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Relationship between nitrate headache and outcome in patients with acute stroke: results from the efficacy of nitric oxide in stroke (ENOS) trial

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Stroke & Vascular Neurology 2021年第2期6卷 180-186页

作者： Lucy Beishon Lisa J Woodhouse Daniel Bereczki Hanne K Christensen ronan collins John Gommans Christina Kruuse George Ntaios Serefnur Ozturk Stephen Phillips Stuart Pocock Szabolcs Szatmari Joanna Wardlaw Nikola Sprigg Philip M Bath Stroke Trials Unit Division of Clinical NeuroscienceUniversity of NottinghamNottinghamUK Department of Neurology Semmelweis UniversityBudapestHungary Bispebjerg Hospital and University of Copenhagen University of CopenhagenCopenhagenDenmark Department of Geriatric and Stroke Medicine Adelaide and Meath HospitalDublinIreland Department of Medicine Hawke's Bay HospitalCamberleyNew Zealand Department of Neurology Herlev Gentofte HospitalUniversity of CopenhagenCopenhagenDenmark Department of Medicine Larissa University HospitalUniversity of ThessalyVolosGreece Department of Neurology Selcuk University Medical FacultyKonyaTurkey Department of Neurology Queen Elizabeth II Health Sciences CentreHalifaxNova ScotiaCanada Medical Statistics Unit London School of Hygiene&Tropical MedicineLondonUK Department of Neurology George Emil Palade University of MedicinePharmacyScience and Technology of Târgu MureșTargu MuresRomania Centre for Clinical Brain Sciences University of EdinburghEdinburghUK Stroke Nottingham University Hospitals NHS TrustNottinghamUK

Introduction Nitrate-induced headache is common and may signify responsive cerebral *** assessed the relationship between nitrate headache and outcome in patients with acute *** and methods Patients were those randomised to glyceryl trinitrate(GTN)versus no GTN in the efficacy of nitric oxide in stroke *** of headache by end of treatment(day 7),and functional outcome(modified Rankin Scale,primary outcome)at day 90,were *** are adjusted for baseline prognostic factors and give OR and mean difference(MD)with 95%*** In 4011 patients,headache was more common in GTN than control(360,18.0% vs 170,8.5%;p<0.001).Nitrate-related headache was associated with:younger age,female sex,higher diastolic blood pressure,non-total anterior circulation syndrome,milder stroke and absence of dysphasia(p<0.05).Nitrate headache was not associated with improved functional outcome(OR 0.90,95% CI 0.73 to 1.10,p=0.30)or death(day 90)(HR 0.64,95% CI 0.40 to 1.02,p=0.062),but reduced death or deterioration(day 7)(OR 0.45,95% CI 0.25 to 0.82),death in hospital(OR 0.44,95% CI 0.22 to 0.88)and improved activities of daily living(Barthel index,MD 3.7,95% CI 0.3 to 7.1)and cognition(telephone interview cognitive screen,MD 2.0,95% CI 0.7 to 3.3)(day 90).Non-nitrate headache was not associated with death,disability or *** and conclusion Development of a nitrate headache by day 7 after stroke may be associated with improved activities of daily living and cognitive impairment at day 90,which was not seen with non-nitrate headache.

关键词： headache patients nitrate

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东莞玩具工厂

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中国建筑装饰装修 2010年第11期 28-33页

作者：刘宇扬蔡晖林秋雷 ronan collins 李德明

本项目为一家世界级的玩具制造厂提供一栋五层楼的装配与储存空间。基地位于具有＂世界工厂＂之称的东莞。

关键词：世界工厂玩具东莞储存空间制造厂趣味性挑战性耐久性

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It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis

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Stroke & Vascular Neurology 2019年第5期4卷 28-35页

作者： Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen ronan collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators Stroke Division of Clinical NeurosciencesUniversity of NottinghamNottinghamUK Stroke Nottingham University Hospitals NHS TrustNottinghamUK Department of Neurology Semmelweis UniversityBudapestHungary Department of Internal Medicine and Cardiology Oslo University HospitalOsloNorway Stroke Unit Santa Maria della Misericordia HospitalUniversity of PerugiaPerugiaItaly Department of Neurology Singapore General HospitalSingaporeSingapore Neurology Bispebjerg and Frederiksberg HospitalCopenhagenDenmark Tallaght Hospital Trinity College DublinDublinIreland Department of Medicine Hawke's Bay District Health BoardHastingsNew Zealand Department of Clinical Science Danderyd HospitalKarolinska InstituteStockholmSweden Department of Medicine University of ThessalyLarissaGreece Neurology Selcuk University Faculty of MedicineKonyaTurkey Neurology Nottingham University Hospitals NHS TrustNottinghamUK Department of Neurology Clinical County Emergency HospitalTargu MuresRomania Neurology Beijing Tiantan HospitalBeijingChina Centre for Clinical Brain Sciences EdinburghUK

Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid *** assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)*** ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of *** on prestroke antihypertensives were also randomised to stop or continue their medication for 7 *** primary outcome was the modified Rankin Scale(mRS)at day *** carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic *** 2023(60.5%)ischaemic stroke participants had carotid *** compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 *** outcomes did not differ across bilateral stenosis *** Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 *** appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis.

关键词： stenosis carotid hypertensive

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Digital surgery for gastroenterological diseases

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World Journal of Gastroenterology 2021年第42期27卷 7240-7246页

作者： Niall Philip Hardy ronan Ambrose Cahill UCD Centre for Precision Surgery University College DublinDublin D07 Y9AWIreland

Advances in machine learning,computer vision and artificial intelligence methods,in combination with those in processing and cloud computing capability,portend the advent of true decision support during interventions in real-time and soon perhaps in automated surgical *** capability,deployed alongside technology intraoperatively,is termed digital surgery and can be delivered without the need for high-end capital robotic *** area close to clinical usefulness right now harnesses advances in near infrared endolaparoscopy and fluorescence guidance for tissue characterisation through the use of biophysics-inspired *** represents a potential synergistic methodology for the deep learning methods currently advancing in ophthalmology,radiology,and recently gastroenterology via *** databanks of more general surgical videos are created,greater analytic insights can be derived across the operative spectrum of gastroenterological disease and operations(including instrumentation and operative step sequencing and recognition,followed over time by surgeon and instrument performance assessment)and linked to value-based ***,issues of legality,ethics and even morality need consideration,as do the limiting effects of monopolies,cartels and isolated data ***,the role of the surgeon,surgical societies and healthcare institutions in this evolving field needs active deliberation,as the default risks relegation to bystander or passive *** editorial provides insight into this accelerating field by illuminating the nearfuture and next decade evolutionary steps towards widespread clinical integration for patient and societal benefit.

关键词： Digital surgery Artificial intelligence Gastrointestinal disease Biophysics Deep learning Fluorescence-guided surgery

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Single access laparoscopic total colectomy for severe refractory ulcerative colitis

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World Journal of Gastroenterology 2020年第39期26卷 6015-6026页

作者： John Burke Des Toomey Frank Reilly ronan Cahill Department of Colorectal Surgery Beaumont HospitalDublin D09Ireland Department of Surgery Mater Misericordiae University HospitalDublin D07Ireland

BACKGROUND Single port laparoscopic surgery allows total colectomy and end ileostomy for medically uncontrolled ulcerative colitis solely via the stoma site *** intuitively appealing,there is sparse evidence for its use beyond *** To examine the usefulness of single access laparoscopy(SAL)in a general series experience of patients sick with ulcerative *** All patients presenting electively,urgently or emergently over a three-year period under a colorectal specialist team were *** was performed via the stoma site on a near-consecutive basis by one surgical team using a“surgical glove port”allowing group-comparative and case-control analysis with a contemporary cohort undergoing conventional multiport ***,straight rigid laparoscopic instrumentation were used without additional *** Of 46 consecutive patients requiring surgery,39(85%)had their procedure begun laparoscopically.27(69%)of these were commenced by single port access with an 89%completion rate thereafter(three were concluded by multi-trocar laparoscopy).SAL proved effective in comparison to multiport access regardless of disease severity providing significantly reduced operative access costs(>100€case)and postoperative hospital stay(median 5 d vs 7.5 d,P=0.045)without increasing operative *** proved especially efficient in those with preoperative albumin>30 g/dL(n=20).Its comparative advantages were further confirmed in ten pairs case-matched for gender,body mass index and preoperative *** outcomes proved durable in the intermediate term(median follow-up=20 mo).CONCLUSION Single port total colectomy proved useful in planned and acute settings for patients with medically refractory *** regarding duration and cost should not be barriers to its implementation.

关键词： Single incision laparoscopy Minimal access surgery Inflammatory bowel disease Ulcerative colitis Total colectomy and end ileostomy Case match analysis

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Nilotinib versus imatinib for newly diagnosed chronic mye|oid leukemia

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中国肿瘤临床 2010年第15期37卷 905-906页

作者： ronan Sword Francis Giles Roben Mesa The Cancer Center at The UT Health Science Center at San Antonio Mayo Clinica

Saglio G, Kim DW, Issaragrisil S, le Coutre P, Etienne G,Lobo C, Pasquini R, Clark RE, Hochhaus A, Hughes TP,Gallagher N, Hoenekopp A, Dong M, Haque A, LarsonRA, Kantarjian HM, ENESTnd Investigators N EngI J Med 2010 ... 详细信息

关键词： CML Nilotinib versus imatinib for newly diagnosed chronic mye|oid leukemia

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What's wrong with sentinel node mapping in colon cancer?

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World Journal of Gastroenterology 2007年第47期13卷 6291-6294页

作者： ronan A Cahill Department of General Surgery Cork University HospitalWiltonCorkIreland

Despite near-universal embrace of the concept and clinical relevance of lymphatic mapping for sentinel node identification and analysis for cancers of the breast and integument,the same technique has struggled to a find a role in gastrointestinal cancers in general and,perhaps,in colon cancer in particular. Despite many studies demonstrating its feasibility in malignancies of the large bowel,concern is continually aroused by the variable and often unacceptably low sensitivity rates. Additionally,many confess uncertainty as to what benefit it could ever confer to patients even if it were proven sufficiently accurate given that standard surgical resection incorporates mesenteric resection anyway. However,the huge impact sentinel node mapping has had on clinical practice in certain cancers means that each of these aspects merit careful reconsideration,from very first principles.

关键词： Sentinel node Lymphatic mapping Colon cancer

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Cytokine orchestration in post-operative peritoneal adhesion formation

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World Journal of Gastroenterology 2008年第31期14卷 4861-4866页

作者： ronan A Cahill H Paul Redmond Department of General Surgery Cork University Hospital Wilton Cork Ireland

Peritoneal adhesions are a near inevitable occurrence after laparotomy and a major cause of both patient and physician misery. To date, clinical attempts at their amelioration have concentrated on manipulating the physical factors that affect their development despite a wealth of experimental data elucidating the molecular mechanisms that underlie their initiation, development and maturation. However, the advent of targeted, specific anti-cytokine agents as directed therapy for inflammatory and neoplastic conditions raises the prospect of a new era for anti-adhesion strategies. To harness this potential will require considerable cross-disciplinary collaboration and that surgeon-scientists propel themselves to the forefront of this emerging fi eld.

关键词： Postoperative peritoneal adhesion formation Cytokines Vascular endothelial growth factor

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First Report of a Successful Development of Yam Hybrids(Dioscorea alata L.)from Lyophilized and Long-Term Stored Pollens

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Phyton-International Journal of Experimental Botany 2023年第10期92卷 2861-2874页

作者： Erick Malédon Elie Nudol Christophe Perrot Marie-Claire Gravillon ronan Rivallan Denis Cornet Hâna Chair Komivi Dossa CIRAD UMR AGAP InstitutPetit BourgGuadeloupe97170France UMR AGAP Institut Univ MontpellierCIRADINRAEInstitut AgroMontpellierF-34398France CIRAD UMR AGAP InstitutMontpellierF-34398France

Various biological constraints including erratic and asynchronous flowering between male and female plants hinder successful hybrid development and genetic gains in greater yam breeding ***,pollen storage has gained much attention to facilitate artificial pollinations and increase the genetic *** 4-year study aimed at developing a practical long-term pollen storage technique for the successful development of yam *** pollens were collected from two Dioscorea alata males,then lyophilized(two lyophilization treatments were applied),followed by storage at room temperature(24℃–25℃)for 12 ***,the lyophilized and stored pollens were tested for viability by crossing with four female *** results showed that lyophilization is effective for achieving viable pollens after 12 months of *** 1(48 h drying)showed higher pollen germination and fertility rates than Treatment 2(72 h drying).Although we observed a reduction in viability of lyophilized pollens after 12 months of storage,we generated hybrid seedlings with success rates from 12%to 21%compared to 21%–31%when using fresh *** testing based on molecular genotyping confirmed the hybrid status of the obtained seedlings,which grew well in a *** is a practical approach for a long-term storage of greater yam pollen *** protocol will positively impact yam breeding programs particularly in developing countries.

关键词： Yam freeze-drying pollen conservation genetic gain

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Arabidopsis Coordinates the Diurnal Regulation of Carbon Allocation and Growth across a Wide Range of Photoperiods

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Molecular Plant 2014年第1期7卷 137-155页

作者： ronan Sulpice Anna Flis Alexander A. Ivakov Federico Apelt Nicole Krohn Beatrice Encke Christin Abel Regina Feil John E. Lunn Mark Stitt Max Planck Institute of Molecular Plant Physiology Am Muehlenberg 1 14476 Potsdam-Golm Germany National University of Galway Plant Systems Biology Lab Plant and AgriBiosciences Research Centre Botany and Plant Science Galway Ireland

In short photoperiods, plants accumulate starch more rapidly in the light and degrade it more slowly at night, ensuring that their starch reserves last until dawn. To investigate the accompanying changes in the timing of growth, Arabidopsis was grown in a range of photoperiods and analyzed for rosette biomass, photosynthesis, respiration, ribosome abundance, polysome loading, starch, and over 40 metabolites at dawn and dusk. The data set was used to model growth rates in the daytime and night, and to identify metabolites that correlate with growth. Modeled growth rates and polysome loading were high in the daytime and at night in long photoperiods, but decreased at night in short photoperiods. Ribosome abundance was similar in all photoperiods. It is discussed how the amount of starch accumulated in the light period, the length of the night, and maintenance costs interact to constrain growth at night in short photoperiods, and alter the strategy for optimizing ribosome use. Significant correlations were found in the day- time and the night between growth rates and the levels of the sugar-signal trehalose 6-phosphate and the amino acid biosynthesis intermediate shikimate, identifying these metabolites as hubs in a network that coordinates growth with diurnal changes in the carbon supply.

关键词： Arabidopsis diurnal growth photoperiod ribosomes trehalose-6-phosphate starch

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