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<i>Schistosoma mansoni</i>: Phytochemical Effect on Aquatic Life Cycle

Open Journal of Veterinary Medicine 2015年第6期5卷 127-132页

作者： ronaldo de carvalho augusto Gabriela Friani Maurício carvalho de Vasconcellos Maria de Lurdes de Azevedo Rodrigues Clélia Christina Mello-Silva Laboratório de Avaliaç &atilde o e Promoç &atilde o da Saúde Ambiental Instituto Oswaldo Cruz Funda&ccedil &atilde o Oswaldo Cruz Rio de Janeiro Brasil departamento de Parasitologia Animal Curso de Pós-Gradua&ccedil &atilde o em Ciências Veterinárias Universidade Federal Rural do Rio de Janeiro Seropédica Brasil

Background: Two aspects need to be considered for schistosomiasis control: morbidity and transmission. In this context, many soluble substances have been tested and Euphorbia milii latex is one of the most promising Brazilian molluscicides. Phytochemical studies involving simulation of the applicability of this latex on all aquatic forms of the S. mansoni life cycle are rare in the literature. The aim of this work was to evaluate the effect of E. milii latex on S. mansoni in the egg, miracidium and different developmental stages in Biomphalaria glabrata. Methods: The laboratory study was designed to simulate the different forms of exposure of the life cycle stages of S. mansoni to the LC50 of E. milii latex;we tested the exposition from four situations of S. mansoni contact with the latex and observed the exposure on different snails’ infection stage too. All snails were analyzed weekly for cercarial shedding and reproductive biology. Results: The results showed that contact of S. mansoni eggs and miracidia with the LC50 of E. milii negatively influenced the development of the parasite life cycle in the intermediate host, with consequent reduction of cercarial shedding. The exposure of infected snails affected the reproductive biology and cercarial shedding in all intra-mollusk development stages of S. mansoni, but the reduction was greater in the first, fourth, fifth, sixth, seventh and eighth weeks of infection. The LC50 of E. milii latex had toxic action on eggs and miracidia, and the number of cercariae shed by snails during the study period declined by about 80%. Conclusions: We can conclude that the use of natural biodegradable compounds containing low concentrations of substances already characterized as having eco-toxico- logical potential can be an important tool to reduce the transmission of Schistosomiasis.

关键词： Schistosomiasis Cercariae Miracidia Eggs Euphorbia milii

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Power Curve Modelling for Wind Turbine Using Artificial Intelligence Tools and Pre-established Inference Criteria

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Journal of Modern Power Systems and Clean Energy 2021年第3期9卷 526-533页

作者： Jonata C.de Albuquerque ronaldo R.B.de Aquino Otoni Nobrega Neto Milde M.S.Lira Aida A.Ferreira Manoel Afonso de carvalho Jr. the department of Electrical Engineering Federal University of PernambucoRecifeBrazil DASE Federal Institute of PernambucoRecifeBrazil

We propose a new way to develop non-parametric models of power curves using artificial intelligence *** parametric model and eight non-parametric models are developed to emulate the behavior described by the power curve of the wind farms.A comparison between the power curve models based on artificial neural networks(ANNs)and those based on fuzzy logic are also *** of the power curve models based on ANNs and fuzzy inference systems(FISs)are used as well as two new FISs with the proposed new *** initial pre-training is proposed,resulting from the characteristics derived from the expert inference followed by a transformation of a fuzzy Mamdani system into a fuzzy Sugeno *** the presented values by the error indicators are comparable,the results show that the new pre-trained FIS models have better precision compared with the ANN and FIS *** comparative study is conducted in two wind farms located in northeastern *** proposed method is a relevant alternative to improve power curve approximation based on an FIS.

关键词： Wind turbine pre-training artificial intelligence artificial neural network(ANN) fuzzy inference system(FIS)

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How to improve colon cancer screening rates

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World Journal of Gastrointestinal Oncology 2015年第12期7卷 484-491页

作者： Luiz ronaldo Alberti Diego Paim carvalho Garcia debora Lucciola Coelho David Correa Alves de Lima Andy Petroianu department of Surgery Federal University of Minas Gerais Medical Sciences of Minas Gerais

Colorectal carcinoma is a common cause of death throughout the world and may be prevented by routine control, which can detect precancerous neoplasms and early cancers before they undergo malignant transformation or metastasis. Three strategies may improve colon cancer screening rates: convince the population about the importance of undergoing a screening test; achieve higher efficacy in standard screening tests and make them more available to the community and develop new more sensitive and efficacious screening methods and make them available as routine tests. In this light, the present study seeks to review these three means through which to increase colon cancer screening rates.

关键词： Colon cancer screening Colon cancer Screening test

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Proton nuclear magnetic resonance-based metabonomic models for non-invasive diagnosis of liver fibrosis in chronic hepatitis C:Optimizing the classification of intermediate fibrosis

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World Journal of Hepatology 2018年第1期10卷 105-115页

作者： Andrea Dória Batista Carlos Jonnatan Pimentel Barros Tássia Brena Barroso Carneiro Costa Michele Maria Goncalves de Godoy ronaldo Dionísio Silva Joelma carvalho Santos Mariana Montenegro de Melo Lira Norma ThoméJucá Edmundo Pessoa de Almeida Lopes Ricardo Oliveira Silva Postgraduate Program in Tropical Medicine Center for Health SciencesUniversidade Federal de PernambucoRecifePernambuco 50670-901Brazil department of Gastroenterology and Hepatology Hospital das ClínicasUniversidade Federal de PernambucoRecifePernambuco 50670-901Brazil department of Fundamental Chemistry Center for Exact and Nature SciencesUniversidade Federal de PernambucoRecifePernambuco 50670-901Brazil Intensive Care Unit Hospital das ClínicasUniversidade Federal de PernambucoRecifePernambuco 50670-901Brazil department of Pathology Hospital das ClínicasUniversidade Federal de PernambucoRecifePernambuco 50670-901Brazi

AIM To develop metabonomic models(MMs), using 1 H nuclear magnetic resonance(NMR) spectra of serum, to predict significant liver fibrosis(SF: Metavir ≥ F2), advanced liver fibrosis(AF: METAVIR ≥ F3) and cirrhosis(C: METAVIR = F4 or clinical cirrhosis) in chronic hepatitis C(CHC) patients. Additionally, to compare the accuracy of the MMs with the aspartate aminotransferase to platelet ratio index(APRI) and fibrosis index based on four factors(FIB-4). METHODS Sixty-nine patients who had undergone biopsy in the previous 12 mo or had clinical cirrhosis were included. The presence of any other liver disease was a criterion for exclusion. The MMs, constructed using partial least squares discriminant analysis and linear discriminant analysis formalisms, were tested by cross-validation, considering SF, AF and C. RESULTS Results showed that forty-two patients(61%) presented SF, 28(40%) AF and 18(26%) C. The MMs showed sensitivity and specificity of 97.6% and 92.6% to predict SF; 96.4% and 95.1% to predict AF; and 100% and 98.0% to predict C. Besides that, the MMs correctly classified all 27(39.7%) and 25(38.8%) patients with intermediate values of APRI and FIB-4, respectively. CONCLUSION The metabonomic strategy performed excellently in predicting significant and advanced liver fibrosis in CHC patients, including those in the gray zone of APRI and FIB-4, which may contribute to reducing the need for these patients to undergo liver biopsy.

关键词： Metabolomics Nuclear magnetic resonance spectroscopy Chronic hepatitis C Liver fibrosis Surrogate markers

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Transmission of severe acute respiratory syndrome coronavirus 2 via fecal-oral:Current knowledge

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World Journal of Clinical Cases 2021年第28期9卷 8280-8294页

作者： Filipe Antônio França da Silva Breno Bittencourt de Brito Maria Luísa Cordeiro Santos Hanna Santos Marques ronaldo Teixeira da Silva Júnior Lorena Sousa de carvalho Samuel de Sousa Cruz Gabriel Reis Rocha Gabriel Lima Correa Santos Kathlen Coutinho de Souza Rebeca Gabrielle Almeida Maciel Daiana Silva Lopes Natália Oliveira e Silva Márcio Vasconcelos Oliveira Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45002175BahiaBrazil departamento de Ciências Naturais Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45002175BahiaBrazil departamento de Bioquímica e Biofísica Universidade Federal da BahiaSalvador 40.110-100BahiaBrazil Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

The pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has resulted in more than 93 million cases and 2 million deaths in the ***-CoV-2 respiratory tract infection and its main clinical manifestations such as cough and shortness of breath are well known to the scientific ***,a growing number of studies have reported SARS-CoV-2-related gastrointestinal involvement based on clinical manifestations,such as diarrhea,nausea,vomiting,and abdominal pain as well as on the pathophysiological mechanisms associated with coronavirus disease ***,current evidence suggests SARS-CoV-2 transmission via the fecal-oral route and aerosol ***,studies have shown a high risk of contamination through hospital surfaces and personal ***,viable SARS-CoV-2 specimens can be obtained from aerosols,which raises the possibility of transmission through aerosolized viral particles from ***,the infection by SARS-CoV-2 via fecal-oral route or aerosolized particles should *** addition,a possible viral spread to sources of drinking water,sewage,and rivers as well as the possible risk of viral transmission in shared toilets become a major public health concern,especially in the least developed *** authors have emphasized the presence of viral RNA and even viable SARS-CoV-2 in human feces,studies on the possible fecal-oral coronavirus disease 2019 transmission become essential to understand better the dynamics of its transmission and,then,to reinforce preventive measures against this infection,leading to a more satisfactory control of the incidence of the infection.

关键词： COVID-19 SARS-CoV-2,Transmission Via fecal-oral

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Osmotic dehydration of Pineapple Stems in Hypertonic Sucrose Solutions

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Agricultural Sciences 2015年第9期6卷 916-924页

作者： ronaldo dos Santos Falcao Filho Rennan Pereira de Gusmao Wilton Pereira da Silva Josivanda Palmeira Gomes Edvaldo Vasconcelos carvalho Filho Anoar Abbas El-Aouar Federal Institute of Rio Grande do Norte Currais NovosBrazil Federal University of Campina Grande Campina GrandeBrazil Federal University of Rio Grande do Norte Santa CruzBrazil Federal University of Paraíba Joao PessoaBrazil

The present study provides the evaluation in the influence of the variables: temperature (T), concentration of the osmotic solution (C) and ratio of fruit and osmotic solution (F:OS) during the osmotic dehydration of slices of pineapple stem variety Perola, on the responses: water loss (WL), mass loss (ML), gain of solids (GS) and ratio of gain of solids and water loss (GS/WL). The centesimal composition was determined both in the raw material and in the dehydrated product. To optmize the process, the studied factors were: temperature (T), with factorial points -1 equal to 30°C and +1 equal to 50°C;concentration of sucrose solution (C), with factorial points -1 equal to 40 g·100 g-1 and +1 equal to 60 g·100 g-1 and ratio of fruit and osmotic dehydration solution (F:OS), with factorial points -1 and +1 equal to 1:20 and 3:20, respectively. In all essays, the dehydration time was 4 hours. The essays showed that F:OS was not significant in any responses;the models adopted were predictive and fitted for WL and ML, and reasonable for GS and GS/WL. The temperature was the most significant variable in the process;the optimized values were: T= 50°C, C = 40 g 100 g-1 e F:OS = 3:20. The product needs a complementary drying to adapt itself to the legislation demands.

关键词： Pineapple Dried Fruit Experimental design

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Inheritance of the Number of Ovules per Ovary and Selection of Cacao Genotypes

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American Journal of Plant Sciences 2013年第7期4卷 1387-1392页

作者： Rita de Cássia Bahia Ronan Xavier Corrêa ronaldo carvalho Santos Regina Celle Reboucas Machado Edna Dora Newman Luz IonáSantos Araújo Dário Ahnert departamento de Ciências Biológicas Universidade Estadual de Santa CruzIlhéusBrasil Centro de Pesquisas do Cacau Comissao Executiva do Plano da Lavoura CacaueiraItabunaBrasil MARS Center for Cocoa Science ItajuípeBrasil

We have characterized the number of ovules per ovary (NoOV) in cacao plants originated from crossing the clones CCN 51 and TSH 1188 (segregating progeny) and determined the heritability of this characteristic in order to select plants with higher NoOV in this progeny. The NoOV was calculated as the average of 10 flowers per plant and ranged from 44.8 to 58.6 between the six clones (two parents and four clones belonging to their genealogy). In the progeny (n = 209 plants) the NoOV averaged 54.3 (range 44.1 to 67.8). The NoOV was distributed uniformly among the progeny indicating that this trait is conditioned by polygenes. Its heritability was estimated at 67.7%. The 32 plants with NoOV similar or superior to the genitor CCN 51 (highest amount among clones) were selected for use in the genetic improvement program. We showed that this population is suitable for genetic mapping, molecular marker identification and selection of superior cacao genotypes.

关键词： Theobroma cacao Flower Trait Heritability Reproductive Biology Genetic Improvement

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Crohn's disease and clinical management today:How it does?

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World Journal of Methodology 2023年第5期13卷 399-413页

作者： ronaldo Teixeira da Silva Júnior Jonathan Santos Apolonio Jessica Oliveira de Souza Nascimento Bruna Teixeira da Costa Luciano Hasimoto Malheiro Marcel Silva Luz Lorena Sousa de carvalho Cleiton da SilvaSantos Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

Crohn’s Disease(CD)is an Inflammatory Bowel Disease and is characterized by an immune-mediated *** etiology results from the interaction between genetic,enviromental and microbial *** pathophysiology,it involves high levels of interleukin(IL)-12,IL-17,and Th1 profile,along with loss of tolerance mechanisms,an increase in pro-inflammatory interleukins,beyond the possibility to affect any part of the gastrointestinal *** symptoms include abdominal pain,chronic diarrhea,weight loss,anorexia,and fatigue,as well as blood in the stool or ***,conditions comprising musculoskeletal,cutaneous,ocular,hepatic,and hematological alterations may be associated with this scenario and extra-intestinal presentation,such as erythema nodosum,anterior uveitis,osteoporosis,and arthritis can also ***,clinical history,exams as fecal calprotectin,ileocolonocopy,and capsule endoscopy can be performed in the diagnosis investigation,along with treatments to induce and maintain *** this sense,anti-inflammatory drugs,such as corticosteroids,immunomodulators,and biological agents,as well as surgery and non-pharmacological interventions plays a role in its *** aim of this review is to bring more current evidence to clinical management of CD,as well as to briefly discuss aspects of its pathophysiology,surveillance,and associated disorders.

关键词： Crohn's disease Inflammatory bowel diseases Diagnosis Treatment Immunomodulation Biological agents

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Usher syndrome:Genetic diagnosis and current therapeutic approaches

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World Journal of Otorhinolaryngology 2024年第1期11卷 1-17页

作者： Beatriz Rocha Cuzzuol Jonathan Santos Apolonio ronaldo Teixeira da Silva Júnior Lorena Sousa de carvalho Luana Kauany de SáSantos Luciano Hasimoto Malheiro Marcel Silva Luz Mariana Santos Calmon Henrique de Lima Crivellaro Fabian Fellipe Bueno Lemos Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

Usher Syndrome(USH)is the most common deaf-blind syndrome,affecting approximately 1 in 6000 people in the deaf *** genetic condition is characterized by a combination of hearing loss(HL),retinitis pigmentosa,and,in some cases,vestibular *** the subtypes of USH,USH type 1 is considered the most severe form,presenting profound bilateral congenital deafness,vestibular areflexia,and early onset *** type 2 is the most common form,exhibiting congenital moderate to severe HL for low frequencies and severe to profound HL for high ***,type 3 is the rarest,initially manifesting mild symptoms during childhood that become more prominent in the first decades of *** dual impact of USH on both visual and auditory senses significantly impairs patients'quality of life,restricting their daily activities and interactions with *** date,9 genes have been confirmed so far for USH:MYO7A,USH1C,CDH23,PCDH15,USH1G,USH2A,ADGRV1,WHRN and *** genes are inherited in an autosomal recessive manner and encode proteins expressed in the inner ear and retina,leading to functional *** non-genetic methods can assist in patient triage and disease extension evaluation,genetic and molecular tests play a pivotal role in providing genetic counseling,enabling appropriate gene therapy,and facilitating timely cochlear implantation(CI).The CRISPR/Cas9 system and viral-based gene replacement therapy have recently emerged as highly promising techniques for treating *** drug therapy,PTC-124 and Nb54 have been identified as promising drug interventions for genetic HL in ***,CI has proven to be critical in the restoration of *** review aims to summarize the genetic and molecular diagnosis of USH and highlight the importance of early diagnosis in Cuzzuol BR et *** and current treatments of USH WJO https://*** 2 January 19,2024 Volume 11 Issue 1 guiding appropriate treatment strategies and i

关键词： Usher syndromes Hearing loss Retinitis pigmentosa Diagnosis Genetic therapies Cochlear implantation Quality of life

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Highlighting COVID-19:What the imaging exams show about the disease

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World Journal of Radiology 2021年第5期13卷 122-136页

作者： Lorena Sousa de carvalho ronaldo Teixeira da Silva Júnior Bruna Vieira Silva Oliveira Yasmin Silva de Miranda Nara Lúcia Fonseca Rebouças Matheus Sande Loureiro Samuel Luca Rocha Pinheiro Regiane Santos da Silva Paulo Victor Silva Lima Medrado Correia Maria José Souza Silva Sabrina Neves Ribeiro Filipe Antônio França da Silva Breno Bittencourt de Brito Maria Luísa Cordeiro Santos Rafael augusto Oliveira Sodré Leal Márcio Vasconcelos Oliveira Fabrício Freire de Melo department of Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

Coronavirus disease 2019(COVID-19),a global emergency,is caused by severe acute respiratory syndrome coronavirus *** gold standard for its diagnosis is the reverse transcription polymerase chain reaction,but considering the high number of infected people,the low availability of this diagnostic tool in some contexts,and the limitations of the test,other tools that aid in the identification of the disease are *** this scenario,imaging exams such as chest X-ray(CXR)and computed tomography(CT)have played important *** is useful for assessing disease progression because it allows the detection of extensive consolidations,besides being a fast and cheap *** the other hand,CT is more sensitive for detecting lung changes in the early stages of the disease and is also useful for assessing disease *** note,ground-glass opacities are the main COVID-19-related CT *** emission tomography combined with CT can be used to evaluate chronic and substantial damage to the lungs and other organs;however,it is an expensive *** ultrasound(LUS)has been shown to be a promising technique in that context as well,being useful in the screening and monitoring of patients,disease classification,and management related to mechanical ***,LUS is an inexpensive alternative available at the ***,magnetic resonance imaging,although not usually requested,allows the detection of pulmonary,cardiovascular,and neurological abnormalities associated with ***,it is important to consider the challenges faced in the radiology field in the adoption of control measures to prevent infection and in the follow-up of post-COVID-19 patients.

关键词： SARS-CoV-2 COVID-19 Pneumonia Pandemic Radiology Tomography

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