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Analysis of the potential biological value of pyruvate dehydrogenase E1 subunitβin human cancer

World Journal of Gastrointestinal Oncology 2024年第1期16卷 144-181页

作者： Yao rong Song-Hua Liu Ming-Zheng Tang Zhi-Hang Wu Guo-rong Ma Xiao-Feng Li Hui cai First Clinical Medical College Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina General Surgery Clinical Medical Center Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina Key Laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology in Gansu Province Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina NHC Key Laboratory of Diagnosis and Therapy of Gastrointestinal Tumor Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND The pyruvate dehydrogenase E1 subunitβ(PDHB)gene which regulates energy metabolism is located in ***,few studies have elucidated the role and mechanism of PDHB in different *** To comprehensive pan-cancer analysis of PDHB was performed based on bioinformatics approaches to explore its tumor diagnostic and prognostic value and tumor immune relevance in *** vitro experiments were performed to examine the biological regulation of PDHB in liver *** Pan-cancer data related to PDHB were obtained from the Cancer Genome Atlas(TCGA)*** of the gene expression profiles of PDHB was based on TCGA and Genotype Tissue Expression Dataset *** regression analysis and Kaplan-Meier methods were used to assess the correlation between PDHB expression and survival prognosis in cancer *** correlation between PDHB and receiver operating characteristic diagnostic curve,clinicopathological staging,somatic mutation,tumor mutation burden(TMB),microsatellite instability(MSI),DNA methylation,and drug susceptibility in pan-cancer was also *** algorithms were used to analyze the correlation between PDHB and immune cell infiltration and tumor chemotaxis environment,as well as the co-expression analysis of PDHB and immune checkpoint(ICP)*** expression and functional phenotype of PDHB in single tumor cells were studied by single-cell sequencing,and the functional enrichment analysis of PDHB-related genes was *** study also validated the level of mRNA or protein expression of PDHB in several ***,in vitro experiments verified the regulatory effect of PDHB on the proliferation,migration,and invasion of liver *** PDHB was significantly and differently expressed in most *** was significantly associated with prognosis in patients with a wide range of cancers,including kidney renal clear cell carcinoma,kidney renal papillary cell carcinoma,breast invasive carcinom

关键词： Cuprotosis Pyruvate dehydrogenase E1 subunitβ Pan-cancer Prognosis Liver cancer

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COVID-19-like symptoms observed in Chinese tree shrews infected with SARS-CoV-2

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Zoological Research 2020年第5期41卷 517-526页

作者： Ling Xu Dan-Dan Yu Yu-Hua Ma Yu-Lin Yao rong-Hua Luo Xiao-Li Feng Hou-rong cai Jian-Bao Han Xue-Hui Wang Ming-Hua Li Chang-Wen Ke Yong-Tang Zheng Yong-Gang Yao Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China Kunming National High-level Biosafety Research Center for Non-Human Primates Center for Biosafety Mega-ScienceKunming Institute of ZoologyChinese Academic of SciencesKunmingYunnan 650107China National Resource Center for Non-Human Primates National Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility)Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650107China Kunming College of Life Science University of Chinese Academy of SciencesKunmingYunnan 650204China Department of Respiratory and Critical Care Medicine the Affiliated Drum Tower Hospital of Nanjing UniversityNanjingJiangsu 210008China Medical Key Laboratory for Repository and Application of Pathogenic Microbiology Guangdong Provincial Center for Disease Control and PreventionGuangzhouGuangdong 510440China CAS Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghai 2Q0Q3AChina

Thecoronavirusdisease2019(COVID-19)pandemic continues to pose a global threat to the human population. Identifying animal species susceptible to infection with the SARS-CoV-2/HCoV-19 pathogen is essential for controlling the outbreak and for testing valid prophylactics or therapeutics based on animal model studies. Here,different aged Chinese tree shrews(adult group, 1 year old;old group, 5–6 years old), which are close relatives to primates, were infected with SARS-CoV-2. X-ray, viral shedding, laboratory, and histological analyses were performed on different days postinoculation(dpi). Results showed that Chinese tree shrews could be infected by SARS-CoV-2. Lung infiltrates were visible in X-ray radiographs in most infected animals. Viral RNA was consistently detected in lung tissues from infected animals at 3,5, and 7 dpi, along with alterations in related parameters from routine blood tests and serum biochemistry, including increased levels of aspartate aminotransferase(AST) and blood urea nitrogen(BUN). Histological analysis of lung tissues from animals at 3 dpi(adult group) and 7 dpi(old group) showed thickened alveolar septa and interstitial hemorrhage. Several differences were found between the two different aged groups in regard to viral shedding peak. Our results indicate that Chinese tree shrews have the potential to be used as animal models for SARS-CoV-2 infection.

关键词： SARS-CoV-2/HCoV-19 Treeshrews Animal model Susceptibility COVID-19

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Differences in pathological changes between two rat models of severe traumatic brain injury

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Neural Regeneration Research 2019年第10期14卷 1796-1804页

作者： Yi-Ming Song Yu Qian Wan-Qiang Su Xuan-Hui Liu Jin-Hao Huang Zhi-Tao Gong Hong-Liang Luo Chuang Gao rong-cai Jiang Department of Neurosurgery General HospitalTianjin Medical UniversityTianjinChina Key Laboratory of Injuries Variations and Regeneration of Nervous SystemTianjin Neurological InstituteTianjinChina

The rat high-impact free weight drop model mimics the diffuse axonal injury caused by severe traumatic brain injury in humans,while severe controlled cortical impact can produce a severe traumatic brain injury model using precise strike *** this study,we compare the pathological mechanisms and pathological changes between two rat severe brain injury models to identify the similarities and *** severe controlled cortical impact model was produced by an electronic controlled cortical impact device,while the severe free weight drop model was produced by dropping a 500 g free weight from a height of 1.8 m through a plastic *** temperature and mortality were recorded,and neurological deficits were assessed with the modified neurological severity *** edema and bloodbrain barrier damage were evaluated by assessing brain water content and Evans blue *** addition,a cytokine array kit was used to detect inflammatory *** apoptosis in the brain and brainstem was quantified by immunofluorescence *** the severe controlled cortical impact and severe free weight drop models exhibited significant neurological impairments and body temperature *** severe motor dysfunction was observed in the severe controlled cortical impact model,while more severe cognitive dysfunction was observed in the severe free weight drop *** edema,inflammatory cytokine changes and cortical neuronal apoptosis were more substantial and blood-brain barrier damage was more focal in the severe controlled cortical impact group compared with the severe free weight drop *** severe free weight drop model presented with more significant apoptosis in the brainstem and diffused blood-brain barrier damage,with higher mortality and lower repeatability compared with the severe controlled cortical impact *** brainstem damage was not found in the severe controlled cortical impact *** results indicate that the

关键词： nerve regeneration severe traumatic brain injury animal model comparison free weight drop controlled cortical impact neurological impairment neuroinflammation blood-brain barrier damage neuronal apoptosis diffuse axonal injury brainstem injury neural regeneration

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合作社农产品质量供给:影响因素及政策启示

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财贸研究 2017年第1期28卷 37-47页

作者：蔡荣南京财经大学粮食安全与战略研究中心江苏南京210003 南京财经大学江苏省现代粮食流通与安全协同创新中心江苏南京210003

随着农产品市场竞争从价格和数量竞争逐步转向差异化质量竞争,合作社肩负起引领发展中国家小农户顺利融入农业价值链参与大市场的重要使命。然而,成员"搭便车"行为却是妨碍合作社优质农产品供给的重要因素。基于山东省135家苹果专业合... 详细信息

随着农产品市场竞争从价格和数量竞争逐步转向差异化质量竞争,合作社肩负起引领发展中国家小农户顺利融入农业价值链参与大市场的重要使命。然而,成员"搭便车"行为却是妨碍合作社优质农产品供给的重要因素。基于山东省135家苹果专业合作社的调查数据,对合作社农产品质量供给的影响因素进行实证分析,研究表明:成员规模对合作社农产品质量的影响为正且边际递减,具有"倒U"型特征;政府规制对合作社农产品质量的影响为正,受政府规制程度越强的合作社,农产品质量越高;目标市场对合作社农产品质量有显著影响,以超市和出口企业为主要目标市场的合作社,农产品质量相对也较高;技术培训对合作社农产品质量供给的影响为正,与未组织技术培训的合作社相比,组织技术培训的合作社的农产品质量相对较高;凝聚力也会影响合作社农产品质量供给,拥有较强凝聚力的合作社往往更有能力提供优质农产品。

关键词：成员规模政府规制目标市场合作社质量供给

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合同生产模式与农户肥料施用结构——基于山东省苹果种植农户调查数据的实证分析

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农业技术经济 2011年第3期 41-51页

作者：蔡荣浙江大学管理学院杭州310027

本文利用山东省苹果种植农户实地调查数据,实证研究合同生产模式对农户肥料施用结构的影响及作用机理。研究发现,合同生产模式通过测土配方技术指导、产品质量检测和"市场参考价+质量奖励价"定价制度,能够有效激励农户提高有机肥的投入... 详细信息

本文利用山东省苹果种植农户实地调查数据,实证研究合同生产模式对农户肥料施用结构的影响及作用机理。研究发现,合同生产模式通过测土配方技术指导、产品质量检测和"市场参考价+质量奖励价"定价制度,能够有效激励农户提高有机肥的投入比重;灌溉便利程度、种植密度、户主受教育程度及环境关注程度、家庭非农收入比例对农户有机肥投入比重具有正向显著影响,但种植规模和当前合同生产模式肥料供应服务对农户有机肥投入比重则具有负向显著影响。

关键词：合同生产模式施肥行为有机肥苹果种植

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Comprehensive analysis of the potential pathogenesis of COVID-19 infection and liver cancer

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 436-457页

作者： Yao rong Ming-Zheng Tang Song-Hua Liu Xiao-Feng Li Hui cai First Clinical Medical College Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina General Surgery Clinical Medical Center Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina Key Laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology in Gansu Province Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina NHC Key Laboratory of Diagnosis and Therapy of Gastrointestinal Tumor Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND A growing number of clinical examples suggest that coronavirus disease 2019(COVID-19)appears to have an impact on the treatment of patients with liver cancer compared to the normal population,and the prevalence of COVID-19 is significantly higher in patients with liver ***,this mechanism of action has not been *** sets for COVID-19(GSE180226)and liver cancer(GSE87630)were obtained from the Gene Expression Omnibus *** identifying the common differentially expressed genes(DEGs)of COVID-19 and liver cancer,functional enrichment analysis,protein-protein interaction network construction and scree-ning and analysis of hub genes were ***,the validation of the differential expression of hub genes in the disease was performed and the regulatory network of transcription factors and hub genes was *** Of 518 common DEGs were obtained by screening for functional *** hub genes including aurora kinase B,cyclin B2,cell division cycle 20,cell division cycle associated 8,nucleolar and spindle associated protein 1,etc.,were further identified from DEGs using the“cytoHubba”*** enrichment analysis of hub genes showed that these hub genes are associated with P53 signalling pathway regulation,cell cycle and other functions,and they may serve as potential molecular markers for COVID-19 and liver ***,we selected 10 of the hub genes for in vitro expression validation in liver cancer *** Our study reveals a common pathogenesis of liver cancer and *** common pathways and key genes may provide new ideas for further mechanistic studies.

关键词： COVID-19 Liver cancer Differentially expressed genes Hub genes Pathogenesis

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妨害传染病防治罪罪过形式的确定——对传统罪过理论的复归

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当代法学 2021年第3期35卷 78-88页

作者：蔡荣南昌大学法学院

妨害传染病防治罪的罪过形式争议较多,依照不同的罪过理论,存在过失说、故意说以及并存罪过说之争。故意说着眼于拒绝执行防疫措施的行为,过失说强调引起甲类传染病传播的结果。并存罪过说违背罪刑均衡原则不应被提倡,罪过形式应是以对... 详细信息

妨害传染病防治罪的罪过形式争议较多,依照不同的罪过理论,存在过失说、故意说以及并存罪过说之争。故意说着眼于拒绝执行防疫措施的行为,过失说强调引起甲类传染病传播的结果。并存罪过说违背罪刑均衡原则不应被提倡,罪过形式应是以对犯罪结果的心理态度为一般的判定标准。将本罪认定为过失犯罪,既是遵从刑法条文和解释性文件的逻辑内涵,又充分体现了本罪所包含的传染病防治秩序、公共安全、个人人身权益等多重法益,并与立法上所配置的法定刑幅度相适应,是自觉遵循罪刑均衡的必然结论。

关键词：罪过形式妨害传染病防治罪过失说

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Women and Nature: Three Women Talk About Their Experience

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Women of China 1995年第9期 59-61页

作者： Song Yanling Zhang Haidi cai rong

People often think about women’s special relationship to nature. Some say women tend to have a greater appreciation of nature, but what deserves our attention is women’s intimacy and affection for nature. It is as i... 详细信息

关键词： In Three Women Talk About Their Experience Women and Nature

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Cosmic inflation from broken conformal symmetry

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Communications in Theoretical Physics 2022年第9期74卷 120-130页

作者： rong-Gen cai Yu-Shi Hao Shao-Jiang Wang CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced Study(HIAS)University of Chinese Academy of Sciences(UCAS)Hangzhou 310024China School of Physical Sciences University of Chinese Academy of Sciences(UCAS)Beijing 100049China

A period of rapidly accelerating expansion is expected in the early Universe implemented by a scalar field slowly rolling down along an asymptotically flat potential preferred by the current *** this paper,we point out that this picture of the cosmic inflation with an asymptotically flat potential could emerge from the Palatini quadratic gravity by adding the matter field in such a way to break the local gauged conformal symmetry in both kinetic and potential terms.

关键词： Palatini gravity modified gravity conformal symmetry cosmic inflation

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Analysis of the risk factors of rebleeding after endoscopic therapy in patients with non-variceal upper gastrointestinal bleeding

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Journal of Hainan Medical University 2017年第4期23卷 56-59页

作者： Guo-Jun Yuan Hua-rong cai Department of Gastroenterology the Third People's Hospital of Mainyang CitySichuan621000

Objective:To explore the risk factors of rebleeding after endoscopic therapy in patients with non-variceal upper gastrointestinal bleeding (NVUGIB). Methods:A total of 254 patients with NVUGIB who were admitted in our hospital for endoscopic therapy were included in the study and divided into the rebleeding group (n=76) and non-bleeding group (n=178) according to whether there was rebleeding or not. The general materials and laboratory examination results in the two groups were recorded. The single factor and multiple factor logistic regression analysis was used to evaluate the risk factors of rebleeding after endoscopic therapy in patients with ***:The single factor analysis showed that the comparison of heart rate after admission >100 times/min, upper gastrointestinal tumor bleeding, gradeⅠa bleeding, initial endoscopic therapy time>24 h, bleeding lesion diameter>2 cm, single endoscopic therapy method, amount of bleeding>800 mL, sequential PPIs insufficiency, and PT≥17 s between the two groups was statistically significant. The multiple factor logistic regression analysis showed that gradeⅠa bleeding, malignant tumor bleeding, bleeding lesion diameter>2 cm, single endoscopic therapy method, and sequential PPIs insufficiency were significantly positively correlated with the occurrence of rebleeding after endoscopic therapy in patients with ***: GradeⅠa bleeding, malignant tumor bleeding, bleeding lesion diameter>2 cm, sequential PPIs insufficiency, and PT≥17 s are the independent risk factors for developing rebleeding after endoscopic therapy in patients with NVUGIB.

关键词： NVUGIB Endoscope Rebleeding Risk factors

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