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Analysis of the potential biological value of pyruvate dehydrogenase E1 subunitβin human cancer

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 144-181页

作者： Yao rong Song-Hua Liu Ming-Zheng Tang Zhi-Hang Wu guo-rong Ma Xiao-Feng Li Hui Cai First Clinical Medical College Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina General Surgery Clinical Medical Center Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina Key Laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology in Gansu Province Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina NHC Key Laboratory of Diagnosis and Therapy of Gastrointestinal Tumor Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND The pyruvate dehydrogenase E1 subunitβ(PDHB)gene which regulates energy metabolism is located in ***,few studies have elucidated the role and mechanism of PDHB in different *** To comprehensive pan-cancer analysis of PDHB was performed based on bioinformatics approaches to explore its tumor diagnostic and prognostic value and tumor immune relevance in *** vitro experiments were performed to examine the biological regulation of PDHB in liver *** Pan-cancer data related to PDHB were obtained from the Cancer Genome Atlas(TCGA)*** of the gene expression profiles of PDHB was based on TCGA and Genotype Tissue Expression Dataset *** regression analysis and Kaplan-Meier methods were used to assess the correlation between PDHB expression and survival prognosis in cancer *** correlation between PDHB and receiver operating characteristic diagnostic curve,clinicopathological staging,somatic mutation,tumor mutation burden(TMB),microsatellite instability(MSI),DNA methylation,and drug susceptibility in pan-cancer was also *** algorithms were used to analyze the correlation between PDHB and immune cell infiltration and tumor chemotaxis environment,as well as the co-expression analysis of PDHB and immune checkpoint(ICP)*** expression and functional phenotype of PDHB in single tumor cells were studied by single-cell sequencing,and the functional enrichment analysis of PDHB-related genes was *** study also validated the level of mRNA or protein expression of PDHB in several ***,in vitro experiments verified the regulatory effect of PDHB on the proliferation,migration,and invasion of liver *** PDHB was significantly and differently expressed in most *** was significantly associated with prognosis in patients with a wide range of cancers,including kidney renal clear cell carcinoma,kidney renal papillary cell carcinoma,breast invasive carcinom

关键词： Cuprotosis Pyruvate dehydrogenase E1 subunitβ Pan-cancer Prognosis Liver cancer

Coupled dynamic response analysis of multi-column floating offshore wind turbine with low center of gravity

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Journal of Ocean Engineering and Science 2024年第1期9卷 25-39页

作者： Jie Yang Yan-ping He Yong-sheng Zhao Xiao-yan Yang guo-rong Zhang State Key Laboratory of Ocean Engineering Shanghai Jiao Tong UniversityShanghai 200240China Collaborative Innovation Center for Advanced Ship and Deep-Sea Exploration(CISSE) Shanghai Jiao Tong UniversityShanghai 200240China School of Naval Architecture Ocean&Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China Faculty of Maritime and Transportation Ningbo UniversityNingbo 315211China

To realize the application of the floating offshore wind turbine(FOWT)from deep to relatively shallow waters,a new concept of multi-column floating wind turbine platform with low center of gravity(CG)is designed and *** multi-column low CG platform is designed to support a 6MW wind turbine class and operated at a water depth of 50m in the South China *** frequency domain software WADAM and time domain software NREL-FAST are used to simulate coupled dynamic responses of the floating wind turbine system with second-order wave loads *** dynamic behaviors of multi-column low CG FOWT system under normal operation and parked conditions are *** influence of second-order wave force on the motion responses of the multi-column platform,fore-aft force and moment of the tower base and mooring force are researched *** results demonstrate that the coupled dynamic responses at rated operating condition and extreme condition meet the normal operating requirements and extreme survival requirements of FOWT system in the shallow water(50m)of South China *** addition,it is found that,the wave frequency response gradually replaces the second-order low frequency response as the main influencing factor of the coupled dynamic response of the FOWT system with the increasing severity of the sea ***,in general,the magnitude of second-order low frequency response increases with the increasing severity of the design load ***,in the subsequent design of the shallow water FOWT system,the second-order effects should be paid enough attention.

关键词： Floating offshore wind turbine Multi-column platform Second-order wave force Concept design Coupled dynamic response

Research and Application of Deep Learning Technology in Prefabricated Buildings

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Journal of World Architecture 2024年第2期8卷 134-139页

作者： rong guo Guangdong Baiyun University Guangzhou 510000Guangdong ProvinceChina

Prefabricated buildings have become an important development trend in the field of modern architecture because of their high efficiency and environmental friendliness. Artificial intelligence and deep learning technology have been increasingly applied in prefabricated buildings. Deep learning technology provides comprehensive optimization of building design, construction, quality control, and cost and schedule management through the learning and analysis of large amounts of data. This paper aims to explore the application of deep learning technology in prefabricated buildings, analyze the revolutionary changes it brings in different stages, and discuss the problems faced when implementing this technology.

关键词： Deep learning Prefabricated building Application

Effects of Bisphenol A and Its Substitute, Bisphenol F, on the Gut Microbiota in Mice

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Biomedical and Environmental Sciences 2024年第1期37卷 19-30页

作者： MENG Li Ying TAO Wen Fu LI Jing ZHU Min ZHONG De Bin ZHOU Jing QIN Xue WEI rong guo Department of Clinical Laboratory The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021GuangxiChina Department of Clinical Laboratory The Fifth Affiliated Hospital of Guangxi Medical UniversityNanning 530021GuangxiChina Jiangsu Key Laboratory of Environmental Engineering Jiangsu Academy of Environmental SciencesNanjing 210000JiangsuChina

Objective The aim of this study was to assess the impact of bisphenol A(BPA)and its substitute,bisphenol F(BPF),on the colonic fecal community structure and function of *** We exposed 6–8-week-old male C57BL/6 mice to 5 mg/(kg∙day)and 50μg/(kg∙day)of BPA or BPF for 14 *** samples from the colon were analyzed using 16S rRNA *** Gut microbiome community richness and diversity,species composition,and function were significantly altered in mice exposed to BPA or *** change was characterized by elevated levels of Ruminococcaceae UCG-010 and Oscillibacter and decreased levels of Prevotella 9 and ***,pathways related to carbohydrate and amino acid metabolism showed substantial *** Mice exposed to different BP analogs exhibited distinct gut bacterial community richness,composition,and related metabolic *** the essential role of gut bacteria in maintaining intestinal homeostasis,our study highlights the intestinal toxicity of BPs in vertebrates.

关键词： Bisphenol A(BPA) Bisphenol F(BPF) 16S rRNA Microbiota

透射式GaAs光电阴极性能提高以及结构优化

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物理学报 2024年第3期73卷 266-272页

作者：吕行富容国常本康郭欣王芝南京理工大学电子工程与光电技术学院南京210094 昆明物理研究所昆明650221 西安应用光学研究所西安710065

为了提高透射式GaAs光电阴极性能,将国内与美国ITT公司的透射式GaAs光电阴极量子效率曲线进行对比,可知我国透射式光电阴极积分灵敏度已经达到2130μA/lm,美国ITT达到了2330μA/lm.利用修正后的量子效率、光学性能以及积分灵敏度的理论... 详细信息

为了提高透射式GaAs光电阴极性能,将国内与美国ITT公司的透射式GaAs光电阴极量子效率曲线进行对比,可知我国透射式光电阴极积分灵敏度已经达到2130μA/lm,美国ITT达到了2330μA/lm.利用修正后的量子效率、光学性能以及积分灵敏度的理论模型,分别对两者进行光学结构拟合.结果表明,国内光电阴极在窗口层和发射层的厚度、电子扩散长度以及后界面复合速率等方面均与ITT有一定差距.为了缩短两者的差距,优化阴极结构参数,具体研究了电子扩散长度和发射层厚度对量子效率的影响,结果表明如果均匀掺杂透射式GaAs光电阴极发射层厚度为1.3μm、电子扩散长度为7μm,则积分灵敏度可以达到2800μA/lm以上.

关键词： Ga As光电阴极透射式结构优化光学性能光电发射性能

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“小案”助推社会治理的内生动力与培育路径探究

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法律适用 2024年第5期 36-46页

作者：郭融北京市第二中级人民法院民事审判第二庭

自2020年以来,全国法院推出了一批具有社会影响力的“小案”,具有回应民众关切、引导社会风气,甚至创新社会规则的重要意义。然而,实践审判中仍然存在“小案”供给力不足、衍生效果薄弱和培育能力欠缺等挑战。“小案”系指聚焦身边人、... 详细信息

自2020年以来,全国法院推出了一批具有社会影响力的“小案”,具有回应民众关切、引导社会风气,甚至创新社会规则的重要意义。然而,实践审判中仍然存在“小案”供给力不足、衍生效果薄弱和培育能力欠缺等挑战。“小案”系指聚焦身边人、身边事,与民生息息相关,反映一定社会价值,且对社会治理发挥重要作用的一类案件。从其功能性上,可将“小案”划分为“唤醒型小案”“重塑型小案”和“创新型小案”。以系统动力学为分析视角,“小案”在社会治理中发挥着重要的规则补强、更新和开拓作用。“小案”培育路径的设计为运用“一核四维”模式激活“小案”判断力,树立“小案透审”理念提升“小案”领悟力,建构传播体系提升“小案”传播力。

关键词：小案社会治理内生动力案件培育

土壤中微塑料与环境污染物的复合作用及其对微生物的影响

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岩矿测试 2024年第1期43卷 1-15页

作者：郭荣沈亚婷国家地质实验测试中心北京 100037 自然资源部生态地球化学重点实验室北京 100037

随着塑料制品在工农业和生产生活中的广泛使用,大量微塑料被释放到土壤中,带来不可忽视的生态环境与健康风险。长久以来,人们更关注微塑料本身的生态毒性,对微塑料与环境中的其他化学污染物的联合作用及其环境效应研究较少。由于土壤微... 详细信息

随着塑料制品在工农业和生产生活中的广泛使用,大量微塑料被释放到土壤中,带来不可忽视的生态环境与健康风险。长久以来,人们更关注微塑料本身的生态毒性,对微塑料与环境中的其他化学污染物的联合作用及其环境效应研究较少。由于土壤微生物在微塑料降解过程中起着关键作用,认识土壤微塑料是如何通过影响土壤环境而直接或间接影响土壤中微生物群落和土壤生态功能的微观机理,已成为未来推进微塑料的降解和科学认识微塑料生态系统风险的关键。本文综述了近年来微塑料在土壤中吸附和迁移机理,以及微塑料的吸附程度和位置对其迁移行为的影响。总结了微塑料与土壤中有机污染物和重金属的复合作用的进展,探讨了这些复合作用对土壤环境风险的影响,包括污染物的毒性、生物利用度和迁移性的变化。评述了微塑料对土壤微生物群落的影响及作用机制,微塑料对微生物的物种丰富度、活性和结构的影响,以及微塑料表面的定殖和选择性富集能力。建议未来应该加强以下三方面的研究:①深入探索微塑料与环境污染物的复合作用及其生态毒理作用的微观机理;②认识土壤中微塑料对土壤微生物群落结构改变的微观机制;③探索通过科学调控土壤理化特性、特异性微生物在微塑料表面的定殖与富集能力等途径来控制土壤中微塑料及微塑料-其他环境污染物复合污染的可能性。

关键词：微塑料微生物群落结构有机污染物重金属复合作用

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王夫之与中国哲学

中山大学学报（社会科学版） 2024年第2期64卷 1-13页

作者：杨国荣华东师范大学中国现代思想文化研究所暨哲学系上海200241 浙江大学马一浮书院杭州310058

在中国哲学史上,王夫之的哲学思想具有总结的意义。以何物存在、如何存在等形而上的问题为关注点,王夫之强调对世界的考察需要联系人自身的存在,由此扬弃对世界的思辨构造。同时,通过将有无之辨转换为隐现、幽明等论题的辨析,王夫之克... 详细信息

在中国哲学史上,王夫之的哲学思想具有总结的意义。以何物存在、如何存在等形而上的问题为关注点,王夫之强调对世界的考察需要联系人自身的存在,由此扬弃对世界的思辨构造。同时,通过将有无之辨转换为隐现、幽明等论题的辨析,王夫之克服了把虚无或虚妄绝对化的趋向。以阐发儒家“诚”的概念为前提,王夫之对虚妄不实的存在规定作了否定。在伦理学上,与“无我”说相对,王夫之肯定了道德主体(“我”)的存在,并将现实的主体视为身与德的统一;“身”表征生命存在,“德”则包含综合的道德品格。与肯定自我相关,王夫之反对人的物化,并肯定了合乎普遍规范的人格境界。在肯定新民的同时,王夫之又注重如何使普遍之理与特定的行为情境结合的问题。通过辨析理欲,王夫之既确认了普遍规范的制约,也关注于道德行为的内在动力。在认识论上,王夫之首先对能与所的统一作了肯定,并将形、神、物三者的交互作用视为知觉发生的现实根据。通过考察格物致知,王夫之分梳了感性与理性在认识过程中的不同作用。在知行关系上,王夫之提出知行相资以为用,肯定了二者的动态统一。除了以上方面,王夫之在哲学上的思考还包含丰富内容,其考察所及,既关乎事、理、势的关系和性命之辨,也涉及对传统的心、性、情等问题的理解,相关论述围绕中国哲学的论域,从更广的层面展现了对古典哲学的反思与超越。

关键词：形上学伦理学认识论古典哲学

1963年伯明翰运动与肯尼迪政府民权法案的出台

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史学集刊 2024年第4期 126-144页

作者：谢国荣华东师范大学历史学系上海200241

自1960年入座运动开展以来,美国民权运动在直接行动阶段取得了一系列丰硕成果,但这种非暴力斗争在奥尔巴尼运动中却遭到重大挫败。为避免重蹈覆辙并防止民权运动进入“冷却期”,马丁·路德·金和南方基督教领导大会周密筹划,特意选择在... 详细信息

自1960年入座运动开展以来,美国民权运动在直接行动阶段取得了一系列丰硕成果,但这种非暴力斗争在奥尔巴尼运动中却遭到重大挫败。为避免重蹈覆辙并防止民权运动进入“冷却期”,马丁·路德·金和南方基督教领导大会周密筹划,特意选择在种族隔离十分严重且容易激起种族暴力的伯明翰市开展民权运动。金不仅公开发表《伯明翰狱中来信》,而且把黑人学童带到民权运动的现场。伯明翰运动促使美国民权运动走向激进化。伯明翰警察局长康纳下令用高压水龙头和警犬对付非暴力的示威民众,甚至连黑人学童亦不例外。这一幕给美国的国家形象、声誉和外交造成巨大伤害,威胁到美国在冷战中对20世纪60年代大量新兴的非洲独立国家的争夺。伯明翰运动唤起了美国社会具有同情心和正义感的白人民众的支持,而且迫使肯尼迪政府从冷战成败的高度出台了民权法案。美国民权运动由此进入民权立法的黄金时代。

关键词：非暴力斗争伯明翰运动《伯明翰狱中来信》冷战民权法案

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