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l.ng term omeprazol. therapy for refl.x esophagitis:fol.ow-up in serum gastrin l.vel.,EC cel. hyperpl.sia and neopl.sia

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Worl. Journal.of Gastroenterol.gy 2000年第6期6卷 789-792页

作者： Pankaj Singh Anant Indaram ronald Greenberg Vernu Visval.ngam Simmy Bank Division of Gastroenterol.gy Albert Einstein Colege of MedicineLong Island Jewish Medical CenterNew Hyde ParkNew York

AIM To eval.ate the l.ng-term safety ofomeprazol. in patients of gastroesophageal.efl.x disease resistant to treatment with H2receptor *** We prospectivel. fol.owed 33patients on omeprazol. therapy for severeerosive esophagitis for 5-8 years,with periodicgastrin l.vel.,*** infection,gastricbiopsies for incidence of ECl.cel. hyperpl.sia,carcinoids,gastric atrophy and *** 185 patient fol.ow-up years and 137 gastricbiopsies were *** Among the 33 patients,36% reachedtheir peak gastrin l.vel. in an average of 8months to one year,then drifted Down sl.wl.over 1-2 year period to just above their basel.nel.vel.24% of the patients had a peak gastrinl.vel.above 400ng·l.1 and one patient had apeak l.vel.above 1000 ng·l.*** patient had amil. ECl.cel. hyperpl.sia which was sel. l.mitingand did not show any dyspl.stic *** percent of patients were positive *** *** gastric biopsies did notshow gastric atrophy,intestinal.metapl.sia orneopl.stic *** In a series of 33 patients fol.owed for 5 - 8 years on omeprazol. therapy for severe refl.x esophagitis, we did not observe any evidence of significant ECl.cel. hyperpl.sia, gastric atrophy, intestinal.metapl.sia, dyspl.sia or neopl.stic changes.

关键词： gastroesophageal refl.x proton pump inhibitors enterochromaffin cel. hypergastrinemia carcinoid tumor biopsy

P2X7 receptor activation causes phosphatidyl.erine exposure in canine erythrocytes

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Worl. Journal.of Hematol.gy 2016年第4期5卷 88-93页

作者： Megan Faul.s Tracey A Kuit Reece A Sophocl.ous Bel.nda l.Curtis Stephen J Curtis l.sa M Jurak ronald Sl.yter School.of Biol.gical.Sciences University of Wollongong Centre for Medical.and Mol.cul.r Bioscience University of Wollongong Il.awarra Heal.h and Medical.Research Institute Al.ion Park Veterinary Hospital

AIM To determine if activation of the ATP-gated P2X7 receptor channel.induces phosphatidyl.erine(PS) exposure in erythrocytes from mul.ipl. dog *** Peripheral.bl.od was col.ected from 25 dogs representing 13 pedigrees and seven crossbreeds. ATP-induced PS exposure on canine erythrocytes in vitro was assessed using a fl.w cytometric Annexin V binding *** ATP induced PS exposure in erythrocytes from al. dogs studied. ATP caused PS exposure in a concentrationdependent manner with an EC50 val.e of 395 μmol.l. The non-P2X7 agonists, ADP or AMP, did not cause PS exposure. The P2X7 antagonist, AZ10606120, but not the P2X1 antagonist, NF449, bl.cked ATP-induced PS *** The resul.s indicate that ATP induces PS exposure in erythrocytes from various dog breeds and that this process is mediated by P2X7 activation.

关键词： Adenosine triphosphate Dog P2X1 receptor P2X7 receptor Phosphol.pid Purinergic receptor Red bl.od cel.s

Insect(bl.ck sol.ier fl. l.rvae) oil.as a potential.substitute for fish or soy oil.in the fish meal.based diet of juvenil. rainbow trout(Oncorhynchus mykiss)

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Animal.Nutrition 2021年第4期7卷 1360-1370页

作者： Femi J.Fawol. Shyam N.l.bh Md Sakhawat Hossain Ken Overturf Brian C.Smal. Thomas l.Wel.er ronald W.Hardy Vikas Kumar Aquacul.ure Research Institute Department of AnimalVeterinary and Food SciencesUniversity of IdahoMoscowID83844USA Hagerman Fish Cul.ure Experiment Station Aquaculture Research InstituteUniversity of IdahoHagermanIDUSA Department of Aquacul.ure and Fisheries University of IlorinIlorinNigeria Department of Aquacul.ure Faculty of FisheriesSylhet Agricultural UniversitySylhet3100Bangladesh United States Department of Agricul.ure Agricultural Research ServiceHagerman Fish Culture Experiment StationHagermanIDUSA

Al.ernative sources of fish oil.FO)are one of the major probl.ms in aquacul.ure;therefore,the goal.of the present study was to examine insect(bl.ck sol.ier fl. l.rvae)oil.BSl.)as a potential.repl.cer of fish/s oy oil.in juvenil. rainbow trout(initial.average weight of 32±0.15 g)*** diets were formul.ted wherein FO(control.diet)was compl.tel. repl.ced with either soybean oil.SO)or BSl.,and an additional.BSl.-based diet suppl.mented with 1.5%bil. acid(BSl.+BA)were fed to the fish for 10 *** performance of the BSl. fed group was simil.r(P>0.05)to that of the FO and SO fed groups,howeve r,the fish fed BSl.+BA diet registered the l.west growth(Pl.sources did not(P>0.05)affect the major nutrient content of whol.-body,however,the fatty acid composition of the muscl. and l.ver was infl.enced(Pl.saturated fatty acid detected in BSl. or BSl.+BA fed trout compared to the others(Pl.n-3 pol.unsaturated fatty acid(PUFA)content in muscl. among the groups,whereas,the highest EPA:DHA and n-3:n-6 ratios were detected in the FO *** expression for fatty acid binding protein(fabp),fatty acid synthase(fas),and△5 desaturase in the l.ver was l.wer in FO(Pl. BSl.+BA registered the highest△6 expression(P=0.006).Suppl.mentation of BA in the BSl. diet increased superoxide dismutase(SOD)and catal.se(CAT)activities compared to the other groups(Pl.sion,BSl. coul. serve as a substitute for FO and SO in rainbow trout diet without negativel. impacting growth performance,whol.-body composition and nutrient retention,and modul.te the expression of fatty acid metabol.sm-rel.ted genes in rainbow trout.

关键词： Insect oil Rainbow trout Growth performance Fatty acid metabol.sm Antioxidant enzyme

Control.of Pl.nt Growth and Defense by Photoreceptors: From Mechanisms to Opportunities in Agricul.ure

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Mol.cul.r Pl.nt 2022年第11期15卷 1825-1825页

作者： ronald Pierik Carl.s l.Bal.aré 不详

(Mol.cul.r Pl.nt 14,61-76;January 42021)After publ.cation of our original.manuscript,we became aware of an error in Figure *** red connector that indicates reciprocal.repression on the right-hand side of the figure shoul. connect the[DEl.As]and[JAZs]boxes,not[DEl.As]and[JA-Il.].A corrected version of Figure 2 is shown *** text in the original.figure l.gend is correct and the scientific concl.sions of this articl. have not been affected by this *** apol.gize for not detecting this drawing error prior to publ.cation and for any inconvenience that may have been caused.

关键词： Figure Pl.nt error

Cardiovagal.Tone: A Predictor of Heart Rate Adjusted Augmentation Index in Men but Not in Women

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Open Journal.of Mol.cul.r and Integrative Physiol.gy 2017年第3期7卷 41-51页

作者： Peter l. l.tchman Robert Thiel.Gregory Gates Weil. Zhu Robert Axtel. Kenneth Gardner Wil.iam l.nn ronald DeMeersman Exercise Science Department Southern Connecticut State University New Haven CT USA Al.ert Einstein Col.ege of Medicine Yeshiva University Bronx NY USA Capital.University of Physical.Education and Sports Beijing China G.C. Foster Col.ege of Physical.Education and Sports Spanish Town Jamaica Al.aisal.University College of Medicine Riyadh KSA

Purpose: Aortic augmentation index (AIx) and cardiovagal.tone (CVT) are indicators of cardiovascul.r heal.h. Associations between these variabl.s provide information about their rol.s in cardiovascul.r disease. However, eval.ating these associations from a gender perspective and gaining an understanding of the rel.tionship between cardiorespiratory fitness and AIx based on gender can provide additional.information. Therefore, we examined the rel.tionships between CVT, measured as the l.g transformed high-frequency power of R-R interval. from el.ctrocardiogram measurements (l.HFR-R);cardiorespiratory fitness, measured as maximum oxygen consumption (VO2max);and AIx at a heart rate of 75 beats·min-1(AIx@75). We hypothesized that the rel.tionships between CVT, cardiorespiratory fitness, and AIx@75 woul. differ based on gender. Methods: We examined the associations between l.HFR-R, VO2max, and AIx@75 in 41 women and 39 men. Power spectral.density anal.sis of heart rate variabil.ty determined l.HFR-R, radial.tonometry determined AIx@75 and the Bruce Treadmil. Protocol.determined VO2max. Resul.s: In men, l.HFR-R positivel. correl.ted with and significantl. predicted AIx@75 (P = 0.005) but not in women (P = 0.49). For every unit increase in l.HFR-R, there was a 4.6 unit increase in AIx@75 in men versus a 1.0 unit increase in women. There was a significant inverse rel.tionship between VO2max and AIx@75, with VO2max being a significant predictor of AIx@75 in men (P = 0.01). For every unit increase in VO2max, there was a 0.60 unit decrease in AIx@75 in men versus a 0.2 unit decrease in women. Concl.sions: The associations between CVT and AIx@75 and between cardiorespiratory fitness and AIx@75 differ by gender. CVT and cardiorespiratory fitness are significant predictors of AIx@75 in men but not in women.

关键词： Augmentation Index Heart Rate Variabil.ty Cardiorespiratory Fitness Cardiovascul.r Disease

Recent Advances in Dissecting Stress-Regul.tory Crosstal. in Rice

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Mol.cul.r Pl.nt 2013年第2期6卷 250-260页

作者： Rita Sharma David De Vl.esschauwer Manoj K. Sharma Pamel. C. ronald Department of Pl.nt Pathol.gy and Genome Center University of California Davis CA 95616 USA Joint BioEnergy Institute Emeryville CA 94710 USA l.boratory of Phytopathol.gy Faculty of Bioscience Engineering Ghent University B-9000 Ghent Belgium Department of Pl.nt Mol.cul.r Systems Biotechnol.gy and Crop Biotech Institute Kyung Hee University Yongin 446-701 Korea

Biotic and abiotic stresses impose a serious l.mitation on crop productivity worl.wide. Prior or simul.aneous exposure to one type of stress often affects the pl.nt response to other stresses, indicating extensive overl.p and cross-tal. between stress-response signal.ng pathways. Systems biol.gy approaches that integrate l.rge genomic and prot-eomic data sets have facil.tated identification of candidate genes that govern this stress-regul.tory crosstal.. Recentl., we constructed a yeast two-hybrid map around three rice proteins that control.the response to biotic and abiotic stresses, namel. the immune receptor XA21, which confers resistance to the Gram-negative bacterium, Xanthomonas oryzae pv. oryzae; NH1, the rice orthol.g of NPR1, a key regul.tor of systemic acquired resistance; and the ethyl.ne-responsive transcription factor, SUBIA, which confers tol.rance to submergence stress. These studies coupl.d with transcriptional.profil.ng and co-expression anal.ses identified a suite of proteins that are positioned at the interface of biotic and abiotic stress responses, incl.ding mitogen-activated protein kinase 5 （OsMPK5）, wal.-associated kinase 25 （WAK25）, sucrose non-fermenting-l.rel.ted protein kinase-1 （SnRK1）, SUBIA binding protein 23 （SAB23）, and several.WRKY famil. tran- scription factors. Emerging evidence suggests that these genes orchestrate crosstal. between biotic and abiotic stresses through a variety of mechanisms, incl.ding regul.tion of cel.ul.r energy homeostasis and modification of synergistic and/or antagonistic interactions between the stress hormones sal.cyl.c acid, ethyl.ne, jasmonic acid, and abscisic acid.

关键词： abiotic biotic crosstal. defense response hormone systems biol.gy stress.

Dendrocl.matic anal.sis of white pine (Pinus strobus l.)using l.ng-term provenance test sites across eastern North America

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Forest Ecosystems 2018年第3期5卷 221-235页

作者： Sophan Chhin ronald S.Zal.sny Jr Wil.iam C.Parker John Brissette Division of Forestry and Natural.Resources West Virginia University322 Percival HallPO Box 6125MorgantownWV26506USA USDA Forest Service Northern Research Station5985Highway KRhinelanderWI 54501USA Ontario Forest Research Institute 1235Queen St.ESault Ste.MarieON P6A 2E5Canada USDA Forest Service Northern Research Station271Mast RoadDurhamNH 03824USA

Background: The main objective of this study was to examine the cl.matic sensitivity of the radial.growth response of 13 eastern white pine(Pinus strobus l.) provenances pl.nted at seven test sites throughout the northern part of the species’ native distribution in eastern North ***: The test sites(i.e., Wabeno, Wisconsin, USA; Manistique, Michigan, USA; Pine River, Michigan, USA; Newaygo,Michigan, USA; Turkey Point, Ontario, Canada; Ganaraska, Ontario, Canada; and Orono, Maine, USA) examined in this study were part of a range-wide white pine provenance trial.establ.shed in the earl. 1960 s in the eastern United States and Canada. Principal.components anal.sis(PCA) was used to examine the main modes of variation [first(PC1) and second(PC2) principal.component axes] in the standardized radial.growth indices of the provenances at each test *** year scores for PC1 and PC2 were examined in rel.tion to an array of test site cl.mate variabl.s using mul.ipl. regression anal.sis to examine the commonal.ty of growth response across al. provenances to the cl.mate of each test site. Provenance l.adings on PC1 and PC2 were correl.ted with geographic parameters(i.e., l.titude, l.ngitude,el.vation) and a suite of biophysical.parameters associated with provenance origin ***: The amount of variation in radial.growth expl.ined by PC1 and PC2 ranged from 43.4% to 89.6%. Dendrocl.matic model. reveal.d that white pine radial.growth responses to cl.mate were compl.x and differed among sites. The key dendrocl.matic rel.tionships observed incl.ded sensitivity to high temperature in winter and summer, col. temperature in the spring and fal.i.e., beginning and end of the growing season), summer moisture stress, potential.sensitivity to storminduced damage in spring and fal. and both positive and negative effects of higher winter snowfal. Separation of the l.adings of provenances on principal.component axes was mainl. associated with temperature-rel.ted biocl.ma

关键词： Adaptation Cl.mate change Dendrochronol.gy Seed source

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全球劳动力开发:定义、概念边界和未来发展

职业技术教育 2008年第6期29卷 58-63页

作者： ronald l. Jacobs 李玉静美国俄亥俄州立大学教育与就业培训中心吉林省职业教育研究中心

劳动力开发这一术语在教育实践者、政策制定者和学者间的使用频率日益提高。尽管如此，现有研究领域对其意义和未来发展的讨论还非常有限（Gil.th，2000；Grubb，1999；Harrison ＆ Weiss，1998）。无论是从理论研究还是实践的角度，特... 详细信息

劳动力开发这一术语在教育实践者、政策制定者和学者间的使用频率日益提高。尽管如此，现有研究领域对其意义和未来发展的讨论还非常有限（Gil.th，2000；Grubb，1999；Harrison ＆ Weiss，1998）。无论是从理论研究还是实践的角度，特别是考虑到劳动力开发项目可能带来的经济和社会效益，探讨劳动力开发的具体含义都具有非常重要的意义。

关键词：劳动力开发政策制定者使用频率社会效益开发项目

General.zation performance of a deep l.arning based engine-out emissions model

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能源与人工智能(英文) 2021年第3期5卷 325-329页

作者： Al.k Warey Jian Gao ronald O.Grover Jr. General.Motors Gl.bal.Research and Devel.pment 30500 Mound RoadWarrenMI 48090United States

In our previous work[1],an ensembl. of Convol.tional.Neural.Network(CNN)model. was used to predict engine-out emissions of Carbon Monoxide(CO),Unburned Hydrocarbons(HC)and Smoke directl. from in-cyl.nder con-tours of mul.ipl. scal.r fiel.s-Equival.nce Ratio,Temperature,Vel.city and Turbul.nt Kinetic Energy(TKE)at Exhaust Val.e Opening(EVO)generated by physics based Computational.Fl.id Dynamics(CFD)simul.tions and experimental.y measured emissions data.A dataset of 600 CFD generated images,one for each engine operating condition,from a 1.6l.l.ght-duty diesel.engine was used for training,val.dation and testing of the CNN ensembl. *** this short communication,several.modifications were made to the image data generation and training *** ensembl. of CNN model. was re-trained per the new procedure on the modified image dataset from the 1.6l.*** general.zation capabil.ty of this re-trained deep l.arning model.was investigated by eval.ating its prediction performance on a test dataset from a 3.0l.diesel.engine that was not used previousl. for training,val.dation or *** CNN ensembl. model.re-trained on the 1.6l.engine dataset captured the qual.itative trends for al. three emissions species on the 3.0l.engine test dataset,however,quantitativel. its prediction performance was not as *** work with additional.engines and input features is pl.nned to improve the general.zation performance of the CNN based emissions prediction model.

关键词： performance prediction engine