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Design,Synthesis,and Applications of Mesoporous Covalent Organic Frameworks

2003年

作者： ronald thompson William Cats-Baril.

来源：畅想之星图书光盘版（南... 评论

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CCS Chemistry 2024年第1期6卷 57-68页

作者： Niyati Arora Cassandra Flores Milinda C.Senarathna Christina M.thompson ronald A.Smaldone Department of Chemistry and Biochemistry University of TexasDallasRichardsonTexas 75080

Covalent organic frameworks(COFs)are highly ordered and permanently porous organic polymers that can be classified as two-dimensional or *** tunable design and crystalline order endow a range of pore sizes,shapes,functions,and applications that differentiate them from other *** COF pore sizes and shapes rely on the geometry of the monomers and dynamic covalent chemistry,while the stacking of the sheets relies on noncovalent *** tunability allows for post-modification or the incorporation of additional functional groups for the reinforcement by various noncovalent *** limits of mesoporous COFs are still being investigated,with the design rules continuing to *** we report a comprehensive review of mesoporous COFs,explore strategies for large pore reinforcement,highlight structural design and features,elucidate their various functions and applications,discuss fundamental challenges faced that need to be addressed,and predict future directions.

关键词： covalent organic frameworks mesoporous supramolecular chemistry polymers pore size

δ^(18)O record and temperature change over the past 100 years in ice cores on the Tibetan Plateau

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Science China Earth Sciences 2006年第1期49卷 1-9页

作者： Lonnie thompson Byrd Polar Research Center the Ohio State UniviersityCohumbusOH 43210USBLaboratory of Environment and Process on Tibetan Plateau Institute of Tibetan Plateau Research Chinese Academy of Sciences Beijing 100085 China

The 213 m ice core from the Puruogangri Ice Field on the Tibetan Plateau facilitates the study of the regional temperature changes with its δ18O record of the past 100 years. Here we combine information from this core with that from the Dasuopu ice core (from the southern Tibetan Plateau), the Guliya ice core (from the northwestern Plateau) and the Dunde ice core (from the northeastern Plateau) to learn about the regional differences in temperature change across the Tibetan Plateau. Theδ18O changes vary with region on the Plateau, the variations being especially large between South and North and between East and West. Moreover, these four ice cores present increasing δ18O trends, indicating warming on the Tibetan Plateau over the past 100 years. A comparative study of Northern Hemisphere (NH) temperature changes, the δ18O-reflected temperature changes on the Plateau, and available meteorological records show consistent trends in overall warming during the past 100 years.

关键词： Tibetan Plateau, ice core, temperature.

Beating the blues:engineering cryptochrome expression improves soybean yield

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Molecular Plant 2021年第2期14卷 202-204页

作者： ronald Pierik Plant Ecophysiology Department of BiologyUtrecht UniversityPadualaan 83584 CH Utrechtthe Netherlands

Phytochrome A overexpression can increase harvest index,as was shown 25 years ago in a breakthrough paper on tobacco(Robson et al.,1996).The impact of this important discovery has,however,not been fully *** at high densities often respond strongly to nearby competitors by strong elongation of their internodes and upward bending of their leaves,i.e.,shade *** is crucial for plants to ascertain access to sunlight,and this navigation through vegetation occurs through light cues that are sensed with various photoreceptors.A spectacular sensitivity is displayed by sun-loving plants that can already sense their nearby competitors even before mutual shading occurs and respond through a first acceleration of shoot *** anticipatory response is triggered through red(R):far-red(FR)light-sensitive phytochrome photoreceptors that detect FR light that is reflected by nearby *** the vegetation continues to grow and true shading occurs,there is also a significant depletion of red and blue light,since the latter two are absorbed for photosynthesis in the overhead leaves(reviewed in Pierik and Ballaré,2021).Plants can respond to blue light depletion,especially when integrating it with signaling of FR enrichment in Arabidopsis(de Wit et al.,2016).

关键词： depletion soybean breakthrough

Geometric morphometric analysis of the early Pleistocene hominin teeth from Jianshi,Hubei Province,China

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Science China Earth Sciences 2010年第8期53卷 1141-1152页

作者： ronald CLARKE University of the Witwatersrand JohannesburgSouth Africa

Although the early Pleistocene hominin fossils found in East Asia continent are widely recognized as the earliest hominins migrated from Africa, debates remain on the morphology and taxonomy of these fossils. In this study, dental crown shape of the three early Pleistocene hominin teeth (P3, M1, and M1) found in Jianshi, Hubei Province of China was analyzed by means of geometric morphometrics. The comparative samples of fossil hominins from Africa, Asia, and Europe as well as those of modern humans (N=257) were used. The results indicate that the contour, asymmetry, and cusp patterns of these three types of teeth differ obviously between the fossil hominins and modern humans. The crown shape of P3 in most fossil hominins including Australopithecus, African early Homo, and Asian Pleistocene hominins are asymmetric with their crown occlusal contours long and curving elliptic-shaped. The occlusal contour of the fossil hominin M1 is symmetric and rectangle-shaped with no marked cusp protrusion. The crown shape of fossil M1 is characterized by asymmetric contour with slightly projected metaconid and hypoconid. On the contrary, in modern Chinese and some European late Pleistocene hominins, the crowns of P3s show symmetric contours with buccal side wider than lingual side; the crown shape of M1 is asymmetric with lingual cusp distalplaced, especially for hypoconid; the M1 has symmetric and round crown contour. Our study reveals that Australopithecus has wide variations in its crown shape, whereas these dental morphospaces of Asian hominins are closely placed. The crown contour, symmetry, and cusp patterns of these three teeth of Jianshi hominin resemble those of Asian early and middle Pleistocene hominins. No marked difference in dental crown shape is shown between the Jianshi hominin and other Chinese Homo erectus, and there is also no evidence in support of the Jianshi hominin's closeness to Australopithecus and African early Homo members.

关键词： human evolution tooth shape geometric morphometric Jianshi Hubei China

Chemokine signaling involving chemokine (C-C motif) ligand 2 plays a role in descending pain facilitation

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Neuroscience Bulletin 2012年第2期28卷 193-207页

作者： ronald Dubner Department of Neural and Pain Sciences School of Dentistry & Program in Neuroscience University of Maryland

Objective Despite accumulating evidence on a role of immune cells and their associated chemicals in mecha- nisms of pain, few studies have addressed the potential role of chemokines in the descending facilitation of persistent pain. The present study was undertaken to test the hypothesis that the chemokine （C-C motif） ligand 2 （CCL2）（commonly known as monocyte chemoattractant protein-1） signaling in the rostral ventromedial medulla （RVM）, a pivotal structure in brainstem pain modulatory circuitry, is involved in descending pain facilitation in rats. Methods An L5 spinal nerve ligation （SNL） was produced in rats under pentobarbital anesthesia. Western blot and immunohistochemistry were used to detect the expression levels of CCL2 and CCL2 receptor （CCR2）, and examine their distributions compared with the neuronal marker NeuN as well as glial markers glial fibrillary acidic protein （GFAP, astroglial） and CD 11 b （microglial）, respectively. Results SNL induced an increase in CCL2 expression in the RVM, and this returned to the control level at 4 weeks after injury. The induced CCL2 colocalized with NeuN, but not with GFAP and CD1 lb. CCR2 was also upregu- lated by SNL in the RVM, and this increase lasted for at least 4 weeks. CCR2 was colocalized with CD1 lb but not GFAP. Few RVM neurons also exhibited CCR2 staining. Neutralizing CCL2 with an anti-CCL2 antibody （0.2-20 ng） or injecting RS-102895 （0.1-10 pmol）, a CCR2b chemokine receptor antagonist, into the RVM on day 1 after SNL, significantly at- tenuated the established thermal and mechanical hypersensitivity. In addition, injection of recombinant rat CCL2 （0.03-3 pmol） into the RVM induced dose-dependent hyperalgesia, which was prevented by pretreatment with RS-102895 （10 pmol）. Interleukin-β （IL-1]3）, a potent inducer of neuronal CCL2, was also selectively upregulated in RVM reactive as- trocytes. Injection of IL-1 ]3 （120 fmol） into the RVM induced behavioral hyperalgesia, which was blocked by RS-102895 （10 pmol

关键词： monocyte chemoattractant protein-l chemokine (C-C motif) receptor 2 rostral ventromedial medulla neu-ron-glial interaction neuropathic pain rat

Artificial enzymes,cancer chemotherapy,conjugation and nanoelectronics,and prebiotic chemistry

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Science China Chemistry 2011年第12期54卷 1803-1814页

作者： BRESLOW ronald Department of Chemistry Columbia University

This is a summary,with extensive references,of several areas of chemistry in which the Breslow lab has been involved,leading to work still underway in several of *** principal conclusions are described,but it will be ... 详细信息

关键词： artificial enzymes cancer chemotherapy conjugation and nanoelectronics prebiotic chemistry

Epidemiology of Sexual dysfunction in Asia compared to the rest of the world

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Asian Journal of Andrology 2011年第1期13卷 152-158页

作者： ronald W Lewis Section of Urology Medical College of Georgia Augusta GA 30912 USA

There have been a limited number of epidemiological studies published on sexual disorders in persons from Asia. This paper aims to assess the reports of sexual dysfunction epidemiological studies published in the English language that involved Asian countries. Key points are summarized in this paper from nine epidemiological papers on sexual dysfunction from Asia that were published in the English language. Seven met the criteria for evidence-based studies reaching a Prins score of at least 10 or more. Papers included in this report came from national and regional representative studies in peer review journals. These results for sexual dysfunction in the nine papers are summarized for various sexual dysfunctions in men and women in Asian countries. In three of these, worldwide data were presented in the same paper allowing comparisons with Asian data on prevalence rates. Detailed descriptions from each of these studies are presented in paragraph form. More detailed data on erectile dysfunction （ED） is presented in a tabular form. Collectively, there seems to be a need for country- and population-specific further descriptive and analytical epidemiological studies in all of the sexual disorders from Asia. This critical review paper should help guide these studies for reachinj[ evidence-based literature standards.

关键词： descriptive epidemiology male and female dysfunction male ED premature ejaculation

Joy of gardening: a hospital-based cooking and gardening program

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World Journal of Pediatrics 2020年第5期16卷 533-536页

作者： Grace Kim Kirsten thompson Department of Pediatrics University of WashingtonSeattleWA 98105USA Department of Nutrition Seattle Children's HospitalOC 7.820PO Box 5371SeattleWA 98105USA

Background Nutrition interventions aid in implementing healthy ***-enhanced nutrition intervention programs have been conducted in *** sought to assess feasibility of a hospital-based cooking and gardening *** The cohort study implemented a 3-week integrated cooking and gardening program in the United States(Seattle,WA).We recruited participants with ages 8-15 years from ambulatory *** conducted three 3-week series hospitalbased cooking and gardening *** and parents were given pre-and post-program(1 year)*** surveys assessed child participation in food preparation and gardening,strengths and weaknesses of the program,and identified parents'opinions towards sustaining healthy *** Eighteen children participated in the hospital-based cooking and gardening *** l-year follow-up,78%of participants were gardening at home and 100%of participants were cooking at *** Novel approaches to combat obesity are needed.A hospital-based cooking and gardening program is a novel intervention to consider for nutrition education.

关键词： Child nutrition Community health education Health education Healthy lifestyle Healthy nutrition

Emerging therapeutic options for the management of hepatitis C infection

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World Journal of Gastroenterology 2014年第23期20卷 7079-7088页

作者： J Richard thompson Department of Pharmacy Practice One University Park DriveLipscomb University College of PharmacyNashvilleTN 37204United States

Until recently the traditional treatment for hepatitis C infection included pegylated interferon and ribavirin combination *** sustained virological response(SVR)seen with this combination is poor and requires lengthy treatment to ***,significant side effects and numerous contraindications prevented many patients from being successfully treated with this *** 2011,two new protease inhibitors,telaprevir and boceprevir,were approved for use with pegylated interferon and ribavirin in the United States by the United States Food and Drug *** agents have significantly improved SVR rates;however significant problems with toxicity remain including severe skin rash and *** are a wide range of compounds in late stage development for the future treatment of hepatitis C that exploit many different mechanisms of viral *** of these compounds include additional protease inhibitors,like telaprevir and boceprevir,as well as inhibitors of other nonstructural proteins in the viral genome such as NS5A and NS5B,and compounds that target host proteins within the *** of these agents are being developed for oral administration once daily and various combinations are being assessed for use without the need for pegylated interferon and *** paper reviews agents in late phase development that may be commercially available within 1-2 years.

关键词： Hepatitis C Pharmacotherapy Interferon Ribavirin Protease inhibitors Polymerase inhibitors Cyclophilin inhibitors