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盛夏的果实

现代装饰 2020年第7期 86-97页

作者： Bogaerts Label VG&P Xlboom Capra Designs Bonaldo ronan&erwan Bouroullec FAINA Axolight RODA SLAMP SCAB Design Mario Alessiani Ed Carpenter Bianca Lambert Thomas Wilson Fabrice Berrux Dondolie Pocci Alain Gilles Victoria Yakusha Silvia Braconi Gordon Guillaumier Adriano Rachele Marcello Ziliani Meneghello Paolelli Associati RadiceOrlandini DesignStudio ronan&erwan 郭映琴(编译) 不详

七月至,庚子年已过半,树上蝉鸣预示着盛夏的到来。夏天是世间万物生长的季节,万千高三学子也即将迎来求知途中最神圣的"验收",祝愿他们皆能摘得心中所想。同样的,设计灵感也大都源于世间万物,在无尽想象力的孕育之下,结出累累硕果。设... 详细信息

七月至,庚子年已过半,树上蝉鸣预示着盛夏的到来。夏天是世间万物生长的季节,万千高三学子也即将迎来求知途中最神圣的"验收",祝愿他们皆能摘得心中所想。同样的,设计灵感也大都源于世间万物,在无尽想象力的孕育之下,结出累累硕果。设计源于生活,是生活的再创造,而艺术高于生活,引导人们追求更加美好的生活。

关键词：庚子年万物生长源于生活设计灵感想象力高三高于生活

Genome-resolved metagenomics of Venice Lagoon surface sediment bacteria reveals high biosynthetic potential and metabolic plasticity as successful strategies in an impacted environment

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Marine Life Science & Technology 2024年第1期6卷 126-142页

作者： Elisa Banchi erwan Corre Paola Del Negro Mauro Celussi Francesca Malfatti National Institute of Oceanography and Applied Geophysics OGS TriesteItaly FR2424 Station Biologique de RoscoffPlateforme ABiMS(Analysis and Bioinformatics for Marine Science)Sorbonne Universite CNRS29680 RoscoffFrance Department of Life Sciences University of TriesteTriesteItaly

Bacteria living in sediments play essential roles in marine ecosystems and deeper insights into the ecology and biogeochemistry of these largely unexplored organisms can be obtained from‘omics’***,we characterized metagenome-assembled-genomes(MAGs)from the surface sediment microbes of the Venice Lagoon(northern Adriatic Sea)in distinct sub-basins exposed to various natural and anthropogenic *** were explored for biodiversity,major marine metabolic processes,anthropogenic activity-related functions,adaptations at the microscale,and biosynthetic gene *** from 126 MAGs,a non-redundant dataset of 58 was compiled,the majority of which(35)belonged to(Alpha-and Gamma-)*** the broad microbial metabolic repertoire(including C,N,and S metabolisms)the potential to live without oxygen emerged as one of the most important *** was also found as a successful *** analysis showed that different MAGs encoded the same metabolic patterns(e.g.,C fixation,sulfate oxidation)thus suggesting metabolic *** and toxic compounds resistance genes were coupled,a condition that could promote the spreading of these genetic *** showed a high biosynthetic potential related to antimicrobial and biotechnological classes and to organism defense and interactions as well as adaptive strategies for micronutrient uptake and cellular *** results highlighted that bacteria living in an impacted environment,such as the surface sediments of the Venice Lagoon,may benefit from metabolic plasticity as well as from the synthesis of a wide array of secondary metabolites,promoting ecosystem resilience and stability toward environmental pressures.

关键词： Antibiotic resistance PAHs Biosynthetic gene clusters Microscale Mobilome Resistome

秸秆-磷石膏联用对赤泥的腐殖质组分和微生物群落的影响

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Journal of Central South University 2024年第2期31卷 460-476页

作者：吴昊朱轩郅唐崇俭黄诗蔚孙伟江钧朱锋杨兴旺 ronan Courtney 薛生国 School of Metallurgy and Environment Central South UniversityChangsha 410083China School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083China Department of Life Sciences Schrodinger BuildingUniversity of LimerickLimerick V94 T9PXIreland

腐殖化过程是赤泥土壤化及堆场生态修复的重要环节。本研究采用腐殖质分级和高通量测序技术,探究了秸秆和磷石膏联用对赤泥腐殖质组分和微生物群落的影响。结果表明,秸秆-磷石膏联用显著增加赤泥胡敏酸和富里酸含量,提高微生物群落多样... 详细信息

腐殖化过程是赤泥土壤化及堆场生态修复的重要环节。本研究采用腐殖质分级和高通量测序技术,探究了秸秆和磷石膏联用对赤泥腐殖质组分和微生物群落的影响。结果表明,秸秆-磷石膏联用显著增加赤泥胡敏酸和富里酸含量,提高微生物群落多样性和丰富度,促进赤泥腐殖化过程。施用秸秆后,赤泥中葡萄糖苷酶、纤维素水解酶、多酚氧化酶和过氧化物酶分别升高7.15~8.76倍、5.64~7.12倍、2.69~4.57倍和2.59~4.24倍,显著增加Devosiaceae、Rhizobiaceae、Flavobacteriaceae、Caulobacteraceae和Cellvibrionaceae等具有纤维素降解和固氮功能微生物类群相对丰度,提高微生物群落稳定性。研究结果为外源生物质促进腐殖质累积、驱动赤泥成土进程提供科学依据。

关键词：赤泥秸秆腐殖质组分微生物群落赤泥土壤化

What's wrong with sentinel node mapping in colon cancer?

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World Journal of Gastroenterology 2007年第47期13卷 6291-6294页

作者： ronan A Cahill Department of General Surgery Cork University HospitalWiltonCorkIreland

Despite near-universal embrace of the concept and clinical relevance of lymphatic mapping for sentinel node identification and analysis for cancers of the breast and integument,the same technique has struggled to a find a role in gastrointestinal cancers in general and,perhaps,in colon cancer in particular. Despite many studies demonstrating its feasibility in malignancies of the large bowel,concern is continually aroused by the variable and often unacceptably low sensitivity rates. Additionally,many confess uncertainty as to what benefit it could ever confer to patients even if it were proven sufficiently accurate given that standard surgical resection incorporates mesenteric resection anyway. However,the huge impact sentinel node mapping has had on clinical practice in certain cancers means that each of these aspects merit careful reconsideration,from very first principles.

关键词： Sentinel node Lymphatic mapping Colon cancer

Cytokine orchestration in post-operative peritoneal adhesion formation

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World Journal of Gastroenterology 2008年第31期14卷 4861-4866页

作者： ronan A Cahill H Paul Redmond Department of General Surgery Cork University Hospital Wilton Cork Ireland

Peritoneal adhesions are a near inevitable occurrence after laparotomy and a major cause of both patient and physician misery. To date, clinical attempts at their amelioration have concentrated on manipulating the physical factors that affect their development despite a wealth of experimental data elucidating the molecular mechanisms that underlie their initiation, development and maturation. However, the advent of targeted, specific anti-cytokine agents as directed therapy for inflammatory and neoplastic conditions raises the prospect of a new era for anti-adhesion strategies. To harness this potential will require considerable cross-disciplinary collaboration and that surgeon-scientists propel themselves to the forefront of this emerging fi eld.

关键词： Postoperative peritoneal adhesion formation Cytokines Vascular endothelial growth factor

Coupled Electromagnetic-thermal Analysis of Segmented PM Consequent Pole Flux Switching Machine

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Chinese Journal of Electrical Engineering 2021年第2期7卷 50-60页

作者： Wasiq Ullah Faisal Khan Muhammad Umair erwan Sulaiman Department of Electrical and Computer Engineering COMSATS University IslamabadAbbottabad CampusAbbottabad 22060Pakistan Department of Electrical Power Engineering Universiti Tun Hussein Onn MalaysiaParit Raja 86400Malaysia

Compact stator structure of flux switching machines(FSMs)encompassing both permanent magnets(PMs)and armature winding slots(AWS)attract research interest whenever high power and density are the basic ***,it also results in temperature rises owing to heat generation by electromagnetic power losses degrading the electromagnetic performance and affecting machine *** this study,a segmented permanent magnet(SPM)consequent pole FSM(SPM-CPFSM)is developed,which provides a stator cooling channel(duct)for improved heat dissipation to avoid demagnetization of PM as well as ***,this study investigates detailed electromagnetic performance analysis and prediction of temperature variation in various machine parts owing to the heat generated by iron,copper,and magnet eddy current losses utilizing coupled electromagnetic-thermal analysis accounting for magnetic flux density *** comparison with the 2D analysis,the developed 3D coupled-field analysis more accurately predicts electromagnetic performance and temperature *** reveals that a cooling duct at the stator significantly assists in stator heat dissipation in the axial direction ensuring a safe operating condition of the PMs as well as machine parts to avoid overheating.

关键词： AC machines coupled field consequent pole permanent magnet loss analysis thermal analysis

Local transgene expression and whole-body transgenesis to model brain diseases in nonhuman primate

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Animal Models and Experimental Medicine 2019年第1期2卷 9-17页

作者： Lucie Chansel-Debordeaux erwan Bezard Institut des Maladies Neurodégénératives University of Bordeaux CNRS Institut des Maladies Neurodégénératives CHU Bordeaux Service de Biologie de la reproduction-CECOS

Animal model is an essential tool in the life sciences research, notably in understanding the pathogenesis of the diseases and for further therapeutic intervention success. Rodents have been the most frequently used animals to model human disease since the establishment of gene manipulation technique. However, they remain inadequate to fully mimic the pathophysiology of human brain disease, partially due to huge differences between rodents and humans in terms of anatomy, brain function, and social behaviors. Nonhuman primates are more suitable in translational perspective. Thus, genetically modified animals have been generated to investigate neurologic and psychiatric disorders. The classical transgenesis technique is not efficient in that model; so, viral vector-mediated transgene delivery and the new genome-editing technologies have been promoted. In this review, we summarize some of the technical progress in the generation of an ad hoc animal model of brain diseases by gene delivery and real transgenic nonhuman primate.

关键词： animal models neuroscience nonhuman primates

Digital surgery for gastroenterological diseases

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World Journal of Gastroenterology 2021年第42期27卷 7240-7246页

作者： Niall Philip Hardy ronan Ambrose Cahill UCD Centre for Precision Surgery University College DublinDublin D07 Y9AWIreland

Advances in machine learning,computer vision and artificial intelligence methods,in combination with those in processing and cloud computing capability,portend the advent of true decision support during interventions in real-time and soon perhaps in automated surgical *** capability,deployed alongside technology intraoperatively,is termed digital surgery and can be delivered without the need for high-end capital robotic *** area close to clinical usefulness right now harnesses advances in near infrared endolaparoscopy and fluorescence guidance for tissue characterisation through the use of biophysics-inspired *** represents a potential synergistic methodology for the deep learning methods currently advancing in ophthalmology,radiology,and recently gastroenterology via *** databanks of more general surgical videos are created,greater analytic insights can be derived across the operative spectrum of gastroenterological disease and operations(including instrumentation and operative step sequencing and recognition,followed over time by surgeon and instrument performance assessment)and linked to value-based ***,issues of legality,ethics and even morality need consideration,as do the limiting effects of monopolies,cartels and isolated data ***,the role of the surgeon,surgical societies and healthcare institutions in this evolving field needs active deliberation,as the default risks relegation to bystander or passive *** editorial provides insight into this accelerating field by illuminating the nearfuture and next decade evolutionary steps towards widespread clinical integration for patient and societal benefit.

关键词： Digital surgery Artificial intelligence Gastrointestinal disease Biophysics Deep learning Fluorescence-guided surgery

Single access laparoscopic total colectomy for severe refractory ulcerative colitis

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World Journal of Gastroenterology 2020年第39期26卷 6015-6026页

作者： John Burke Des Toomey Frank Reilly ronan Cahill Department of Colorectal Surgery Beaumont HospitalDublin D09Ireland Department of Surgery Mater Misericordiae University HospitalDublin D07Ireland

BACKGROUND Single port laparoscopic surgery allows total colectomy and end ileostomy for medically uncontrolled ulcerative colitis solely via the stoma site *** intuitively appealing,there is sparse evidence for its use beyond *** To examine the usefulness of single access laparoscopy(SAL)in a general series experience of patients sick with ulcerative *** All patients presenting electively,urgently or emergently over a three-year period under a colorectal specialist team were *** was performed via the stoma site on a near-consecutive basis by one surgical team using a“surgical glove port”allowing group-comparative and case-control analysis with a contemporary cohort undergoing conventional multiport ***,straight rigid laparoscopic instrumentation were used without additional *** Of 46 consecutive patients requiring surgery,39(85%)had their procedure begun laparoscopically.27(69%)of these were commenced by single port access with an 89%completion rate thereafter(three were concluded by multi-trocar laparoscopy).SAL proved effective in comparison to multiport access regardless of disease severity providing significantly reduced operative access costs(>100€case)and postoperative hospital stay(median 5 d vs 7.5 d,P=0.045)without increasing operative *** proved especially efficient in those with preoperative albumin>30 g/dL(n=20).Its comparative advantages were further confirmed in ten pairs case-matched for gender,body mass index and preoperative *** outcomes proved durable in the intermediate term(median follow-up=20 mo).CONCLUSION Single port total colectomy proved useful in planned and acute settings for patients with medically refractory *** regarding duration and cost should not be barriers to its implementation.

关键词： Single incision laparoscopy Minimal access surgery Inflammatory bowel disease Ulcerative colitis Total colectomy and end ileostomy Case match analysis