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Thoracic aorta thickness and histological changes with aging: an experimental rat model

Journal of Geriatric Cardiology 2019年第7期16卷 580-584页

作者： Giulio Cesar Gequelim Djanira Aparecida da Luz Veronez Gustavo Lenci Marques Camila Harumi Tabushi ronaldo da rocha loures bueno Master’s Degree Student in Postgraduate Program of Internal Medicine Federal University of Paraná(UFPR)Medical Resident in Cardiology in Hospital de Clínicas UFPRCuritiba-PRBrazil Department of Anatomy School of MedicineUFPRCuritiba-PRBrazil Master’s Degree in Internal Medicine Adjunct ProfessorDepartment of Internal MedicineSchool of MedicineUFPRCuritiba-PRBrazil Medical Student Department of Internal MedicineSchool of MedicineUFPRCuritiba-PRBrazil Department of Internal Medicine School of MedicineUFPRCuritiba-PRBrazil

The three main components of the media layer of the aorta are elastic fibers,collagen fibers and smooth muscle cells(SMC).[1]This layer’s elastic properties are major determinants of its biomechanics in health and disease states.[2,3]Age-related changes in such elastic properties are associated with altered hemodynamic parameters,such as systolic hypertension,[4,5]and end-organ damage,[6,7]and are thought to result from changes of its main components.

关键词： Aging Collagen Elastic fibers Smooth muscle cells

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Helicobacter pylori infection in pregnant women:Gastrointestinal symptoms and pregnancy-related disorders

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World Journal of Clinical Infectious Diseases 2023年第5期13卷 49-57页

作者： Luana Kauany de SáSantos Jonathan Santos Apolonio Beatriz rocha Cuzzuol Bruna Teixeira da Costa Vinícius Lima de Souza Gonçalves ronaldo Teixeira da Silva Júnior Marcel Silva Luz Fabian Fellipe bueno Lemos Samuel Luca rocha Pinheiro Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Universidade Estadual do Sudoeste da Bahia Campus Vitória da ConquistaVitória da Conquista 45083-900BahiaBrazil

Helicobacter pylori(***)is a gram-negative,flagellated and spiral-shaped bacterial pathogen that impacts approximately 46%among pregnant women globally and has been associated with various maternal-fetal *** deficiency anemia,fetal growth restriction,cardiovascular diseases,and insufficient nutrient absorption can be observed in pregnant women,as well as miscarriages and pregnancy-specific hypertensive disease,such as ***,the evidence supports the influence of *** infection on fetal implantation/placentation failure,and positive strains of the cytotoxin-associated gene A of *** were reported as the most prevalent in these ***,current knowledge indicates a relationship between this infection and the occurrence of hyperemesis gravidarum,characterized by frequent nausea and *** the diagnosis of this bacterial infection,non-invasive approaches such as stool antigen test,urea breath test,and serological tests are more accepted during pregnancy,as they are easy to carry out and ***,the bacteria eradication therapy should consider the risks and benefits for the pregnant woman and her child,with pharmacological intervention depending on the clinical presentation.

关键词： Helicobacter pylori Pregnancy Hyperemesis gravidarum Iron deficiency anemia Pre-eclampsia Fetal growth restriction Miscarriage

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Usher syndrome:Genetic diagnosis and current therapeutic approaches

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World Journal of Otorhinolaryngology 2024年第1期11卷 1-17页

作者： Beatriz rocha Cuzzuol Jonathan Santos Apolonio ronaldo Teixeira da Silva Júnior Lorena Sousa de Carvalho Luana Kauany de SáSantos Luciano Hasimoto Malheiro Marcel Silva Luz Mariana Santos Calmon Henrique de Lima Crivellaro Fabian Fellipe bueno Lemos Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

Usher Syndrome(USH)is the most common deaf-blind syndrome,affecting approximately 1 in 6000 people in the deaf *** genetic condition is characterized by a combination of hearing loss(HL),retinitis pigmentosa,and,in some cases,vestibular *** the subtypes of USH,USH type 1 is considered the most severe form,presenting profound bilateral congenital deafness,vestibular areflexia,and early onset *** type 2 is the most common form,exhibiting congenital moderate to severe HL for low frequencies and severe to profound HL for high ***,type 3 is the rarest,initially manifesting mild symptoms during childhood that become more prominent in the first decades of *** dual impact of USH on both visual and auditory senses significantly impairs patients'quality of life,restricting their daily activities and interactions with *** date,9 genes have been confirmed so far for USH:MYO7A,USH1C,CDH23,PCDH15,USH1G,USH2A,ADGRV1,WHRN and *** genes are inherited in an autosomal recessive manner and encode proteins expressed in the inner ear and retina,leading to functional *** non-genetic methods can assist in patient triage and disease extension evaluation,genetic and molecular tests play a pivotal role in providing genetic counseling,enabling appropriate gene therapy,and facilitating timely cochlear implantation(CI).The CRISPR/Cas9 system and viral-based gene replacement therapy have recently emerged as highly promising techniques for treating *** drug therapy,PTC-124 and Nb54 have been identified as promising drug interventions for genetic HL in ***,CI has proven to be critical in the restoration of *** review aims to summarize the genetic and molecular diagnosis of USH and highlight the importance of early diagnosis in Cuzzuol BR et *** and current treatments of USH WJO https://*** 2 January 19,2024 Volume 11 Issue 1 guiding appropriate treatment strategies and i

关键词： Usher syndromes Hearing loss Retinitis pigmentosa Diagnosis Genetic therapies Cochlear implantation Quality of life

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