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Experimental investigation of measurement incompatibility of mutually unbiased bases

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Chip 2023年第1期2卷 51-57页

作者： Yu Guo Shuming Cheng Xiao-Min Hu Bi-Heng Liu Yun-feng huang Chuan-feng Li Guang-Can Guo CAS Key Laboratory of Quantum Information University of Science and Tech-nology of ChinaHefei 230026China CAS Center For Excellence in Quan-tum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China The Department of Control Science and Engineer-ing Tongji UniversityShanghai 201804China Shanghai Institute of Intelligent Science and Technology Tongji UniversityShanghai 201804China Institute for Advanced Study Tongji UniversityShanghai 200092China

Incompatible measurements are of fundamental importance to re-vealing the peculiar features of quantum theory,and are also use-ful resources in various quantum information *** this work,we investigate the quantum incompatibility of mutually unbiased bases(MUBs)within the operational framework of quantum resource the-ory,and report an experimental validation via the task of state *** particular,we construct an experimentally friendly witness to detect incompatible MUBs,based on the probability of cor-rectly discriminating quantum ***,we prove that the noise robustness of MUBs can be retrieved from violating the above ***,we experimentally test the incompatibility of MUBs of dimensionality ranging from 2 to 4,and demonstrate that it is more robust to noise,as either the dimensionality of measurements or the number of MUBs *** results may aid the exploration of the essential roles of incompatible measurements in both theoretical and practical applications in quantum information.

关键词： Quantum incompatibility Mutually unbiased bases Robust-ness of incompatibility

2020年全国医院感染监控网丙型肝炎病毒感染监测报告

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中国感染控制杂志 2024年第1期23卷 1-8页

作者：文细毛任南李福琴战榕方旭孟庆兰杨怀李卫光刘丁郭凤玲鲜于舒铭赖晓全逄崇杰黄勋吴安华中南大学湘雅医院医院感染控制中心湖南长沙410008 中南大学湘雅医院临床护理学教研室湖南长沙410008 郑州大学第一附属医院医院感染管理科河南郑州450052 福建医科大学附属协和医院医院感染管理科福建福州350001 云南省第一人民医院感染管理科云南昆明650032 内蒙古医科大学附属医院医院感染管理部内蒙古呼和浩特010017 贵州省人民医院医院感染管理科贵州贵阳550002 山东第一医科大学附属省立医院医院感染管理办公室山东济南250021 陆军特色医学中心疾病预防控制科重庆400042 河南省中医院(河南中医药大学第二附属医院河南中医药大学第二临床医学院)感染管理科河南郑州450002 海南省人民医院医院感染管理办公室海南海口570311 华中科技大学同济医学院附属同济医院医院感染管理科湖北武汉430030 天津医科大学总医院感染科天津300052

目的了解医疗机构住院患者丙型肝炎病毒(HCV)感染情况及变化趋势,为制定HCV感染防控策略提供参考依据。方法对2020年上报至全国医院感染监控网医院感染横断面调查资料中HCV感染监测结果进行汇总分析,HCV阳性为血清抗-HCV阳性或HCV RNA阳... 详细信息

目的了解医疗机构住院患者丙型肝炎病毒(HCV)感染情况及变化趋势,为制定HCV感染防控策略提供参考依据。方法对2020年上报至全国医院感染监控网医院感染横断面调查资料中HCV感染监测结果进行汇总分析,HCV阳性为血清抗-HCV阳性或HCV RNA阳性,并与2003年调查结果进行比较。结果2020年1573所医院调查住院患者1071368例,其中738535例患者进行了HCV相关检测,4014例存在HCV感染,检测率为68.93%,HCV阳性率为0.54%。男性患者HCV阳性率为0.60%,女性患者为0.48%,两者比较差异有统计学意义(χ^(2)=47.18,P10000例,HCV阳性率为0.19%~0.81%,以海南省最高;不同科室HCV阳性率为0.06%~0.82%,以儿科HCV阳性率最低,内科HCV阳性率最高。2003、2020年HCV阳性率均以感染病科最高,分别为7.95%、3.48%,2003年其次为整形科(7.72%)、消化科(3.77%)、肾病科(3.57%)、综合重症监护病房(ICU,3.10%),2020年其次为消化科(1.35%)、肾病科(1.18%)、内分泌科(0.91%)、综合ICU(0.79%)。结论与2003年相比,2020年HCV阳性率明显下降。HCV感染患者主要分布在感染病科,其次为消化科、肾病科及综合ICU,HCV感染阳性率存在性别、年龄、地域的差异。

关键词：肝炎病毒,丙型丙型肝炎病毒流行病学调查住院患者发病率

运用尿蛋白组学技术探索凝血酶与炎症因子相互作用参与IgA血管炎发病的机制

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中国当代儿科杂志 2024年第7期26卷 683-689页

作者：刘萌萌侯改灵杨晓青张秋爽梅晓峰丁樱宋兰黄岩杰河南中医药大学儿科医学院河南郑州450046 河南中医药大学第一附属医院儿科医院河南郑州450046 北京蛋白质组学研究中心北京102206 上海市儿童医院/上海交通大学医学院附属儿童医院中医科上海200062

目的运用蛋白质组学方法探索高凝状态参与IgA血管炎(IgA vasculitis,IgAV)发病的证据、尿生物标志物及部分机制。方法采用高效液相色谱-串联质谱技术筛选10例正常儿童和10例IgAV患儿尿液中差异表达的蛋白,进行Reactome通路分析。运用STR... 详细信息

目的运用蛋白质组学方法探索高凝状态参与IgA血管炎(IgA vasculitis,IgAV)发病的证据、尿生物标志物及部分机制。方法采用高效液相色谱-串联质谱技术筛选10例正常儿童和10例IgAV患儿尿液中差异表达的蛋白,进行Reactome通路分析。运用STRING和Cytoscape软件进行蛋白质-蛋白质相互作用(proteinprotein interaction,PPI)网络分析。在验证队列中,纳入15例正常儿童和25例IgAV患儿,采用酶联免疫吸附测定方法验证尿液差异蛋白的表达水平。结果IgAV患儿与正常组之间共筛选出772个差异蛋白(上调蛋白768个,下调蛋白4个)。Reactome通路富集结果显示中性粒细胞脱颗粒、血小板活化及止血通路参与IgAV的发生。差异蛋白中巨噬细胞迁移抑制因子(macrophage migration inhibitory factor,MIF)在中性粒细胞脱颗粒和止血过程中起着重要作用,凝血酶是参与血小板活化和止血通路的关键蛋白。PPI分析结果显示,凝血酶与多种参与炎症反应的差异蛋白具有直接作用,并通过它们与MIF相互作用。验证结果显示,与正常儿童相比,IgAV患儿尿凝血酶/肌酐、尿MIF/肌酐水平均显著升高(P<0.05)。结论凝血酶通过与炎症因子相互作用参与IgAV的发病;尿凝血酶和MIF可作为反映IgAV患儿高凝与炎症状态的生物标志物。

关键词： IgA血管炎蛋白质组学凝血酶高凝炎症儿童

Identification of novel mammalian viruses in tree shrews (Tupaia belangeri chinensis)

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Serum Myeloperoxidase Level in Systemic Lupus Erythematosus

动物学研究 2024年第2期 429页

作者： Hong Zhou Ren-rong Tian Xiu-rong Wang Jin-Xuan Yang Yun-Xiao Wang Ming-Liang Zhao Xu-Dong Zhang Yu-Hua Ma Long-Bao Lv Edward C.Holmes Yong-Tang Zheng Wei-feng Shi

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Chinese Medical Sciences Journal 2015年第3期30卷 199-202页

作者： Ming-jian Bai Jing feng feng Yu Cun-ling Yan Chan-juan Cui Lei huang Zhen-ru feng Department of Clinical Laboratory Aerospace Central Hospital Department of Nephrology Peking University First Hospital Department of Clinical Laboratory Peking University First Hospital

SYSTEMIC lupus erythematosus （SLE） is a systemicautoimmune disease. Several mechanismshave been put forward as underlying the loss ofself-tolerance and development of organdysfunction, such as genetic, environmental... 详细信息

关键词： myeloperoxidase systemic lupus erythematosus

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复合植物美白面膜的制备研究

广东化工 2024年第5期51卷 47-49,13页

作者：陈艳玲黄荣魏馨杨秋文曲别啥啥成都师范学院化学与生命科学学院功能分子结构优化与应用四川省高校重点实验室四川成都611130

本研究分别从三百草中提取黄酮,从石榴中提取有机酸和多酚,从苦参根中提取苦参碱,黄酮和多酚具有抑制酪氨酸酶活性和抗氧化的功效,有机酸具有温和去角质和亮肤的作用,苦参碱具有抗炎的作用,在研究中将其制备为复合植物美白面膜,并进行... 详细信息

本研究分别从三百草中提取黄酮,从石榴中提取有机酸和多酚,从苦参根中提取苦参碱,黄酮和多酚具有抑制酪氨酸酶活性和抗氧化的功效,有机酸具有温和去角质和亮肤的作用,苦参碱具有抗炎的作用,在研究中将其制备为复合植物美白面膜,并进行了配方设计和功效评价。制成的植物复合美白面膜对酪氨酸酶活性的抑制率为87.56%,说明植物复合美白面膜对皮肤黑色素有一定的抑制效果,具有一定美白作用。

关键词：面膜三百草石榴苦参根美白

Single-nucleotide polymorphisms based genetic risk score in the prediction of pancreatic cancer risk

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World Journal of Gastroenterology 2020年第22期26卷 3076-3086页

作者： Xiao-Yi Wang Hai-Tao Chen rong Na De-Ke Jiang Xiao-Ling Lin feng Yang Chen Jin De-Liang Fu Jian-feng Xu Department of Pancreatic Surgery Pancreatic Disease InstituteHuashan HospitalFudan UniversityShanghai 200040China State Key Laboratory of Organ Failure Research Guangdong Key Laboratory of Viral Hepatitis ResearchDepartment of Infectious Diseases and Hepatology UnitNanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Shanghai Medical College Fudan UniversityShanghai 200043China Department of Urology Ruijin HospitalShanghai Jiaotong University School of MedicineShanghai 200025China State Key Laboratory of Genetic Engineering School of Life ScienceFudan UniversityShanghai 200433China Program for Personalized Cancer Care and Department of Surgery North Shore University Health SystemEvanstonIL 60201United States

BACKGROUND Disease-related single nucleotide polymorphisms(SNPs)based genetic risk score(GRS)has been proven to provide independent inherited risk other than family history in multiple cancer *** To evaluate the potential of GRS in the prediction of pancreatic cancer *** In this case-control study(254 cases and 1200 controls),we aimed to evaluate the association between GRS and pancreatic ductal adenocarcinoma(PDAC)risk in the Chinese *** GRS was calculated based on the genotype information of 18 PDAC-related SNPs for each study subject(personal genotyping information of the SNPs)and was weighted by external odd ratios(ORs).RESULTS GRS was significantly different in cases and controls(1.96±3.84 in PDACs vs 1.09±0.94 in controls,P<0.0001).Logistic regression revealed GRS to be associated with PDAC risk[OR=1.23,95%confidence interval(CI):1.13-1.34,P<0.0001].GRS remained significantly associated with PDAC(OR=1.36,95%CI:1.06-1.74,P=0.015)after adjusting for age and *** analysis revealed an association of increased risk for PDAC with higher *** with low GRS(<1.0),subjects with high GRS(2.0)were 99%more likely to have PDAC(OR:1.99,95%CI:1.30-3.04,P=0.002).Participants with intermediate GRS(1.0-1.9)were 39%more likely to have PDAC(OR:1.39,95%CI:1.03-1.84,P=0.031).A positive trend was observed(P trend=0.0006).CONCLUSION GRS based on PDAC-associated SNPs could provide independent information on PDAC risk and may be used to predict a high risk PDAC population.

关键词： Pancreatic cancer Single nucleotide polymorphisms Genetic risk score Chinese population Genome-wide association study

一种新型查耳酮衍生物C13通过ErbB4/PI3K/AKT信号通路抑制人胃癌细胞的生长

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药学学报 2024年第4期59卷 957-964页

作者：谭鹏张云封王龙燕黄惠铭王飞魏雪娇王柱国李军胡仲冬北京中医药大学北京中医药研究院中药现代研究中心北京100029

3ʹ-羟基-4ʹ-甲氧基-2-羟基-5-溴查耳酮(以下简称C13)是本课题组对龙血竭抗肿瘤活性化合物DHMMF进行结构修饰过程中获得的一个新型查耳酮衍生物。本研究探讨了C13对人胃癌HGC-27、AGS细胞增殖、凋亡的影响及其潜在的作用机制。首先采用... 详细信息

3ʹ-羟基-4ʹ-甲氧基-2-羟基-5-溴查耳酮(以下简称C13)是本课题组对龙血竭抗肿瘤活性化合物DHMMF进行结构修饰过程中获得的一个新型查耳酮衍生物。本研究探讨了C13对人胃癌HGC-27、AGS细胞增殖、凋亡的影响及其潜在的作用机制。首先采用噻唑蓝(methyl thiazolyl tetrazolium,MTT)、集落形成实验、5-乙炔基-2′-脱氧尿苷(5-ethynyl-2ʹ-deoxyuridine,EdU)染色法发现C13能显著抑制人胃癌HGC-27、AGS细胞的增殖能力。采用流式细胞术和免疫印迹法检测发现C13能诱导人胃癌HGC-27、AGS细胞发生凋亡,并上调剪切的聚腺苷酸二磷酸核糖转移酶(cleaved-poly ADP-ribose polymerase,cleaved-PARP)的蛋白水平。转录组测序分析结果显示C13可能通过调控人表皮生长因子受体4/磷脂酰肌醇3-激酶/蛋白激酶B(Erb-B2 receptor tyrosine kinase 4/phosphoinositide 3-kinase/AKT,ErbB4/PI3K/AKT)信号通路发挥抗胃癌作用。最后免疫印迹实验结果表明,C13处理后能下调人胃癌细胞中ErbB4总蛋白及磷酸化水平,并能够抑制其下游PI3K及AKT蛋白磷酸化水平,进一步验证了转录组测序结果。综上所述,新型查耳酮衍生物C13能够显著抑制人胃癌HGC-27、AGS细胞增殖并诱导其发生凋亡,其机制可能与下调ErbB4/PI3K/AKT信号通路有关。本研究能够为胃癌治疗提供一个候选研究药物。

关键词：查耳酮衍生物C13 人胃癌细胞增殖凋亡 ErbB4/PI3K/AKT信号通路

Stability of SARS-CoV-2 on the Surfaces of Three Meats in the Setting That Simulates the Cold Chain Transportation

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Virologica Sinica 2021年第5期36卷 1069-1072页

作者： Xiao-Li feng Bei Li Hao-feng Lin Hong-Yi Zheng Ren-rong Tian rong-Hua Luo Mei-Qin Liu Ren-Di Jiang Yong-Tang Zheng Zheng-Li Shi Yu-Hai Bi Xing-Lou Yang Kunming National High-Level Biosafety Research Center for Non-Human Primates Center for Biosafety Mega-ScienceKunming Institute of ZoologyChinese Academic of SciencesKunming 650107China CAS Key Laboratory of Special Pathogens Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan 430071China University of Chinese Academy of Sciences Beijing 101408China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyCenter for Influenza Research and Early-Warningarning(CASCIRE)CASTWAS Center of Excellence for Emerging Infectious Diseases(CEEID)Chinese Academy of SciencesBeijing 100101China

Dear Editor,The coronavirus disease 2019(COVID-19)pandemic presents a severe threat to public health and the global economy and the direct origin of the causative agent severe acute respiratory syndrome coronavirus 2(SARS-Co V-2)remains unresolved(WHO 2020).The outbreak in China was successfully contained by the implementation of a strict quarantine strategy,however sporadic outbreaks still occurred and were associated with trade markets in Beijing and Dalian *** COVID-19 outbreak in Beijing was traced to contaminated salmon meat sold at the Xinfadi market,Beijing,China(Chinese CDC 2020)。

关键词： acute respiratory Chain