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Journal of Rock Mechanics and Geotechnical Engineering 2019年第2期11卷 369-378页

作者： Eclesielter Batista Moreira Jair Arrieta Baldovino Juliana Lundgren Rose ronaldo luis dos santos izzo Department of Civil Construction Federal University of Technology e ParanaCampus Curitiba

One of the conventional ways to improve the mechanical behavior of soils is to mix them with cementing agents such as cement, lime and fly ash. Recently, introduction to alternative materials or sub-products that can be adopted to improve the soil strength is of paramount importance. Therefore, the present study aims to investigate the effects of porosity(h), dry unit weight(gd) of molding, cement content(C)and porosity/volumetric cement content ratio(h/Civ) or void/cement ratio on the unconfined compressive strength(quor UCS) of silty soileroof tile waste(RT) mixtures. Soil samples are molded into four different dry unit weights(i.e. 13 kN/m^3, 13.67 kN/m^3, 14.33 kN/m^3 and 15 kN/m^3) using 3%, 6% and 9%cement and 5%, 15% and 30% RT. The results show that with the addition of cement, the strength of the RT esoil mixtures increases in a linear manner. On the other hand, the addition of RT decreases quof the samples at a constant percentage of cement, and the decrease in porosity can increase qu. A dosage equation is derived from the experimental data using the porosity/volumetric cement content ratio(h/C_(iv)) where the control variables are the moisture content, crushed tile content, cement content and porosity.

关键词： Roof tile waste (RT) Voids/cement ratio Reuse Ground improvement

Optimizing the evolution of strength for lime-stabilized rammed soil

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Journal of Rock Mechanics and Geotechnical Engineering 2019年第4期11卷 882-891页

作者： Jair de Jesus Arrieta Baldovino ronaldo luis dos santos izzo Eclesielter Batista Moreira Juliana Lundgren Rose Department of Civil Construction Federal University of Technology-Parana

In the present study,unconfined compressive strength(qu)values of two lime-treated soils(soil 1 and 2)with curing times of 28 d,90 d and 360 d were *** influence of void/lime ratio was represented by the porosity/volumetric lime content ratio(η/Liv)as the main parameter.η/Liv represents the volume of void influenced by compaction effort and lime *** evolution of qu was analyzed for each soil using the coefficient of determination as the optimization *** at providing adjustments to the mechanical resistance values,the η/Liv parameter was modified to η/LivC using the adjustment exponent C(to make qu-η/Liv variation rates compatible).The results show that with the decrease of η/*** increases potentially and the optimized values of C were *** mechanical resistance data show similar trends between qu and η/LivC for the studied silty soil-ground lime mixtures,which were cured at ambient temperature(23±2)℃ with different curing times of 28-360 ***,optimized equations were presented using the normalized strengths and the proposed optimization model,which show 6% error and 95% acceptability on average.

关键词： Lime-treated soil Void/lime ratio Ground improvement

Mechanical properties of a clay soil reinforced with rice husk under drained and undrained conditions

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第10期15卷 2676-2686页

作者： Claudia Regina Bernardi Baldin Maiky Yamato Kawanami Weiner Gustavo Silva Costa Vitor Reinaldo Bordignon Cristhyano Cavali da Luz ronaldo luis dos santos izzo Federal University of Technology-Paraná CuritibaBrazil

Fiber-reinforced soils have been increasingly used in geotechnical *** the years,research has sought to understand and investigate the influences of fibers as reinforcement in soilefiber *** study assessed the behavior of clayey soil in the city of Curitiba(Paraná,Brazil),adding rice husk fiber(RHF),an industrial waste from Cooperativa Agroindustrial in Alegrete(Rio Grande do Sul,Brazil).To evaluate the effect of the presence of natural RHF on the mechanical behavior of compacted soil,aspects such as the influence of fiber content and the drained and undrained behaviors of the soil were evaluated through unconfined triaxial compression *** following tests were realized:soil granulometry,specific mass of solids and Atterberg *** were produced in quadruplicate for the soil and mixtures using the RHF contents of 0.5%,0.75%,1%and 1.5%to determine the unconfined compressive strength(UCS).Triaxial tests were realized on a pure soil specimen and the specimens with 1%RHF under confining pressures of 50 kPa,100 kPa,200 kPa and 400 *** interactions at the interface between husk surface and soil were analyzed using scanning electron microscopy(SEM).In UCS tests,specimens with RHF percentages of 1%and 1.5%presented the highest results,with an increment of 36%compared to the soil without *** results of the consolidated drained triaxial compression tests show that in terms of effective stress,there was a small difference in the strength of the compacted pure soil and soil with the addition of *** the undrained tests,the strength increased with the inclusion of husk,with a reduction of 50%in cohesion and an increment of 22%in friction angle for specimens containing RHF compared to the soil without RHF additions.

关键词： Clay soil Rice husk Soil reinforcemen

Corrigendum to “Optimizing the evolution of strength for lime-stabilized rammed soil” [J Rock Mech Geotech Eng 11(2019)882-891]

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Journal of Rock Mechanics and Geotechnical Engineering 2020年第1期12卷 212-212页

作者： Jair de Jesús Arrieta Baldovino ronaldo luis dos santos izzo Eclesielter Batista Moreira Juliana Lundgren Rose Department of Civil Construction Federal University of Technology-ParanaCampus CuritibaCuritibaBrazil

The authors regret that in the paper of Baldovino et al.(2019),published in Journal of Rock Mechanics and Geotechnical Engineering(JRMGE),Eq.(2)must be ***.(2)in the original paper describes a formula to calculate the unconfined compressive strength(q_u).But Authors wrote it as if it were the formula for calculating the split tensile strength(qt).To amend this error,Eq.(1)and Eq.(2)are the correct expressions for q_u and q_t measurements,respectively.

关键词： Corrigendum to J Rock Mech Geotech Eng 11 Optimizing the evolution of strength for lime-stabilized rammed soil

New avenues for the treatment of immunotherapy-resistant pancreatic cancer

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1134-1153页

作者： luis Guilherme de Oliveira Silva Fabian Fellipe Bueno Lemos Marcel Silva Luz Samuel Luca Rocha Pinheiro Mariana dos santos Calmon Gabriel Lima Correa santos Gabriel Reis Rocha Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

Pancreatic cancer(PC)is characterized by its extremely aggressive nature and ranks 14th in the number of new cancer cases ***,due to its complexity,it ranks 7th in the list of the most lethal cancers *** pathogenesis of PC involves several complex processes,including familial genetic factors associated with risk factors such as obesity,diabetes mellitus,chronic pancreatitis,and *** in genes such as KRAS,TP53,and SMAD4 are linked to the appearance of malignant cells that generate pancreatic lesions and,consequently,*** this context,some therapies are used for PC,one of which is immunotherapy,which is extremely promising in various other types of cancer but has shown little response in the treatment of PC due to various resistance mechanisms that contribute to a drop in immunotherapy *** is therefore clear that the tumor microenvironment(TME)has a huge impact on the resistance process,since cellular and non-cellular elements create an immunosuppressive environment,characterized by a dense desmoplastic stroma with cancerassociated fibroblasts,pancreatic stellate cells,extracellular matrix,and immunosuppressive *** to this are genetic mutations in TP53 and immunosuppressive factors that act on T cells,resulting in a shortage of CD8+T cells and limited expression of activation markers such as *** this way,finding new strategies that make it possible to manipulate resistance mechanisms is ***,techniques such as the use of TME modulators that block receptors and stromal molecules that generate resistance,the use of genetic manipulation in specific regions,such as microRNAs,the modulation of extrinsic and intrinsic factors associated with T cells,and,above all,therapeutic models that combine these modulation techniques constitute the promising future of PC ***,this study aims to elucidate the main mechanisms of resistance to immunotherapy in PC and new ways of manipulating thi

关键词： Pancreatic cancer Immunotherapy Resistance Tumor microenvironment manipulation Combined immunotherapy

Diversity of filamentous fungi in leaf litter and aerial litter in semideciduous forest,Bahia,Brazil

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Journal of Forestry Research 2015年第2期26卷 479-485页

作者： Marcos Fabio Oliveira Marques Edemir Barbosa dos santos luis Fernando Pascholati Gusmaao Laborato rio de Biologia Molecular de Fungos Universidade do Estado da BahiaCampus VIIBr 407Km 127Rod.Lomanto JuoniorSenhor do BonfimBA 44230-000Brazil Laboratorio de Micologia (LAMIC) Universidade Estadual de Feira de SantanaCaixa Postal 252Feira de SantanaBA 44036-900Brazil

The fungi have wide distribution in ecosystems and can be found colonizing various substrates,where they act as efficient decomposers,participating in cycling of *** present study aimed to assess the diversity,richness and composition of filamentous fungi in leaf litter and aerial litter in a semi-deciduous forest in the Chapada Diamantina,Bahia,*** of leaf litter and aerial litter were collected monthly from October/2009 to September/2010 in eight installments in the studied *** samples were washed,placed in moist chambers and incubated.47 taxa were identified,37 in leaf litter and 35 in aerial litter,with 25 species common to both.A similarity of 69 % according to Sorensen *** similarity was considered low when the sample points were compared to the same *** fungi showed sporadic intervals.

关键词： Plant debris Species richness Tropical microfungi

Nutrition and exercise can attenuate inflammatory and psychobiological changes in hypoxia?

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Asian Pacific Journal of Tropical Biomedicine 2017年第1期7卷 86-90页

作者： Aline Venticinque Caris Wanessa Ysis Valdir de Aquino Lemos Ricardo Bottura ronaldo Vagner Thomatieli dos santos Department of Psychobiology Federal University of Sao Paulo(UNIFESP)SantosBrazil Department of Bioscience Federal University of Sao Paulo(UNIFESP)SantosBrazil

Exposure to hypoxia causes damage in several physiological systems, whose tissues are dependent on the O2 supply. Recently, there has been growing attention on the immunosuppressive and inflammatory potential of the hypoxia, including stimulation, nuclear factor kappa B pathway in macrophages and Th2 response from lymphocytes. These changes may result in transient immunosuppression and happen at the same time to worsening of cognition and other psychobiological aspects. Furthermore, exercise and nutrition, especially glutamine supplementation may provide important role, not pharmacological partially reversing the effects of hypoxia. In fact, recent studies show that moderate exercise can improve cognition in people exposed to hypoxia while the exercise associated with glutamine supplementation can reverse the increase in inflammatory markers and the Th1/Th2 balance. This review aims to bring the light of the discussion about nonpharmacological ways to prevent the effects of hypoxia on the connection between the immune system and the central nervous system.

关键词： Physical exercise High altitude Inflammation Cognition Glutamine

Dealing with Multisource Information for Estuarine Flood Risk Appraisal in Two Western European Coastal Areas

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International Journal of Disaster Risk Science 2022年第2期13卷 199-213页

作者： Ana Rodrigues Rilo Alexandre Manuel de Oliveira Soares Tavares Paula Maria dos santos Freire José luis Zêzere Estuarine and Coastal Zones Unit LNEC-National Civil Engineering Laboratory.1700-075 LisbonPortugal Centre of Geographical Studies Institute of Geography and Spatial PlanningUniversidade de Lisboa1700-066 LisbonPortugal Centre for Social Studies and Earth Sciences Department Coimbra University3030-790 CoimbraPortugal

Estuaries are usually affected by compound flooding triggers that cause diverse territorial *** fluvial flood risk assessment frameworks are well established in the literature,integrated management instruments that deal with estuarine flood risk remain incomplete and often *** research presents a methodology to extract relevant information from multiple sources post-event and a database building process that is applied to two contrasting estuaries(the Tagus River estuary in Portugal,and the Shannon River estuary in Ireland)in the Western European coastal ***,a total of 274 documents were analyzed and the information was stored in two *** correspondence analysis was applied to extract the most informative and relevant estuarine flood *** integrated estuarine flood risk assessment framework is presented and discussed based on the extracted *** framework is driven by two distinct dimensions(oceanic and hydrographic)and revealed the transversal position of triggers of estuarine floods,reflecting the compounding effects usually present in these *** results also highlight two levels of flood risk mostly based on damage typology.

关键词： Estuarine floods Estuarine flood indicators Multiple correspondence analysis Post-hazard multisource information Western Europe

Development of Junction Elements from Study of the Bionics

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Journal of Bionic Engineering 2007年第1期4卷 41-46页

作者： Wilson Kindlein Junior luis Henrique Alves Cndido André Canal Marques Sandra Souza dos santos Maurício da Silva Viegas Laboratory of Design and Material Selection-LdSM-Materials Department (DEMAT) School of Engineering–EE Federal University of Rio Grande do Sul-Brazil-UFRGS Brazil

The applications of bionic methodology developed by the Laboratory of Design and Material Selection as basis in the creation of junction elements were demonstrated. These elements favor the application of Ecodesign in reference to the effectiveness of product dismount aiming the reduction of ambient impact in all its phases of use. The creation, the development and the confection of new junction elements were described, and case studies of new products developed specifically with this purpose were presented.

关键词： bionics Ecodesign junction elements

Examining effective use of data sources and modeling algorithms for improving biomass estimation in a moist tropical forest of the Brazilian Amazon

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International Journal of Digital Earth 2017年第10期10卷 996-1016页

作者： Yunyun Feng Dengsheng Lu Qi Chena Michael Keller Emilio Moran Maiza Nara dos-santos Edson luis Bolfe Mateus Batistella The Nurturing Station for the State Key Laboratory of Subtropical Silviculture Key Laboratory of Carbon Cycling in Forest Ecosystems and Carbon Sequestration of Zhejiang ProvinceSchool of Environmental&Resource SciencesZhejiang Agriculture and Forestry UniversityLin AnPeople’s Republic of China Center for Global Change and Earth Observations Michigan State UniversityEast LansingMIUSA Department of Geography University of Hawaii at ManoaHonoluluHIUSA Brazilian Agricultural Research Corporation–Embrapa Informática Agropecuária CampinasBrazil USDA Forest Service International Institute of Tropical ForestryRio PiedrasPRUSA Brazilian Agricultural Research Corporation–Embrapa Secretariat of Intelligence and Macro StrategyBrasíliaBrazil Brazilian Agricultural Research Corporation(Embrapa) BrasíliaBrazil

Previous research has explored the potential to integrate lidar and optical data in aboveground biomass(AGB)estimation,but how different data sources,vegetation types,and modeling algorithms influence AGB estimation is poorly *** research conducts a comparative analysis of different data sources and modeling approaches in improving AGB ***-based spectral responses and textures,lidar-derived metrics,and their combination were used to develop AGB estimation *** results indicated that(1)overall,RapidEye data are not suitable for AGB estimation,but when AGB falls within 50–150 Mg/ha,support vector regression based on stratification of vegetation types provided good AGB estimation;(2)Lidar data provided stable and better estimations than RapidEye data;and stratification of vegetation types cannot improve estimation;(3)The combination of lidar and RapidEye data cannot provide better performance than lidar data alone;(4)AGB ranges affect the selection of the best AGB models,and a combination of different estimation results from the best model for each AGB range can improve AGB estimation;(5)This research implies that an optimal procedure for AGB estimation for a specific study exists,depending on the careful selection of data sources,modeling algorithms,forest types,and AGB ranges.

关键词： Lidar RapidEye aboveground biomass moist tropical forest support vector regression random forest linear regression stratification