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Proton nuclear magnetic resonance-based metabonomic models for non-invasive diagnosis of liver fibrosis in chronic hepatitis C:Optimizing the classification of intermediate fibrosis

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World Journal of Hepatology 2018年第1期10卷 105-115页

作者： Andrea Dória Batista Carlos Jonnatan Pimentel Barros Tássia Brena Barroso Carneiro Costa Michele Maria Goncalves de Godoy ronaldo dionísio silva Joelma Carvalho Santos Mariana Montenegro de Melo Lira Norma ThoméJucá Edmundo Pessoa de Almeida Lopes Ricardo Oliveira silva Postgraduate Program in Tropical Medicine Center for Health SciencesUniversidade Federal de PernambucoRecifePernambuco 50670-901Brazil Department of Gastroenterology and Hepatology Hospital das ClínicasUniversidade Federal de PernambucoRecifePernambuco 50670-901Brazil Department of Fundamental Chemistry Center for Exact and Nature SciencesUniversidade Federal de PernambucoRecifePernambuco 50670-901Brazil Intensive Care Unit Hospital das ClínicasUniversidade Federal de PernambucoRecifePernambuco 50670-901Brazil Department of Pathology Hospital das ClínicasUniversidade Federal de PernambucoRecifePernambuco 50670-901Brazi

AIM To develop metabonomic models(MMs), using 1 H nuclear magnetic resonance(NMR) spectra of serum, to predict significant liver fibrosis(SF: Metavir ≥ F2), advanced liver fibrosis(AF: METAVIR ≥ F3) and cirrhosis(C: METAVIR = F4 or clinical cirrhosis) in chronic hepatitis C(CHC) patients. Additionally, to compare the accuracy of the MMs with the aspartate aminotransferase to platelet ratio index(APRI) and fibrosis index based on four factors(FIB-4). METHODS Sixty-nine patients who had undergone biopsy in the previous 12 mo or had clinical cirrhosis were included. The presence of any other liver disease was a criterion for exclusion. The MMs, constructed using partial least squares discriminant analysis and linear discriminant analysis formalisms, were tested by cross-validation, considering SF, AF and C. RESULTS Results showed that forty-two patients(61%) presented SF, 28(40%) AF and 18(26%) C. The MMs showed sensitivity and specificity of 97.6% and 92.6% to predict SF; 96.4% and 95.1% to predict AF; and 100% and 98.0% to predict C. Besides that, the MMs correctly classified all 27(39.7%) and 25(38.8%) patients with intermediate values of APRI and FIB-4, respectively. CONCLUsioN The metabonomic strategy performed excellently in predicting significant and advanced liver fibrosis in CHC patients, including those in the gray zone of APRI and FIB-4, which may contribute to reducing the need for these patients to undergo liver biopsy.

关键词： Metabolomics Nuclear magnetic resonance spectroscopy Chronic hepatitis C Liver fibrosis Surrogate markers

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Ultrafast synthesis and sintering of materials in a single running experiment approach by using electric fields

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Journal of Advanced Ceramics 2019年第2期8卷 265-277页

作者： Lílian M.JESUS ronaldo S.silva Jean-Claude M’PEKO Sao Carlos Institute of Physics University of Sao Paulo(USP)P.O.Box:369CEP:13560-970 Sao CarlosSPBrazil Group of Advanced Ceramic Materials Department of PhysicsFederal University of Sergipe(UFS)CEP:49100-000 Sao CristovaoSEBrazil Department of Physics Federal University of Sao Carlos(UFSCar)13560-905 Sao CarlosSPBrazil

Processing of materials in the form of ceramics normally involves several steps including calcination at a relatively low temperature for synthesis of the end-product powder and sintering at a high temperature for *** work we have been developing introduces a novel approach enabling synthesis plus sintering of materials in a single running experiment by using electric fields,ending with dense ceramics that display grains noticeably finer than in conventional *** new paradigm is fully illustrated with experiments conducted on amorphous CaCu3Ti4O12 precursor powder,shown to experience,on heating,crystallization through intermediate phases,followed by chemical reaction leading to synthesis of the end-product powder,plus densification depending on field *** processing time and furnace temperature are considerably reduced,demonstrating that enhanced synthesis and sintering rates applied under field *** results found in Bi2/3Cu3Ti4O12are also *** different factors that may contribute to this unique scenario,including Joule heating,defect generation,and reduction of free energy for nuclei formation promoted by the applied field,are briefly ***,the findings we bring here are exclusive as they show an exploitable way that allows rapid processing of materials with good control over particle and grain coarsening.

关键词： field-assisted processing synthesis sintering microstructure dielectric response

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Mapping summer soybean and corn with remote sensing on Google Earth Engine cloud computing in Parana state – Brazil

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International Journal of Digital Earth 2020年第12期13卷 1624-1636页

作者： Alex Paludo Willyan ronaldo Becker Jonathan Richetti Laíza Cavalcante De Albuquerque silva Jerry Adriani Johann Agricultural Engineering(PGEAGRI) Western ParanáState University(UNIOESTE)CascavelBrazil Geotechnology and Data Science Research Center(GeoScience) Western ParanáState University(UNIOESTE)CascavelBrazil

Brazilian farming influences directly the worldwide ***,fast and reliable information on areas sown with the main crops is essential for planning logistics and public or private commodity market *** farming practices have embraced remote sensing to provide fast and reliable information on commodity ***-to-low resolution free orbital images,such as those from Landsat 8 and Sentinel 2,have been used for crop mapping;however,satellite image processing requires high computing power,especially when monitoring vast ***,cloud data processing has been the only feasible option to deal with a large amount of orbital data and its processing and ***,our goal was to develop a method to map the two main crops(soybeans and corn)in Paraná,one of the major Brazilian state ***-8,Sentinel-2,SRTM+,and field data from 2016 to 2018 were used with the Simple Non-Iterative Clustering segmentation method and the Continuous Naive Bayes classifier,to identify cropped areas.A minimum global accuracy of 90%was found for both *** with field data showed correlations of 0.96 and agreement coefficients no lower than *** ensures mapping quality when using Sentinel and/or Landsat imagery on the GEE platform.

关键词： Continuous Naive Bayes segmentation machine learning land classification

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The“microwave oven”practice in Brazil

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Forensic Sciences Research 2022年第4期7卷 628-632页

作者： Yara Vieira Lemos Luciene Menrique Corradi Melina Calmon silva Lorena de Oliveira Couto Giovanna Hooper Bittencourt Alexander Santos dionísio Adriana Zatti Lima Márcio Alberto Cardoso Eugénia Cunha Forensic Anthropology Laboratory Medico-Legal Institute AndréRoquette in Belo HorizonteMinas GeraisBrazil Medical Sciences Faculty of Minas Gerais Minas GeraisBrazil Brazilian Association of Forensic Anthropology(ABRAF) BrasíliaBrazil.

This article presents a forensic case of an unusual illegal cremation of a person using a process colloquially known as the“microwave oven”practice in *** microwave process involves two actions:placing the victim in a tire stack and then setting the structure on fire using flammable substances to accelerate the *** practice,identified as“necklacing”,has also been reported in other countries such as South *** report presents a case of microwave oven cremation of a body found in a rural area of Minas Gerais,*** forensic work helped determine the biological profile and identity of the victim using radiological *** the microwave oven cremation practice is rare,it can impose challenges for ***,fully understanding this practice can be helpful to the academic and forensic communities.

关键词： Forensic sciences carbonization cremation homicide human identification

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Mechanical properties of a clay soil reinforced with rice husk under drained and undrained conditions

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第10期15卷 2676-2686页

作者： Claudia Regina Bernardi Baldin Maiky Yamato Kawanami Weiner Gustavo silva Costa Vitor Reinaldo Bordignon Cristhyano Cavali da Luz ronaldo Luis dos Santos Izzo Federal University of Technology-Paraná CuritibaBrazil

Fiber-reinforced soils have been increasingly used in geotechnical *** the years,research has sought to understand and investigate the influences of fibers as reinforcement in soilefiber *** study assessed the behavior of clayey soil in the city of Curitiba(Paraná,Brazil),adding rice husk fiber(RHF),an industrial waste from Cooperativa Agroindustrial in Alegrete(Rio Grande do Sul,Brazil).To evaluate the effect of the presence of natural RHF on the mechanical behavior of compacted soil,aspects such as the influence of fiber content and the drained and undrained behaviors of the soil were evaluated through unconfined triaxial compression *** following tests were realized:soil granulometry,specific mass of solids and Atterberg *** were produced in quadruplicate for the soil and mixtures using the RHF contents of 0.5%,0.75%,1%and 1.5%to determine the unconfined compressive strength(UCS).Triaxial tests were realized on a pure soil specimen and the specimens with 1%RHF under confining pressures of 50 kPa,100 kPa,200 kPa and 400 *** interactions at the interface between husk surface and soil were analyzed using scanning electron microscopy(SEM).In UCS tests,specimens with RHF percentages of 1%and 1.5%presented the highest results,with an increment of 36%compared to the soil without *** results of the consolidated drained triaxial compression tests show that in terms of effective stress,there was a small difference in the strength of the compacted pure soil and soil with the addition of *** the undrained tests,the strength increased with the inclusion of husk,with a reduction of 50%in cohesion and an increment of 22%in friction angle for specimens containing RHF compared to the soil without RHF additions.

关键词： Clay soil Rice husk Soil reinforcemen

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Usher syndrome:Genetic diagnosis and current therapeutic approaches

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World Journal of Otorhinolaryngology 2024年第1期11卷 1-17页

作者： Beatriz Rocha Cuzzuol Jonathan Santos Apolonio ronaldo Teixeira da silva Júnior Lorena Sousa de Carvalho Luana Kauany de SáSantos Luciano Hasimoto Malheiro Marcel silva Luz Mariana Santos Calmon Henrique de Lima Crivellaro Fabian Fellipe Bueno Lemos Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

Usher Syndrome(USH)is the most common deaf-blind syndrome,affecting approximately 1 in 6000 people in the deaf *** genetic condition is characterized by a combination of hearing loss(HL),retinitis pigmentosa,and,in some cases,vestibular *** the subtypes of USH,USH type 1 is considered the most severe form,presenting profound bilateral congenital deafness,vestibular areflexia,and early onset *** type 2 is the most common form,exhibiting congenital moderate to severe HL for low frequencies and severe to profound HL for high ***,type 3 is the rarest,initially manifesting mild symptoms during childhood that become more prominent in the first decades of *** dual impact of USH on both visual and auditory senses significantly impairs patients'quality of life,restricting their daily activities and interactions with *** date,9 genes have been confirmed so far for USH:MYO7A,USH1C,CDH23,PCDH15,USH1G,USH2A,ADGRV1,WHRN and *** genes are inherited in an autosomal recessive manner and encode proteins expressed in the inner ear and retina,leading to functional *** non-genetic methods can assist in patient triage and disease extension evaluation,genetic and molecular tests play a pivotal role in providing genetic counseling,enabling appropriate gene therapy,and facilitating timely cochlear implantation(CI).The CRISPR/Cas9 system and viral-based gene replacement therapy have recently emerged as highly promising techniques for treating *** drug therapy,PTC-124 and Nb54 have been identified as promising drug interventions for genetic HL in ***,CI has proven to be critical in the restoration of *** review aims to summarize the genetic and molecular diagnosis of USH and highlight the importance of early diagnosis in Cuzzuol BR et *** and current treatments of USH WJO https://*** 2 January 19,2024 Volume 11 Issue 1 guiding appropriate treatment strategies and i

关键词： Usher syndromes Hearing loss Retinitis pigmentosa Diagnosis Genetic therapies Cochlear implantation Quality of life

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Biomass-glycerol briquettes are not necessarily mechanically stable and energetically effective

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Waste Disposal and Sustainable Energy 2020年第4期2卷 291-303页

作者： Bruno Rafael de Almeida Moreira ronaldo da silva Viana Samuel Dias Moreira Monique dos Santos Lima Anderson Chagas Magalhães Celso Tadao Miasaki JoséClaudio Caraschi Department of Phytosanitary Rural Engineering and SoilsSchool of EngineeringSão Paulo State University(Unesp)Ilha SolteiraSão PauloBrazil Department of Plant Production College of Agricultural and Technological SciencesSão Paulo State University(Unesp)DracenaBrazil São Paulo State University(Unesp) ItapevaSão PauloBrazil

The re-use of glycerol from biodiesel industry as an alternative lubricant for making high-performance briquettes is ***,the technical performance of this agro-industrial residue is not *** study outlines,accordingly,the real risk of introducing glycerol into the co-briquetting of highly caloric by-products of *** production of hybrid briquettes consisted of pressing mixtures of residues of sugarcane and sorghum with the liquid additive at 10,20,and 30 wt.%in bench-scale hydraulic piston presser *** of the blend,briquettes containing the supplement at the highest level as part of their composition ended up being much more hygroscopic(20.10%)and less energetic(3.15 GJ m^(−3)).The explanation for the negative impact of glycerol on the thermomechanical behavior of briquettes would be overconcen-tration of additive capable of effectively defying compacting *** degree of compaction during co-briquetting has likely gone down quickly with a maximizing level of *** long as the additive is not able to lubricate the feedstock suitably,improbability of biomass particles to successfully bond together to form themselves into mechanically stable and energetically effective briquettes is *** lower density(273.80 kg m^(−3))and higher relaxation(22.75%),briquettes with glycerol at 30 wt.%generally were aesthetically ***,these products resisted no longer to handling,transportation,and *** lost their shape easily during emptying and shifting them,thus,releasing larger quanti-ties of biomass to the *** evidence of high-viscosity glycerol capable of limiting safe and effective production of high-performance briquettes for heating and power exists.

关键词： Additive Agro-residues Densification Biosolids Waste-to-energy

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Valorization of semi-solid by-product from distillation of cellulosic ethanol into blends for heating and power

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Waste Disposal and Sustainable Energy 2021年第1期3卷 49-61页

作者： Bruno Rafael de Almeida Moreira Victor Hugo Cruz Matheus Luís Oliveira Cunha Nathaly Proença Lopes Anderson Chagas Magalhães Celso Tadao Miasaki JoséClaudio Caraschi ronaldo da silva Viana Department of Phytosanitary Rural Engineering and SoilsSchool of EngineeringSão Paulo State University(Unesp)Ilha SolteiraSão PauloBrazil Department of Plant Production College of Agricultural and Technological SciencesSão Paulo State University(Unesp)DracenaSão PauloBrazil São Paulo State University(Unesp) ItapevaSão PauloBrazil

Burning down on semi-solid by-product from distillation of cellulosic ethanol to power upstream steps of its manufacturing is ***,this feedstock is homogenous in size and shape,hygroscopic and poorly *** disadvantages make its re-use in the industrial plant very *** of this agro-residue into high-performance blends for heating and power is,accordingly,the scientific point of this *** pilot-scale manufacturing of composite pellets consisted of systematically pressing the residue with sugarcane bagasse at the mass ratios of 1:4,2:4,and 3:4 on an automatic pelletizer machine at 200 MPa and 125℃.The process of compaction lasted for 90 *** and energy density,both increased significantly,from 95.85%to 99.55%and from 27.95 GJ m^(−3) to 32.20 GJ m^(−3) with blending at 3:***,the semi-solid by-product considerably improved the feeding,thus,enabling the layers of particles to go smoothly through the channel-forming die of the ***,blends became stiffer and denser than pellets purely consisting of sugarcane *** evidence of the process of pelleting capable of highly valorizing the semi-solid by-product from distillation of cellulosic bioethanol into mechanically stable and energetically effective hybrid fuel grade biosolids *** major findings of this paper should be of great relevance to ensure safe and effective transportation and storage of biomass in indoor facili-ties where the risk for the generation of dust and fines and the subsequent off-gassing and self-firing is ***,pelletization may optimize the co-generation of heat and steam at the large-scale bioethanol station.

关键词： Fuel grade biosolids Non-woody biomass Pelletization Second-generation biofuel Sustainable waste-to-energy technique

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Transmission of severe acute respiratory syndrome coronavirus 2 via fecal-oral:Current knowledge

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World Journal of Clinical Cases 2021年第28期9卷 8280-8294页

作者： Filipe Antônio França da silva Breno Bittencourt de Brito Maria Luísa Cordeiro Santos Hanna Santos Marques ronaldo Teixeira da silva Júnior Lorena Sousa de Carvalho Samuel de Sousa Cruz Gabriel Reis Rocha Gabriel Lima Correa Santos Kathlen Coutinho de Souza Rebeca Gabrielle Almeida Maciel Daiana silva Lopes Natália Oliveira e silva Márcio Vasconcelos Oliveira Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45002175BahiaBrazil Departamento de Ciências Naturais Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45002175BahiaBrazil Departamento de Bioquímica e Biofísica Universidade Federal da BahiaSalvador 40.110-100BahiaBrazil Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

The pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has resulted in more than 93 million cases and 2 million deaths in the ***-CoV-2 respiratory tract infection and its main clinical manifestations such as cough and shortness of breath are well known to the scientific ***,a growing number of studies have reported SARS-CoV-2-related gastrointestinal involvement based on clinical manifestations,such as diarrhea,nausea,vomiting,and abdominal pain as well as on the pathophysiological mechanisms associated with coronavirus disease ***,current evidence suggests SARS-CoV-2 transmission via the fecal-oral route and aerosol ***,studies have shown a high risk of contamination through hospital surfaces and personal ***,viable SARS-CoV-2 specimens can be obtained from aerosols,which raises the possibility of transmission through aerosolized viral particles from ***,the infection by SARS-CoV-2 via fecal-oral route or aerosolized particles should *** addition,a possible viral spread to sources of drinking water,sewage,and rivers as well as the possible risk of viral transmission in shared toilets become a major public health concern,especially in the least developed *** authors have emphasized the presence of viral RNA and even viable SARS-CoV-2 in human feces,studies on the possible fecal-oral coronavirus disease 2019 transmission become essential to understand better the dynamics of its transmission and,then,to reinforce preventive measures against this infection,leading to a more satisfactory control of the incidence of the infection.

关键词： COVID-19 SARS-CoV-2,Transmission Via fecal-oral

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Non-pharmacological management of pediatric functional abdominal pain disorders:Current evidence and future perspectives

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World Journal of Clinical Pediatrics 2022年第2期11卷 105-119页

作者： Maria Luísa Cordeiro Santos ronaldo Teixeira da silva Júnior Breno Bittencourt de Brito Filipe Antônio França da silva Hanna Santos Marques Vinícius Lima de SouzaGonçalves Talita Costa dos Santos Carolina Ladeia Cirne Natália Oliveira e silva Márcio Vasconcelos Oliveira Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45083-900BahiaBrazil

Functional abdominal pain disorders(FAPDs) are an important and prevalent cause of functional gastrointestinal disorders among children, encompassing the diagnoses of functional dyspepsia, irritable bowel syndrome, abdominal migraine, and the one not previously present in Rome Ⅲ, functional abdominal pain not otherwise specified. In the absence of sufficiently effective and safe pharmacological treatments for this public problem, non-pharmacological therapies emerge as a viable means of treating these patients, avoiding not only possible side effects, but also unnecessary prescription, since many of the pharmacological treatments prescribed do not have good efficacy when compared to placebo. Thus, the present study provides a review of current and relevant evidence on non-pharmacological management of FAPDs, covering the most commonly indicated treatments, from cognitive behavioral therapy to meditation, acupuncture, yoga, massage, spinal manipulation, moxibustion, and physical activities. In addition, this article also analyzes the quality of publications in the area, assessing whether it is possible to state if non-pharmacological therapies are viable, safe, and sufficiently well-based for an appropriate and effective prescription of these treatments. Finally, it is possible to observe an increase not only in the number of publications on the non-pharmacological treatments for FAPDs in recent years, but also an increase in the quality of these publications. Finally, the sample selection of satisfactory age groups in these studies enables the formulation of specific guidelines for this age group, thus avoiding the need for adaptation of prescriptions initially made for adults, but for children use.

关键词： Functional abdominal pain disorder Pediatrics Rome IV Behavioral intervention Nonpharmacological treatment Complementary medicine

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