genes from the isolate were amplified by RT-PCR and sequenced. Phylogenetic analysis indicated that the isolate belonged to classic rabies virus, and shared a higher homology with the street viruses from dogs in the main endemic areas in China and the street virus from dogs in Indonesia than with other known strains. Further comparison of the deduced amino acid sequences between the isolate and the vaccine strains used in China showed that the virus had a higher level of homology with the vaccine strain CTN than with the other vaccine strains (3aG, PV, PM and ERA). In particular, amino acid residues substitutions located in antigenic site Ⅲ in the G protein, which could react with the neutralizing antibodies, were observed. These results suggested that the virus belonged to the classic rabies virus, and both N and G genes diverged from the current vaccine strains used in China at either the nucleotide or the amino acid level.

关键词：狂犬病病毒遗传特性检测核蛋白基因糖蛋白基因

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实际海浪环境中大尺度自航船模的水弹性与耐波性试验研究（英文）

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2016年第6期17卷 468-484页

作者： Jia-long JIAO hui-long REN Shu-zheng SUN Christiaan Adika ADENYA College of Shipbuilding Engineering Harbin Engineering UniversityHarbin 150001China Department of Marine Engineering and Maritime Operations Jomo Kenyatta University of Agriculture and TechnologyNairobiKenya

目的:为研究船舶在实际海浪环境中的水弹性与耐波性,本文提出一种新型模型试验技术。将相同船型不同尺度的模型分别在近海环境和水池环境中测量的试验数据进行比较,分析两种试验方法所得结果的差异,以说明水池模型试验方法所存在的问题... 详细信息

目的:为研究船舶在实际海浪环境中的水弹性与耐波性,本文提出一种新型模型试验技术。将相同船型不同尺度的模型分别在近海环境和水池环境中测量的试验数据进行比较,分析两种试验方法所得结果的差异,以说明水池模型试验方法所存在的问题,从而进一步证明新型试验技术的优越性。创新点:1.提出大尺度自航模型在实际海浪环境中实施水动力试验的技术和方法;2.将大尺度模型试验结果与传统水池模型试验结果进行比较,分析二者的差异。方法:针对某母型船,分别建造缩尺比为1:25和1:50的大尺度模型和小尺度模型。大尺度模型在自然海域的三维海浪中进行试验测量,而小尺度模型在水池长峰不规则波中进行试验测量。测量过程中保证两者的控制参数相似,并分析试验结果存在的差异。将数值计算的结果与大尺度模型试验的结果进行比较,并基于数值计算分析海浪的方向分布函数对结果的影响。结论:在近海海域中开展的大尺度模型耐波性与波浪载荷试验表明,本文提出的试验测试系统和试验方案是可行的。大尺度模型试验是在自然海浪环境中进行的,比水池环境更接近实船的实际航行环境,所得数据对于船舶设计和研发具有更高的参考价值和意义。

关键词：水弹性耐波性分段模型试验大尺度模型试验海试尺度效应

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应用CFD于风电场风速分布预估的可行性探讨

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工程热物理学报 2008年第12期29卷 2040-2042页

作者：康顺魏慧荣华北电力大学电站设备状态监测与控制教育部重点实验室北京102206

为使CFD技术更广泛地应用于风电场地形绕流的数值模拟,并为风电场出力预报提供详细的风功率密度分布,本文针对圆形陡坡地形,在分析了地形坡度、地面粗糙度以及大气边界层厚度对此地形风场速度分布影响的基础上,任意选择一个位置并以先... 详细信息

为使CFD技术更广泛地应用于风电场地形绕流的数值模拟,并为风电场出力预报提供详细的风功率密度分布,本文针对圆形陡坡地形,在分析了地形坡度、地面粗糙度以及大气边界层厚度对此地形风场速度分布影响的基础上,任意选择一个位置并以先前计算的速度分布为条件,计算整个域中的风场数据并与先前的计算值进行比较,以探讨直接采用风电场中测风塔的有限数据,进行风电场大气流动CFD模拟的可行性。

关键词：地面粗糙度大气边界层厚度风电场

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Rapid generation of ACE2 humanized inbred mouse model for COVID-19 with tetraploid complementation

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National Science Review 2021年第2期8卷 14-16页

作者： Feng-Liang Liu Kaixin Wu Jiaoyang Sun Zilei Duan Xiongzhi Quan Junqi Kuang Shilong Chu Wei Pang Han Gao Ling Xu Ying-Chang Li Hai-Lin Zhang Xue-hui ang rong-Hua Luo Xiao-Li Feng Hans R.Sch?ler Xinwen Chen Duanqing Pei Guangming Wu Yong-Tang zheng Jiekai Chen Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesKunming Institute of ZoologyChinese Academy of Sciences Center for Cell Fate and Lineage (CCLA) Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory) CAS Key Laboratory of Regenerative Biology Guangdong Provincial Key Laboratory of Stem Cell and Regenerative MedicineGuangzhou Institutes of Biomedicine and HealthChinese Academy of Sciences Department of Developmental Biology School of Basic Medical SciencesSouthern Medical University Central Laboratory The Sixth Affiliated Hospital of Guangzhou Medical UniversityQingyuan People's Hospital University of the Chinese Academy of Sciences Joint School of Life Science Guangzhou Medical University Kunming National High-level Biosafety Research Center for Non-human Primates Center for Biosafety Mega-ScienceKunming Institute of Zoology Chinese Academic of Sciences Department of Cell and Developmental Biology Max Planck Institute for Molecular Biomedicine Medical Faculty University of Münster

Although monkeys and pigs can be infected with SARS-Co V-2, they generally have a long growth cycle and a large size that is difficult to handle in large quantities. However, the readily available rats and mice are not susceptible to SARSCo V-2 because of differences in ACE2(angiotensin-converting enzyme 2), the receptor mediating cell entry of SARSCo V-2 [1]. Thus, the key to establishing a mouse model of COVID-19 is to make the mice express human ACE2 protein, and therefore become SARS-Co V-2 *** reported COVID-19 mouse models using a random insertion transgene approach [2,3] or adenoviral approach to express h ACE2 [4], lack the tissue-specificity of h ACE2 expression and might not replicate COVID-19 precisely, limiting their applications in certain studies.

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High spindle and kinetochore-associated complex subunit-3 expression predicts poor prognosis and correlates with adverse immune infiltration in hepatocellular carcinoma

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世界胃肠外科杂志:英文版(电子版) 2023年第8期15卷 1600-1614页

作者： Lin-Lin zheng Ya-Ru Wang Zhen-rong Liu Zhi-Hao Wang Chang-Cheng Tao Yong-Gang Xiao Kai Zhang An-Ke Wu Hai-Yang Li Jian-Xiong Wu Ting Xiao Wei-Qi rong Department of Hepatobiliary Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China State Key Laboratory of Molecular Oncology Department of Etiology and CarcinogenesisNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Hepatobiliary Hernia Surgery Liaocheng Dongcangfu People's HospitalLiaocheng 252000Shandong ProvinceChina The Second Ward of Hepatobiliary Surgery Qianxinan People's HospitalXingyi 562400Guizhou ProvinceChina Department of Interventional Therapy Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin's Clinical Research Center for CancerTianjin 300000China

BACKGROUND Spindle and kinetochore-associated complex subunit 3(SKA3)is a malignancyassociated gene that plays a critical role in the regulation of chromosome separation and cell ***,the molecular mechanism through which SKA3 regulates tumor cell proliferation in hepatocellular carcinoma(HCC)has not been fully *** To investigate the molecular mechanisms underlying the role of SKA3 in *** SKA3 expression,clinicopathological,and survival analyses were performed using multiple public database platforms,and the results were verified by Western blot and immunohistochemistry staining using collected clinical *** enrichment analyses were performed to evaluate the biological functions and molecular mechanisms of SKA3 in ***,the Tumor Immune Estimation Resource and single-sample Gene Set Enrichment Analysis(ssGSEA)algorithms were utilized to investigate the abundance of tumor-infiltrating immune cells in *** response to chemotherapeutic drugs was evaluated by the R package“pRRophetic”.RESULTS We found that upregulated SKA3 expression was significantly correlated with poor prognosis in patients with *** Cox regression analysis indicated that SKA3 was an independent risk factor for *** revealed that SKA3 expression may facilitate proliferation and migratory processes by regulating the cell cycle and DNA ***,patients with high SKA3 expression had significantly decreased ratios of CD8+T cells,natural killer cells,and dendritic *** sensitivity analysis showed that the high SKA3 group was more sensitive to sorafenib,sunitinib,paclitaxel,doxorubicin,gemcitabine,and *** High SKA3 expression led to poor prognosis in patients with HCC by enhancing HCC proliferation and repressing immune cell infiltration surrounding ***3 may be used as a biomarker for poor prognosis and as a therapeutic target in HCC.

关键词： Spindle and kinetochore-associated protein 3 Hepatocellular carcinoma Prognosis Immune infiltration cells

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Effect of Ticagrelor on Coronary Blood Flow and Prognosis in Patients with Acute Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention in Real World

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Chinese Medical Journal 2018年第21期131卷 2634-2636页

作者： Yan-Yan Jin rong Bai hui Ai Shao-Pin Nie Emergency and Critical Care Center Beijing Anzhen Hospital Capital Medical University Beijing 100029 China Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing 100029 China

To the Editor： Current treatment guidelines for patients with acute coronary syndrome （ACS） undergoing percutaneous coronary intervention （PCI） recommend dual antiplatelet therapy, a combination of aspirin and a P2YI2 inhibitor （i.e., clopidogrel, prasugrel, and ticagrelor） for a minimum of 12 months. Ticagrelor, an oral reversibly binding platelet P2Y 12 receptor inhibitor, generates a greater and more consistent inhibitory effect with rapid onset of action as compared to clopidogrel.

关键词： CLINICAL-OUTCOMES NO-REFLOW ADENOSINE CLOPIDOGREL REGISTRY

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Cryotherapy for cirrhosis-based hepatocellular carcinoma： a single center experience from 1595 treated cases

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Frontiers of Medicine 2015年第1期9卷 63-71页

作者： Guanghua rong Wenlin Bai zheng Dong Chunping Wang Yinying Lu Zhen Zeng Jianhui Qu Min Lou Hong Wang Xudong Gao Xiujuan Chang Linjing An Yan Chen Yongping Yang Center of Therapeutic Research for Hepatoeellular Carcinoma the 302 Hospital Beijing 100039 China

Cryoablation is a less prevalent percutaneous ablative therapy for hepatocellular carcinoma （HCC）, and current evidence about its usefulness is limited. We report our experience in treating 1595 HCC cases with percutaneous cryoablation to give a comprehensive profile about the effectiveness, safety and long-term outcome of this therapy. From January 2003 to December 2013, 1595 patients with 2313 HCC nodules were ablated with 2958 cryoablation sessions in our center. Complete ablation was achieved in 1294 patients for 1893 nodules with a mean diameter of 3.4 ＋ 2.2 cm. The complete ablation rate was 81.2%, 99.4%, 94.4%, and 45.6% in all tumors, tumors 〈 3 cm, tumors 〈 5 cm, and tumors 〉 5 cm, respectively. Major complications were observed after 80 （3.4%） of the 2958 cryoablations and minor complications were observed after 330 cryoablations with no treatment-related deaths. After a median follow-up of 33.4 months, 937 patients developed different types of recurrence. The 5- and 10-year overall survival was 25.7% and 9.2%, respectively. Cryoablation showed reliable safety and efficacy and should be considered as a promising technique, particularly when a large zone of ablation is required.

关键词： hepatocellular carcinoma percutaneous cryoablation efficacy safety

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重症高甘油三酯血症性急性胰腺炎的风险预测模型构建

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国际医药卫生导报 2024年第17期30卷 2850-2855页

作者：冯仕川张玲杜保利沈虎万锦怡张忆欣郑荣李秋忆汉中市中心医院全科医学科汉中723000 汉中市中心医院检验科汉中723000 汉中市西乡县医院老年病科汉中723500 四川大学华西医院临床药学部成都610047

目的通过LASSO回归模型构建预测重症高甘油三酯血症性急性胰腺炎(sHTGAP)风险模型。方法回顾性分析,选取2019年1月至2022年3月在汉中市中心医院治疗的315例高甘油三酯血症性急性胰腺炎(HTGAP)患者作为研究对象,根据疾病严重程度分为sHT... 详细信息

目的通过LASSO回归模型构建预测重症高甘油三酯血症性急性胰腺炎(sHTGAP)风险模型。方法回顾性分析,选取2019年1月至2022年3月在汉中市中心医院治疗的315例高甘油三酯血症性急性胰腺炎(HTGAP)患者作为研究对象,根据疾病严重程度分为sHTGAP组(94例)和Non-sHTGAP组(221例)。sHTGAP组男59例、女35例,年龄(37.51±7.08)岁;Non-sHTGAP组男135例、女86例,年龄(41.87±6.28)岁。对比两组患者临床资料和实验室指标,统计学方法采用t检验、秩和检验、χ^(2)检验。采用LASSO回归模型筛选特征因素并构建风险评分模型。结果两组患者性别、糖尿病史、高血压、吸烟史、酗酒史、饮食习惯比较,差异均无统计学意义(均P>0.05)。sHTGAP组急性生理学与慢性健康评估Ⅱ(APACHEⅡ)评分、多层螺旋CT严重指数(MCTSI)评分、白细胞计数(WBC)、C反应蛋白(CRP)、血糖(Glu)、甘油三酯(TG)均高于Non-sHTGAP组[9.00(7.00,11.00)分比4.00(3.00,6.00)分、6.00(5.00,7.00)分比4.00(3.00,6.00)分、12.22(9.89,14.34)10^(9)/个比10.44(8.58,12.39)10^(9)/个、164.25(128.32,217.58)mg/L比56.15(37.13,76.95)mg/L、(12.16±2.99)mmol比(6.27±2.42)mmol、(14.05±5.10)mmol/L比(11.46±4.78)mmol/L],住院时间长于Non-sHTGAP组[13.00(8.00,16.00)d比9.00(5.00,13.00)d],钙离子(Ca^(2+))低于Non-sHTGAP组[(2.12±0.09)mmol/L比(2.17±0.09)mmol/L],差异均有统计学意义(均P<0.05)。LASSO风险评分模型的曲线下面积(AUC)为0.998,优于单一指标。结论APACHEⅡ评分、MCTSI评分、住院时间、WBC、CRP、Glu、Ca^(2+)和TG水平与sHTGAP的发生和严重程度密切相关,综合评估这些指标对于提高sHTGAP患者预后意义重大。

关键词：急性胰腺炎高甘油三酯血症严重程度 LASSO回归风险评分

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京都胃炎分类评分系统识别我国胃癌高风险人群的应用价值

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胃肠病学和肝病学杂志 2024年第7期33卷 829-832页

作者：李超王晓辉闫志辉罗哲李辉郑岩崔立红中国人民解放军总医院第六医学中心消化内科北京100048

目的探讨京都胃炎分类评分系统对我国胃癌高风险人群提示的有效性,为我国胃癌筛查提供借鉴。方法回顾性分析中国人民解放军总医院第六医学中心行胃镜检查的1250例患者,其中胃癌患者145例(观察组),非胃癌患者1105例(对照组)。根据京都胃... 详细信息

目的探讨京都胃炎分类评分系统对我国胃癌高风险人群提示的有效性,为我国胃癌筛查提供借鉴。方法回顾性分析中国人民解放军总医院第六医学中心行胃镜检查的1250例患者,其中胃癌患者145例(观察组),非胃癌患者1105例(对照组)。根据京都胃炎分类评分标准,白光胃镜下对患者背景胃黏膜进行评分比较。结果观察组京都胃炎分类评分总分显著高于对照组[(3.29±2.20)分vs(1.06±1.46)分,P<0.01],且观察组在萎缩、肠上皮化生、弥漫性发红评分均高于对照组(P<0.01)。Logistic回归分析显示,萎缩评分高(OR=5.944)和黏膜弥漫性发红评分高(OR=3.105)是胃癌患病的危险因素。此外,早期胃癌患者在萎缩、肠上皮化生、弥漫性发红、鸡皮样改变评分及总分上也高于对照组(P<0.01)。结论京都胃炎分类评分系统有助于在白光胃镜下识别胃癌及早期胃癌高风险人群。

关键词：胃癌内镜京都胃炎分类

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