检索结果-南通市图书馆

Prognostic significance and relationship of SMAD3 phosphoisoforms and VEGFR-1 in gastric cancer:A clinicopathological study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2024年第1期16卷 118-132页

作者： Shi-Lin Lv Pei Guo Jun-rong zou Ren-Sheng Chen Ling-Yu Luo De-Qiang Huang Hospital of Gastroenterology Institute of Digestive DiseasesThe First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina Department of Pathology Shenzhen Hospital of Southern Medical UniversityShenzhen 518000Guangdong ProvinceChina Institute of Urology The First Affiliated Hospital of Gannan Medical UniversityGanzhou 341000Jiangxi ProvinceChina Department of Pathology The First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina

BACKGROUND The TGF-β/SMAD3 and VEGFR-1 signaling pathways play important roles in gastric cancer ***3 phosphorylation is a crucial prognostic marker in gastric *** To determine the prognostic value and relationship of SMAD3 phospho-isoforms and VEGFR-1 in gastric *** This was a single-center observational study which enrolled 98 gastric cancer patients and 82 adjacent normal gastric tissues from patients aged 32-84 years(median age 65)between July 2006 and April *** were followed up until death or the study ended(median follow-up duration of 28.5 mo).The samples were used to generate tissue microarrays(TMAs)for immunohistochemical(IHC)*** expressions of TGF-β1,pSMAD3C(S423/425),pSMAD3L(S204),and VEGFR-1 in gastric cancer(GC)tumor tissue and normal tissue were measured by IHC staining using TMAs obtained from 98 GC *** and survival information of the patients was recorded by Outdo Biotech from May 2007 to July *** relationship between TGF-β1,pSMAD3C(S423/425),pSMAD3L(S204),and VEGFR-1 protein expression levels was analyzed using Pearson's correlation *** relationship between protein expression levels and clinicopathological parameters was analyzed using the Chi-squared test.A survival curve was generated using the Kaplan-Meier survival *** TGFβ-1 and VEGFR-1 expression was significantly upregulated in gastric cancer tissue compared to adjacent noncancerous *** positive expression of phosphorylated isoforms of Smad3 varied depending on the phosphorylation site[pSMAD3C(S423/425):51.0%and pSMAD3L(S204):31.6%].High expression of pSMAD-3L(S204)was significantly correlated with larger tumors(P=0.038)and later N stages(P=0.035).Additionally,high expression of VEGFR-1 was closely correlated with tumor size(P=0.015)and pathological grading(P=0.013).High expression of both pSMAD3L(S204)and VEGFR-1 was associated with unfavorable outcomes in terms of overall survival(OS).Multiva

关键词： Gastric cancer pSMAD3L(S204) pSMAD3C(S423/425) Survival Transforming growth factor-β1 VEGFR-1

论发展不平衡视野下的乡村建设行动——兼议乡村转型的两种类型

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

西北师大学报（社会科学版） 2024年第1期61卷 118-126页

作者：桂华邹蓉武汉大学社会学院湖北武汉430072

改革开放以来,我国乡村转型过程与社会发展的整体形态紧密相关。改革开放后乡村市场化程度逐步提高,农村人财物纳入到全国统一的市场体系中配置,乡村在消除贫困的同时出现了发展不平衡问题。我国东部地区率先启动工业化和城镇化,获得了... 详细信息

改革开放以来,我国乡村转型过程与社会发展的整体形态紧密相关。改革开放后乡村市场化程度逐步提高,农村人财物纳入到全国统一的市场体系中配置,乡村在消除贫困的同时出现了发展不平衡问题。我国东部地区率先启动工业化和城镇化,获得了优势积累,形成了城市经济带动的乡村持续发展;与此同时,中西部地区人财物大量流出,乡村不断收缩。由此,我国乡村现代化变迁过程中出现了中西部地区“收缩型”与东部地区“扩张型”两种基本形态。这种现代化不均衡格局及其带来的乡村转型地区差异,要求政府主导的乡村建设行动必须在做到因地制宜的同时,将乡村建设放在城乡关系动态演变这一框架下规划,在行动策略上将不平衡现状当作机遇,利用好城乡二元条件,努力推动发展并实现更高水平的平衡,为进一步实现中国式现代化作准备。

关键词：乡村转型发展不平衡收缩型扩张型乡村建设

Spontaneous dislodgment of a peritoneal dialysis catheter inserted using the Seldinger technique:A case report

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2024年第21期12卷 4789-4793页

作者： Ruo-Yu Wu Yao Tan Hang Li Yu-rong zou Xiu-Ling Chen Jin Chen School of Medicine University of Electronic Science and Technology of ChinaChengdu 610000Sichuan ProvinceChina Department of Nephrology Anzhou District People’s HospitalMianyang 62100Sichuan ProvinceChina Department of Radiology Sichuan Academy of Medical Sciences and Sichuan Provincial People's HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610000Sichuan ProvinceChina Department of Nephrology Sichuan Academy of Medical Sciences and Sichuan Provincial People’s HospitalSichuan Clinical Research Center for Kidney DiseasesSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610000Sichuan ProvinceChina

BACKGROUND Peritoneal dialysis(PD)is an important renal replacement therapy in patients with end-stage renal *** catheters remain the lifeline for patients undergoing *** catheter technique survival rate is considered a core PD outcome *** SUMMARY The PD catheter spontaneously dislodged in a patient undergoing PD during regular fluid exchange without *** computed tomography showed a tunnel infection.A double-cuff straight Tenckhoff catheter had been inserted using the Seldinger *** this incident,the patient had a history of tunnel *** speculate that recurrent tunnel infections and catheter insertion using the Seldinger technique may have led to catheter *** The present case suggests that clinicians should more rigorously assess the persistence of catheter-related infections concerning the potential complications arising from catheter dislodgement associated with the Seldinger technique.

关键词： Catheter Dislodgment Seldinger technique Infection Peritoneal dialysis,Case report

Effect of Jianpi Shengxue Tablet on Iron Metabolism and Nutritional Status in Patients with Renal Anemia:A Prospective,Randomized,Open,Parallel Controlled and Multicenter Clinical Study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Current Medical Science 2024年第3期44卷 603-610页

作者： Juan YANG Meng-yuan LIANG Yu LI Hao ZHANG Wei LI Jing LV Li-ping DONG Jing-song JIN Cheng YANG Qing-hong ZHANG Li LONG rong zou Yi GAO Dan SONG Chun-qin PAN Ying YAO Xiao-lin ZHAN Xiao-hui WANG Department of Nephrology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Nephrology The First People’s Hospital of GuiyangGuiyang550000China Department of Nephrology The Third Xiangya HospitalCentral South UniversityChangsha410000China Department of Nephrology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an710061China Department of Nephrology Wuhan No. 4 HospitalWuhan430033China Department of Nephrology Hubei Provincial Hospital of Traditional Chinese MedicineWuhan430060China Department of Nephrology Central Theater General Hospital of PLAWuhan430064China Department of Nephrology Taihe HospitalShiyan442000China Department of Nephrology Third People’s Hospital of Hubei ProvinceWuhan430033China Department of Nephrology Hubei Province Integrated Traditional Chinese and Western Medicine Hospital of Hubei provinceWuhan430024China Department of Nephrology Xi’an No.3 HospitalAffiliated Hospital of Northwest UniversityXi’an710000China Department of Nephrology Shenzhen Guangming District People’s HospitalShenzhen518000China Department of Nephrology Xiantao First People’s HospitalXiantao433000China Department of Nutrition Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Nephrology Huangshi Central HospitalHuangshi435000China Department of Nephrology The Fifth Hospital of WuhanWuhan430050China

Objective This study aimed to analyze the clinical efficacy of the Jianpi Shengxue tablet for treating renal *** A total of 200 patients with renal anemia from December 2020 to December 2022 were enrolled and randomly divided into two *** in the control group were treated with polysaccharide-iron complex,and those in the experimental group were administered Jianpi Shengxue *** 8 weeks of continuous treatment,the therapeutic outcomes regarding anemia were compared between the two *** After treatment,the red blood cell(RBC)count,hematocrit(HCT),reticulocyte percentage(RET),ferritin(SF),serum iron(SI),transferrin saturation(TSAT),and serum albumin(ALB)all increased(P<0.01),and the clinical symptom score and total iron binding capacity decreased(P<0.01)in the experimental ***,the improvements in RBC,HCT,RET,SF,SI,TAST,ALB,and clinical symptoms(fatigue,anorexia,dull skin complexion,numbness of hands and feet)in the experimental group were significantly greater than those in the control group(P<0.05).The total effective rate for treating renal anemia was significantly higher in the experimental group than in the control group(P<0.01).Conclusion The Jianpi Shengxue tablet demonstrates efficacy in treating renal anemia,leading to significant improvements in the laboratory examination results and clinical symptoms of patients with renal anemia.

关键词： Jianpi Shengxue tablet renal anemia randomized open parallel control multicenter clinical study

大型煤化工项目低温甲醇装置工艺技术优化分析

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

石化技术 2024年第2期31卷 37-39页

作者：邹荣陕西长青能源化工有限公司陕西宝鸡721405

以某大型煤化工厂的低温甲醇装置工艺技术优化改造项目为例,从甲醇消耗过高、冷量消耗过大、热再生系统多项指标偏离设计值、甲醇水塔运行稳定性偏低这几方面入手,详细说明了低温甲醇装置工艺问题与处理思路。在此基础上,对改造的经济... 详细信息

以某大型煤化工厂的低温甲醇装置工艺技术优化改造项目为例,从甲醇消耗过高、冷量消耗过大、热再生系统多项指标偏离设计值、甲醇水塔运行稳定性偏低这几方面入手,详细说明了低温甲醇装置工艺问题与处理思路。在此基础上,对改造的经济效果进行了分析与计算,结果证实本文所述改造策略有效,且取得的效果理想。

关键词：煤化工低温甲醇工艺优化

大型煤化工甲醇合成装置水冷器在线除蜡技术分析

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

石化技术 2024年第2期31卷 34-36页

作者：邹荣陕西长青能源化工有限公司陕西宝鸡721405

分析了甲醇性质与合成工艺流程,介绍了大型煤化工甲醇合成装置水冷器蜡的成因、危害以及在线除蜡技术,最后介绍了在线除蜡具体操作流程,以期给相关人士提供有效参考。

关键词：大型煤化工甲醇合成装置水冷器结蜡在线除蜡

ACEI和ARB治疗COVID-19合并高血压患者的效果分析

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

广东医学 2024年第4期45卷 439-446页

作者：陈凤邹容容王君中山大学附属第七医院消化医学中心广东深圳518107 深圳市第三人民医院感染科广东深圳518112

目的血管紧张素转换酶抑制剂(ACEI)和血管紧张素Ⅱ受体阻滞剂(ARB)治疗是否有利于合并高血压的新型冠状病毒感染(COVID-19)患者仍存在争议。该研究旨在探讨ACEI和ARB在COVID-19合并高血压患者中的治疗效果。方法采用回顾性分析方法,选... 详细信息

目的血管紧张素转换酶抑制剂(ACEI)和血管紧张素Ⅱ受体阻滞剂(ARB)治疗是否有利于合并高血压的新型冠状病毒感染(COVID-19)患者仍存在争议。该研究旨在探讨ACEI和ARB在COVID-19合并高血压患者中的治疗效果。方法采用回顾性分析方法,选择收治的COVID-19合并高血压患者,根据患者是否使用抗高血压药物ACEI或ARB治疗分为ACEI/ARB组(n=18)和非ACEI/ARB组(n=29),并根据患者的疾病严重程度分为普通型和重型患者,比较分析患者的临床特征、实验室检测结果、影像学数据、临床结局参数等资料。结果所有患者的年龄中位数为65.0岁(57.0~69.0岁),57.4%为男性,76.6%患者有明确的接触史,发病至入院的中位数时间为3.0 d(1.0~7.0 d),比较常见的临床表现为发热(74.5%)、咳嗽(48.9%)、乏力(27.7%)和咳痰(25.5%)。ACEI/ARB组和非ACEI/ARB组的临床分型比较差异无统计学意义(P>0.05),两组患者基线期的临床特征和实验室检查结果的比较均差异无统计学意义(P均>0.05)。在ACEI/ARB组和非ACEI/ARB组中,重型患者的淋巴细胞计数(LYMPH)相对低于普通型患者,乳酸脱氢酶(LDH)、C反应蛋白(CRP)、白细胞介素-6(IL-6)、降钙素原(PCT)和D-二聚体(D-dimer)都普遍高于普通型患者。在病程第15天,非ACEI/ARB组重型患者的LDH、CRP、IL-6、PCT和D-dimer水平均高于ACEI/ARB组的重型患者,但两组间的比较差异无统计学意义(P均>0.05)。非ACEI/ARB组有1例死亡患者,其余患者经过治疗均痊愈出院。所有患者中,ACEI/ARB组的发热持续时间、胸部X线计算机断层扫描(CT)改善时间均短于非ACEI/ARB组,住院时间和病毒核酸转阴时间长于非ACEI/ARB组,但比较均差异无统计学意义(P均>0.05)。普通型患者中,ACEI/ARB组的住院时间、病毒核酸转阴时间和胸部CT改善时间长于非ACEI/ARB组,但仅有病毒核酸转阴时间的比较具差异有统计学意义(P0.05)。结论ACEI或ARB治疗可缩短患者发热持续时间,对合并高血压的重症COVID-19患者可能有积极保护作用。

关键词：新型冠状病毒感染高血压血管紧张素转换酶抑制剂血管紧张素Ⅱ受体阻滞剂治疗效果

在线全文

学校读者我要写书评

暂无评论

城市地下空间三维建模方法及应用

现代测绘 2024年第2期47卷 70-73页

作者：马飞邹荣张家港市基础地理信息中心江苏苏州215600 园测信息科技股份有限公司江苏苏州215000

城市地下空间的合理开发利用对于优化国土空间布局,缓解地上城市资源和空间压力起着重要作用,随着智慧城市、数字城市的提出,城市地下空间三维建模逐渐成为当下城市治理的热点与难点问题。从地下空间数据获取方法入手,以吴中区某地下停... 详细信息

城市地下空间的合理开发利用对于优化国土空间布局,缓解地上城市资源和空间压力起着重要作用,随着智慧城市、数字城市的提出,城市地下空间三维建模逐渐成为当下城市治理的热点与难点问题。从地下空间数据获取方法入手,以吴中区某地下停车场为例,基于多源数据融合的三维建模方法,对当下城市地下空间三维建模研究方法及应用进行介绍和梳理。结果表明,通过各类型数据优势互补,采用基于多源数据融合的三维建模方法较好地完成了地下停车场的建模,使其能够更好地反映城市地下空间的三维结构,为建筑设计人员提供了客观完整的数据支持。

关键词：城市地下空间三维建模点云智慧城市

保健食品行政监管中对安全性监管的缺失与完善

在线全文

学校读者我要写书评

暂无评论

卫生法学 2024年第5期32卷 23-28页

作者：邹荣屈文妮华东政法大学上海200042

我国将保健食品确定为一种特殊食品,隶属于食品,但是保健食品与食品实际上存在较为明显的不同,在具体的行政监管中,应当考虑基于保健食品特有的功效所可能引发的安全性问题,从而进行安全性监管。当前对于安全性监管,由于对公众生命安全... 详细信息

我国将保健食品确定为一种特殊食品,隶属于食品,但是保健食品与食品实际上存在较为明显的不同,在具体的行政监管中,应当考虑基于保健食品特有的功效所可能引发的安全性问题,从而进行安全性监管。当前对于安全性监管,由于对公众生命安全保障目的的弱化、相关法律法规存在不足、制度本身存在的不足使得安全性监管在实践中缺失,影响了保健食品行政监管的实践。鉴于此,应当强化保健食品行政监管维护公众生命安全保障的目的,完善《食品安全法》及相关法律的监管规定。在注册与备案双轨制下完善对于复合原料的备案注册监管,最后在有可能的情况下引入第三方监管机制,从而促进我国保健食品行政监管制度的完善,更好维护公共安全,保障保健食品市场发展。

关键词：保健食品功效安全性行政监管