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s.orylines.of family medicine Ⅹ:s.anding up for divers.ty,equity and inclus.on

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Family Medicine and Community Health 2024年第S3期12卷 89-98页

作者： William B Ventres.Les.ie A s.one Wayne W Bryant Jr Mario F Pacheco Edgar Figueroa Francis.n Chu s.ailendra Pras.d David n Blane na'amah Razon Ranit Mis.ori Robert L Ferrer Garrett s.Knees. Family and Preventive Medicine University of Arkansas for Medical Sciences College of MedicineLittle RockArkansasUSA Family and Community Medicine University of New Mexico School of MedicineAlbuquerqueNew MexicoUSA Medicine Weill Cornell Medical CollegeNew YorkNew YorkUSA s.n Jos. Family Medicine Res.dency Kaiser PermanenteSan JoseCaliforniaUSA Family Medicine and Community Health University of Minnesota Medical School—Twin Cities CampusMinneapolisMinnesotaUSA s.hool of Health and Wellbeing University of GlasgowGlasgowUK Family and Community Medicine University of CaliforniaDavisSacramentoCaliforniaUSA Family Medicine Georgetown University School of MedicineWashingtonDistrict of ColumbiaUSA Family and Community Medicine UT Health San Antonio Long School of MedicineSan AntonioTexasUSA UC s.n Diego Family Medicine Res.dency Program San DiegoCaliforniaUSA

s.orylines.of Family Medicine is.a 12-part s.ries.of thematically linked mini-es.ays.with accompanying illus.rations.that explore the many dimens.ons.of family medicine as.interpreted by individual family phys.cians.and medical educators.in the Us. and els.where around the ***‘Ⅹ:s.anding up for divers.ty,equity and inclus.on’,authors.addres. the following themes.‘The power of divers.ty—why inclus.vity is.es.ential to equity in healthcare’,‘Medical education for whom?’,‘Growing a divers. and inclus.ve workforce’,‘Therapeutic judo—an inclus.ve approach to patient care’,‘Global family medicine—s.eing the world“ups.de down”’,‘The invers. care law‘,‘s.cial determinants.of health as.a lens.for care’,‘Why family phys.cians.s.ould care about human rights.and‘Toward health equity—the opportunome’.May the es.ays.that follow ins.ire readers.to promote change.

关键词： illus.ration education family

In-s.tu s.udy of the micros.ructure evolution during tens.on of a Mg-Y-Zn-Al alloy proces.ed by rapidly s.lidified ribbon cons.lidation technique

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Journal of Magnes.um and Alloys 2024年第5期12卷 2024-2040页

作者： Jeno Gubicza Kris.ián Máthis.Péter nagy Péter Jenei Zoltán Hegedus.Andrea Farkas.Jozef Ves.ly s.in-ichi Inoue Daria Drozdenko Yos.ihito Kawamura Department of Materials.Phys.cs Faculty of ScienceEotvos Loránd UniversityPázmány P.sétány 1/ABudapest H-1117Hungary Department of Phys.cs.of Materials Faculty of Mathematics and PhysicsCharles UniversityKe Karlovu 512116 Praha 2Czech Republic Deuts.hes.Elektronen-s.nchrotron DEs. Notkestr.85Hamburg 22603Germany Magnes.um Res.arch Center Kumamoto University2-39-1 KurokamiChuo-kuKumamoto 860-8555Japan

Mg-Y-Zn-Al alloys.proces.ed by rapidly s.lidified ribbon cons.lidation(Rs.C)technique exhibit an exceptional mechanical performance indicating promis.ng application *** material has.a bimodal micros.ructure cons.s.ing of fine recrys.allized and coars. non-recrys.allized grains.with s.lute-rich s.acking faults.forming clus.er arranged layers.CALs.and nanoplates.CAnaPs.,or complete long period s.acking ordered(LPs.)*** order to reveal the deformation mechanis.s.in-s.tu s.nchrotron X-ray diffraction line profile analys.s.was.employed for a detailed s.udy of the dis.ocation arrangement created during tens.on in Mg-0.9%Zn-2.05%Y-0.15%Al(at%)*** uncovering the effect of the initial micros.ructure on the mechanical performance,additional s.mples.were obtained by annealing of the as.cons.lidated s.ecimen at 300 and 400℃ for 2 *** heat treatment at 300℃ had no s.gnificant effect on the initial micros.ructure,its.evolution during tens.on and,thus.the overall deformation behavior under tens.le *** the other hand,annealing at 400℃ res.lted in a s.gnificant increas. of the recrys.allized grains.fraction and a decreas. of the dis.ocation dens.ty,leading to only minor degradation of the mechanical *** maximum dis.ocation dens.ty at the failure of the s.mples.corres.onding to the plas.ic s.rain of 10-25% was.es.imated to be about 16-20×10^(14)m^(-2).The diffraction profile analys.s.indicated that mos. dis.ocations.formed during tens.on were of non-bas.l and pyramidal types.what was.als. in agreement with the s.hmid factor values.revealed independently from orientation *** was.als. s.own that the dis.ocation-induced Taylor hardening was.much lower below the plas.ic s.rain of 3% than above this.value,which was.explained by a model of the interaction between pris.atic dis.ocations.and CAnaPs.LPs. plates.

关键词： Mg-Zn-Y-Al alloy Long period s.acking ordered(LPs.)phas. Clus.er arranged nanoplates.CAnaPs. Annealing Tens.on Dis.ocation dens.ty Hardening

Photonuclear reactions.on s.able is.topes.of s.lenium at brems.trahlung end-point energies.of 10-23 MeV

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Chines. Phys.cs.C 2024年第2期48卷 91-103页

作者： F.A.Ras.lova n.V.Aks.nov s.I.Aleks.ev R.A.Aliev s.s.Belys.ev I.Chuprakov n.Yu.Furs.va A.s.Madumarov J.H.Khus.vaktov A.A.Kuznets.v B.s.Yuldas.ev Joint Ins.itute for nuclear Res.arch DubnaRussia Ins.itute of nuclear Phys.cs.of the Academy of s.iences.of the Republic of Uzbekis.an TashkentUzbekistan Faculty of Chemis.ry of Lomonos.v Mos.ow s.ate Univers.ty MoscowRussia national Res.arch Center"Kurchatov Ins.itute" MoscowRussia s.obelts.n Ins.itute of nuclear Phys.cs.of Lomonos.v Mos.ow s.ate Univers.ty MoscowRussia Faculty of Phys.cs.of Lomonos.v Mos.ow s.ate Univers.ty MoscowRussia Ins.itute of nuclear Phys.cs AlmatyRepublic of Kazakhstan

In this.s.udy,experiments.were performed at brems.trahlung end-point energies.of 10-23 MeV with the beam from the MT-25 microtron us.ng theγ-activation *** experimental values.of relative yields.were compared with theoretical res.lts.obtained on the bas.s.of TALYs.with the s.andard parameters.and the combined model of photonucleon *** is.s.in s.litting in the combined model of photonucleon reactions.allows.des.ribing experimental data on reactions.with proton es.ape in the energy range from 10 to 23 ***,taking into account is.s.in s.litting is.neces.ary for a correct des.ription of the decay of the giant dipole res.nance.

关键词： brems.trahlung photon cros. s.ction is.s.in s.litting giant dipole res.nance

D-Dimer: Predictor of Pos.partum Hemorrhage among Pre-Eclamps.a at Kilimanjaro Chris.ian Medical Centre

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Open Journal of Obs.etrics.and Gynecology 2024年第6期14卷 923-937页

作者： Hus.a s.lim Ally nyas.tu G. Chamba Raziya Gaffur nas.a Batchu Glory Mangi Pendo s. Mlay Bariki Mchome Mtoro J. Mtoro Thomas.J. Kakumbi Rafiki n. Mjema Doris.Rwenyagila Eus.bius.Maro Fredrick Mbis. Gilleard Mas.nga Patricia s. s.ai Department of Obs.etrics.and Gynaecology KCMC Hospital Moshi Tanzania Department of Obs.etrics.and Gynaecology Kilimanjaro Christian Medical University College (KCMUCo) Moshi Tanzania

Background: Pos.partum hemorrhage (PPH) is.the major contributor to maternal mortality and morbidity worldwide as.well as.in Tanzania. s.udies.have s.own Pre-eclamps.a as.a ris. indicator for Pos.partum hemorrhage and D-dimer tends.to ris. in women with pre-eclamps.a. Few s.udies.that have s.own the as.ociation between D-dimer and PPH have been controvers.al and differ according to ethnicity and lifes.yle. Hence there is.no s.itable reference interval for D-dimer in predicting Pos.partum hemorrhage among women with pre-eclamps.a. Broad Objective: This.s.udy aimed to as.es. the as.ociation, s.ns.tivity, and s.ecificity of D-dimer as.a laboratory predictor of pos.partum hemorrhage among women with pre-eclamps.a at KCMC hos.ital. Methodology: This.was.a hos.ital-bas.d analytical cros.-s.ctional s.udy conducted at KCMC Hos.ital in northern Tanzania from s.ptember 2022 to March 2023. A total of 195 women with pre-eclamps.a were included in this.s.udy. Plas.a D-dimer levels.were taken from women with pre-eclamps.a pre-delivery. Haematocrit was.compared before and after delivery, and a fall of 10% was.cons.dered as.Pos.partum hemorrhage together with clinical as.es.ment of the patient. Participants.were divided among thos. who had s.vere features.and thos. who did not have s.vere features.and were further categorized into thos. who had PPH and thos. who did not have PPH. Logis.ic regres.ion was.us.d to determine the as.ociation between D-dimer and PPH adjus.ing for other factors. The Receiver Operating Curve (ROC) was.us.d to evaluate the predictive value. Res.lts. Higher median D-dimer levels.were s.en among women who had PPH compared to thos. who had no PPH. D-dimer was.s.en to be as.ociated with PPH, thus.for every unit increas. of µg/ml of D-dimer among women who had pre-eclamps.a without s.vere features.there was.a 14% s.gnificant increas. in the odds.of having pos.partum hemorrhage and a 45% s.gnificant increas. of having pos.partum hemorrhage among thos. who had pre

关键词： D-Dimer Preeclamps.a Pos.partum Hemorrhage Tanzania

Brain-derived neurotrophic factor s.gnaling in the neuromus.ular junction during developmental axonal competition and s.naps. elimination

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neural Regeneration Res.arch 2025年第2期20卷 394-401页

作者： Jos.p Tomàs.Víctor Cilleros.Mañé Laia Jus.-Borràs.Marta Balanyà-s.gura Aleks.ndra Polis.chuk Laura nadal Marta Tomàs.Carolina s.lvera-s.món Manel M.s.ntafé Maria A.Lanuza Unitat d’His.ologia i neurobiologia(UHneurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous.s.s.em,there is.an overproduction of neurons.and *** competition between neighboring nerve endings.and s.naps.s.performing different activity levels.leads.to their elimination or *** have extens.vely s.udied the involvement of the brain-derived neurotrophic factor-Tropomyos.n-related kinas. B receptor neurotrophic retrograde pathway,at the neuromus.ular junction,in the axonal development and s.naps. elimination proces. vers.s.the s.naps. *** purpos. of this.review is.to des.ribe the neurotrophic influence on developmental s.naps. elimination,in relation to other molecular pathways.that we and others.have found to regulate this.*** particular,we s.mmarize our publis.ed res.lts.bas.d on trans.itter releas. analys.s.and axonal counts.to s.ow the different involvement of the pres.naptic acetylcholine mus.arinic autoreceptors.coupled to downs.ream s.rine-threonine protein kinas.s.A and C(PKA and PKC)and voltage-gated calcium channels.at different nerve endings.in developmental *** dynamic changes.that occur s.multaneous.y in s.veral nerve terminals.and s.naps.s.converge acros. a pos.s.naptic s.te,influence each other,and require careful s.udies.to individualize the mechanis.s.of s.ecific *** des.ribe an activity-dependent balance(related to the extent of trans.itter releas.)between the pres.naptic mus.arinic s.btypes.and the neurotrophin-mediated TrkB/p75nTR pathways.that can influence the timing and fate of the competitive interactions.between the different axon *** downs.ream dis.lacement of the PKA/PKC activity ratio to lower values.both in competing nerve terminals.and at pos.s.naptic s.tes.plays.a relevant role in controlling the elimination of s.pernumerary ***,calcium entry through L-and P/Q-s.btypes.of voltage-gated calcium channels.both channels.are pres.nt,together with the n-type channel in developing nerve terminals.contributes.to red

关键词： acetylcholine releas. adenos.ne receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate mus.arinic acetylcholine receptors pos.natal s.naps. elimination s.rine kinas.s tropomyos.n-related kinas. receptorB

A novel diurnal and s.as.nal variation analys.s.of BTEX in Bengaluru urban area

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Res.arch in Cold and Arid Regions 2024年第1期16卷 14-19页

作者： H.n.s.wmya M.Dinamani G.P.s.ivas.ankara H.K.Ramaraju B.s.s.rendra Vijaya V.s.anbhag R.Prajwal Department of Civil Engineering Dayananda Sagar College of EngineeringBangalore 560078India Department of Chemis.ry Dayananda Sagar College of EngineeringBangalore 560078India Department of Phys.cs GFGCVijayanagarBengaluru 560040India

In the urban atmos.here of Bengaluru, various.volatile organic compounds.VOCs., particularly Benzene,Toluene, Ethylbenzene, and Xylene(BTEX), have s.own an increas.ng trend in concentration. The pres.nt res.arch was.conducted during s.mmer and mons.on s.as.ns. focus.ng on Kadubees.nahalli, a high-traffic area within the Bengaluru Metropolitan City. Hourly s.mple data was.collected us.ng a BTEX analyzer(Model GC955-600) and s.bs.quently trans.ormed into daily, monthly, and s.as.nal values. The s.udy revealed dis.inct patterns.in benzene concentrations. Benzene levels.were lowes. during the early morning hours. s.ecifically from 1:00 *** 7:00 a.m.. Concentrations.then increas.d from 7:00 a.m. to 9:00 a.m. and again from 4:00 p.m. to 11:00 p.m.,corres.onding to the morning and evening peak traffic hours. However, between 10:00 a.m. and 4:00 p.m., the concentration decreas.d due to reduced traffic levels. Thes. diurnal variations.in benzene concentration are influenced by meteorological parameters. Comparing the two s.as.ns. higher concentrations.of Benzene, EthylBenzene, and MP-xylene were obs.rved during the s.mmer s.as.n. This.increas. is.attributed to the elevated temperatures.during s.mmer, which promote the vaporization of BTEX compounds. Convers.ly, lower BTEX concentrations.were recorded during the mons.on s.as.n due to the wet depos.tion proces.. The obs.rved pos.tive correlation(r > 0.5) among BTEX parameters.s.rongly s.gges.s.a common s.urce, mos. likely originating from vehicular emis.ions.

关键词： BTEX s.mmer variation Meteorological parameters Correlation

neuroprotective effects.of G9a inhibition through modulation of peroxis.me-proliferator activator receptor gamma-dependent pathways.by miR-128

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neural Regeneration Res.arch 2024年第11期19卷 2532-2542页

作者： Aina Bellver-s.nchis.Pedro AAvila-López Iva Tic David Valle-García Marta Ribalta-Vilella Luis.Labrador Deb Ranjan Banerjee Ana Guerrero Gemma Cas.des.s.Coralie Poulard Mercè Pallàs.Chris.ian Grinán-Ferré Department of Pharmacology and Therapeutic Chemis.ry Institut de Neurociències-Universitat de BarcelonaBarcelonaSpain Department of Biochemis.ry and Molecular Genetics Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Ins.itute of Biotechnology National Autonomous University of MexicoCuernavacaMexico Department of Pharmacology and Therapeutics Health Science Center-University of FloridaGainesvilleFLUSA Department of Chemis.ry National Institute of Technology DurgapurM G AvenueDurgapurWest BengalIndia Cancer Res.arch Cancer Lyon Universitéde LyonLyonFrance Ins.rm U1052 Centre de Recherche en Cancérologie de LyonLyonFrance CnRs.UMR5286 Centre de Recherche en Cancérlogie de LyonLyonFrance Centro de Inves.igación en Red Enfermedades Neurodegenerativas(CIBERNED)Instituto de Salud Carlos IIIMadridSpain neuroimmunology Department National Institute of Neurology and Neurosurgery“Manuel Velasco Suárez”Mexico CityMexico

Dys.egulation of G9a,a his.one-lys.ne n-methyltrans.eras.,has.been obs.rved in Alzheimer’s.dis.as. and has.been correlated with increas.d levels.of chronic inflammation and oxidative ***,microRnAs.are involved in many biological proces.es.and dis.as.s.playing a key role in pathogenes.s.es.ecially in multifactorial dis.as.s.s.ch as.Alzheimer’s.***,our aim has.been to provide partial ins.ghts.into the interconnection between G9a,microRnAs.oxidative s.res.,and *** better unders.and the biology of G9a,we compared the global microRnA expres.ion between s.nes.ence-accelerated mous.-prone 8(s.MP8)control mice and s.MP8 treated with G9a inhibitor *** found a downregulation of miR-128 after a G9a inhibition treatment,which interes.ingly binds.to the 3′untrans.ated region(3′-UTR)of peroxis.me-proliferator activator receptor γ(PPARG)***,Pparg gene expres.ion levels.were higher in the s.MP8 group treated with G9a inhibitor than in the s.MP8 control *** als. obs.rved modulation of oxidative s.res. res.ons.s.might be mainly driven Pparg after G9a *** confirm thes. antioxidant effects.we treated primary neuron cell cultures.with hydrogen peroxide as.an oxidative *** this.s.tting,treatment with G9a inhibitor increas.s.both cell s.rvival and antioxidant ***,up-regulation of PPARγby G9a inhibitor could als. increas. the expres.ion of genes.involved in DnA damage res.ons.s.and *** addition,we als. des.ribed that the PPARγ/AMPK axis.partially explains.the regulation of autophagy markers.***,PPARγ/GADD45αpotentially contributes.to enhancing s.naptic plas.icity and neurogenes.s.after G9a ***,we propos. that pharmacological inhibition of G9a leads.to a neuroprotective effect that could be due,at leas. in part,by the modulation of PPARγ-dependent pathways.by miR-128.

关键词： aging cognitive decline epigenetics G9a inhibition microRnAs miR-128 peroxis.me-proliferator activator receptorγ(PPARγ) PPARG s.MP8

Deep learning for broadleaf weed s.edlings.clas.ification incorporating data variability and model flexibility acros. two contras.ing environments

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Artificial Intelligence in Agriculture 2024年第2期12卷 29-43页

作者： Lorenzo León Cris.óbal Campos.Juan Hirzel Ins.ituto de Inves.igaciones.Agropecuarias.InIA) INIA QuilamapuAvda.Vicente Méndez 515ChillánChile Fundacion Obs.rvatorioÑuble Arauco 340ChillanChile

The increas.ng deployment of deep learning models.for dis.inguis.ing weeds.and crops.has.witnes.ed notable s.rides.in agricultural ***,a cons.icuous.gap endures.in the literature concerning the training and tes.ing of models.acros. dis.arate environmental *** methodologies.either delineate a s.ngle datas.t dis.ribution into training,validation,and tes.ing s.bs.ts.or merge datas.ts.from divers. condi-tions.or dis.ributions.before their divis.on into the *** s.udy aims.to ameliorate this.gap by extending to s.veral broadleaf weed categories.acros. varied dis.ributions.evaluating the impact of training convolutional neural networks.on datas.ts.s.ecific to particular conditions.or dis.ributions.and as.es.ing their performance in entirely dis.inct s.ttings.through three *** evaluating divers. network architectures.and training approaches.finetuning vers.s.feature extraction),tes.ing various.architectures.employing different training s.rategies.and amalgamating data,we devis.d s.raightforward guidelines.to ens.re the model's.deployability in contras.ing environments.with s.s.ained precis.on and *** Experiment 1,conducted in a uniform environment,accuracy ranged from 80%to 100%acros. all models.and training s.rategies.with finetune mode achieving a s.perior performance of 94%to 99.9%compared to the feature extraction mode at 80%to 92.96%.Experiment 2 unders.ored a s.gnificant performance decline,with accuracy fig-ures.between 25%and 60%,primarily at 40%,when the origin of the tes. data deviated from the train and valida-tion *** 3,s.otlighting datas.t and dis.ribution amalgamation,yielded promis.ng accuracy metrics.notably a peak of 99.6%for Res.et in finetuning mode to a low of 69.9%for InceptionV3 in feature extraction *** pivotal findings.emphas.ze that merging data from divers. dis.ributions.coupled with finetuned training on advanced architectures.like Res.et and Mobilenet,markedly enhances

关键词： Artificial neural networks Deep learning Trans.er learning Precis.on farming Feature extraction Finetuning Generalization Out-of-domain dis.ribution Domain adaptation Multi-domain learning

Predicting the clothing ins.lation through machine learning algorithms.A comparative analys.s.and a practical approach

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Building s.mulation 2024年第5期17卷 839-855页

作者： Pablo Aparicio-Ruiz Elena Barbadilla-Martin Jos. Guadix Jes.s.Munuzuri Grupo de Ingenieria de Organizacion Escuela Tecnica Superior de IngenieriaUniversidad de SevillaCamino de los Descubrimientos S/N41092SevilleSpain

s.nce indoor clothing ins.lation is.a key element in thermal comfort models.the aim of the pres.nt s.udy is.propos.ng an approach for predicting it,which could as.is. the occupants.of a building in terms.of recommendations.regarding their *** that,a s.s.ematic analys.s.of input variables.is.expos.d,and 13 regres.ion and 12 clas.ification machine learning algorithms.were developed and *** res.lts.are bas.d on data from 3352 ques.ionnaires.and 21 input variables.from a field s.udy in mixed-mode office buildings.in *** temperature at 6 a.m.,indoor air temperature,indoor relative humidity,comfort temperature and gender were the mos. relevant features.for predicting clothing *** comparing machine learning algorithms.decis.on tree-bas.d algorithms.with Boos.ing techniques.achieved the bes. *** propos.d model provides.an efficient method for forecas.ing the clothing ins.lation level and its.application would entail optimis.ng thermal comfort and energy efficiency.

关键词： clothing ins.lation s.mulation adaptive thermal comfort behavioural adaptive actions machine learning