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Unbound^(28)O,the heaviest oxygen isotope observed:a cutting-edge probe for testing nuclear models

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Nuclear Science and Techniques 2024年第2期35卷 1-2页

作者： Jian-Guo Li Bai-Shan Hu Shuang Zhang fu-rong Xu School of Physics and State Key Laboratory of Nuclear Physics and TechnologyPeking UniversityBeijing 100871China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Southern Center for Nuclear-Science Theory(SCNT) Institute of Modern PhysicsChinese Academy of SciencesHuizhou 516000China

The beyond-dripline oxygen isotopes^(27,28)O were recently observed at RIKEN,and were found to be unbound decaying into^(24)O by emitting *** unbound feature of the heaviest oxygen isotope,^(28)O,provides an excellent test for stateof-the-art nuclear *** atomic nucleus is a self-organized quantum manybody system comprising specific numbers of protons Z and neutrons N.

关键词： testing quantum system

Study on Influencing Factors of Mental Health of Mobile Young White-Collar Workers in China

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International Journal of Mental Health Promotion 2024年第2期26卷 127-138页

作者： Tao Liu Lin Liu Zeyu Chen rong fu Department of Sociology Hangzhou Dianzi UniversityHangzhou310018China College of Economics Hangzhou Dianzi UniversityHangzhou310018China

Mobile young white-collar workers not only have the characteristics of mobile young people,but also have the characteristics of general white-collar *** the influence of both,their mental health may be suffering from“double disadvantage”.So,based on an ecological model of the stress process,this paper tries to use the data of the questionnaire on the mental health of mobile young white-collar workers in Zhejiang Province to explore the influence of some factors in the middle workplace and residence place on the mental health of micro *** results show that:(1)The working environment with high control and low freedom and the workplace discrimination against the mobile status will have a negative impact on the mental health of mobile young white-collar workers;(2)Financial anxiety in daily life will lead to a decline in the mental health level of mobile young white-collar workers;(3)Good organizational support and neighborhood social relations can significantly relieve life pressure,so as to effectively improve the mental health of mobile young white-collar *** can be seen that we also need to pay more attention to the mental health of mobile young white-collar workers in order to improve their situation.

关键词： Mobile population young white-collar workers mental health ecological model stress process

A Study on the Influence of Social Media Use on Psychological Anxiety among Young Women

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International Journal of Mental Health Promotion 2024年第3期26卷 199-209页

作者： Tao Liu Huiyin Shi Chen Chen rong fu Department of Sociology Hangzhou Dianzi UniversityHangzhou310018China College of Economics Hangzhou Dianzi UniversityHangzhou310018China

To explore the relationship between social influence,social comparison,clarity of self-concept,and psychological anxiety among young women during their usage of social networking sites,our study selected 338 young women aged 14-34 from the social site platforms of Little Red Book and Weibo for questionnaire *** Passive Social Network Utilization Scale,Social Comparison Scale(SCS),Social Influence Questionnaire,Self-Concept Clarity Scale(SCCS),and Generalized Anxiety Disorder Scale(GAD-7)were employed to measure the *** results show that the frequency of passive social media use is positively related to the level of psychological *** comparison,social influence,and unclear self-concepts under social media use are negatively predictive of psychological *** chain mediation effects indicate that social comparison and social influence under social media use negatively predict the clarity of self-concept,thus having a negative impact on the psychological health of young ***,young women should strengthen their self-concepts,control their frequency of social media usage,avoid addiction,and pay special attention to their frequency of passive use,in order to protect their psychological *** study provides some practical implications and insights regarding the relationship between young women’s social media use and psychological health.

关键词： Social media young women mental health social comparison and influence clear self-concept

Single-cell RNA sequencing reveals abnormal transcriptome signature of erythroid progenitors in pure red cell aplasia

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Genes & Diseases 2024年第1期11卷 49-52页

作者： Yumei Liu Haiyue Niu Jie Ren Zhiqin Wang Li Yan Limin Xing Zonghong Shao rong fu Zhigang Cai Huaquan Wang Department of Hematology Tianjin Medical University General HospitalTianjin 300052China School of Basic Medical Sciences Tianjin Medical UniversityTianjin 300070China

Pure red cell aplasia(PRCA)is a bone marrow failure syndrome characterized by severe anemia,reticulocytopenia,selective reduction,and even the absence of bone marrow erythroid precursors,while leukocyte and platelet counts are normal.1 Acquired PRCA can be divided into primary and *** are mediated by immune *** in the quantity and dysfunction of committed erythroid progenitors(EPs),including burst forming uniterythroid(Bfu-E)and colony forming unit-erythroid(Cfu-E),may be the source of reduced erythropoiesis and needs to be elucidated.

关键词： progenitor anemia leukocyte

Multimorbidity and mortality among older patients with coronary heart disease in Shenzhen,China

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Journal of Geriatric Cardiology 2024年第1期21卷 81-89页

作者： fu-rong LI Shuang WANG Xia LI Zhi-Yuan CHENG Cheng JIN Chun-Bao MO Jing ZHENG Feng-Chao LIANG Dong-Feng GU Shenzhen Key Laboratory of Cardiovascular Health and Precision Medicine Southern University of Science and TechnologyShenzhenGuangdongChina School of Public Health and Emergency Management Southern University of Science and TechnologyShenzhenGuangdongChina Shenzhen Health Development Research and Data Management Center ShenzhenChina School of Medicine Southern University of Science and TechnologyShenzhenGuangdongChina

BACKGROUND The current understanding of the magnitude and consequences of multimorbidity in Chinese older adults with coronary heart disease(CHD)is *** aimed to assess the association and population-attributable fractions(PAFs)between multimorbidity and mortality among hospitalized older patients who were diagnosed with CHD in Shenzhen,*** We conducted a retrospective cohort study of older Chinese patients(aged≥65 years)who were diagnosed with *** proportional hazards models were used to estimate the associations between multimorbidity and all-cause and cardiovascular disease(CVD)*** also calculated the *** The study comprised 76,455 older hospitalized patients who were diagnosed with CHD between January 1,2016,and August 31,*** them,70,217(91.9%)had multimorbidity,defined as the presence of at least one of the predefined 14 chronic *** with cancer,hemorrhagic stroke and chronic liver disease had the worst overall death risk,with adjusted HRs(95%CIs)of 4.05(3.77,4.38),2.22(1.94,2.53),and 1.85(1.63,2.11),*** CVD mortality,the highest risk was observed for hemorrhagic stroke,ischemic stroke,and chronic kidney disease;the corresponding adjusted HRs(95%CIs)were 3.24(2.77,3.79),1.91(1.79,2.04),and 1.81(1.64,1.99),***-cause mortality was mostly attributable to cancer,heart failure and ischemic stroke,with PAFs of 11.8,10.2,and 9.1,*** for CVD mortality,the leading PAFs were heart failure,ischemic stroke and diabetes;the corresponding PAFs were 18.0,15.7,and 6.1,*** Multimorbidity was common and had a significant impact on mortality among older patients with CHD in Shenzhen,***,heart failure,ischemic stroke and diabetes are the primary contributors to ***,prioritizing improved treatment and management of these comorbidities is essential for the survival prognosis of CHD patients from a holistic public health perspective.

关键词： patients morbidity mortality

论抵押可售规则——以从《物权法》走向《民法典》的转变为视角

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河北学刊 2024年第5期44卷 192-203页

作者：付荣华北电力大学人文学院

不同于《物权法》明文限制抵押财产的转让,《民法典》背景下,只有在禁止或限制抵押财产转让的约定已经登记的情况下,才存在抵押可售规则的适用空间。抵押财产抵债有别于抵押财产转让,抵押可售规则不能适用于存在以物抵债的情形。抵押财... 详细信息

不同于《物权法》明文限制抵押财产的转让,《民法典》背景下,只有在禁止或限制抵押财产转让的约定已经登记的情况下,才存在抵押可售规则的适用空间。抵押财产抵债有别于抵押财产转让,抵押可售规则不能适用于存在以物抵债的情形。抵押财产转让存在限制时,抵押权人同意转让抵押财产是为了便于办理后续的登记手续,而非放弃抵押权。在抵押权追及效力之下,办理抵押权注销登记、抵押权人受领转让价金或将转让价金提存之前抵押权不会消灭。在追及效力规则不足以保护抵押权人之时,有必要例外承认抵押权对转让价金的物上代位效力。关于受让人的权利救济,可通过代为履行制度消灭抵押权,消费型购房人可以直接排除抵押权人的执行。程序上,受让人主要通过提起执行异议之诉的方式,但一般不宜提起第三人撤销之诉。

关键词：抵押可售追及效力价金代位购房人执行异议之诉

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论执行程序中的以物抵债

法学家 2024年第2期 130-142,195页

作者：付荣华北电力大学人文与社会科学学院

以物抵债系一个聚合性法律概念,包括担保型以物抵债和清偿型以物抵债。依据新债与旧债系并存关系抑或取代关系,清偿型以物抵债又可进一步分为新债清偿与债之更改。债之更改型以物抵债债权人因具备与不动产买受人相同的法律地位,当其满... 详细信息

以物抵债系一个聚合性法律概念,包括担保型以物抵债和清偿型以物抵债。依据新债与旧债系并存关系抑或取代关系,清偿型以物抵债又可进一步分为新债清偿与债之更改。债之更改型以物抵债债权人因具备与不动产买受人相同的法律地位,当其满足《执行异议复议规定》第28条各项要件时,即有权排除抵债房屋的执行。以物抵债权利受让人仅在其与不动产实际登记的权利人签订买卖合同,并满足《执行异议复议规定》第28条各项要件时方能排除抵债房屋的执行。以物抵债之“物”之受让人权益受侵害时,依据其权利性质为债权或物权期待权可分别通过竞买规则或执行异议之诉、第三人撤销之诉加以救济。执行法院可依法出具合意性以物抵债裁定和强制性以物抵债裁定,当以物抵债裁定错误时,当事人可以通过执行异议之诉或执行监督程序获得救济。

关键词：以物抵债以物抵债裁定物权期待权执行异议之诉权利救济

A naturally derived small molecule compound suppresses tumor growth and metastasis in mice by relieving p53-dependent repression of CDK2/Rb signaling and the Snail-driven EMT

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Chinese Journal of Natural Medicines 2024年第2期22卷 112-126页

作者： REN Boxue LI Yang DI Lei CHENG Ranran LIU Lijuan LI Hongmei LI Yi TANG Zhangrui YAN Yongming LU Tao fu rong CHENG Yongxian WU Zhaoqiu State Key Laboratory of Natural Medicines Department of PharmacologySchool of PharmacyChina Pharmaceutical UniversityNanjing 211198China Institute for Inheritance-Based Innovation of Chinese Medicine School of Pharmaceutical SciencesShenzhen University Health Science CenterShenzhen 518060China

The tumor suppressor protein p53 is central to cancer biology,with its pathway reactivation emerging as a promising therapeutic strategy in *** study introduced LZ22,a novel compound that selectively inhibits the growth,migration,and metastasis of tumor cells expressing wild-type p53,demonstrating ineffectiveness in cells devoid of p53 or those expressing mutant ***22’s mechanism of action involves a high-affinity interaction with the histidine-96 pocket of the MDM2 *** interaction disrupted the MDM2-p53 binding,consequently stabilizing p53 by shielding it from proteasomal ***22 impeded cell cycle progression and diminished cell proliferation by reinstating the p53-dependent suppression of the CDK2/Rb signaling ***,LZ22 alleviated the p53-dependent repression of Snail transcription factor expression and its consequent EMT,effectively reducing tumor cell migration and distal ***,LZ22 administration in tumor-bearing mice did not manifest notable side *** findings position LZ22 as a structurally unique reactivator of p53,offering therapeutic promise for the management of human cancers with wild-type TP53.

关键词： LZ22 Wild-type p53 p53 Reactivator Snail-driven EMT Tumor growth and metastasis

冻融及耦合酸化作用下土壤中重金属的浸出性及其机制解析

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Journal of Central South University 2024年第4期31卷 1197-1206页

作者：付田雨李捷付融冰 State Key Laboratory of Pollution Control and Resources Reuse College of Environmental Science and EngineeringTongji UniversityShanghai 200092China Institute of Environmental and Municipal Engineering Qingdao University of TechnologyQingdao 266033China

冻融与不同pH溶液的耦合作用下土壤中重金属浸出行为尚缺乏研究。本研究采用TCLP测试评估了冻融及耦合酸化处理前后土壤中重金属的浸出毒性,并采用孔隙(颗粒)与裂隙图像识别与分析系统(PCAS)和地球化学模拟软件(PHREEQC)分别探究土壤矿... 详细信息

冻融与不同pH溶液的耦合作用下土壤中重金属浸出行为尚缺乏研究。本研究采用TCLP测试评估了冻融及耦合酸化处理前后土壤中重金属的浸出毒性,并采用孔隙(颗粒)与裂隙图像识别与分析系统(PCAS)和地球化学模拟软件(PHREEQC)分别探究土壤矿物颗粒的微观结构和矿物学演化特征。结果表明,经过30次冻融循环后,As、Cd、Cu、Mn、Pb和Zn的最大浸出浓度分别为0.22 mg/L、0.61 mg/L、2.46 mg/L、3.08 mg/L、29.36 mg/L和8.07 mg/L。在冻融和酸化的耦合作用下,土壤颗粒的孔隙度增加了4.79%。孔隙和裂缝的演化所引起的颗粒结构破坏证实了这一结果。在冻融作用下,土壤颗粒的各向异性增加,而在冻融与酸化的耦合作用下,土壤颗粒的各向异性降低。SEM-EDS、PCAS量化和PHREEQC模拟的结果表明,重金属的释放机制不仅与矿物颗粒的微观结构演化特征有关,还受质子腐蚀以及矿物的溶解和沉淀的影响。这些结果将为季节性冻土地区污染场地土壤修复评价提供重要参考。

关键词：污染土壤重金属浸出性冻融循环酸化孔隙(颗粒)与裂隙图像识别与分析系统(PCAS) PHREEQC软件